A Double-Blind Trial of Terfenadine and Placebo in Hay Fever Using a Substitution Technique for Non-Responders

1980 ◽  
Vol 8 (6) ◽  
pp. 404-407 ◽  
Author(s):  
G Kagan ◽  
E Dabrowicki ◽  
L Huddlestone ◽  
T R Kapur ◽  
P Wolstencroft
Keyword(s):  
Active Drug ◽  
Hay Fever ◽  
Blind Study ◽  
Skin Tests ◽  
Double Blind Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Reference Drug ◽  
Blind Trial ◽  
Novel Technique

A double-blind study of terfenadine and placebo in 110 patients suffering from hay fever (confirmed by skin tests) was conducted. A novel technique was applied using an escape envelope containing a reference drug which could be taken under controlled conditions if, after 48 hours, the patient experienced no relief. Significantly more patients on placebo opened the envelope than patients taking the active drug. Terfenadine was demonstrated to be an effective drug in hay fever and produced no more drowsiness than placebo.

Controlled double-blind trial with Baryta carbonica 15 CH versus placebo in a group of hypertensive subjects confined to bed in two old people's homes

1987 ◽  
Vol 76 (03) ◽  
pp. 114-119 ◽  
Author(s):  
M. Bignamini ◽  
A. Bertoli ◽  
A.M. Consolandi ◽  
N. Dovera ◽  
M. Saruggia ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Active Drug ◽  
Point Of View ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Positive Results ◽  
Old People's Homes

AbstractTaking into account the toxicology of soluble barium salts, the authors treated 32 hypertensive subjects who were confirned to bed in two old people's homes with Baryta carbonica 15 CH versus placebo in a randomized double-blind study. Seventeen patients were given Baryta carbonica and 15 placebo. Taking the groups as a whole, no statistically significant differences were found between the effects of placebo and active drug on the blood pressure. But the four subjects who had been prospectively considered sensitive and were treated with Baryta carbonica gave strongly positive results. Some interesting conclusions were arrived at both from the general medical and the homœopathic point of view.

Comparison of a New Hypnotic (Finorgal) with Placebo in a Double-Blind Trial

1979 ◽  
Vol 7 (5) ◽  
pp. 387-390
Author(s):  
Gianni Baiotti
Keyword(s):  
Placebo Treatment ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
The Mean ◽  
Mean Time

The hypnotic effects of Finorgal (ethchlorvynol with diphenhydramine) were compared with those of placebo in a double-blind study with crossover of treatments in thirty-five hospital in-patients. During the four-week period of Finorgal treatment there was a significant reduction in the mean time elapsing between the administration of the hypnotic and the onset of sleep, and a significant increase in the duration of sleep, compared with the four weeks of placebo treatment. There was also a significant increase in the proportion of nights when the patients felt they had slept well, and in the incidence of morning ‘hangover’ and nocturnal confusion during the Finorgal treatment periods. Patients had to be actively woken in the morning significantly more often following Finorgal administration. In patients experiencing pain in the night there was a significant reduction in the occurrence of pain during the nights when Finorgal had been given.

Double Blind Study of Lecithin in Patients with Alzheimer's Disease

1981 ◽  
Vol 26 (6) ◽  
pp. 426-428 ◽  
Author(s):  
M. Fisman ◽  
H. Merskey ◽  
E. Helmes ◽  
J. Mccready ◽  
E.H. Colhoun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Levels ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial

Twenty-one patients with a diagnosis of Alzheimer's disease completed a double blind trial on lecithin 25 g daily. Equal improvement was noted in both the lecithin and placebo groups. Serum levels of lecithin measured 12-14 hours after its administration were also not increased compared with the levels in control patients. These findings of the ineffectiveness of lecithin inpatients with Alzheimer's disease are discussed in relation to the literature on this subject.

Double-Blind Study of Imipramine versus Phenelzine in Melancholias and Dysthymic Disorders

1987 ◽  
Vol 151 (5) ◽  
pp. 639-642 ◽  
Author(s):  
J. Vallejo ◽  
C. Gasto ◽  
R. Catalan ◽  
M. Salamero
Keyword(s):  
Major Depression ◽  
Blind Study ◽  
Dysthymic Disorder ◽  
Clinical Implications ◽  
High Dose ◽  
Double Blind Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
High Doses

In a 6-week double-blind trial, the efficacy of imipramine and high dose phenelzine were compared in the treatment of Major Depression with Melancholia, and Dysthymic Disorder (DSM-III). Both drugs were found to be equally efficacious in the treatment of 32 patients suffering from Major Depression. In 32 Dysthymic patients, phenelzine in high doses was found to be superior to imipramine. The clinical implications of these findings are discussed.

Treatment of hay fever by Allerglobuline: a randomized double-blind study

1988 ◽  
Vol 18 (4) ◽  
pp. 393-400 ◽  
Author(s):  
J. P. GIRARD ◽  
G. EL-HABIB ◽  
P. GRANJARD
Keyword(s):  
Hay Fever ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind
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