The activity of theAng/Tie-2system in the brain that suffered acute carbon monoxide poisoning

2013 ◽  
Vol 32 (10) ◽  
pp. 1038-1047 ◽  
Author(s):  
Suping Wang ◽  
Zanhua Liu ◽  
Jing Qu ◽  
Xiaoting Wang
Keyword(s):  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning ◽  
The Brain

Computed tomography of the brain in acute carbon monoxide poisoning

1996 ◽  
Vol 51 (7) ◽  
pp. 480-483 ◽  
Author(s):  
D.A.T. Silver ◽  
M. Cross ◽  
B. Fox ◽  
R.M. Paxton
Keyword(s):  
Computed Tomography ◽  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning ◽  
The Brain

Sequential changes in mr images of the brain in acute carbon monoxide poisoning

1993 ◽  
Vol 17 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Masaki Gotoh ◽  
Hideyuki Kuyama ◽  
Shoji Asari ◽  
Takashi Ohmoto ◽  
Tatsuroh Akioka ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Mr Images ◽  
Acute Carbon Monoxide Poisoning ◽  
The Brain

scholarly journals Bilateral brachial plexus injury following acute carbon monoxide poisoning

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Mounia Rahmani ◽  
Halima Belaidi ◽  
Maria Benabdeljlil ◽  
Wafa Bouchhab ◽  
Nadia El Jazouli ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Brachial Plexus ◽  
Brachial Plexus Injury ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning

Cardiovascular, metabolic and neurologic effects of acute carbon monoxide poisoning in the rat

1989 ◽  
Vol 45 (2-3) ◽  
pp. 207-213 ◽  
Author(s):  
David G. Penney ◽  
Kuldeep Verma ◽  
Julie A. Hull
Keyword(s):  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning

Application of Perfluorooctylbromide Nanoparticles with Ulinastatin for Early Brain Injury Caused by Carbon Monoxide Poisoning

2021 ◽  
Vol 13 (7) ◽  
pp. 1383-1390
Author(s):  
Guangcong Li ◽  
Dan Li
Keyword(s):  
Carbon Monoxide ◽  
Particle Size ◽  
Treatment Group ◽  
Cell Apoptosis ◽  
High Speed ◽  
Carbon Monoxide Poisoning ◽  
Neuronal Cell ◽  
Early Brain Injury ◽  
Group A ◽  
The Brain

ABSTRACTThis study aimed to explore the mechanism of perfluorooctylbromide (PFOB) nanoparticles (NPs) combined with ulinastatin (UTI) on early brain injury (EBI) caused by carbon monoxide poisoning (CMP). Firstly, PFOB NPs were prepared by high-speed dispersion and high-speed homogenization. The physicochemical characteristics of the particle size distribution and Zeta potential distribution of the NPs were analyzed using a laser particle size analyzer. The thermal and photoinduced phase transition characteristics of the NPs were analyzed under heating and laser irradiation conditions. Then, 50 Sprague Dawley (SD) rats were deemed as the research objects to establish the CMP rat models using hyperbaric oxygen chambers. According to different treatment methods, they were rolled into a healthy control group, a carbon monoxide (CO) model group, a PTOB treatment group, an UTI treatment group, and a PTOB + UTI treatment group. The brain tissues of each group of rats were collected 3 days after treatment. The neuronal cell apoptosis, expression of Caspase-3, messenger ribonucleic acid (mRNA) of inflammatory factors interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in rat brain tissue were detected through immunohistochemical staining, in situ cell apoptosis detection, Reverse transcription-polymerase chain reaction (RT-PCR), and Western blotting, so did the relative expression of target proteins B-cell lymphoma-2 (Bcl-2), Bcl2-Associated X (Bax) and myelin basic protein (MBP). As a result, the average particle size and the average Zeta potential of the prepared PFOB NPs was 103±31 nm and −23 ± 15 mV, respectively. When the PFOB NPs were heated to 80 °C, the particle size increased greatly and cracks appeared. The particle size of PFOB NPs also increased obviously after laser irradiation, and the PFOB inside the particles changed into gas phase. Compared to CO group, expression of Caspase-3, neuronal cell apoptosis rate, mRNA expression of IL-1β and TNF-α, and protein expression of Bax and Bcl-2 in the brain tissue of PTOB group, UTI group, and PFOB + UTI group were notably decreased (P < 0.05), while the MBP protein expression increased considerably (P < 0.05). Changes in PFOB + UTI group were more obvious than those in PTOB group and UTI group, and those indicators weren’t considerably different from the controls. In summary, PFOB NPs were successfully prepared with favorable phase transition characteristics. Moreover, PFOB NPs combined with UTI could reduce the apoptosis of brain neurons after CMP, improve the inflammatory response, and play a protective effect on EBI of CMP.

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