A Comparison of Near-Infrared Imaging and Computerized Tomography Scan for Detecting Maxillary Sinusitis

2021 ◽  
pp. 000348942110606
Author(s):  
Mehdi Abouzari ◽  
Brooke Sarna ◽  
Joon You ◽  
Adwight Risbud ◽  
Kotaro Tsutsumi ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Computerized Tomography ◽  
Sensitivity And Specificity ◽  
Near Infrared ◽  
Maxillary Sinusitis ◽  
Tertiary Care ◽  
Pixel Intensity ◽  
Sinus Disease ◽  
Nir Imaging ◽  
Average Pixel Intensity

Objective: To investigate the use of near-infrared (NIR) imaging as a tool for outpatient clinicians to quickly and accurately assess for maxillary sinusitis and to characterize its accuracy compared to computerized tomography (CT) scan. Methods: In a prospective investigational study, NIR and CT images from 65 patients who presented to a tertiary care rhinology clinic were compared to determine the sensitivity and specificity of NIR as an imaging modality. Results: The sensitivity and specificity of NIR imaging in distinguishing normal versus maxillary sinus disease was found to be 90% and 84%, normal versus mild maxillary sinus disease to be 76% and 91%, and mild versus severe maxillary sinus disease to be 96% and 81%, respectively. The average pixel intensity was also calculated and compared to the modified Lund-Mackay scores from CT scans to assess the ability of NIR imaging to stratify the severity of maxillary sinus disease. Average pixel intensity over a region of interest was significantly different ( P < .001) between normal, mild, and severe disease, as well as when comparing normal versus mild ( P < .001, 95% CI 42.22-105.39), normal versus severe ( P < .001, 95% CI 119.43-174.14), and mild versus severe ( P < .001, 95% CI 41.39-104.56) maxillary sinus disease. Conclusion: Based on this data, NIR shows promise as a tool for identifying patients with potential maxillary sinus disease as well as providing information on severity of disease that may guide administration of appropriate treatments.

Antroscopy in maxillary sinus disease associated with nasal polyposis

1989 ◽  
Vol 103 (9) ◽  
pp. 861-863 ◽  
Author(s):  
J. G. Gilbert
Keyword(s):  
Maxillary Sinus ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Maxillary Sinusitis ◽  
X Rays ◽  
Sinus Disease ◽  
High Incidence ◽  
Satisfactory Method ◽  
Careful Assessment

AbstractAlthough the association of maxillary sinusitis with nasal polyps is widely recognized little has been written on its precise incidence and degree. Antroscopy of 70 antra with ipsilateral polyps showed a high incidence of mucosal abnormalities, retained secretions and ostial narrowing. Comparison of these findings with pre-operative X-rays showed the latter were unreliable in detecting retained antral fluid. It is concluded that in nasal polyposis the antra warrant careful assessment and that antroscopy is a highly satisfactory method for this purpose.

Computed tomography evidence of dental restoration as aetiological factor for maxillary sinusitis

2000 ◽  
Vol 114 (7) ◽  
pp. 510-513 ◽  
Author(s):  
S. E. J. Connor ◽  
S. V. Chavda ◽  
A. L. Pahor
Keyword(s):  
Computed Tomography ◽  
Periodontal Disease ◽  
Maxillary Sinus ◽  
Maxillary Sinusitis ◽  
Dental Disease ◽  
Restorative Dentistry ◽  
Sinus Disease ◽  
Sinus Floor ◽  
Chronic Maxillary Sinusitis ◽  
Mucosal Thickening

Maxillary sinusitis due to dental causes is usually secondary to periodontal disease or periapical infection and is commonly associated with mucosal thickening of the floor of the maxillary antrum. Computed tomography (CT) is currently the modality of choice for evaluating the extent of disease and any predisposing factors in patients with symptoms of chronic maxillary sinusitis, but it is unable to diagnose dental disease reliably. The presence of restorative dentistry is, however, easily seen at CT and is associated with both periapical and periodontal disease. We aimed to determine whether its presence at CT may predispose to maxillary sinusitis, and in particular to focal mucosal thickening of the sinus floor characteristic of dental origin.Three hundred and thirty maxillary sinus CT images in 165 patients were reviewed for the presence of restorative dentistry in the adjacent teeth, focal maxillary sinus floor mucosal thickening, any maxillary sinus disease (including complete opacification, air fluid levels, diffuse mucosal thickening, focal mucosal thickening) and evidence of a rhinogenic aetiology (osteomeatal complex pathology, mucosal thickening in other sinuses).One hundred and ninety two sinuses adjacent to restorative dentistry and 178 sinuses not adjacent to restorative dentistry were analysed. Focal floor thickening both with, and without, evidence of a rhinogenic aetiology, was significantly more common adjacent to restorative dentistry. Maxillary sinus disease overall was no more common adjacent to restorative dentistry.This work demonstrated that the presence of restorative dentistry predisposes to focal mucosal thickening in the floor of the maxillary sinus and its presence should prompt clinical and radiographical assessment to exclude dental disease as a source of chronic maxillary sinusitis.

scholarly journals Accessory maxillary sinus ostia in superior meatus: a retrospective study and its clinical application

2021 ◽  
Author(s):  
Hsiao-Wei Lu ◽  
Pin-Zhir Chao ◽  
Fei-Peng Lee ◽  
Cheng-Jung Wu ◽  
Hsing-Won Wang
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Maxillary Sinus ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinus ◽  
Maxillary Sinusitis ◽  
Tertiary Care ◽  
Care Hospital ◽  
Computed Tomography Scans ◽  
Superior Meatus

Objectives: To investigate the incidence of accessory maxillary sinus ostia in superior meatus in patients with clinical and radiological signs of maxillary sinusitis and the association with the development of chronic rhinosinusitis. Design: Retrospective study Setting: Tertiary care hospital Participant: 159 patients examined with paranasal sinus computed tomography scans Main outcome measures: We retrospectively evaluated patients who visited the outpatient department at an academic medical facility between January and April 2020 with a clinical diagnosis of chronic rhinosinusitis. Paranasal sinus axial and coronal computed tomography scans were evaluated for accessory maxillary sinus ostia in superior meatus and confirmed by reconstructed three-dimensional simulation images. The demographic information and incidence of accessory ostia in superior meatus were assessed. The Lund–Mackay score was used to rate chronic rhinosinusitis severity. Analysis of variance was performed to correlate the severity of chronic rhinosinusitis with presenting accessory ostia in superior meatus. Results: Of 159 patients (81 males; 78 females), 41.5% had accessory maxillary sinus ostia in superior meatus. Of these, two-thirds were bilateral and one-third was unilateral. The severity of rhinosinusitis was not correlated with having accessory maxillary sinus ostia in superior meatus, but the presence of accessory ostia was significantly associated with less severe chronic rhinosinusitis (P < 0.001). Conclusions: Accessory maxillary sinus ostia in superior meatus are significantly associated with less severe chronic rhinosinusitis and most cases are bilateral.

scholarly journals Reversible Endoscopic Medial Maxillectomy: Endonasal Approach to Diseases of the Maxillary Sinus

2020 ◽  
Vol 24 (02) ◽  
pp. e247-e252 ◽  
Author(s):  
Miguel Soares Tepedino ◽  
Ana Clara Miotello Ferrão ◽  
Hana Caroline Morais Higa ◽  
Leonardo Lopes Balsalobre Filho ◽  
Enrique Iturriaga ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Maxillary Sinusitis ◽  
Case Series ◽  
Inferior Turbinate ◽  
Lateral Wall ◽  
Nasolacrimal Duct ◽  
Sinus Disease ◽  
Patient Series ◽  
Medial Maxillectomy ◽  
Maxillary Diseases

Abstract Introduction The endoscopic access has reduced the morbidity associated with external approaches in diseases of the maxillary sinus. A reversible endoscopic medial maxillectomy (REMM) is presented as an alternative for treatment of benign maxillary diseases. Objective To describe the REMM technique and report four cases of patients with benign maxillary sinus conditions treated through this approach. Methods The present study was divided into two parts: anatomical and case series. Two cadaveric dissections confirmed the feasibility of the REMM approach. The same technique was performed on four consecutive patients with benign maxillary sinus disease. Results The cadaveric dissections confirmed wide exposure to the maxillary cavity, preserving the anatomy of the maxillary sinus. In the patient series, one patient presented with an antrochoanal polyp, one had a silent sinus syndrome, one had a chronic maxillary sinusitis secondary to a gunshot, and the last one had an inverted papilloma in the maxillary sinus. In all of the cases, the REMM approach provided excellent access and adequate resection, as well as preservation of the inferior turbinate, nasolacrimal duct, and lateral wall of the nose (including its osteomucosal component). Finally, all of the patients had an uneventful postoperative course. Conclusion The REMM technique is an excellent surgical approach to benign conditions of the maxillary sinus. It has few limitations and appears to be associated with less morbidity than conventional techniques.

Results of Endoscopic Maxillary Mega-antrostomy in Recalcitrant Maxillary Sinusitis

2008 ◽  
Vol 22 (6) ◽  
pp. 658-662 ◽  
Author(s):  
Do-Yeon Cho ◽  
Peter H. Hwang
Keyword(s):  
Maxillary Sinus ◽  
Revision Rate ◽  
Maxillary Sinusitis ◽  
Maxillofacial Surgery ◽  
Inferior Turbinate ◽  
Symptomatic Improvement ◽  
Sinus Surgery ◽  
Sinus Disease ◽  
Mucus Clearance ◽  
Maxillary Sinuses

Background In patients with chronically diseased maxillary sinuses, poor mucociliary clearance may result from long-standing inflammation or scarring from previous surgery. This subset of patients often has persistent sinus disease despite medical therapy and adequate antrostomy. Endoscopic maxillary mega-antrostomy (EMMA) is a mucosal sparing technique that facilitates mucus clearance and sinus irrigation in terminally dysfunctional maxillary sinuses. EMMA involves extending the antrostomy through the posterior half of the inferior turbinate down to the floor of the nose, creating a significantly enlarged antrostomy. This study describes our results of EMMA in recalcitrant maxillary sinusitis. Methods A retrospective review was performed of patients who underwent EMMA for recalcitrant maxillary sinusitis between July 2005 and September 2007. We studied diagnoses, comorbid factors, clinical efficacy, revision rate, and complications. Results Twenty-eight patients (average age, 48 years) underwent 42 EMMAs for recalcitrant maxillary sinusitis. Average follow-up was 11 months. All patients had previous maxillary sinus surgery (mean = 2.3). Relevant comorbid factors included prior Caldwell-Luc or maxillofacial surgery (16/42), cystic fibrosis (11/42), asthma (11/42), and IgG deficiency (3/42). The most common symptoms reported were facial pain/pressure and purulent rhinorrhea. At the time of the most recent postoperative examination, 74% of patients reported complete resolution of symptoms while 26% reported partial symptomatic improvement. There were no complications and the revision rate was 0%. Conclusion Maxillary sinuses that appear to be terminally diseased may be rehabilitated surgically without the need for surgical stripping. EMMA is an effective and safe treatment option for the management of recalcitrant maxillary sinus disease.

Indications for the Caldwell-Luc approach in the endoscopic era

2005 ◽  
Vol 132 (2) ◽  
pp. 219-220 ◽  
Author(s):  
Geva Barzilai ◽  
Elhanan Greenberg ◽  
Nechama Uri
Keyword(s):  
Surgical Treatment ◽  
Maxillary Sinus ◽  
Surgical Approach ◽  
Nasal Polyposis ◽  
Chronic Sinusitis ◽  
Maxillary Sinusitis ◽  
Dentigerous Cyst ◽  
Inverted Papilloma ◽  
Sinus Disease ◽  
Medial Maxillectomy

OBJECTIVE: Caldwell and Luc described the Caldwell-Luc operation more than 100 years ago as the surgical treatment for maxillary sinus disease. During the last decades less radical interventions using endoscopic approach have mainly replaced the classical procedures done for chronic and recurrent maxillary sinusitis. STUDY DESIGN AND SETTING: Between 1991 and 2002, 62 patients had the Caldwell-Luc approach for different indications. RESULTS: Twenty (32%) patients had chronic sinusitis, 16 (26%) patients had inverted papilloma, 9 (15%) patients had suffered from nasal polyposis, 4 patients (6%) had dentigerous cyst, 4 (6%) patients had fungal ball, and 9 (15%) patients were operated for other indications. CONCLUSIONS: The use of this surgical approach is rational in cases of fungal disease and in endoscopic medial maxillectomy for treating inverted papilloma. In all other cases, the preferred approach should now be endoscopic.

The Role of NIR Fluorescence in MDR Cancer Treatment: From Targeted Imaging to Phototherapy

2020 ◽  
Vol 27 (33) ◽  
pp. 5510-5529
Author(s):  
Zengtao Wang ◽  
Qingqing Meng ◽  
Shaoshun Li
Keyword(s):  
Cancer Treatment ◽  
Near Infrared ◽  
Combined Therapy ◽  
Efflux Pumps ◽  
Cross Resistance ◽  
Great Promise ◽  
Drug Efflux ◽  
Nir Dyes ◽  
Nir Imaging ◽  
Drug Efflux Pumps

Background: Multidrug Resistance (MDR) is defined as a cross-resistance of cancer cells to various chemotherapeutics and has been demonstrated to correlate with drug efflux pumps. Visualization of drug efflux pumps is useful to pre-select patients who may be insensitive to chemotherapy, thus preventing patients from unnecessary treatment. Near-Infrared (NIR) imaging is an attractive approach to monitoring MDR due to its low tissue autofluorescence and deep tissue penetration. Molecular NIR imaging of MDR cancers requires stable probes targeting biomarkers with high specificity and affinity. Objective: This article aims to provide a concise review of novel NIR probes and their applications in MDR cancer treatment. Results: Recently, extensive research has been performed to develop novel NIR probes and several strategies display great promise. These strategies include chemical conjugation between NIR dyes and ligands targeting MDR-associated biomarkers, native NIR dyes with inherent targeting ability, activatable NIR probes as well as NIR dyes loaded nanoparticles. Moreover, NIR probes have been widely employed for photothermal and photodynamic therapy in cancer treatment, which combine with other modalities to overcome MDR. With the rapid advancing of nanotechnology, various nanoparticles are incorporated with NIR dyes to provide multifunctional platforms for controlled drug delivery and combined therapy to combat MDR. The construction of these probes for MDR cancers targeted NIR imaging and phototherapy will be discussed. Multimodal nanoscale platform which integrates MDR monitoring and combined therapy will also be encompassed. Conclusion: We believe these NIR probes project a promising approach for diagnosis and therapy of MDR cancers, thus holding great potential to reach clinical settings in cancer treatment.

scholarly journals Performance Evaluation of Dorsal Vein Network of Hand Imaging Using Relative Total Variation-Based Regularization for Smoothing Technique in a Miniaturized Vein Imaging System: A Pilot Study

2021 ◽  
Vol 18 (4) ◽  
pp. 1548 ◽  
Author(s):  
Kyuseok Kim ◽  
Hyun-Woo Jeong ◽  
Youngjin Lee
Keyword(s):  
Image Quality ◽  
Total Variation ◽  
Near Infrared ◽  
Imaging System ◽  
Histogram Equalization ◽  
Evaluation Performance ◽  
Visual Evaluation ◽  
Évaluation Performance ◽  
Nir Imaging ◽  
Relative Total Variation

Vein puncture is commonly used for blood sampling, and accurately locating the blood vessel is an important challenge in the field of diagnostic tests. Imaging systems based on near-infrared (NIR) light are widely used for accurate human vein puncture. In particular, segmentation of a region of interest using the obtained NIR image is an important field, and research for improving the image quality by removing noise and enhancing the image contrast is being widely conducted. In this paper, we propose an effective model in which the relative total variation (RTV) regularization algorithm and contrast-limited adaptive histogram equalization (CLAHE) are combined, whereby some major edge information can be better preserved. In our previous study, we developed a miniaturized NIR imaging system using light with a wavelength of 720–1100 nm. We evaluated the usefulness of the proposed algorithm by applying it to images acquired by the developed NIR imaging system. Compared with the conventional algorithm, when the proposed method was applied to the NIR image, the visual evaluation performance and quantitative evaluation performance were enhanced. In particular, when the proposed algorithm was applied, the coefficient of variation was improved by a factor of 15.77 compared with the basic image. The main advantages of our algorithm are the high noise reduction efficiency, which is beneficial for reducing the amount of undesirable information, and better contrast. In conclusion, the applicability and usefulness of the algorithm combining the RTV approach and CLAHE for NIR images were demonstrated, and the proposed model can achieve a high image quality.

Development of a Novel SNAP-Epitope Tag/Near-Infrared Imaging Assay to Quantify G Protein-Coupled Receptor Degradation in Human Cells

2021 ◽  
pp. 247255522097979
Author(s):  
Kyung-Soon Lee ◽  
Edelmar Navaluna ◽  
Nicole M. Marsh ◽  
Eric M. Janezic ◽  
Chris Hague
Keyword(s):  
G Protein ◽  
Adrenergic Receptor ◽  
Near Infrared ◽  
Human Cells ◽  
Receptor Subtypes ◽  
G Protein Coupled Receptor ◽  
Functional Responses ◽  
Epitope Tag ◽  
Nir Imaging ◽  
G Protein Coupled

We have developed a novel reporter assay that leverages SNAP-epitope tag/near-infrared (NIR) imaging technology to monitor G protein-coupled receptor (GPCR) degradation in human cell lines. N-terminal SNAP-tagged GPCRs were subcloned and expressed in human embryonic kidney (HEK) 293 cells and then subjected to 24 h of cycloheximide (CHX)-chase degradation assays to quantify receptor degradation half-lives ( t1/2) using LICOR NIR imaging–polyacrylamide gel electrophoresis (PAGE) analysis. Thus far, we have used this method to quantify t1/2 for all nine adrenergic (ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3), five somatostatin (SSTR1, SSTR2, SSTR3, SSTR4, SSTR5), four chemokine (CXCR1, CXCR2, CXCR3, CXCR5), and three 5-HT2 (5HT2A, 5HT2B, 5HT2C) receptor subtypes. SNAP-GPCR-CHX degradation t1/2 values ranged from 0.52 h (ADRA1D) to 5.5 h (SSTR3). On the contrary, both the SNAP-tag alone and SNAP-tagged and endogenous β-actin were resistant to degradation with CHX treatment. Treatment with the proteasome inhibitor bortezomib produced significant but variable increases in SNAP-GPCR protein expression levels, indicating that SNAP-GPCR degradation primarily occurs through the proteasome. Remarkably, endogenous β2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay. We subsequently adapted this assay into a 96-well glass-bottom plate format to facilitate high-throughput GPCR degradation screening. t1/2 values quantified for the α1-adrenergic receptor subtypes (ADRA1A, ADRA1B, ADR1D) using the 96-well-plate format correlated with t1/2 values quantified using NIR-PAGE imaging analysis. In summary, this novel assay permits precise quantitative analysis of GPCR degradation in human cells and can be readily adapted to quantify degradation for any membrane protein of interest.

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