The visual evoked potential can save sight in patients with radiation-induced optic neuropathy

2021 ◽  
pp. 112067212110491
Author(s):  
Ali Nouraeinejad

Radiation-induced optic neuropathy (RION) is a late complication of radiation therapy for brain and skull base tumors. RION leads to the devastating total vision loss in one or both eyes. Therefore, the early detection of RION is vital. Since visual symptoms and clinical signs of RION are not present at early stages of the radiation injury, it is essential to apply a diagnostic test to detect RION as early as possible in order to start therapeutic interventions. The author proposes to apply visual evoked potential (VEP) as a diagnostic test in the interval time after radiation therapy.

Eye ◽  
2020 ◽  
Author(s):  
Xin Qi ◽  
Boding Tong ◽  
Weikun Hu ◽  
Ban Luo

Abstract Objective To determine the diagnostic ability of isolated-check visual evoked potential (icVEP), pattern visual evoked potential (pVEP), and standard automated perimetry (SAP) between dysthyroid optic neuropathy (DON) and thyroid-associated ophthalmopathy (TAO) without DON (non-DON). Methods This is a case-control study, 49 bilateral patients (26 DON and 23 non-DON) were included. icVEP, pVEP, and SAP were conducted in all the subjects, icVEP parameters compared were signal-to-noise ratios (SNRs) under 8, 16, and 32% depth of modulation (DOM). pVEP parameters compared were amplitude and latency. SAP parameters were mean deviation (MD) and pattern standard deviation (PSD). The area under the receiver operating characteristic (ROC) curve (AUC), net reclassification index (NRI), integrated discrimination index (IDI), and decision curve analysis (DCA) were applied for analysis. Results In icVEP, values of SNR in DON were significantly smaller than non-DON (p < 0.05). In pVEP, P100 latent time in DON was significantly larger than non-DON (p = 0.0026). In SAP, value of PSD in DON was larger than non-DON (p = 0.0006), and value of MD in DON was smaller (p = 0.0007). AUC, NRI, and IDI among the three tests were not significantly different. DCA showed that SNR of icVEP under 8% DOM was the farthest from the two extreme curves. Conclusions icVEP, pVEP, and SAP have equal diagnostic capabilities to discern between DON and non-DON. In addition, icVEP may represent a significant ancillary diagnostic approach to DON detection, with more clinical benefit.


The Lancet ◽  
1991 ◽  
Vol 337 (8740) ◽  
pp. 517-518 ◽  
Author(s):  
J.G. van Dijk ◽  
M. Dorresteijn ◽  
J. Haan ◽  
M.D. Ferrari

2010 ◽  
Vol 121 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Manju Jayaraman ◽  
S. Ambika ◽  
Rashmin Anilkumar Gandhi ◽  
Shikha Rajesh Bassi ◽  
Priya Ravi ◽  
...  

2016 ◽  
Vol 15 (2) ◽  
pp. 249-251
Author(s):  
Prastiya Indra Gunawan ◽  
Desi Primayani ◽  
Darto Saharso

Background: Acute encephalitis syndrome (AES) is one of cortical visual impairment (CVI) causes. There were only few studies about cortical visual involvement in children with AES. Objective: To describe CVI in children with AES. Methods: This study included all children with AES during January to March 2014, were examined for visual evoked potential (VEP) to evaluate cortical visual pathway. AES was defined as clinical condition characterized by acute onset of fever, a change in mental status, and/or new onset of seizures. CVI was defined as vision loss caused by central nervous system damage confirmed by VEP. Results: There were 9 children with AES and all showed bilateral CVI. The age range between 6 to 48 months old, with 7 males and 2 females. Visual evoked potential result showed 8 children with demyelinating type and 1 with axonal type. Conclusion: Type of CVI caused by AES can be demyelinating type or axonal type.Bangladesh Journal of Medical Science Vol.15(2) 2016 p.249-251


Sign in / Sign up

Export Citation Format

Share Document