scholarly journals Transient neonatal hyperpigmentation of the proximal nail fold in a Chinese infant: a case report

2022 ◽  
Vol 50 (1) ◽  
pp. 030006052110677
Author(s):  
Lu Wang ◽  
Daming Zuo ◽  
Ledong Sun

Cutaneous alterations are common in neonates and usually occur in the first few days of life. Most of these are transient and benign, appearing as physiological responses to birth. Skin pigmentation disorders are considered transitory dermatoses of newborn infants. Nail pigmentation manifests as asymptomatic brown to bluish-black skin pigmentation over the fingers and toes in newborns. Hyperpigmentation of the distal phalanx of both hands and feet is commonly found in dark-skinned newborns, but it is rare in fair-skinned newborns and East Asian populations. We herein describe a Chinese infant with transient neonatal hyperpigmentation of the proximal nail fold.

2015 ◽  
Vol 27 (4) ◽  
pp. 520-525 ◽  
Author(s):  
Katherine Eaton ◽  
Melissa Edwards ◽  
S. Krithika ◽  
Gillian Cook ◽  
Heather Norton ◽  
...  

PLoS Genetics ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. e1000867 ◽  
Author(s):  
Melissa Edwards ◽  
Abigail Bigham ◽  
Jinze Tan ◽  
Shilin Li ◽  
Agnes Gozdzik ◽  
...  

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3951 ◽  
Author(s):  
Lida Rawofi ◽  
Melissa Edwards ◽  
S Krithika ◽  
Phuong Le ◽  
David Cha ◽  
...  

Background Currently, there is limited knowledge about the genetics underlying pigmentary traits in East Asian populations. Here, we report the results of the first genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry. Methods We obtained quantitative skin pigmentation measures (M-index) in the inner upper arm of the participants using a portable reflectometer (N = 305). Quantitative measures of iris color (expressed as L*, a* and b* CIELab coordinates) were extracted from high-resolution iris pictures (N = 342). We also measured the color differences between the pupillary and ciliary regions of the iris (e.g., iris heterochromia). DNA samples were genotyped with Illumina’s Infinium Multi-Ethnic Global Array (MEGA) and imputed using the 1000 Genomes Phase 3 samples as reference haplotypes. Results For skin pigmentation, we did not observe any genome-wide significant signal. We followed-up in three independent Chinese samples the lead SNPs of five regions showing multiple common markers (minor allele frequency ≥ 5%) with good imputation scores and suggestive evidence of association (p-values < 10−5). One of these markers, rs2373391, which is located in an intron of the ZNF804B gene on chromosome 7, was replicated in one of the Chinese samples (p = 0.003). For iris color, we observed genome-wide signals in the OCA2 region on chromosome 15. This signal is driven by the non-synonymous rs1800414 variant, which explains 11.9%, 10.4% and 6% of the variation observed in the b*, a* and L* coordinates in our sample, respectively. However, the OCA2 region was not associated with iris heterochromia. Discussion Additional genome-wide association studies in East Asian samples will be necessary to further disentangle the genetic architecture of pigmentary traits in East Asian populations.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1188-P
Author(s):  
JOAO M. CONCEICAO ◽  
CLAUDIO D. GONZALEZ ◽  
SAMUEL S. ENGEL ◽  
JONGHO AHN ◽  
SHIGERU TOKITA ◽  
...  

2020 ◽  
Vol 36 (05) ◽  
pp. 592-601
Author(s):  
Stephanie Ming Young ◽  
Yoon-Duck Kim

AbstractDouble eyelid surgery remains one of the most popular aesthetic surgeries, especially among East Asian populations. Complications related to double eyelid surgery can be divided into various categories: (1) patient dissatisfaction, (2) problems with the eyelid crease, (3) problems with the eyelid height, (4) suture-related complications, and (5) complications related to eyelid surgery in general. As with all eyelid surgeries, it is important to understand and appreciate the normal and abnormal function and anatomy of the Asian eyelid to reduce the risk of complications. It is also important to recognize the various complications and their underlying causes so that the surgeon can confidently revise the surgery to achieve optimal outcomes.


Author(s):  
Yibo Hu ◽  
Hongliang Zeng ◽  
Jiaxing Jiang ◽  
Sheng Yang ◽  
Jinhua Huang ◽  
...  

2017 ◽  
Vol 6 (12) ◽  
pp. 823-832 ◽  
Author(s):  
Takahiko Aoyama ◽  
Yoshimasa Ishida ◽  
Masato Kaneko ◽  
Aoi Miyamoto ◽  
Yoshiro Saito ◽  
...  

1997 ◽  
Vol 25 (2) ◽  
pp. 143-159 ◽  
Author(s):  
Mamoru Toda ◽  
Mutsumi Nishida ◽  
Masafumi Matsui ◽  
Gan-Fu Wu ◽  
Hidetoshi Ota

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