scholarly journals The association of hepatitis C virus infection and thyroid disease: A systematic review and meta-analysis

2021 ◽  
pp. 172460082110569
Author(s):  
Hongpeng Wang ◽  
Yixiu Liu ◽  
Yanguang Zhao
Keyword(s):  
Thyroid Cancer ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Thyroid Disease ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Hepatitis C Virus Infection ◽  
Increased Risk ◽  
The Impact

Background Previous studies have reported that hepatitis C virus infection may increase the risk of thyroid disease and even thyroid cancer, but quantitative assessments of risk were rare and the results were not consistent. The purpose of this study was to evaluate the impact of hepatitis C virus infection on thyroid disease and thyroid cancer, and to provide clues to explore their relationship. Methods A literature retrieval was performed up to August 20, 2021 in the database of PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and Wang Fang. The risk of hepatitis C virus for thyroid disease or thyroid cancer was expressed with odds ratio (OR) and 95% confidence intervals (CI). Subgroup analysis was used to explore the source of heterogeneity. Eight articles (Five studies published as articles and three as abstracts) were included in this meta-analysis, with a total of 5398 controls and 1925 cases of hepatitis C. Results The results of a meta-analysis found that hepatitis C virus infection was significantly associated with an increased risk of thyroid disease (sum OR = 1.80, 95% CI = 1.54–2.10, P < 0.001, I2 = 74.3%) and thyroid cancer (sum OR = 16.74, 95% CI = 4.78–58.55, P < 0.001, I2 = 0%). Hepatitis C virus infection may increase the risk of thyroid disease and thyroid cancer. Conclusion More work is needed in the future to establish a causal role; however, an awareness of the possibility of increased risk of thyroid disease and thyroid cancer may lead to earlier diagnosis and better outcomes in patients with hepatitis C.

Hepatitis C virus infection and risk of thyroid cancer: A systematic review and meta-analysis

2017 ◽  
Vol 18 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Peng Wang ◽  
Zhaohai Jing ◽  
Changjiang Liu ◽  
Meihua Xu ◽  
Pei Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Meta Analysis ◽  
Hepatitis C Virus Infection

The impact of hepatitis C virus infection on survival in dialysis patients: meta-analysis of observational studies

2007 ◽  
Vol 0 (0) ◽  
pp. 070501060544002-??? ◽  
Author(s):  
F. Fabrizi ◽  
B. Takkouche ◽  
G. Lunghi ◽  
V. Dixit ◽  
P. Messa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Observational Studies ◽  
Meta Analysis ◽  
Hepatitis C Virus Infection ◽  
Dialysis Patients ◽  
The Impact

scholarly journals Prevalence of Hepatitis C Virus in Nigeria: a Protocol for Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Helen Chioma Okoye ◽  
Emmanuel Okechukwu Nna ◽  
Samuel Onuka ◽  
Bamgboye M Afolabi ◽  
Daniel Onwusulu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Hepatitis C Virus Infection ◽  
Statistical Heterogeneity ◽  
Registration Number

Abstract Background: Hepatitis C virus infection is a major cause of liver cirrhosis and is responsible for a quarter of all cases of liver cancers. Globally, about 71 million people are estimated to have chronic hepatitis C, with nearly 399,000 people dying from this infection, essentially due to liver cirrhosis and liver cancer. However, the exact pooled prevalence of hepatitis C virus infection in Nigeria is unknown, hence the burden of the disease has not been adequately estimated. Methods: A search strategy is developed using MeSH, text words, and entry terms. Nine databases will be searched, including PubMed, African Journals Online (AJOL), Embase, Google Scholar, Scopus, Cochrane Library, CINAHL, Web of Science, and ResearchGate. Eligible studies will be a) observational studies; b) published or retrievable in the English language; c) must have been conducted in Nigeria, and d) must report the main measurable outcome which is the prevalence of hepatitis C virus infection in Nigeria. Searches from databases will be exported into Distiller SR software for screening, selection and extraction of data items based on inclusion and exclusion criteria. Both quality scores and the risk of bias for individual studies will be assessed and reported in Distiller SR. Extracted data items will exported into the Comprehensive Meta-Analysis Software version 3 for for statistical analysis and forest plots. Studies will be assessed for methodological, clinical, and statistical heterogeneity. Funnel Plots will be used for assessing publication bias. Subgroup analysis will be performed using categorical data. The systematic review and meta-analysis will be reported according to the PRISMA 2015 Statement. Discussion: Ethical approval will not be required since this study will be based on published data. This review will provide important data on the prevalence of hepatitis C virus infection in Nigeria and the burden of the disease. The final report of this study will be published in a peer-reviewed journal and the findings will be made available to various policymakers and health experts that manage patients at risk or infected with the hepatitis C virus.Trial Registration Number: This protocol has been registered in PROSPERO; registration number: CRD42020213806

Chronic Hepatitis C Virus Infection is Associated with an Increased Risk of Lung Cancer: A Systematic Review and Meta-analysis

Lung ◽  
2020 ◽  
Vol 198 (4) ◽  
pp. 705-714 ◽  
Author(s):  
Ben Ponvilawan ◽  
Nipith Charoenngam ◽  
Pongprueth Rujirachun ◽  
Phuuwadith Wattanachayakul ◽  
Surapa Tornsatitkul ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Meta Analysis ◽  
Hepatitis C Virus Infection ◽  
Increased Risk ◽  
Chronic Hepatitis C Virus

scholarly journals Seroprevalence of hepatitis c virus infection among blood donors in Ethiopia: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eyasu Alem Lake ◽  
Robera Olana Fite ◽  
Lielt Gebreselassie Gebrekirstos ◽  
Meron Hadis Gebremedhin ◽  
Mohammed Suleiman Obsa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Publication Bias ◽  
Blood Donors ◽  
Meta Analysis ◽  
Google Scholar ◽  
Cochrane Library ◽  
Hepatitis C Virus Infection

Abstract Background Blood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving. However, this intervention is related to several transfusion-related infections. Hepatitis C viral infection is one of the most common causes of transfusion-related hepatitis. Subsequently, this systematic review and meta-analysis was aimed to estimate the seroprevalence of hepatitis C virus infection among blood donors in Ethiopia. Methods PubMed, Google Scholar, Health InterNetwork Access to Research Initiative (HINARI), Excerpta Medica database (EMBASE), and Cochrane library, the web of science, African journal of online (AJOL), and Google Scholar was searched. The data were extracted using Microsoft Excel and analyzed by using STATA version 14. Publication bias was checked by funnel plot, contour-enhanced funnel plots, trim and fill analysis and more objectively through Egger’s regression test, with P <  0.05 considered to indicate potential publication bias. The heterogeneity of studies was checked using I2 statistics. Pooled analysis was conducted using a weighted inverse variance random-effects model. Subgroup analysis was done by region and study period. A sensitivity analysis was employed. Result A total of 25 studies with 197,172 study participants were used to estimate the seroprevalence of hepatitis c virus among blood donors. The overall seroprevalence of hepatitis C virus was 0.819% (95% CI: 0.67–0.969; I2 = 92.3%). Regional sub-group analysis showed that the pooled prevalence of hepatitis c virus infection among blood donors found to be 0.563% in Somali, 1.08% in Oromia, 0.847% in Amhara, and 0.908% in south nations nationalities and peoples region. Conclusion The pooled seroprevalence of hepatitis C virus infection among blood donors in Ethiopia found to be low. Moreover, there should be systematic strategies that enhance donor screening and retention of safe regular donors.

scholarly journals Prevalence of Hepatitis C Virus Infection among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Birye Dessalegn Mekonnen
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Antiviral Treatment ◽  
Hcv Infection ◽  
Cochrane Library ◽  
Hepatitis C Virus Infection ◽  
Pooled Prevalence

Background. Hepatitis C virus infection during pregnancy is associated with a high risk of maternal complications and poor birth outcomes. There are variable reports on the prevalence of hepatitis C virus infection among pregnant women in Ethiopia. Therefore, this study aims to estimate the pooled prevalence of hepatitis C virus infection among pregnant women in Ethiopia. Methods. A comprehensive search of electronic databases including PubMed, Scopus, EMBASE, the Cochrane Library, Web of Sciences, and Google Scholar was conducted from April 03, 2020, to May 03, 2020. The quality of included article was evaluated by the JBI. Heterogeneity between the studies was assessed using Cochrane Q and I2 test. The presence of publication bias was tested by funnel plots and Egger’s test. A random-effects meta-analysis was computed to determine the pooled prevalence of HCV infection among pregnant women. Results. Of 502 studies, 6 studies with a total of 2117 pregnant women were included in the meta-analysis. The overall pooled prevalence of hepatitis C virus infection among pregnant women in Ethiopia was 1.83% (95% CI: 0.61, 3.06). Besides, subgroup analysis revealed that the highest HCV prevalence among pregnant women was observed in Oromia region, 5.10% (95% CI: −0.53, 10.73). Conclusions. This study shows an intermediate level of HCV infection among pregnant women in Ethiopia. The finding suggests the need of implementing a routine hepatitis C virus screening program for all pregnant women, which enables women to access HCV antiviral treatment to minimize vertical transmission to the newborn infants. Moreover, national and regional health programs should mandate and monitor the screening procedures so as to reduce the risk of hepatitis C virus infection.

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