Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

2019 ◽  
Vol 61 (3) ◽  
pp. 395-403
Author(s):  
Biao Li ◽  
Yu-Xin Liu ◽  
Hai-Jun Li ◽  
Qing Yuan ◽  
Pei-Wen Zhu ◽  
...  
Keyword(s):  
White Matter ◽  
Retinal Detachment ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cingulate Gyrus ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter

Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

scholarly journals Fluctuating Asymmetry and Individual Variation in Regional Gray and White Matter Volumes: A Voxel-Based Morphometry Study

2008 ◽  
Vol 6 (4) ◽  
pp. 147470490800600 ◽  
Author(s):  
Matthew Euler ◽  
Robert J. Thoma ◽  
Lauren Parks ◽  
Steven W. Gangestad ◽  
Ronald A. Yeo
Keyword(s):  
White Matter ◽  
Fluctuating Asymmetry ◽  
Gray Matter Volume ◽  
Brain Mri ◽  
Brain Regions ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter ◽  
Mri Scans

Composite measures of fluctuating asymmetry (FA) of skeletal features are commonly used to estimate developmental instability (DI), the imprecise expression of developmental design due to perturbations during an individual's growth and maturation. Though many studies have detailed important behavioral correlates of FA, very little is known about its possible neuroanatomical correlates. In this study we obtained structural brain MRI scans from 20 adults and utilized voxel-based morphometry (VBM) to identify specific regions linked to FA. Greater FA predicted greater whole brain white matter volume, and a trend in the same direction was noted for whole brain gray matter volume. Greater FA was associated with significantly greater gray and white matter volumes in discrete brain regions, most prominently in the frontal lobes and in the right cerebral hemisphere. Developmental studies are needed to identify when FA-related brain differences emerge and to elucidate the specific neurobiological mechanisms leading to these differences.

scholarly journals Predicting sleep quality from brain white matter volume: A voxel-based morphometry study

2021 ◽  
Author(s):  
Youling Bai ◽  
Li Zhang ◽  
Chengwei Liu ◽  
Xiaobing Cui ◽  
Li Dan ◽  
...  
Keyword(s):  
White Matter ◽  
Sleep Quality ◽  
Quality Data ◽  
Precentral Gyrus ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Matter Volume ◽  
Brain White Matter ◽  
The Right ◽  
The Relationship

Abstract Most previous studies have explored the relationship between gray matter volume and sleep quality, but little is known about the relationship between white matter volume and sleep quality. Data were collected using the Pittsburgh Sleep Quality Index and voxel-based morphometry among 352 healthy college students. Results showed that the global PSQI score was negatively associated with the white matter volume, including in the right middle occipital gyrus, the left superior temporal gyrus, the right the precentral gyrus, the left supramarginal gyrus, the left middle frontal gyrus, the left precunes, and the right superior frontal gyrus. Results also indicated that the white matter volume in specific regions negatively predicted the factor of PSQI. These specific brain regions may be replicated in brain areas related to sleep quality. In summary, we suggested that an investigation of white matter structural alterations in the specific regions might be beneficial to tackle underlying neurological mechanisms of sleep quality.

Global and regional volume changes in the brains of patients with phenylketonuria

Neurology ◽  
2006 ◽  
Vol 66 (7) ◽  
pp. 1074-1078 ◽  
Author(s):  
B. Pérez-Dueñas ◽  
J. Pujol ◽  
C. Soriano-Mas ◽  
H. Ortiz ◽  
R. Artuch ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Premotor Cortex ◽  
Gray Matter Volume ◽  
Relative Increase ◽  
Volume Reduction ◽  
Periventricular White Matter ◽  
White Matter Volume ◽  
Volume Changes ◽  
Matter Volume

Background: Although phenylketonuria is a treatable disease, patients with late or nonoptimal phenylalanine-restricted diet may experience brain damage. The authors used tridimensional MRI and a voxelwise analysis method to investigate possible volume changes in the brain parenchyma of patients with phenylketonuria.Methods: The authors assessed 27 treated patients (mean age ± SD, 20 ± 7 years) and 27 matched control subjects. Global tissue volumes were compared, and statistical parametric maps of between-group regional volume differences were obtained for gray and white matter. Anatomic data were correlated with relevant clinical and biochemical variables.Results: Patients with phenylketonuria showed smaller gray matter volumes that were associated with lower IQ and older age at diagnosis. Voxel-based maps revealed that significant gray matter volume reduction occurred in motor and premotor cortex and thalamus. A relative increase in gray matter volume was observed in the ventral part of the striatum. The authors found no group differences for global white matter measurements. Higher recent phenylalanine levels, however, were associated with larger global white matter volume in early-treated patients. Voxel-based maps showed a relative volume reduction in periventricular white matter and a relative increase in the region of the internal capsule, extending to the adjacent thalamus and striatum.Conclusions: Treated patients may show significant gray and white matter volume changes related to the duration and strict observation of dietary treatment. Further studies are needed to investigate whether the presence of neurologic symptoms may be explained by specific anatomic alterations.

Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis — A longitudinal voxel-based morphometry study

NeuroImage ◽  
2009 ◽  
Vol 45 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Kerstin Bendfeldt ◽  
Pascal Kuster ◽  
Stefan Traud ◽  
Hanspeter Egger ◽  
Sebastian Winklhofer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Lesions ◽  
Volume Loss ◽  
Voxel Based Morphometry ◽  
Matter Volume

P3-203: BRAIN WHITE MATTER HYPERINTENSITIES MEDIATE THE RELATION OF GRAY MATTER VOLUME TO PERCEPTUAL SPEED IN INDIVIDUALS WITHOUT COGNITIVE IMPAIRMENT

2014 ◽  
Vol 10 ◽  
pp. P704-P705
Author(s):  
Zoe Arvanitakis ◽  
Debra A. Fleischman ◽  
Konstantinos Arfanakis ◽  
Sue Leurgans ◽  
Lisa L. Barnes ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Perceptual Speed ◽  
Matter Volume ◽  
Brain White Matter

scholarly journals Menstrual Cycle Variations in Gray Matter Volume, White Matter Volume and Functional Connectivity: Critical Impact on Parietal Lobe

2020 ◽  
Vol 14 ◽  
Author(s):  
Timothy J. Meeker ◽  
Dieuwke S. Veldhuijzen ◽  
Michael L. Keaser ◽  
Rao P. Gullapalli ◽  
Joel D. Greenspan
Keyword(s):  
White Matter ◽  
Menstrual Cycle ◽  
Functional Connectivity ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Gonadal Hormones ◽  
White Matter Volume ◽  
Menstrual Phase ◽  
Hormone Levels ◽  
Matter Volume

The role of gonadal hormones in neural plasticity remains unclear. This study aimed to examine the effects of naturally fluctuating hormone levels over the menstrual cycle in healthy females. Gray matter, functional connectivity (FC) and white matter changes over the cycle were assessed by using functional magnetic resonance imaging (fMRI), resting state fMRI, and structural MRIs, respectively, and associated with serum gonadal hormone levels. Moreover, electrocutaneous sensitivity was evaluated in 14 women in four phases of their menstrual cycle (menstrual, follicular, ovulatory, and luteal). Electrocutaneous sensitivity was greater during follicular compared to menstrual phase. Additionally, pain unpleasantness was lower in follicular phase than other phases while pain intensity ratings did not change over the cycle. Significant variations in cycle phase effects on gray matter volume were found in the left inferior parietal lobule (IPL) using voxel-based morphometry. Subsequent Freesurfer analysis revealed greater thickness of left IPL during the menstrual phase when compared to other phases. Also, white matter volume fluctuated across phases in left IPL. Blood estradiol was positively correlated with white matter volume both in left parietal cortex and whole cortex. Seed-driven FC between left IPL and right secondary visual cortex was enhanced during ovulatory phase. A seed placed in right IPL revealed enhanced FC between left and right IPL during the ovulatory phase. Additionally, we found that somatosensory cortical gray matter was thinner during follicular compared to menstrual phase. We discuss these results in the context of likely evolutionary pressures selecting for enhanced perceptual sensitivity across modalities specifically during ovulation.

scholarly journals Application of voxel-based morphometric measurement to brain magnetic resonance imaging in children with non-cyanotic congenital heart disease

2019 ◽  
Author(s):  
Xuan Jia ◽  
XIAOHUI MA ◽  
JIAWEI LIANG ◽  
HAICHUN ZHOU
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Gray Matter ◽  
Congenital Heart ◽  
Healthy Controls ◽  
White Matter Volume ◽  
Resonance Imaging ◽  
Whole Brain ◽  
Matter Volume ◽  
Central Gyrus

Abstract Background Congenital heart disease（CHD） is a cardiovascular malformation caused by abnormal heart and/or vascular development in the fetus. In children with CHD, abnormalities in the development and function of the nervous system are common. At present, there is a lack of research on the preoperative neurological development and injury of young children with non-cyanotic CHD. The objective of the current study is to determine the changes in white matter, gray matter, and cerebrospinal fluid (CSF) by magnetic resonance imaging (MRI) in children with noncyanotic CHD as compared with healthy controls. MethodsChildren diagnosed with non-cyanotic CHD on ultrasonography (n=54) and healthy control subjects (n=35) aged 1–3 years. Brain MRI was performed prior to surgery for CHD. The SPM v12 software was used to calculate the volumes of the gray matter, white matter, CSF, and the whole brain (sum of the gray-matter, white-matter, and CSF volumes). Volume differences between the two groups were analyzed. Voxelbased morphometry was used to compare specific brain regions with statistically significant atrophy.ResultsCompared with the control group, the study group had significantly reduced whole-brain white-matter volume (P<0.05), but similar whole-brain graymatter, CSF, and whole-brain volumes(P>0.05). As compared with the healthy controls, children with non-cyanotic CHD had mild atrophy in the white matter of the anterior central gyrus, the posterior central gyrus and the pulvinar. ConclusionsChildren with non-cyanotic CHD show decreased white-matter volume before surgery, and this volume reduction is mainly concentrated in the somatosensory and somatic motor nerve regions.

scholarly journals Occipital bending in schizophrenia

2016 ◽  
Vol 51 (1) ◽  
pp. 32-41 ◽  
Author(s):  
Jerome J Maller ◽  
Rodney J Anderson ◽  
Richard H Thomson ◽  
Zafiris J Daskalakis ◽  
Jeffrey V Rosenfeld ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Healthy Subjects ◽  
Psychiatric Illness ◽  
Gray Matter Volume ◽  
Occipital Lobe ◽  
Healthy Controls ◽  
White Matter Volume ◽  
Matter Volume ◽  
Control Subjects

Objective: To investigate the prevalence of occipital bending (an occipital lobe crossing or twisting across the midline) in subjects with schizophrenia and matched healthy controls. Method: Occipital bending prevalence was investigated in 37 patients with schizophrenia and 44 healthy controls. Results: Ratings showed that prevalence was nearly three times higher among schizophrenia patients (13/37 [35.1%]) than in control subjects (6/44 [13.6%]). Furthermore, those with schizophrenia had greater normalized gray matter volume but less white matter volume and had larger brain-to-cranial ratio. Conclusion: The results suggest that occipital bending is more prevalent among schizophrenia patients than healthy subjects and that schizophrenia patients have different gray matter–white matter proportions. Although the cause and clinical ramifications of occipital bending are unclear, the results infer that occipital bending may be a marker of psychiatric illness.

scholarly journals Greater hippocampal gray matter volume in subjective hyperosmia: a voxel-based morphometry study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pengfei Han ◽  
Franz Paul Stiller-Stut ◽  
Alexander Fjaeldstad ◽  
Thomas Hummel
Keyword(s):  
Gray Matter ◽  
Emotional Experience ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Precentral Gyrus ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Superior Frontal Gyrus ◽  
Matter Volume ◽  
Olfactory Ability

Abstract Subjective hyperosmia refers to a self-reported olfactory ability that is superior to a normal, intact sense of smell (normosmia), and is associated with olfactory emotional experience. The current study used voxel-based morphometry to investigate the gray matter volume (GMV) in people with self-rated hyperosmia (subjective hyperosmia, SH, N = 18) in comparison to people with self-rated normal olfaction (subjective normosmia, SN, N = 14). Participants’ olfactory function were assessed by the extensive olfactory test battery, the “Sniffin’ Sticks” test. Within the predicted brain regions (regions-of-interest analyses), the SH participants showed larger GMV of the left hippocampus as compared to SN participants (FWE corrected p < 0.05). Further, the whole-brain search indicated that SH had larger GMV of the bilateral hippocampus, the right hypothalamus, the left precuneus, and the left superior frontal gyrus as compared to the SN group. ROI analyses showed positive correlations between the left hippocampal GMV and odor threshold or discrimination scores across all participants. In addition, the whole-brain analysis suggested that the self-rated olfactory ability was positively associated with GMV in the cerebellum, superior frontal gyrus and the precentral gyrus among SH participants. In conclusion, the current results suggest that SH was associated with increased GMV in several brain regions that were previously shown to be involved in the processing of cognitive aspects of odors.

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