Viral and Nonviral Uses of Imiquimod: A Review

2004 ◽  
Vol 8 (5) ◽  
pp. 338-352 ◽  
Author(s):  
Aditya K. Gupta ◽  
Andrea M. Cherman ◽  
Stephen K. Tyring
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Diseases ◽  
Interleukin 12 ◽  
Antitumor Effects ◽  
Skin Reactions ◽  
Local Skin ◽  
Actinic Keratoses ◽  
Skin Conditions

Background: Imiquimod is a topical immunomodulator that is indicated for the treatment of external genital and perianal warts. This drug has been recently approved for the treatment of actinic keratoses and superficial basal cell carcinoma. There is a growing body of evidence for its effectiveness in treating a variety of other skin conditions. Objective: This review examines the role of imiquimod 5% cream in the treatment of skin diseases such as actinic keratoses, basal cell carcinoma, Bowen's disease, lentigo maligna, and extramammary Paget's disease. Methods: Published literature containing the words “Imiquimod” or “Aldara” was reviewed and summarized. Results: This agent has demonstrated indirect antiviral and antitumor effects in animal models. Although the exact mechanism of action is unknown, imiquimod is an agonist for toll-like receptor (TLR) 7 and is thought to act by inducing cytokines, such as interferon alpha (IFN-α), interleukin-12 (IL-12), and tumor necrosis factor alpha (TNF-α). These cytokines trigger the immune system to recognize the presence of a viral infection or tumor and the associated lesion is ultimately eradicated. Side effects are generally well tolerated with local skin reactions reported most frequently. Conclusion: Imiquimod has been shown to be a safe and effective treatment for a variety of skin conditions.

Emerging medical treatments for actinic keratoses, squamous cell carcinoma and basal cell carcinoma

2012 ◽  
Vol 2 (9) ◽  
pp. 909-921 ◽  
Author(s):  
Nasreen Ghuznavi ◽  
Nadia F Nocera ◽  
Andrew R Guajardo ◽  
Jeffrey M Weinberg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Medical Treatments ◽  
Actinic Keratoses

scholarly journals Assistant Diagnosis of Basal Cell Carcinoma and Seborrheic Keratosis in Chinese Population Using Convolutional Neural Network

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Kai Huang ◽  
Xiaoyu He ◽  
Zhentao Jin ◽  
Lisha Wu ◽  
Xinyu Zhao ◽  
...  
Keyword(s):  
Neural Network ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Chinese Population ◽  
Skin Diseases ◽  
Area Under The Curve ◽  
Seborrheic Keratosis ◽  
Clinical Images ◽  
Learning Techniques

Objectives. To evaluate CNN models’ performance of identifying the clinical images of basal cell carcinoma (BCC) and seborrheic keratosis (SK) and to compare their performance with that of dermatologists. Methods. We constructed a Chinese skin diseases dataset which includes 1456 BCC and 1843 SK clinical images and the corresponding medical history. We evaluated the performance using four mainstream CNN structures and transfer learning techniques. We explored the interpretability of the CNN model and compared its performance with that of 21 dermatologists. Results. The fine-tuned InceptionResNetV2 achieved the best performance, with an accuracy and area under the curve of 0.855 and 0.919, respectively. Further experimental results suggested that the CNN model was not only interpretable but also had a performance comparable to that of dermatologists. Conclusions. This study is the first on the assistant diagnosis of BCC and SK based on the proposed dataset. The promising results suggested that CNN model’s performance was comparable to that of expert dermatologists.

scholarly journals Nonsyndromic Type of Multiple Basal Cell Carcinoma

2010 ◽  
Vol 1 (1) ◽  
pp. 25-28
Author(s):  
D'Cruz Anil ◽  
Chaturvedi Pankaj ◽  
Chaukar Devendra ◽  
Ghatge Amit ◽  
Pai Prathamesh ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Chemical Warfare ◽  
Unique Case ◽  
Actinic Keratoses ◽  
The Face ◽  
Multiple Variable ◽  
History Of ◽  
Indian Male

Abstract We report a case of nonsyndromic type of multiple basal cell carcinoma associated purely with actinic keratoses. A 69-year-old Indian male had suffered from multiple, variable-sized papules and nodules on the face, neck and chest for 13 years previous to treatment. He had no history of arsenic intake, irradiation, herb medication, or exposure to chemical warfare gases. Family histories for basal cell carcinoma and xeroderma pigmentosum were negative. Classical features of Gorlin's syndrome were conspicuous by their absence. Histopathologically, the tumors revealed typical findings of basal cell carcinoma arising from actinic keratoses. The case in point is a very rare and unique case in itself as being nonsyndromic, nonhereditary and occurring in the absence of various other environmental conditions as already mentioned in literature.

Corrigendum

2015 ◽  
Vol 19 (6) ◽  
pp. 604-604
Keyword(s):  
Primary Prevention ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratoses ◽  
Non Melanoma Skin Cancer ◽  
Cancer Guidelines ◽  
Melanoma Skin

Guenther LC, Barber K, Searles GE, Lynde CW, Janiszewski P, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 1: Introduction to the Guidelines. J Cutan Med Surg. 2015;19(3):205-215. Original DOI: 10.1177/1203475415588652 Barber K, Searles GE, Vender R, Teoh H, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 2: Primary Prevention of Non-melanoma Skin Cancer. J Cutan Med Surg. 2015;19(3):216-226. Original DOI: 10.1177/1203475415576465 Poulin Y, Lynde CW, Barber K, Vender R, Claveau J, Bourcier M, Ashkenas J, for the Canadian non-Melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses. J Cutan Med Surg. 2015;19(3):227-238. Original DOI: 10.1177/1203475415583414 Zloty D, Guenther LC, Sapijaszko M, Barber K, Claveau J, Adamek T, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma. J Cutan Med Surg. 2015;19(3):239-248. Original DOI: 10.1177/1203475415586664 Sapijaszko M, Zloty D, Bourcier M, Poulin Y, Janiszewski P, Ashkenas J, for the Canadian Non-melanoma Skin Cancer Guidelines Committee. J Cutan Med Surg. 2015;19(3):249-259. Original DOI: 10.1177/1203475415582318 In the above articles, the following disclaimer from the Canadian Dermatology Association should have been included: The Canadian Dermatology Association (CDA) recognizes the scientific merit of these guidelines. The CDA did not participate in their development or provide content.

scholarly journals Arborizing Vessels on Dermoscopy in Various Skin Diseases Other Than Basal Cell Carcinoma

2017 ◽  
Vol 29 (3) ◽  
pp. 288 ◽  
Author(s):  
Hyunju Jin ◽  
Min-Young Yang ◽  
Jeong-Min Kim ◽  
Gun-Wook Kim ◽  
Hoon-Soo Kim ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Skin Diseases
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