Atrial Fibrillation Is Not Associated With Sudden Sensorineural Hearing Loss

Objectives: The aim of this study is to assess the association between atrial fibrillation (AF) and sudden sensorineural hearing loss (SSNHL). Methods: This study was conducted by searching the longitudinal health insurance database of the Taiwan National Health Insurance Program for relevant information from January 1, 2000, to December 31, 2011. Patients with AF were matched with non-AF controls with a 1:1 strategy according to propensity scores. Multiple logistic regression analyses were performed to determine the risk of SSNHL. Results: In total, 14 698 patients with AF were matched with the same number of non-AF patients as controls. After propensity score matching, the use of antiplatelet or anticoagulation medications and the occurrence of SSNHL were found to have a significant difference between AF and non-AF patients. The occurrence of SSNHL was found to be higher in men, those of 45 to 74 years old, and patients with hypertension in both AF and non-AF groups. Multiple logistic regression analyses revealed that male gender, age between 45 and 74 years, hyperlipidemia, and hypertension are risk factors for SSNHL. The use of aspirin was found to reduce the rate of SSNHL (odds ratio [OR]: 0.67, 95% CI: 0.49-0.94, P = .019), but AF was not found to be a risk factor for SSNHL (OR: 0.89, 95% CI: 0.64-1.23, P = .467). Conclusion: The association between AF and SSNHL is not significant.

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Association of αENaC p. Ala663Thr Gene Polymorphism With Sudden Sensorineural Hearing Loss

Frontiers in Genetics ◽

10.3389/fgene.2021.659517 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jialei Chen ◽

Jing He ◽

Jing Luo ◽

Shixun Zhong

Keyword(s):

Hearing Loss ◽

Gene Polymorphism ◽

Sensorineural Hearing Loss ◽

Allele Frequency ◽

Low Frequency ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Control Group ◽

Increased Risk ◽

Significant Difference

Objective: The etiology of sudden sensorineural hearing loss (SSNHL) is still unknown. It has been demonstrated that normal endolymph metabolism is essential for inner ear function and that epithelial sodium channels (ENaC) may play an important role in the regulation of endolymphatic Na+. This study aimed to explore the potential association between αENaC p. Ala663Thr gene polymorphism and SSNHL.Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine the genotype and allele frequency of the αENaC p. Ala663Thr polymorphism in 20 cases of low-frequency SSNHL (LF-SSNHL), 19 cases of high-frequency SSNHL (HF-SSNHL), 31 cases of all frequency SSNHL (AF-SSNHL), 42 cases of profound deafness SSNHL (PD-SSNHL), and 115 normal controls.Results: The T663 allele was found to be significantly associated with an increased risk of LF-SSNHL (p = 0.046, OR = 2.16, 95% CI = 1.01–4.62). The TT genotype and T663 allele, on the other hand, conferred a protective effect for PD-SSNHL (AA vs. TT: p = 0.012, OR = 0.25, 95% CI = 0.08–0.74; A vs. T: p = 0.001, OR = 0.36, 95% CI = 0.21–0.61). However, there was no statistically significant difference in genotype or allele frequency between the two groups (HF-SSNHL and AF-SSNHL) and the control group.Conclusion: The αENaC p. Ala663Thr gene polymorphism plays different roles in different types of SSNHL.

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Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Bioscience Reports ◽

10.1042/bsr20181183 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 1

Author(s):

Shuaifei Ji ◽

Xuemin Chen ◽

Heng Shi ◽

Babo Zhang ◽

Shun Yao ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Meta Analysis ◽

Geographical Area ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Distribution Width ◽

Eastern Country ◽

Standard Mean Difference ◽

Significant Difference

Recent years, the discussion about whether platelets participant in the development of sudden sensorineural hearing loss (SSHL) continues and many studies on the relationship between them have come to our attention. Some studies believe that platelet parameters have significantly changed in patients with SSHL, while some not, controversially. Therefore, to investigate the association between platelet parameters, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PLT), and SSHL, expecting to resolve controversy and provide clinical evidence for diagnosis and monitoring of SSHL. Basic methods: Literature was retrieved searching electronic databases (PubMed, Embase, Cochrane, and Scopus) and searching references of related articles by hand. A total of 18 case–control studies involving 1837/1734 subjects (SSHL/control) were included. Meta-analysis showed there was no difference between the patients who suffered SSHL and healthy controls in MPV level [standard mean difference (SMD) (95% confidence interval (CI)) = 0.16 (−0.07, 0.40), I2 = 80%, P<0.00001] and PLT [SMD (95% CI) = −0.03(−0.18, 0.12), I2 = 73%, P<0.00001]. While PDW exhibited significant difference [SMD (95% CI) = 0.85 (0.20, 1.49), I2 = 93%, P<0.00001]. Subgroup analysis about geographical area suggested PLT have obvious evidence for SSHL in Eastern country [SMD (95% CI) = 0.23 (0.14, 0.33), I2 = 0%, P=0.81]. Our study did not support a correlation between MPV and SSHL, while PLT may have clinical significance for SSHL in Eastern country. With insufficient data to explore the resource of heterogeneity for PDW, there is no decisive conclusion reached.

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Methylenetetrahydrofolate reductase C677T gene mutation as risk factor for sudden sensorineural hearing loss: association with plasma homocysteine, folate and cholesterol concentrations

The Journal of Laryngology & Otology ◽

10.1017/s002221511000099x ◽

2010 ◽

Vol 124 (12) ◽

pp. 1268-1273 ◽

Cited By ~ 6

Author(s):

E J Lee ◽

Y J Cho ◽

Y J Yoon

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Gene Mutation ◽

Methylenetetrahydrofolate Reductase ◽

Gene Mutations ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Reductase Gene ◽

Significant Difference ◽

C677t Mutation

AbstractObjective:Impaired cochlear perfusion appears to be the most important event in the development of sudden sensorineural hearing loss. Methylenetetrahydrofolate reductase gene mutations at nucleotide 677 cause reduced methylenetetrahydrofolate reductase enzyme activity, resulting in vascular impairment.Methods:Thirty-three patients and 68 control subjects underwent audiological and haematological investigation.Results:No statistically significant association was found between sudden sensorineural hearing loss and the methylenetetrahydrofolate reductase C677T gene mutation. Mean homocysteine and cholesterol concentrations were significantly higher in patients than in controls. Mean folate levels were significantly lower in patients than in controls. Amongst patients with sudden sensorineural hearing loss, no significant differences in mean cholesterol, homocysteine or folate concentration were found, comparing patients with methylenetetrahydrofolate reductase C677T mutation genotypes with those without.Conclusion:No statistically significant association was found between the methylenetetrahydrofolate reductase C677T gene mutation and sudden sensorineural hearing loss. There was a statistically significant difference between the homocysteine, folate and cholesterol concentrations of sudden sensorineural hearing loss patients, compared with controls. However, there was no statistically significant difference in these levels, comparing patients with and without the methylenetetrahydrofolate reductase C677T mutation.

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Steroid Therapy in the Management of Sudden Sensorineural Hearing Loss: A Nonrandomized Clinical Trial

Annals of Otology and Neurotology ◽

10.1055/s-0039-1695677 ◽

2019 ◽

Vol 2 (02) ◽

pp. 59-65

Author(s):

Gowri Swaminathan ◽

Ravi Ramalingam ◽

Ramalingam Kombupalayam Kumarappa Gounder

Keyword(s):

Clinical Trial ◽

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Steroid Therapy ◽

Pure Tone Audiometry ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Tertiary Referral Center ◽

Significant Difference ◽

The Mean

Abstract Objective The aim of this study was to compare the effectiveness of intratympanic (IT) steroid therapy and combined intravenous-cum-intratympanic (IVIT) steroid therapy in the management of sudden sensorineural hearing loss (SSNHL). Study Design This was a nonrandomized clinical trial. Setting Tertiary referral center. Patients Forty-four patients, who presented to the outpatient department or the emergency room and those who fulfilled the inclusion criteria, were enrolled in this study. The patients were put into two groups: Group IT—that received intratympanic steroid therapy alone and Group IVIT—that received intratympanic as well as intravenous steroid therapies. Intervention Therapeutic—in the form of IVIT steroid therapy. Main Outcome Measure Impact of the steroid therapy in patients with SSNHL was measured objectively with the help of pure tone audiometry (PTA). The improvement in hearing was assessed in terms of decibels gained after the intervention in both the groups. Results The mean improvement in PTA after 3 months in Group IT was 19.78 (±18.918) dB, whereas the mean improvement after 3 months in Group IVIT was 22.29 (±16.147) dB, statistically showing no significant difference between the groups. Conclusion The authors recommend the use of IT steroid therapy alone in the management of SSNHL.

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Idiopathic Sudden Sensorineural Hearing Loss in Children: A Systematic Review and Meta-analysis

Otolaryngology ◽

10.1177/0194599820976571 ◽

2020 ◽

pp. 019459982097657

Author(s):

Leonardo Franz ◽

Chiara Gallo ◽

Gino Marioni ◽

Cosimo de Filippis ◽

Andrea Lovato

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Case Reports ◽

Meta Analysis ◽

Treatment Options ◽

Case Series ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Systemic Steroid ◽

Significant Difference

Objective Idiopathic sudden sensorineural hearing loss (ISSNHL) is uncommon in children, and its treatment and outcome are debated. We aimed to critically review evidence in the literature about treatment options and functional outcomes of pediatric ISSNHL. Additionally, we performed a meta-analysis of the results of combined systemic-intratympanic steroid therapy versus solely systemic treatment. Data Sources A search was run in the PubMed, Scopus, and Google Scholar databases. Review Methods Included articles were original ISSNHL case series, written in English, with a population age ranging from 2 to 19 years. Other study types (single case reports, editorials, and reviews) and case series with known etiology of sudden hearing loss were excluded. Descriptive data of patients, treatments, outcomes, and possible prognostic factors were extracted and recorded for every included study. Results Twelve articles (7 cohort and 5 case-control studies) met all the selection criteria. Based on only the studies that provided sufficient data about clinical outcome, the pooled overall recovery rate was 67.91% (95% CI, 58.34%-77.48%). No studies showed a significant difference between systemic steroid and combined systemic-intratympanic steroid. The pooled odds ratio for combined systemic-intratympanic steroid versus systemic steroid alone was 0.90 (95% CI, 0.36-2.27) based on a random effects model, ruling out any significant difference between these treatment options. Conclusions The results of our meta-analysis did not support combination therapy more than systemic steroid alone. Further prospective clinical trials are necessary to establish evidence-based therapies.

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Intratympanic Dexamethasone as First-Line Treatment for Selected Patients With Hearing Loss

Revista de Chimie ◽

10.37358/rc.18.3.6155 ◽

2018 ◽

Vol 69 (3) ◽

pp. 587-590

Author(s):

Dragos Cristian Stefanescu ◽

Razvan Hainarosie ◽

Viorel Zainea ◽

Anca Pantea Stoian ◽

Cornelia Nitipir ◽

...

Keyword(s):

Hearing Loss ◽

Health Insurance ◽

Sensorineural Hearing Loss ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Line Treatment ◽

First Line ◽

Intratympanic Dexamethasone ◽

Nose And Throat ◽

First Line Treatment

There is no consensus among ENT (ear, nose and throat) physicians on the causes, diagnosis and especially therapeutic approach in sensorineural hearing loss (SSHL). The present paper describes our experience with intratympanic dexamethasone injection as initial treatment for selected patients with the sudden sensorineural hearing loss. The results obtained were fully encouraging. The sustained and coherent approaches of the national ENT society through his section of otoneurology, can lead to a diagnostic and therapeutic consensus in the sensorineural hearing loss. Further, the National Health Insurance House must introduce in the methodological norms the therapeutic variants and the concrete conditions for their realisation, in order to have a common medical practice.

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Clinical efficacy of initial intratympanic steroid treatment on sudden sensorineural hearing loss with diabetes

Otolaryngology ◽

10.1016/j.otohns.2009.06.084 ◽

2009 ◽

Vol 141 (5) ◽

pp. 572-578 ◽

Cited By ~ 44

Author(s):

Chi-Sung Han ◽

Jong-Ryul Park ◽

Sung-Hyun Boo ◽

Joon-Man Jo ◽

Kyung-Won Park ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Initial Treatment ◽

Sudden Sensorineural Hearing Loss ◽

Steroid Treatment ◽

Sensorineural Hearing ◽

Systemic Steroid ◽

Significant Difference ◽

Before And After ◽

Patients With Diabetes

Objective: The purpose of this study is to compare the efficacy of intratympanic steroid injection (ITSI) with that of systemic steroids as an initial treatment of sudden sensorineural hearing loss (SNHL) with diabetes. Study Design: Prospective, nonrandomized multicenter clinical trial. Setting: Multicenter study in Busan and Masan, South Korea. Subjects and Methods: A total of 114 sudden SNHL patients who were diagnosed with diabetes were divided into peroral (PO) group (n = 48), intravenous (IV) group (n = 32), and intratympanic (IT) group (n = 34). In the PO group, prednisolone was used orally for 10 days, per schedule. In the IV group, prednisolone was administered intravenously for seven days, followed by oral administration of tapered doses for another several days. In the IT group, dexamethasone was injected into the tympanic cavity four times within a two-week period. Hearing outcome was assessed before and after the treatment. Results: All groups showed significant improvement with criteria of 15 dB ( P < 0.05). However, there was no significant difference in hearing gain and recovery rate among groups ( P > 0.05). Systemic steroid treatment was stopped for two patients in the IV group and for one in the PO group due to uncontrolled hyperglycemia. However, in the IT group, there were no patients who failed to control their blood sugar level. Conclusion: ITSI is as effective as systemic steroid treatment for sudden SNHL patients with diabetes and it can avoid undesirable side effects. Therefore, we consider ITSI to be a more reasonable alternative as an initial treatment for sudden SNHL patients with diabetes.

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Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study

Frontiers in Neurology ◽

10.3389/fneur.2021.747561 ◽

2021 ◽

Vol 12 ◽

Author(s):

Zhong Zheng ◽

Chengqi Liu ◽

Ying Shen ◽

Liang Xia ◽

Lili Xiao ◽

...

Keyword(s):

Hearing Loss ◽

Logistic Regression ◽

Liver Function ◽

Sensorineural Hearing Loss ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Control Group ◽

Hearing Level ◽

Normal Ranges ◽

Potential Marker

Objectives: As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging. This study aims to identify and investigate the association of liver functions with SSNHL.Methods: A total of 135 SSNHL patients and 135 sex- and age-matched controls were prospectively enrolled. The baseline and clinical characteristics, along with liver function levels of participators, were collected. Linear correlation, logistic regression, and receiving operator characteristic curve analysis tests were applied to examine the association between liver function levels and SSNHL.Results: There were no differences in baseline characteristics between SSNHL and control groups. The albumin (ALB) level of the SSNHL group was significantly lower than that in the control group (p < 0.001). The logistic regression showed that the low ALB level may be a predictive factor of SSNHL with an adjusted OR of 0.809 (95% CI, 0.742–0.882, p < 0.001). By comparing the indicators of different prognosis groups, we found that the effective group had a significantly lower hearing impair onset and higher ALB (p = 0.001) and AGR (p = 0.003) levels than the ineffective group. Logistic regression revealed that the hearing level onset (OR, 0.976; 95% CI, 0.956–0.997; p = 0.026) and ALB level (OR, 1.181; 95% CI, 1.071–1.301; p = 0.001) showed strong associations with treatment outcome.Conclusions: Lower ALB levels, within the normal ranges, were associated with the occurrence and unfavorable outcome of SSNHL. However, further research on the underlying mechanisms needs to be conducted.

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Comparison of Steroid Treatment with and without Hyperbaric Oxygen Therapy for Idiopathic Sudden Sensorineural Hearing Loss

Journal of Audiology & Otology ◽

10.7874/jao.2019.00486 ◽

2020 ◽

Vol 24 (3) ◽

pp. 127-132 ◽

Cited By ~ 1

Author(s):

Abitter Yücel ◽

Yaşar Özbuğday

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Hyperbaric Oxygen ◽

Sudden Sensorineural Hearing Loss ◽

Steroid Treatment ◽

Sensorineural Hearing ◽

Profound Hearing Loss ◽

Hearing Gain ◽

Admission Time ◽

Significant Difference

Background and Objectives: In this study, we compared the outcomes of patients with idiopathic sudden sensorineural hearing loss who underwent steroid treatment with or without hyperbaric oxygen (HBO) therapy and were followed-up in our clinic.Subjects and Methods: Patients were divided into two groups according to their treatment regimen. Steroid group received intravenous 1 mg/kg methylprednisolone which was due to be completed in 2-3 weeks with decreasing doses, and five doses of 0.5 mL intratympanic dexamethasone. Steroid+HBO group received the same steroid treatment with the addition of HBO therapy. The audiologic results of both treatment groups were compared after considering the patients’ risk factors.Results: There was no significant difference between the steroid and Steroid+HBO groups in terms of hearing gain and degree of recovery, both at all degrees of hearing loss, and in severe and profound hearing loss. Hearing gain was similar when evaluated by audiogram type and admission time in both treatment groups.Conclusions: We found that the addition of HBO therapy to systemic plus intratympanic steroid treatment did not affect hearing gain at all degrees of hearing loss in this study. Furthermore, audiogram type and admission time did not affect hearing gain between the two groups.

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Evaluation of cardiovascular risks and recovery of idiopathic sudden sensorineural hearing loss in hospitalised patients: comparison between complete and partial sudden sensorineural hearing loss

The Journal of Laryngology & Otology ◽

10.1017/s0022215117001736 ◽

2017 ◽

Vol 131 (10) ◽

pp. 919-924 ◽

Cited By ~ 5

Author(s):

C Haremza ◽

N Klopp-Dutote ◽

V Strunski ◽

C Page

Keyword(s):

Risk Factors ◽

Hearing Loss ◽

Cardiovascular Risk ◽

Sensorineural Hearing Loss ◽

Cardiovascular Risk Factors ◽

Pure Tone ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Hospitalised Patients ◽

Significant Difference

AbstractObjective:To evaluate the presence of cardiovascular risk factors and recovery of idiopathic sudden sensorineural hearing loss in hospitalised patients.Methods:A single-centre retrospective study of 80 patients hospitalised for idiopathic sudden sensorineural hearing loss was conducted over a 6-year period. Mean pure tone hearing thresholds were assessed by pure tone audiometry.Results:Twenty-three of 80 patients (28.75 per cent) initially had no cardiovascular risk factors. Forty-five patients had hyperlipidaemia, 22 patients had hypertension, 7 patients had diabetes mellitus and 7 patients were obese. No statistically significant difference was observed between patients with complete versus partial sudden sensorineural hearing loss (p = 0.0708) concerning the cardiovascular risk factors. At long-term follow up, the hearing recovery rate was not significantly different between the two groups of patients (p = 0.7541).Conclusion:The lack of a clear relationship between idiopathic sudden sensorineural hearing loss and cardiovascular risk factors suggests that sudden sensorineural hearing loss has a predominantly multifactorial disease profile regardless of hearing impairment severity.

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