Low-cost management of mushroom poisoning in a limited-resource area: a 12-year retrospective study

Amatoxin poisoning is the main cause of death from accidental ingestion of poisonous mushrooms and a mortality rate of 27.3% has been reported in Thailand. Symptoms of mushroom ingestion are often confused with food poisoning; thus, gastroenteritis is not recognised as the first phase of poisoning. Our study assessed the efficacy of N-acetylcysteine (NAC) as a treatment for amatoxin poisoning. We retrospectively analysed 74 medical records over 12 years. The majority (70/74) were treated successfully with NAC; death in the remaining 4 (5.4%) patients was attributed to late presentation in three and advanced alcoholic cirrhosis in one.

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Wild mushroom poisoning in Kumaon region of Uttarakhand: a case series

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20214856 ◽

2021 ◽

Author(s):

Vinita Nikhurpa ◽

Mamta Nikhurpa

Keyword(s):

Clinical Laboratory ◽

Case Series ◽

Preventive Measure ◽

Mushroom Poisoning ◽

Accidental Ingestion ◽

Mushroom Species ◽

Poisonous Mushroom ◽

Laboratory Profile ◽

Poisonous Mushrooms ◽

Renal Support

Mushrooms have been dietary source in hilly and ethnic tribes of India. More than 5000 mushroom species are known worldwide and nearly 100 species are known to be poisonous for humans. Mushroom poisoning occurs due to unintentional and accidental ingestion of poisonous mushroom due to misidentification of poisonous variety as edible one. There has been increasingly incidence of reporting of mushroom poisoning cases nowadays. Here we are reporting case series of 4 patients admitted hailing from same village with accidental ingestion of poisonous mushrooms with clinical-laboratory profile and outcome at our institution. Mushroom Poisoning is an emerging healthcare concern nowadays. Education and mass awareness for identification of poisonous mushrooms is an important preventive measure. Early hospitalization, proper hydration, gastric decontamination, silibinin and N- acetyl cysteine therapy with hepato-renal support constitutes mainstay of treatment. Delay in treatment and complications results in poor prognosis and mortality.

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POISONING CASES OF NOXIOUS SUBSTANCES EATEN AS FOOD: A RETROSPECTIVE STUDY AT A TEACHING HOSPITAL IN MALAYSIA

Malaysian Journal of Public Health Medicine ◽

10.37268/mjphm/vol.21/no.2/art.911 ◽

2021 ◽

Vol 21 (2) ◽

pp. 178-189

Author(s):

Xi Kei Fong ◽

Chia Wei Phan ◽

Noorasyikin Shamsuddin ◽

Liyana Mazni Zulkifli ◽

Yee Shin Tan ◽

...

Keyword(s):

Retrospective Study ◽

Medical Records ◽

Food Poisoning ◽

Male Gender ◽

Mushroom Poisoning ◽

Limited Information ◽

Poisoning Case ◽

Poisonous Mushroom ◽

The University ◽

Noxious Substances

There is limited information regarding the epidemiology of food poisoning in Malaysia as the issue of food poisoning is often perceived as not as huge as compared to other poisoning cases like intoxication by drugs and chemicals. Patients who experience severe food poisoning require hospitalisation, aggressive hydration, and some even require antibiotic treatment. In this study, we aimed to determine an overview of food poisoning cases reported in UMMC. A 10-year retrospective study on the poisoning of other noxious substances eaten as food (ICD10: T62.0-T62.9) in the University of Malaya Medical Centre (UMMC) was performed. A total of 23 medical records of patients, admitted from January 2009 to December 2019 were reviewed. The greatest proportion of food poisoning occurred between the ages of 0 and 9 years, with a predominance of the male gender. Malay patients accounted for most food poisoning cases. All cases of poisoning, including a mushroom poisoning case (T62.0), were accidental. The mushroom poisoning case was then carefully reviewed. To conclude, this study revealed that the most common cause involved in the poisoning was unspecified food poisoning, followed by ingestion of poisonous mushroom. Most patients were given symptomatic and supportive treatments. All patients had favourable outcomes and were discharged with full recovery.

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Rapid and Visual Identification of Chlorophyllum molybdites With Loop-Mediated Isothermal Amplification Method

Frontiers in Microbiology ◽

10.3389/fmicb.2021.638315 ◽

2021 ◽

Vol 12 ◽

Author(s):

Nan Wang ◽

Zhiyong Zhao ◽

Jie Gao ◽

Enjing Tian ◽

Wenjie Yu ◽

...

Keyword(s):

Color Change ◽

Low Cost ◽

Food Poisoning ◽

Lamp Assay ◽

Forensic Analysis ◽

Isothermal Amplification ◽

Mushroom Poisoning ◽

Lamp Method ◽

Mushroom Species ◽

Loop Mediated Isothermal Amplification

Chlorophyllum molybdites is a kind of common poisonous mushroom in China that is widely distributed in different areas. Food poisoning caused by accidentally eating C. molybdites has become more frequent in recent years. In 2019, there were 55 food poisoning incidents caused by eating this mushroom in China. Mushroom poisoning continues to be a common health issue of global concern. When mushroom poisoning occurs, an effective, simple, and rapid detection method is required for accurate clinical treatment or forensic analysis. For the first time, we established a loop-mediated isothermal amplification (LAMP) assay for the visual detection of C. molybdites. A set of specific LAMP primers was designed, and the specificity was confirmed against 43 different mushroom species. The LAMP method could detect as low as 1 pg of genomic DNA. Boiled mushrooms and artificial gastric-digested mushroom samples were prepared to test the applicability of the method, and the results showed that as low as 1% C. molybdites in boiled and digested samples could be successfully detected. The LAMP method can also be completed within 45 min, and the reaction results could be directly observed based on a color change under daylight by the naked eye. Therefore, the LAMP assay established in this study provides an accurate, sensitive, rapid, and low-cost method for the detection of C. molybdites.

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Development of IoT Enabled Low Cost Management System for m-Cardiology

SSRN Electronic Journal ◽

10.2139/ssrn.3573502 ◽

2020 ◽

Author(s):

Devashish Sen ◽

Rohini Srivastava ◽

Nitin Sahai ◽

R. P. Tewari ◽

Basant Kumar

Keyword(s):

Management System ◽

Cost Management ◽

Low Cost ◽

Cost Management System

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Aryepiglottoplasty for Severe Laryngomalacia

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1070 ◽

2014 ◽

Vol 4 (1) ◽

pp. 10-12

Author(s):

Akanksha Saxena ◽

Madhumita Kumar ◽

Bini Faizal

Keyword(s):

Retrospective Review ◽

Medical Records ◽

Low Cost ◽

Favorable Outcome ◽

Medical Sciences ◽

Common Cause

ABSTRACT Laryngomalacia is the most common cause of stridor in children below the age of 1 year. In majority of the cases it can be managed conservatively, but in severe cases intervention becomes necessary. Objectives To evaluate the outcome of aryepiglottoplasty (Cold steel method) in cases of severe laryngomalacia. Methods Retrospective. Review of medical records of 8 cases treated in Department of ENT, Amrita Institute of Medical Sciences from 2006 to 2011. Results Seven out of eight children had a favorable outcome. Conclusion Aryepiglottoplasty (Cold steel method) is an efficient, simple and low cost method for treating severe cases of laryngomalacia. How to cite this article Saxena A, Kumar M, Faizal B. Aryepiglottoplasty for Severe Laryngomalacia. Int J Phonosurg Laryngol 2014;4(1):10-12.

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AnemoCheck-LRS: an optimized, color-based point-of-care test to identify severe anemia in limited-resource settings

BMC Medicine ◽

10.1186/s12916-020-01793-6 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Marina S. Perez-Plazola ◽

Erika A. Tyburski ◽

Luke R. Smart ◽

Thad A. Howard ◽

Amanda Pfeiffer ◽

...

Keyword(s):

Screening Tool ◽

Point Of Care ◽

Low Cost ◽

Limited Resource ◽

Absolute Difference ◽

Severe Anemia ◽

Detection Range ◽

Point Of Care Test ◽

Colour Scale ◽

Life Saving

Abstract Background Severe anemia is common and frequently fatal for hospitalized patients in limited-resource settings. Lack of access to low-cost, accurate, and rapid diagnosis of anemia impedes the delivery of life-saving care and appropriate use of the limited blood supply. The WHO Haemoglobin Colour Scale (HCS) is a simple low-cost test but frequently inaccurate. AnemoCheck-LRS (limited-resource settings) is a rapid, inexpensive, color-based point-of-care (POC) test optimized to diagnose severe anemia. Methods Deidentified whole blood samples were diluted with plasma to create variable hemoglobin (Hb) concentrations, with most in the severe (≤ 7 g/dL) or profound (≤ 5 g/dL) anemia range. Each sample was tested with AnemoCheck-LRS and WHO HCS independently by three readers and compared to Hb measured by an electronic POC test (HemoCue 201+) and commercial hematology analyzer. Results For 570 evaluations within the limits of detection of AnemoCheck-LRS (Hb ≤ 8 g/dL), the average difference between AnemoCheck-LRS and measured Hb was 0.5 ± 0.4 g/dL. In contrast, the WHO HCS overestimated Hb with an absolute difference of 4.9 ± 1.3 g/dL for samples within its detection range (Hb 4–14 g/dL, n = 405). AnemoCheck-LRS was much more sensitive (92%) for the diagnosis of profound anemia than WHO HCS (22%). Conclusions AnemoCheck-LRS is a rapid, inexpensive, and accurate POC test for anemia. AnemoCheck-LRS is more accurate than WHO HCS for detection of low Hb levels, severe anemia that may require blood transfusion. AnemoCheck-LRS should be tested prospectively in limited-resource settings where severe anemia is common, to determine its utility as a screening tool to identify patients who may require transfusion.

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