Diffusion Tensor Imaging of Auditory Pathway in Patients With Crigler-Najjar Syndrome Type I: Correlation With Auditory Brainstem Response

2021 ◽  
pp. 088307382110258
Author(s):  
Ahmed Abdel Khalek Abdel Razek ◽  
Mohamed Ezz El Regal ◽  
Mortada El-Shabrawi ◽  
Mohamed Moustafa Abdeltawwab ◽  
Ahmed Megahed ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Inferior Colliculus ◽  
Cochlear Nucleus ◽  
Auditory Brainstem Response ◽  
Diffusion Tensor ◽  
Auditory Brainstem ◽  
Type I ◽  
Syndrome Type ◽  
Brainstem Response ◽  
Olivary Nucleus

Aim: To evaluate the role of diffusion tensor imaging of the auditory pathway in patients with Crigler Najjar syndrome type I and its relation to auditory brainstem response. Methods: Prospective study was done including 12 patients with Crigler Najjar syndrome type I and 10 age- and sex-matched controls that underwent diffusion tensor imaging of brain. Mean diffusivity and fractional anisotropy at 4 regions of the brain and brainstem on each side were measured and correlated with the results of auditory brainstem response for patients. Results: There was significantly higher mean diffusivity of cochlear nucleus, superior olivary nucleus, inferior colliculus, and auditory cortex of patients versus controls on both sides for all regions ( P = .001). The fractional anisotropy of cochlear nucleus, superior olivary nucleus, inferior colliculus, and auditory cortex of patients versus controls was significantly lower, with P values of, respectively, .001, .001, .003, and .001 on the right side and .001, .001, .003, and .001 on left side, respectively. Also, a negative correlation was found between the maximum bilirubin level and fractional anisotropy of the left superior olivary nucleus and inferior colliculus of both sides. A positive correlation was found between the mean diffusivity and auditory brainstem response wave latency of the right inferior colliculus and left cochlear nucleus. The fractional anisotropy and auditory brainstem response wave latency of the right superior olivary nucleus, left cochlear nucleus, and inferior colliculus of both sides were negatively correlated. Conclusion: Diffusion tensor imaging can detect microstructural changes in the auditory pathway in Crigler Najjar syndrome type I that can be correlated with auditory brainstem response.

Brainstem pathology of infantile Gaucher's disease with only wave I and II of auditory brainstem response

1998 ◽  
Vol 112 (11) ◽  
pp. 1069-1073 ◽  
Author(s):  
Kimitaka Kaga ◽  
Masae Ono ◽  
Kazuhiro Yakumaru ◽  
Masao Owada ◽  
Toshlo Mizutani
Keyword(s):  
Cochlear Nucleus ◽  
Auditory Brainstem Response ◽  
Failure To Thrive ◽  
Auditory Brainstem ◽  
Pathological Findings ◽  
Gaucher's Disease ◽  
Gaucher’S Disease ◽  
Brainstem Response ◽  
Ventral Nucleus ◽  
Olivary Nucleus

AbstractWe studied the auditory brainstem response (ABR) and neuropathology in a female infant who died at six months of age because of typical infantile Gaucher's disease. The patient was hospitalized for hepatosplenomegaly and failure to thrive. Her ABR showed only waves I and II.The neuropathological study disclosed that: (1) Gaucher's cells were found in the perivascular region of the cerebrum and anterior ventral nucleus of the thalamus. (2) Gliosis was found in the dorsal part of the brainstem rather than the ventral part. (3) Neuronal cells in the superior olivary nucleus were lost, and marked gliosis was found in the cochlear nucleus. The disappearance of wave III and later waves of ABR could be supported by these pathological findings.

Diffusion Tensor Imaging of Microstructural Changes in the Gray and White Matter in Patients With Crigler-Najjar Syndrome Type I

2020 ◽  
Vol 44 (3) ◽  
pp. 393-398 ◽  
Author(s):  
Ahmed Abdel Khalek Abdel Razek ◽  
Saher Ebrahiem Taman ◽  
Mohamed Ezz El Regal ◽  
Ahmed Megahed ◽  
Sherine Elzeny ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Type I ◽  
Syndrome Type ◽  
Microstructural Changes

Thalamocortical abnormalities in auditory brainstem response patterns distinguish DSM-IV bipolar disorder type I from schizophrenia

2014 ◽  
Vol 169 ◽  
pp. 105-111 ◽  
Author(s):  
Mia Sköld ◽  
Johan Källstrand ◽  
Sara Nehlstedt ◽  
Annelie Nordin ◽  
Sören Nielzén ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Type I ◽  
Response Patterns ◽  
Brainstem Response ◽  
Dsm Iv ◽  
Disorder Type

scholarly journals Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yasuhiro Ishihara ◽  
Kouichi Itoh ◽  
Ami Oguro ◽  
Yoichi Chiba ◽  
Masaki Ueno ◽  
...  
Keyword(s):  
Inferior Colliculus ◽  
Neurotrophic Factor ◽  
Auditory Brainstem Response ◽  
Global Analysis ◽  
Protein A ◽  
Auditory Pathway ◽  
Brain Derived Neurotrophic Factor ◽  
Auditory Brainstem ◽  
Protective Role ◽  
Brainstem Response

Abstract Methylmercury (MeHg) is well known to induce auditory disorders such as dysarthria. When we performed a global analysis on the brains of mice exposed to MeHg by magnetic resonance imaging, an increase in the T1 signal in the inferior colliculus (IC), which is localized in the auditory pathway, was observed. Therefore, the purpose of this study is to examine the pathophysiology and auditory dysfunction induced by MeHg, focusing on the IC. Measurement of the auditory brainstem response revealed increases in latency and decreases in threshold in the IC of mice exposed to MeHg for 4 weeks compared with vehicle mice. Incoordination in MeHg-exposed mice was noted after 6 weeks of exposure, indicating that IC dysfunction occurs earlier than incoordination. There was no change in the number of neurons or microglial activity, while the expression of glial fibrillary acidic protein, a marker for astrocytic activity, was elevated in the IC of MeHg-exposed mice after 4 weeks of exposure, indicating that astrogliosis occurs in the IC. Suppression of astrogliosis by treatment with fluorocitrate exacerbated the latency and threshold in the IC evaluated by the auditory brainstem response. Therefore, astrocytes in the IC are considered to play a protective role in the auditory pathway. Astrocytes exposed to MeHg increased the expression of brain-derived neurotrophic factor in the IC, suggesting that astrocytic brain-derived neurotrophic factor is a potent protectant in the IC. This study showed that astrogliosis in the IC could be an adaptive response to MeHg toxicity. The overall toxicity of MeHg might be determined on the basis of the balance between MeHg-mediated injury to neurons and protective responses from astrocytes.

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