scholarly journals World trade organization’s export-oriented compulsory licensing mechanism: Foreseen policy concern for Africa to mitigate the COVID-19 pandemic

2021 ◽  
pp. 174113432110102
Author(s):  
Muhammad Z Abbas
Keyword(s):  
World Trade ◽  
Local Community ◽  
Pharmaceutical Manufacturing ◽  
Compulsory Licensing ◽  
High Prevalence ◽  
Policy Concern ◽  
History Of ◽  
Community Transmission ◽  
Future Policy ◽  
Priority Policy

Africa has a history of grappling with outbreaks and high prevalence of disease. It currently confronts COVID-19 which is escalating because of local community transmission of the disease. Poorly resourced health systems in Africa are ill-prepared for the surging number of COVID-19 cases. This paper emphasizes that in the current battle against COVID-19, policymakers should not lose sight of future policy challenges. COVID-19 vaccine has become available, but patent exclusivities might play a major role in hindering access to it. With little or no indigenous pharmaceutical manufacturing capacity of its own, Africa will almost entirely rely on importing COVID-19 vaccines or treatment from third parties. The World Trade Organization’s (WTO’s) Paragraph 6 System, which relates to export-oriented compulsory licensing, is excessively formal and does not suit a pandemic situation which requires swift action. This paper draws policymakers’ attention of to a high priority policy concern for Africa.

Clinical and anamnestic characteristics of patients with adenomyosis, accompanied by pelvic pain syndrome

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 77-80
Author(s):  
M R Orazov ◽  
V E Radzinsky ◽  
M B Khamoshina ◽  
A O Dukhin ◽  
L R Toktar ◽  
...  
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Reproductive Age ◽  
Pelvic Pain Syndrome ◽  
Common Disease ◽  
Contributing Factors ◽  
High Prevalence ◽  
Inflammatory Processes ◽  
History Of

Pelvic pain syndrome associated with adenomyosis is a common disease in women of reproductive age. Frequency of detection in the population varies from 10 to 53%. The aim - to study the clinical and anamnestic risk factors of pelvic pain, with adenomiose. Materials and methods. The study included 120 (n=120) patients with diffuse adenomyosis with pain and painless form of the disease who underwent examination and treatment in the gynecological Department of the Central clinical hospital №6 of Russian Railways in Moscow. Each patient was provided with an individual card, which was encrypted 171 sign. The studied parameters reflected the passport and anthropometric data, information about education, social status, presence of occupational hazards, complaints, illness. Results. Burdened gynecological and somatic histories, manifested a low health index, a more pronounced hereditary a family history of neoplastic diseases are contributing factors, and high prevalence of postponed surgeries, chronic, long-term ongoing inflammatory processes of the pelvic organs to create a favorable background for the further progression of chronic pelvic pain syndrome in adenomiose.

ZAANGAŻOWANIA KOŚCIOŁA KATOLICKIEGO NA RZECZ MIGRANTÓW – PRZESŁANKI DOKTRYNALNO-PRAWNE

2017 ◽  
Vol 13 (`1) ◽  
pp. 49-68
Author(s):  
Piotr Wojnicz
Keyword(s):  
Pastoral Care ◽  
Social Integration ◽  
Catholic Church ◽  
Local Community ◽  
Primary Objective ◽  
Human Migration ◽  
Religious Orders ◽  
Important Thing ◽  
History Of ◽  
The Catholic Church

The Catholic Church is naturally associated with migrants and its history and doctrine areinextricably linked with the migration of people. Many of the documents of the Catholic Church referto the history of human migration. The responsibility of the Catholic Church for migrants has deephistorical and theological roots. The Catholic Church sees both the positive and the negative sidesof this phenomenon The pastoral care of migrants is a response to the needs of these people. It doesnot replace the territorial structures. They both work closely together and complement each other.The primary objective of the pastoral care of migrants is to enable migrants to integrate with thelocal community. An important element of these structures are religious orders of men and women.The most important thing for migrants is the Christian attitude of the local community tothem. Church repeatedly stressed the importance of hospitality to migrants. Both human andChristian attitude towards migrants expresses itself in a good reception, which is the main factorin overcoming the inevitable difficulties, preventing opposites and solving various problems. Thisattitude helps to alleviate the problems associated with the process of social integration.

General Principles for Integration

2017 ◽  
Author(s):  
Henning Grosse Ruse-Khan
Keyword(s):  
Conflict Resolution ◽  
Intellectual Property ◽  
World Trade ◽  
Dispute Settlement ◽  
World Trade Organisation ◽  
Resolution Function ◽  
Wto Dispute Settlement ◽  
History Of ◽  
Prior Analysis

This chapter reviews the broader principles in the international intellectual property (IP) system that fulfil an indirect integration or conflict resolution function, with a focus on those emanating from and applicable to the Trade Related Aspects of International Property Rights (TRIPS) Agreement. In focusing on Articles 7 and 8 of TRIPS, the chapter builds on prior analysis about the role of these provisions in establishing an agreed, common object and purpose of the principal global IP treaty with relevance beyond TRIPS. In light of the origins and negotiation history of Articles 7 and 8 TRIPS, the chapter shows how these provisions can be applied to integrate ‘external’ objectives and interests via interpretation and implementation. Next, this chapter reviews their very poor record of application in the first twenty years of World Trade Organisation (WTO) dispute settlement. It concludes with suggestions for an appropriate recognition of external norms, objectives, and interests via Articles 7 and 8.

scholarly journals Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Shweta R Singh ◽  
Bunsoth Mao ◽  
Konstantin Evdokimov ◽  
Pisey Tan ◽  
Phana Leab ◽  
...  
Keyword(s):  
Final Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Middle Income ◽  
E Coli ◽  
Middle Income Countries ◽  
Siem Reap ◽  
High Prevalence ◽  
Significant Public Health ◽  
History Of

Abstract Background The rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries. Methods We conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage. Results Forty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts. Conclusions The high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread.

scholarly journals Ultrasonographic Evaluation of the Shoulders and Its Associations with Shoulder Pain, Age, and Swim Training in Masters Swimmers

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 29
Author(s):  
Yuta Suzuki ◽  
Noriaki Maeda ◽  
Junpei Sasadai ◽  
Kazuki Kaneda ◽  
Taizan Shirakawa ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Shoulder Pain ◽  
Structural Changes ◽  
Partial Tear ◽  
Increased Risk ◽  
High Prevalence ◽  
History Of ◽  
Long Head ◽  
Competitive Swimmers ◽  
Rotator Cuff Tendinopathy

Background and objectives: The long head of the biceps (LHB) and rotator cuff tendinopathy is the major cause of shoulder pain in competitive swimmers. The risk of tendinopathy increases with aging; however, the structural changes of LHB and rotator cuff in populations of masters swimmers have not been well examined. The purpose of this study was to investigate the prevalence of ultrasonographic abnormalities of the shoulders in masters swimmers, and the association of pain, age, and swim training with structural changes in this population. Materials and Methods: A total of 60 subjects participated in this study, with 20 masters swimmers with shoulder pain, 20 asymptomatic masters swimmers, and 20 sex- and age-matched controls. All swimmers completed a self-reported questionnaire for shoulder pain, their history of competition, and training volume. Each subject underwent ultrasonographic examination of both shoulders for pathologic findings in the LHB tendon, rotator cuff (supraspinatus (SSP) and subscapularis (SSC)) tendons, and subacromial bursa (SAB) of both shoulders and had thickness measured. Results: The prevalence of tendinosis (LHB, 48.8%; SSP, 17.5%; SSC, 15.9%), partial tear (SSP, 35.0%), and calcification (SSC, 10.0%) were higher in swimmers than in controls. LHB and SSP tendinosis were associated with shoulder pain. Older age and later start of competition were associated with an increased risk of LHB tendinosis and SSC calcification. Earlier initiation of swimming and longer history of competition were associated with an increased risk of SSP and SSC tendinosis. The thicker SSP tendon significantly increased the risk of tendinosis and partial tear. Conclusions: A high prevalence of structural changes in the rotator cuff and biceps tendons in masters swimmers reflects the effect of shoulder symptoms, aging, and swim training.

Book Reviews: Studies in Sociology, Race Mixture, Hunger and Work in a Savage Tribe, Interpretations, 1931–1932, Faith, Hope and Charity in Primitive Religion, Genetic Principles in Medicine and Social Science, The Reorganisation of Education in China, Social Decay and Eugenical Reform, The Social and Political Ideas of Some Representative Thinkers of the Revolutionary Era, L. T. Hobhouse, His Life and Work, Corner of England, World Agriculture—An International Study, Small-Town Stuff, Methods of Social Study, Does History Repeat Itself? The New Morality, Culture and Progress, Language and Languages: An Introduction to Linguistics, The Theory of Wages, The Santa Clara Valley, California, Social Psychology, A History of Fire and Flame, Sin and New Psychology, Sociology and Education, Mental Subnormality and the Local Community: Am Outline or a Practical Program, Tyneside Council op Social Service, Reconstruction and Education in Rural India, The Contribution of the English Le Play School to Rural Sociology, Kagami Kenkyu Hokoku, President's, Pioneer Settlement: Co-Operative Studies, Birth Control and Public Health, Pioneer Settlement: Co-Operative Studies, Ourselves and the World: The Making of an American Citizen, The Emergence of the Social Sciences from Moral Philosophy, The Comparable Interests of the Old Moral Philosophy and the Modern Social Sciences, The World in Agony, Sheffield Social Survey Committee, Housing Problems in Liverpool, Council for the Preservation of Rural England, Forest Land Use in Wisconsin, The Growth Cycle of the Farm Family, The Farmer's Guide to Agricultural Research in 1931, A History of the Public Library Movement in Great Britain and Ireland, The Retirement of National Debts, Public and Private Operation of Railways in Brazil, The Indian Minorities Problem, The Meaning of the Manchurian Crisis, The Drama of the Kingdom, Social Psychology, Competition in the American Tobacco Industry, New York School Centers and Their Community Policy, Desertion of Alabama Troops from the Confederate Army, Plans for City Police Jails and Village Lockups

1933 ◽  
Vol a25 (1) ◽  
pp. 72-109
Author(s):  
R. R. Marbtt ◽  
E. E. Evans-Pritchard ◽  
E. O. Jambs ◽  
Florence Ayscough ◽  
C. H. Desch ◽  
...  
Keyword(s):  
Social Sciences ◽  
Social Psychology ◽  
Moral Philosophy ◽  
Local Community ◽  
Agricultural Research ◽  
Public Library ◽  
The Social ◽  
The World ◽  
History Of ◽  
Pioneer Settlement

Season of birth interacts with measures of inbreeding in multiplex schizophrenia pedigrees: evidence from genetic isolates in Daghestan

Open Medicine ◽  
2006 ◽  
Vol 1 (4) ◽  
pp. 392-398
Author(s):  
Kazima Bulayeva ◽  
John McGrath
Keyword(s):  
Genetic Diversity ◽  
Family History ◽  
Age Of Onset ◽  
Population Genetic Study ◽  
Season Of Birth ◽  
High Genetic Diversity ◽  
Low Genetic Diversity ◽  
High Prevalence ◽  
History Of ◽  
Genetic Isolates

AbstractWhile the season-of-birth effect is one of the most consistent epidemiological features of schizophrenia, there is a lack of consistency with respect to the interaction between season of birth and family history of schizophrenia. Apart from family history, measures related to consanguinity can be used as proxy markers of genomic heterogeneity. Thus, these measures may provide an alternate, indirect index of genetic susceptibility. We had the opportunity to explore the interaction between season of birth and measure of consanguinity in well-described genetic isolates in Daghestan, some of which are known for their relatively high prevalence of schizophrenia. Our previous population-genetic study showed Daghestan has an extremely high genetic diversity between the ethnic populations and a low genetic diversity within them. The isolates selected for this study include some with more than 200 and some with less than 100 generations of demographical history since their founding. Based on pedigrees of multiply-affected families, we found that among individuals with schizophrenia, the measure of consanguinity was significantly higher in the parents of those born in winter/spring compared to those born in summer/autumn. Furthermore, compared to summer/autumn born, winter/spring born individuals with schizophrenia had an earlier age-of-onset, and more prominent auditory hallucinations. Our results suggest that the offspring of consanguineous marriages, and thus those with reduced allelic heterogeneity, may be more susceptible to the environmental factor(s) underpinning the season-of-the effect in schizophrenia.

scholarly journals Incidence of diabetes in South Asian young adults compared to Pima Indians

2021 ◽  
Vol 9 (1) ◽  
pp. e001988
Author(s):  
K M Venkat Narayan ◽  
Dimple Kondal ◽  
Sayuko Kobes ◽  
Lisa R Staimez ◽  
Deepa Mohan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
South Asians ◽  
Diabetes Incidence ◽  
Pima Indians ◽  
Men And Women ◽  
High Prevalence ◽  
History Of ◽  
Indian Men ◽  
Design And Methods

IntroductionSouth Asians (SA) and Pima Indians have high prevalence of diabetes but differ markedly in body size. We hypothesize that young SA will have higher diabetes incidence than Pima Indians at comparable body mass index (BMI) levels.Research design and methodsWe used prospective cohort data to estimate age-specific, sex, and BMI-specific diabetes incidence in SA aged 20–44 years living in India and Pakistan from the Center for Cardiometabolic Risk Reduction in South Asia Study (n=6676), and compared with Pima Indians, from Pima Indian Study (n=1852).ResultsAt baseline, SA were considerably less obese than Pima Indians (BMI (kg/m2): 24.4 vs 33.8; waist circumference (cm): 82.5 vs 107.0). Age-standardized diabetes incidence (cases/1000 person-years, 95% CI) was lower in SA than in Pima Indians (men: 14.2, 12.2–16.2 vs 37.3, 31.8–42.8; women: 14.8, 13.0–16.5 vs 46.1, 41.2–51.1). Risk of incident diabetes among 20–24-year-old Pima men and women was six times (relative risk (RR), 95% CI: 6.04, 3.30 to 12.0) and seven times (RR, 95% CI: 7.64, 3.73 to 18.2) higher as compared with SA men and women, respectively. In those with BMI <25 kg/m2, however, the risk of diabetes was over five times in SA men than in Pima Indian men. Among those with BMI ≥30 kg/m2, diabetes incidence in SA men was nearly as high as in Pima men. SA and Pima Indians had similar magnitude of association between age, sex, BMI, and insulin secretion with diabetes. The effect of family history was larger in SA, whereas that of insulin resistance was larger in Pima IndiansConclusionsIn the background of relatively low insulin resistance, higher diabetes incidence in SA is driven by poor insulin secretion in SA men. The findings call for research to improve insulin secretion in early natural history of diabetes.

Industrial heritage: towards a sustainable adaptive reuse of wheat milling heritage buildings in Jordan

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Monther Jamhawi ◽  
Shatha Mubaideen ◽  
Basem Mahamid
Keyword(s):  
Cultural History ◽  
20Th Century ◽  
Local Community ◽  
Adaptive Reuse ◽  
Local Context ◽  
Urban Context ◽  
Content Type ◽  
Industrial Heritage ◽  
Heritage Buildings ◽  
History Of

PurposeThe purpose of this paper is to present a framework for the adaptive re-use of wheat milling buildings setting in modern urban contexts in Jordan. This paper also aims to highlight the industrial heritage with a focus on wheat milling buildings, which date back to the beginning of the 20th century, as they document and represent significant aspects of the socio-cultural history of Jordan.Design/methodology/approachThe approach to this statement will be through a theoretical investigation into the notion of industrial heritage, a historical overview of wheat milling in Jordan, as well as a case study analysis to support the theoretical framework following a value-based approach for the case of Baboor Al-Qisar. Baboor Al-Qisar is a wheat milling structure that the Department of Antiquities (DoA) is willing to adaptively reuse as an industrial museum that tells the local narrative of wheat milling and points out the non-physical values associated with the building’s original use.FindingsThe paper introduces a framework for wheat milling buildings incorporation within the modern urban context as industrial heritage museums or socio-cultural facilities. The findings offer a reflection on approaching similar case studies as a tool for their conservation, management and promotion to create new tourist destinations as a form of sustainable urban regeneration.Originality/valueThis research bridges the gap between practice and theory in terms of adaptive reuse strategies within the Jordanian local context. No similar studies have been done on wheat milling structures from the 20th century in the country with local community engagement as an integral part that is carried out within the functionality and future use of the site.

scholarly journals High prevalence of undiagnosed COPD among patients evaluated for suspected myocardial ischaemia

Open Heart ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. e000848 ◽  
Author(s):  
Andreas Jönsson ◽  
Artur Fedorowski ◽  
Gunnar Engström ◽  
Per Wollmer ◽  
Viktor Hamrefors
Keyword(s):  
Myocardial Ischaemia ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Clinical Factors ◽  
Obstructive Pulmonary Disease ◽  
Presenting Symptoms ◽  
High Prevalence ◽  
History Of ◽  
Artery Disease ◽  
Global Initiative

ObjectiveChronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are leading causes of global morbidity and mortality. Despite the well-known comorbidity between COPD and CAD, the presence of COPD may be overlooked in patients undergoing coronary evaluation. We aimed to assess the prevalence of undiagnosed COPD among outpatients evaluated due to suspected myocardial ischemia.MethodsAmong 500 outpatients who were referred to myocardial perfusion imaging due to suspected stable myocardial ischaemia, 433 patients performed spirometry. Of these, a total of 400 subjects (age 66 years; 45% women) had no previous COPD diagnosis and were included in the current study. We compared the prevalence of previously undiagnosed COPD according to spirometry criteria from The Global Initiative for Chronic Obstructive Lung Disease (GOLD) or lower limit of normal (LLN) and reversible myocardial ischaemia according to symptoms and clinical factors.ResultsA total of 134 (GOLD criteria; 33.5 %) or 46 patients (LLN criteria; 11.5%) had previously undiagnosed COPD, whereas 55 patients (13.8 %) had reversible myocardial ischaemia. The presenting symptoms (chest discomfort, dyspnoea) did not differ between COPD, myocardial ischaemia and normal findings. Except for smoking, no clinical factors were consistently associated with previously undiagnosed COPD.ConclusionsAmong middle-aged outpatients evaluated due to suspected myocardial ischaemia, previously undiagnosed COPD is at least as common as reversible myocardial ischaemia and the presenting symptoms do not differentiate between these entities. Patients going through a coronary ischaemia evaluation should be additionally tested for COPD, especially if there is a positive history of smoking.

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