Synergistic Effects of Low-Intensity Exercise Conditioning and β-Blockade on Cardiovascular and Autonomic Adaptation in Pre- and Postmenopausal Women With Hypertension

2012 ◽  
Vol 15 (4) ◽  
pp. 433-442 ◽  
Author(s):  
Catherine L. Goldie ◽  
C. Ann Brown ◽  
Sylvia M. J. Hains ◽  
Joel L. Parlow ◽  
Richard Birtwhistle
Keyword(s):  
Baroreflex Sensitivity ◽  
Synergistic Effects ◽  
Exercise Group ◽  
Rate Pressure Product ◽  
Control Group ◽  
Cardiac Autonomic Function ◽  
Low Intensity ◽  
Walking Program ◽  
Low Intensity Exercise ◽  
Sedentary Women

The effects of a 12-week low-intensity exercise conditioning program (walking) on blood pressure (BP), heart rate (HR), rate–pressure product (RPP), and cardiac autonomic function were measured in 40 sedentary women with hypertension. Women were assigned to either an exercise group ( n = 20) or a control group ( n = 20), matched for β-blockade treatment. They underwent testing at the beginning and at the end of the 12-week study period in three conditions: supine rest, standing, and low-intensity steady state exercise. The exercise group participated in a 12-week, low-intensity walking program, while the control group continued with usual sedentary activity. Compared with the control group, women in the exercise group showed reductions in systolic and diastolic BP and RPP (i.e., the estimated cardiac workload). β-Blockers increased baroreflex sensitivity and lowered BP and HR in all participants; however, those in the exercise group showed the effects of both treatments: a greater reduction in HR and RPP. The combination of exercise training and β-blockade produces cardiac and autonomic adaptations that are not observed with either treatment alone, suggesting that β-blockade enhances the conditioning effects of low-intensity exercise in women with hypertension.

Effects of Low-Intensity Exercise Conditioning on Blood Pressure, Heart Rate, and Autonomic Modulation of Heart Rate in Men and Women with Hypertension

2009 ◽  
Vol 11 (2) ◽  
pp. 129-143 ◽  
Author(s):  
Lien P.T. Hua ◽  
C. Ann Brown ◽  
Sylvia J.M. Hains ◽  
Marshall Godwin ◽  
Joel L. Parlow
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Diastolic Blood Pressure ◽  
Baroreflex Sensitivity ◽  
Autonomic Modulation ◽  
Men And Women ◽  
Low Intensity ◽  
Walking Program ◽  
Spontaneous Baroreflex ◽  
Low Intensity Exercise

Untreated hypertension increases cardiovascular risk 2-fold to 3-fold, leading to serious cardiovascular problems that include left ventricular hypertrophy, stroke, ischemic heart disease, myocardial infarction, vascular disease, renal disease, and death. Exercise conditioning is recommended as one of the initial treatments for hypertension. The purpose of this pretest—posttest study was to quantify the effects of a 12-week home-based low-intensity exercise conditioning (walking) program in hypertensive men and women on systolic and diastolic blood pressure, heart rate, and autonomic modulation of heart rate. A total of 20 mildly hypertensive men and women who were assigned to a structured exercise (walking) program were compared with a control group of 20 nonexercising mildly hypertensive participants. Electrocardiographic heart rate and R-R interval data and beat-by-beat arterial blood pressure data were collected continuously for 10 min with participants in the supine and standing postures and during low-intensity steady-state exercise. The results show that systolic and diastolic blood pressure and R-R interval decreased and spontaneous baroreflex sensitivity increased in the exercise group. The decline in blood pressure was significant statistically and clinically. The increase in spontaneous baroreflex sensitivity indicates that the ability of the cardiovascular system to respond rapidly to changing stimuli improved after the 12-week walking protocol. The low-intensity exercise conditioning program achieved a training effect in this population.

scholarly journals The Effect of Low and Moderate Exercise on Hyperuricemia: Protocol for a Randomized Controlled Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuning Hou ◽  
Renyan Ma ◽  
Song Gao ◽  
Keneilwe Kenny Kaudimba ◽  
Hongmei Yan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Heart Rate ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Controlled Study ◽  
Control Group ◽  
Maximum Heart Rate ◽  
Moderate Intensity Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise

BackgroundHyperuricemia (HUA) is a metabolic disease by purine metabolism disorders. It is a risk factor for many chronic diseases, including diabetes, hypertension, and heart disease. Studies have shown that exercise can effectively reduce serum uric acid (SUA), but the optimal exercise dose, intensity, and mode of exercise for improving HUA have not been verified in clinical studies. Therefore, this study aims to explore the effect of different exercise intensities in improving SUA of patients with HUA.Methods and AnalysisA randomized, single-blind, parallel controlled trial will be conducted in this study. 186 HUA patients who meet the inclusion criteria will be randomly divided into a 1:1:1 ratio (1): control group (2), low-intensity exercise group (brisk walking, 57-63% maximum heart rate, 150 min/week, 12 months), and (3) moderate-intensity exercise group (jogging, 64-76% maximum heart rate, 150 min/week, 12 months). The three groups of subjects will receive the same health education and prohibition of high-purine diet during the intervention period. The primary outcomes will be SUA concentration, SUA concentration change (mg/dL), SUA change rate (%), and the proportion of HUA patients. Secondary outcomes will include anthropometric parameters (body weight, waist circumference, hip circumference, BMI); physiological indicators (blood pressure, grip, vital capacity, maximum oxygen); biochemical indicators (blood lipid, blood sugar, liver enzyme, creatinine, and blood urea nitrogen). Each group of patients will go through an assessment at baseline, 3rd, 6th, and 12th months.DiscussionThis study will evaluate the effect of 12-month low-intensity exercise and moderate-intensity exercise on HUA patients. We hypothesize that both low-intensity and moderate-intensity exercise would improve HUA as compared with no-exercise control, and that moderate-intensity exercise would be more effective than low-intensity exercise in improving HUA. These results can provide a basis for the current physical activity guidelines for HUA’s healthy lifestyle management.Ethics and DisseminationThis study has been approved by the Ethical Review Committee of the Shanghai University of Sport (approval number: 102772020RT005). Informed consent will be obtained from all participants or their guardians. The authors intend to submit the study findings to peer-reviewed journals or academic conferences to be published.Clinical Trial RegistrationChinese Clinical Trial Registry, identifier ChiCTR2100042643.

Effect of Early Low-Intensity Exercise on Rat Hind-Limb Muscles Following Acute Ischemic Stroke

2006 ◽  
Vol 7 (3) ◽  
pp. 163-174 ◽  
Author(s):  
Myoung-Ae Choe ◽  
Gyeong Ju An ◽  
Yoon-Kyong Lee ◽  
Ji Hye Im ◽  
Smi Choi-Kwon ◽  
...  
Keyword(s):  
Hind Limb ◽  
Gastrocnemius Muscle ◽  
Exercise Group ◽  
Cross Sectional Area ◽  
Type I ◽  
Sectional Area ◽  
Muscle Type ◽  
Cross Sectional ◽  
Low Intensity ◽  
Low Intensity Exercise

This study examined the effects of daily low-intensity exercise following acute stroke on mass, Type I and II fiber cross-sectional area, and myofibrillar protein content of hind-limb muscles in a rat model. Adult male Sprague-Dawley rats were randomly assigned to 1 of 4 groups (n = 7-9 per group): stroke (occlusion of the right middle cerebral artery [RMCA]), control (sham RMCA procedure), exercise, and stroke-exercise. Beginning 48 hours post-stroke induction/sham operation, rats in the exercise group had 6 sessions of exercise in which they ran on a treadmill at grade 10 for 20 min/day at 10 m/min. At 8 days poststroke, all rats were anesthetized and soleus, plantaris, and gastrocnemius muscles were dissected from both the affected and unaffected sides. After 6 sessions of exercise following acute ischemic stroke, the stroke-exercise group showed the following significant (p < .05) increases compared to the stroke-only group: body weight and dietary intake, muscle weight of affected soleus and both affected and unaffected gastrocnemius muscle, Type I fiber cross-sectional area of affected soleus and both affected and unaffected gastrocnemius muscle, Type II fiber cross-sectional area of the unaffected soleus, both affected and unaffected plantaris and gastrocnemius muscle, Type II fiber distribution of affected gastrocnemius muscle, and myofibrillar protein content of both affected and unaffected soleus muscle. Daily low-intensity exercise following acute stroke attenuates hind-limb muscle atrophy in both affected and unaffected sides. The effects of exercise are more pronounced in the soleus and gastrocnemius as compared to the plantaris muscle.

scholarly journals Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Physical Characteristics and Functions of the Elderly: A Randomized Controlled Trial

2021 ◽  
Vol 18 (5) ◽  
pp. 2463
Author(s):  
Eun Mi Jang ◽  
So Hyun Park
Keyword(s):  
Electrical Stimulation ◽  
Muscle Mass ◽  
Lower Limb ◽  
Neuromuscular Electrical Stimulation ◽  
Exercise Program ◽  
The Elderly ◽  
Exercise Group ◽  
Low Intensity ◽  
Strengthening Exercise ◽  
Low Intensity Exercise

(1) Background—The application of neuromuscular electrical stimulation (NMES) combined with low-intensity exercise to the elderly can be more efficient than low-intensity exercise only in terms of delaying the loss of muscle mass. We aimed to assess the adjunct of NMES to low-intensity lower limb strengthening exercise to prevent falls in frail elderly for a relatively short period of 4 weeks. (2) Methods—Thirty elderly women aged 65 or above were randomly categorized into three groups: control group (CON, n = 8), exercise group (EX, n = 10), and NMES with exercise group (EX + NMES, n = 9). The exercise group took part in a lower limb strengthening exercise program for one hour three times a week for four weeks. Furthermore, the NMES with exercise group had added NMES stimulation when exercising. The limbs’ muscle mass, body fat mass, calf circumference, grip force, five times sit-to-stand test, timed up-and-go test (TUG), one-leg stand test, and Y-balance test (YBT) were evaluated at baseline and 4 weeks after. (3) Results—Comparisons between the three groups showed that the TUG was significantly decreased and the YB was significantly increased in NMES with exercise group (p < 0.05). (4) Conclusions—These results suggested that a combination of NMES stimulation and exercises was more helpful in strengthening balance than exercises alone in the short term.

Controlled 5-mo aerobic training improves heart rate but not heart rate variability or baroreflex sensitivity

2000 ◽  
Vol 89 (5) ◽  
pp. 1825-1829 ◽  
Author(s):  
Antti Loimaala ◽  
Heikki Huikuri ◽  
Pekka Oja ◽  
Matti Pasanen ◽  
Ilkka Vuori
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Exercise Training ◽  
High Intensity ◽  
Baroreflex Sensitivity ◽  
Aerobic Training ◽  
Control Group ◽  
Resting Heart Rate ◽  
Endurance Time ◽  
Low Intensity

Endurance-trained athletes have increased heart rate variability (HRV), but it is not known whether exercise training improves the HRV and baroreflex sensitivity (BRS) in sedentary persons. We compared the effects of low- and high-intensity endurance training on resting heart rate, HRV, and BRS. The maximal oxygen uptake and endurance time increased significantly in the high-intensity group compared with the control group. Heart rate did not change significantly in the low-intensity group but decreased significantly in the high-intensity group (−6 beats/min, 95% confidence interval; −10 to −1 beats/min, exercise vs. control). No significant changes occurred in either the time or frequency domain measures of HRV or BRS in either of the exercise groups. Exercise training was not able to modify the cardiac vagal outflow in sedentary, middle-aged persons.

Mood States of Formerly Sedentary Younger and Older Women at Weeks 1 and 10 of a Moderate Exercise Program

2004 ◽  
Vol 94 (3_suppl) ◽  
pp. 1337-1342 ◽  
Author(s):  
James J. Annesi
Keyword(s):  
Older Women ◽  
Exercise Program ◽  
Exercise Group ◽  
Mood States ◽  
Control Group ◽  
Profile Of Mood States ◽  
Moderate Exercise ◽  
Mood Changes ◽  
Mood Score ◽  
Sedentary Women

This study assessed and contrasted mood changes associated with a 10-wk. moderate exercise program in 64 formerly sedentary women of different ages. Analyses of covariance, with Week 1 mood scores as the covariates, indicated that the younger exercise group ( n = 32; M age = 33 yr.) and older exercise group ( n = 32; M age = 63 yr.) showed significantly ( p < .05) more residual improvement in scores on McNair, Lorr, and Droppleman's Profile of Mood States Tension, Depression, Vigor, and Fatigue scales than a no-exercise control group ( n = 32; M age = 48 yr.). There were no significant differences in amount of improvement between the younger and older exercise groups. Across both exercise groups, amount of mood score changes over 10 weeks were negatively correlated with initial mood scores ( rs = –.22 to –.75). Limitations and research implications were discussed.

scholarly journals EFFECT OF 12-WEEK LOW-INTENSITY EXERCISE ON INTERLEUKIN-2, INTERFERON-GAMMA AND INTERLEUKIN-4 CYTOKINE PRODUCTION IN RAT SPLEENS

2018 ◽  
Vol 14 (3) ◽  
pp. e14-e19
Author(s):  
Eun-Ju Choi ◽  
Chang-Jin Lee ◽  
Hyo-Hyun Park ◽  
Wi-Young So
Keyword(s):  
Interferon Gamma ◽  
Cytokine Production ◽  
Interleukin 2 ◽  
Male Rats ◽  
Interleukin 4 ◽  
Control Group ◽  
T Helper ◽  
Low Intensity ◽  
Low Intensity Exercise ◽  
Helper Type

Background and Objective High-intensity exercise has been linked to immunity; however, the relationship between low-intensity exercise and the immune system is unclear. In this study, the effects of exercise on cytokine production in T helper 1 (interleukin-2 [IL-2] and interferon-gamma [INF-g]) and T helper 2 cells (interleukin-4 [IL-4]) in spleens were investigated. Material and Methods Sprague–Dawley male rats were divided into a control group (CON, n = 10) and a low-intensity exercise group (EX, n = 10). EX rats were trained on a treadmill (8 m/min, 50 min/day, 5 times over 12 weeks). Spleen tissues were analyzed by hematoxylin-eosin staining and real-time PCR to quantify IL-4, INF-γ, and IL-2 expression. Results IL-4 expression was significantly higher in the EX group than in the CON group (p < 0.05). However, IL-2 and INF-γ expression did not differ between groups (p > 0.05). Conclusion These results suggest that exercise in rats enhances immune function by regulating cytokine production in T helper type 2 (IL-4) cells, but not in T helper type 1 (IL-2 and IFN-g) cells of the activated spleen.

scholarly journals Impact of Low Intensity Exercise on Liver Enzymes (ALT & ALP)

2021 ◽  
pp. 370-377
Author(s):  
Alamgir Khan ◽  
Muhammad Zafar Iqbal Butt ◽  
Shahzaman Khan ◽  
Sobia Nazir ◽  
Ejaz Asghar ◽  
...  
Keyword(s):  
Liver Enzymes ◽  
Daily Basis ◽  
Moderate Intensity ◽  
Control Group ◽  
Moderate Intensity Exercise ◽  
Low Intensity ◽  
Post Test ◽  
Low Intensity Exercise ◽  
The Impact ◽  
Experimental Group

This particular research study was basically carried out for the purpose to examine the impact of low intensity exercise on two particular liver enzymes i.e. alanine transaminase (ALT) and alkaline phosphate (ALP). 20 Non sportsmen were selected as subjects of the study (n=20, age 20 to 30 years (20.95±3.79), Body Mass Index (BMI) from 18 to 30 (25.90±5.54). Similarly the subjects were divided into two groups (Experimental Group and Control Group) through the application of International Physical Activity Questionnaire (IPAQ) and measurement of Maximum Heart Rate (MHR). 12 weeks self-made low intensity exercise protocol was applied to an experimental group.  5ml blood was collected from all subjects to measure the effect of low intensity exercise on ALT and ALP. The data of pre and post-test were processed through SPSS version 24. Based on analysis and findings, the researcher concluded that in experimental group (EXG) the level of ALT and ALP was found significantly higher (p<0.05) as compared to control group (CG). Based on conclusion, it is hereby recommended by the researcher that for the purpose to promote the functional capacity of liver, low as well as moderate intensity exercise should be performed on daily basis. In addition, in this study due to lack of financial resources, two basic liver enzymes i.e.ALT and ALP were measured, therefore the other enzymes like as AST and bilirubin also need to be examined in such other research studies.

scholarly journals Absence of left ventricular and arterial adaptations to exercise in octogenarians

2004 ◽  
Vol 97 (5) ◽  
pp. 1654-1659 ◽  
Author(s):  
Robert J. Spina ◽  
Timothy E. Meyer ◽  
Linda R. Peterson ◽  
Dennis T. Villareal ◽  
Morton R. Rinder ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Exercise Group ◽  
Left Ventricular ◽  
Applanation Tonometry ◽  
Rate Pressure Product ◽  
Control Group ◽  
Modest Improvement ◽  
Dimensional Echocardiography ◽  
And Function

Recent evidence suggests that octogenarians exhibit attenuated adaptations to training with a small increase in peak O2 consumption (V̇o2) that is mediated by a modest improvement in cardiac output without an increase in arteriovenous O2 content difference. This study was designed to determine whether diminished increases in peak V̇o2 and cardiac output in the octogenarians are associated with absence of left ventricular and arterial adaptations to exercise training. We studied 22 octogenarians (81.9 ± 3.7 yr, mean ± SD) randomly assigned a group that exercised at an intensity of 82.5 ± 5% of peak heart rate for 9 mo and 14 (age 83.1 ± 4.1) assigned to a control group. Peak V̇o2 increased 12% in the exercise group but decreased slightly (−7%) in the controls. The exercise group demonstrated significant but small decreases in the heart rate (6%, P = 0.002) and the rate-pressure product (9%, P = 0.004) during submaximal exercise at an absolute work rate. Training induced no significant changes in the left ventricular size, geometry (wall thickness-to-radius ratio), mass, and function assessed with two-dimensional echocardiography or in arterial stiffness evaluated with applanation tonometry. Data suggest that the absence of cardiac and arterial adaptations may in part account for the limited gain in aerobic capacity in response to training in the octogenarians.

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