Abstract
Background: Blood culture negative sepsis is a diagnostic challenge to both clinicians and microbiologists. We aimed to investigate blood culture negative cases of community-acquired sepsis among children admitted at pediatric intensive care unit of Cairo University Specialized Children Hospital, Egypt. Methodology: Our cross-sectional study was carried out over a period of six months. Electrical cardiometry was used to assess the patients’ status. For blood culture negative samples, broad range bacterial and fungal PCR amplification and sequencing were performed. Results: Among 43 patients, 9 samples were positive to pan bacterial 16srRNA gene, while five samples (20,22,23,24,25) were identified as Helicobacter pylori positive with the following sequence accession numbers respectively (KT198991.1, JQ323580.1, APEL01000010.1, APEL01000010.1, CP007603.1). Patients H pylori positive higher C reactive protein, longer duration of ventilation, higher stroke volume variation and pre-ejection period (P value= 0.005, 0.005, 0.043 & 0.043) Conclusion: Detection of Helicobacter pylori in community acquired septic children alarms the necessity to conduct epidemiological studies on populations of septic shock in countries with high prevalence of H. pylori such as Egypt.
The diagnostic challenge among young onset dementia syndromes and primary psychiatric diseases: Results of a retrospective, 20‐year cross‐sectional study