scholarly journals Evaluation of Alangium lamarckii Bark for Antiplasmodial and Cytotoxic Constituents and Isolation of a Novel Tubulosine Analogue

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301
Author(s):  
Venkata Siva Satyanarayana Kantamreddi ◽  
Gemma Marston ◽  
Steven D. Shnyder ◽  
Colin W. Wright
Keyword(s):  
Cancer Cells ◽  
Methanolic Extract ◽  
Human Cancer ◽  
Biological Activities ◽  
Chloroform Fraction ◽  
Human Cancer Cell ◽  
Selective Toxicity ◽  
Malaria Parasites ◽  
Human Cancer Cell Lines ◽  
Partial Activity

Alangium lamarkii is traditionally used in India for the treatment of malaria. Partial activity guided-fractionation of the basic chloroform fraction of the methanolic extract of the bark led to the isolation of a novel tubulosine analogue, 10-demethyl-9'- N-methyltubulosine (1), for which the trivial name tubulosatine is suggested. In addition, the known A. lamarkii constituents, tubulosine (2), cephaeline and emetine were isolated as potent antiplasmodial and cytotoxic constituents, but 1 was up to 1000-fold less potent than the former alkaloids against both malaria parasites and human cancer cell lines. The compounds were active against both chloroquine-sensitive and chloroquine-resistant malaria parasites, but no selective toxicity was observed towards malaria parasites compared with cancer cells with any of the alkaloids. Further work to explore the basis for the relatively weak biological activities of 1 would be worthwhile. Betulinic acid, stigmasterol and its 3- O-glucoside were isolated from the neutral chloroform fraction of the methanolic extract.

An IMDAF approach to annellated 1,4:5,8-diepoxynaphthalenes and their metathesis reaction leading to novel scaffolds displaying an antiproliferative activity toward cancer cells

2021 ◽  
Author(s):  
Elizaveta A. Kvyatkovskaya ◽  
Kseniya K. Borisova ◽  
Polina P. Epifanova ◽  
Aleksey A. Senin ◽  
Victor N. Khrustalev ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Metathesis Reaction ◽  
Human Cancer Cell Lines ◽  
Antiproliferative Agent

A 3,5a-epoxyfuro[2,3,4-de]isoquinoline scaffold, the product of ROCM of 1,4:5,8-diepoxynaphthalenes, is a promising antiproliferative agent toward breast and prostate human cancer cell lines.

scholarly journals In vitro photodynamic treatment of cancer cells induced by aza-BODIPYs

2020 ◽  
Vol 19 (6) ◽  
pp. 790-799
Author(s):  
Miryam Chiara Malacarne ◽  
Stefano Banfi ◽  
Enrico Caruso
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Iodine Atom ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Photodynamic Treatment ◽  
Human Cancer Cell Lines

Two new aza-BODIPY photosensitizers featuring an iodine atom on each pyrrolic unit of their structure, were synthesized in fairly good yields and tested in vitro on two human cancer cell lines to assess their photodynamic efficacy.

Bioguided Identification of Antifungal and Antiproliferative Compounds from the Brazilian Orchid Miltonia flavescens Lindl.

2014 ◽  
Vol 69 (1-2) ◽  
pp. 46-52 ◽  
Author(s):  
Leticia F. Porte ◽  
Silvana M. O. Santin ◽  
Lucas U. R. Chiavelli ◽  
Cleuza C. Silva ◽  
Terezinha J. Faria ◽  
...  
Keyword(s):  
Human Cancer ◽  
Antifungal Compound ◽  
Chloroform Fraction ◽  
Human Cancer Cell ◽  
Human Ovary ◽  
Therapeutic Application ◽  
Human Cancer Cell Lines ◽  
Human Cancer Cells ◽  
Cladosporium Herbarum ◽  
Hydrocinnamic Acid

The Orchidaceae family is appreciated worldwide for the beauty of its flowers, and hundreds of species of this family occur in Brazil. Yet little is known about the potential of orchids for therapeutic application. We have investigated bioactive compounds produced by the South Brazilian orchid Miltonia flavescens Lindl. Bioguided studies with the fungus Cladosporium herbarum allowed the identification of hydrocinnamic acid as the active antifungal compound. In addition, the chloroform fraction exhibited an interesting activity against human cancer cells, and 5,7-dihydroxy-6,4'- dimethoxyflavone isolated from this fraction was found to be active against seven human cancer cell lines, including NCI/ADR-RES ovary sarcoma, with an IC50 value of 2.6 mg/mL. This is the first report on the cytostatic activity of this flavone against human ovary sarcoma.

Sesquiterpene lactones from Carpesium rosulatum with potential cytotoxicity against five human cancer cell lines

2010 ◽  
Vol 30 (8) ◽  
pp. 1083-1087 ◽  
Author(s):  
Hyung-In Moon ◽  
Okpyo Zee
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Sesquiterpene Lactone ◽  
Cell Lines ◽  
Human Cancer ◽  
Sesquiterpene Lactones ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Human Cancer Cells ◽  
Whole Plant

In search for plant-derived cytotoxicity compound against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited significant cytotoxic activity. Four sesquiterpene lactone, CRC1 (2α, 5-epoxy-5,10-dihydroxy-6-angeloyl-oxy-9β-isobutyloxy-germacran-8α,12-olide), CRC2 (2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide), CRC3 (2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methyl-butanoyloxy)-gemacran-8α,12-olide), CRC4 (2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide) were isolated from the whole parts of C. rosulatum. 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide (CRC2) showed the most potent cytotoxicity with IC50 value of 6.01 μM against SK-MEL-2.

scholarly journals Compounds with Antiproliferative Activity on Five Human Cancer Cell Lines from South Korean Carpesium triste

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Hyung-In Moon
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Sesquiterpene Lactones ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Human Cancer Cells ◽  
South Korean ◽  
Whole Plant

In the search for antiproliferative compounds against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum Miq. (Compositae) exhibited significant cytotoxic activity. Two sesquiterpene lactones, CT-1 (2α,5-epoxy-5,10-dihydroxy-6-angeloyloxy-9β-isobutyloxy-germacran-8α,12-olide), and CT-2 (2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide) were isolated from the whole plant. CT-2 showed the most potent cytotoxicity with an IC50 value of 7.88 μM against SK-MEL-2.

scholarly journals New Antiproliferative Dibenzo-α-Pyrone From Whole Plants of Centella asiatica

2021 ◽  
Vol 16 (3) ◽  
pp. 1934578X2110030
Author(s):  
Yi Liu ◽  
Wei Wang ◽  
Jian Miao
Keyword(s):  
Cancer Cells ◽  
Chemical Structure ◽  
Inhibitory Concentration ◽  
Human Cancer ◽  
Centella Asiatica ◽  
Mass Spectrometric ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Whole Plants ◽  
Mcf 7

A new compound, 1,3,7,9-tetrahydroxy-6 H-dibenzo[ b, d]pyran-6-one (1), together with 6 known compounds (2-7), was isolated from the extract of whole plants of Centella asiatica. The chemical structure was elucidated on the basis of spectroscopic and mass spectrometric analyses. All the isolates were evaluated for their cytotoxicities against 4 human cancer cell lines (MCF-7, HepG2, Hela, and A549). Among them, compound 1 was found to exhibit significant cytotoxicity on MCF-7 and HepG2 cancer cells with half-maximal inhibitory concentration values of 4.1 and 7.2 µM, respectively.

Novel Artemisinin-Derived Dimers: Synthesis and Evaluation of Anti-cancer Activities

2016 ◽  
Vol 14 (1) ◽  
pp. 102-111 ◽  
Author(s):  
Vu Tuan Kien ◽  
Le Huy Binh ◽  
Phan Hai Phong ◽  
Doan Thi Hien ◽  
Nguyen Thi Thuy My ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Anticancer Compounds ◽  
Human Cancer Cell Lines ◽  
Ic50 Values ◽  
Mcf 7

In continuation of our study on anticancer compounds, a series of novel artemisinin dimers have been synthesized and evaluated for their cytotoxic effects against three human cancer cell lines, including HepG2 (liver cancer), MCF-7(breast cancer) and HL-60 (leukemia cancer). The assay results showed that most of the compounds displayed inhibitory effects against all three human cancer cell lines tested, and seemed to be more cytotoxic toward the blood cancer cells (HL-60) than liver (HepG2), and breast (MCF-7) cancer cells. Among the synthesized artemisinin dimers, the compound 10d with a double bond bridge exhibited the most potent cytotoxicity with IC50 values of 5.08, 4.82 and 1.32 µg/mL against the HepG2, MCF-7, and HL-60 cell lines, respectively.

Ferrocene–cinchona hybrids with triazolyl-chalcone linkers act as pro-oxidants and sensitize human cancer cell lines to paclitaxel

Metallomics ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 1132-1141 ◽  
Author(s):  
Ana Podolski-Renić ◽  
Szilvia Bősze ◽  
Jelena Dinić ◽  
László Kocsis ◽  
Ferenc Hudecz ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Oxidative Agents

Epimeric ferrocene–quinidine hybrids with triazolyl-chalcone linkers act as pro-oxidative agents and autophagy modulators in paclitaxel resistant cancer cells.

scholarly journals Unnatural C-1 homologues of pancratistatin — Synthesis and promising biological activities

2012 ◽  
Vol 90 (11) ◽  
pp. 932-943 ◽  
Author(s):  
Sergey Vshyvenko ◽  
Jon Scattolon ◽  
Tomas Hudlicky ◽  
Anntherese E. Romero ◽  
Alexander Kornienko ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Solid Phase ◽  
Human Cancer ◽  
Biological Activities ◽  
Positive Control ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Hydroxy Compounds ◽  
Key Steps ◽  
New Compounds

Several C-1 homologues of pancratistatin and 7-deoxypancratistatin were synthesized by a phenanthrene–phenathridone oxidative recyclization strategy. The key steps involved the enzymatic dihydroxylation of bromobenzene, addition of an aryl alane to an epoxyaziridine, an intramolecular aziridine opening on silica gel in solid phase, and the above-mentioned recylization strategy. Experimental and spectral data are reported for all new compounds. All synthesized C-1 homologues of pancratistatin and 7-deoxypancratistatin were evaluated for antiproliferative activity in a panel of human cancer cell lines. As expected, the 7-hydroxy compounds were found to be more potent and the activity of the C-1 benzoxymethyl analogue exceeded that of narciclasine, which was used as a positive control.

Sign in / Sign up

Export Citation Format

Share Document