scholarly journals Acquired smooth muscle hamartoma: A case report on the lower extremity with hidrosis

2019 ◽  
Vol 7 ◽  
pp. 2050313X1989383
Author(s):  
Malika A Ladha ◽  
Todd Remington
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Lower Extremity ◽  
Smooth Muscle Cells ◽  
English Literature ◽  
Surgical Excision ◽  
Muscle Cells ◽  
Clinical Spectrum ◽  
Rare Entity ◽  
First Case

Smooth muscle hamartomas are benign dermal proliferations of smooth muscle cells. Smooth muscle hamartomas are sub-divided into congenital or acquired; the latter is a rare entity with less than 20 cases being reported in the English literature. Most often asymptomatic, acquired smooth muscle hamartomas follow an indolent course. Treatment in the form of surgical excision can be utilized for symptomatic or cosmetic purposes. Here, we report the first case of an acquired smooth muscle hamartomas of the shin which also uniquely presented with hidrosis. This case highlights the varied clinical spectrum of acquired smooth muscle hamartomas.

Lymphangioma of the Pancreas With “Ovarian-like” Mesenchymal Stroma: A Case Report With Emphasis on Histogenesis

2003 ◽  
Vol 127 (11) ◽  
pp. 1513-1516 ◽  
Author(s):  
Lizhen Gui ◽  
Steven A. Bigler ◽  
Charu Subramony
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mesenchymal Cells ◽  
Developmental Anomaly ◽  
Mesenchymal Stroma ◽  
Multiple Cysts ◽  
Lymphoid Aggregates

Abstract Pancreatic lymphangiomas, which occur predominantly in women, are rare and account for only 1% of all lymphangiomas. The characteristic histologic features include multiple cysts lined by endothelial cells, irregularly distributed smooth muscle cells, and lymphoid aggregates in the wall of the cyst. We describe a 36-year-old woman with lymphangioma of the pancreas with “ovarian-like” mesenchymal stroma in the wall. This stroma, composed of uncommitted mesenchymal cells, has not been described previously in the wall of pancreatic lymphangiomas. Multiple small lymphatic channels that are found in this stroma recapitulate the development of lymphatic channels in the embryo. Lymphangioma of the pancreas may arise from distension of these lymphatic channels. Pancreatic lymphangioma may, therefore, be a developmental anomaly rather than a true neoplasm.

Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast - A Case Report -

2010 ◽  
Vol 44 (4) ◽  
pp. 431
Author(s):  
Ga-Eon Kim ◽  
Young Kim ◽  
Eun-Hui Jeong ◽  
Jo-Heon Kim ◽  
Min-Ho Park ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Cells ◽  
Muscle Cells

New evidence for vascular interactions between aldosterone, angiotensin II and antioxidants in isolated smooth muscle cells of rats

Open Medicine ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. 704-712
Author(s):  
Raducu Popescu ◽  
Walther Bild ◽  
Alin Ciobica ◽  
Veronica Bild
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Nitrosative Stress ◽  
Reactive Oxygen ◽  
Muscle Cells ◽  
No Production ◽  
Nitrogen Species ◽  
First Case

AbstractAccumulating evidence suggests that the nongenomic cardiovascular actions of aldosterone are produced by varied cellular pathways and mediated by a multitude of messenger systems including the reactive oxygen and nitrogen species. Considering the involvement of the oxidative and nitrosative stress in the pathways leading to the activation of the angiotensin — aldosterone system, in the current study we tried to evaluate the functional interactions between aldosterone, angiotensin II and antioxidants in isolated vascular smooth muscle of aortic rings from rats. Our data provide additional arguments that the nongenomic actions of aldosterone on aortic smooth muscle cells of rats are a question of cross-talk and balance between its rapid vasoconstrictor and vasodilator effects, as result of the activation of reactive oxygen species in the first case and of nitrogen species in the second. In this way, it seems that at low ambient oxidative stress, aldosterone promotes nitric oxide (NO) production and vasodilatation, while in situations with increased oxidative stress the endothelial dysfunction and detrimental effects induced by vasoconstriction will prevail. Thus, aldosterone could be considered both “friend and foe”. This could be relevant for the ways in which aldosterone damages cardiovascular functions and could lead to significant therapeutic improvements.

scholarly journals GRIA2/ENPP3 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells in the Restenosis Process Post-PTA in Lower Extremity Arteries

2021 ◽  
Vol 12 ◽  
Author(s):  
Mi Zhou ◽  
Lixing Qi ◽  
Yongquan Gu
Keyword(s):  
Smooth Muscle ◽  
Lower Extremity ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Enrichment Analysis ◽  
Muscle Cells ◽  
Differentially Expressed ◽  
And Migration ◽  
Proliferation And Migration

Restenosis is the main restriction on the long-term efficacy of percutaneous transluminal angioplasty (PTA) therapy for peripheral artery disease (PAD). Interventions to prevent restenosis are poor, and the exact mechanism is unclear. Here, we aimed to elucidate the role of GRIA2 in the restenosis process post-PTA in lower extremity arteries. We searched the differentially expressed genes (DEGs) between atherosclerotic and restenotic artery plaques in the Gene Expression Omnibus (GEO), and five DEGs were identified. Combined with Gene Ontology (GO) enrichment analysis, GRIA2 was significantly correlated with the restenosis process. Tissue samples were used to examine GRIA2 expression by immunofluorescence staining of atherosclerotic and restenotic artery plaques. The regulation of GRIA2 in vascular smooth muscle cells (VSMCs) was confirmed by lentiviral transfection. Overexpression of GRIA2 promoted the proliferation and migration of VSMCs. Using Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and protein–protein interaction (PPI) network, a strong connection between ENPP3 and GRIA2 was discovered. In vitro results showed that the high expression of GRIA2 in VSMCs enhanced the expression of ENPP3, while downregulation of GRIA2 downregulated ENPP3. GRIA2 is highly differentially expressed in restenotic arterial plaques, promoting the proliferation and migration of VSMCs through upregulation of ENPP3. These discoveries will help us to obtain a better understanding of restenosis in lower extremity arteries.

scholarly journals A rare case of uterine leiomyosarcoma: A case report

2021 ◽  
Vol 8 (3) ◽  
pp. 404-407
Author(s):  
Bhuvana Preethi ◽  
Usha Rajesh ◽  
Mala Vijayakrishnan
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Cells ◽  
Postmenopausal Women ◽  
Malignant Tumor ◽  
Rare Case ◽  
Muscle Cells ◽  
Uterine Leiomyosarcoma ◽  
Postmenopausal Bleeding

Uterine leiomyosarcoma is a rare malignant tumor that arises from smooth muscle cells. It comprises of 1% of all uterine malignancy. We report a case of 54 year old Postmenopausal women with 2 episodes of postmenopausal bleeding and was diagnosed with Leiomyosarcoma of uterus.

scholarly journals Leiomyoma of the Cheek

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Ricardo Roberto de Souza Fonseca ◽  
Mário Augusto Ramos Junior ◽  
Douglas Baruchi ◽  
Tabata Resque Beckmann Carvalho ◽  
Andresa Borges Soares ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Tract ◽  
Smooth Muscle Cells ◽  
Rare Case ◽  
Surgical Excision ◽  
Muscle Cells ◽  
Benign Tumors ◽  
Tunica Media ◽  
The Right

Leiomyomas are rare benign tumors that grow in the tunica media of smooth muscle cells. Leiomyomas occur most frequently in the uterus or gastrointestinal tract and only very rarely in the area of the cheek. This study reports on a rare case of a leiomyoma in the cheek of a 43-year-old woman, who presented with a well-circumscribed, asymptomatic, mobile swelling in the right cheek. This swelling was slightly purplish in color and measured approximately 4 cm×3 cm. Surgical excision was the treatment of choice, and the diagnosis was based on histopathological and immunohistochemical stains, which were positive for actin and desmin and negative for AE1/AE3, CD34, and S100. The patient’s follow-up, two years later, showed no recurrence, and she has been asymptomatic since the surgery.

scholarly journals Uterine Angioleiomyoma with Atypia, Raised CA-125 Levels, and Pseudo-Meigs Syndrome: An Alarming Presentation

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sunitha Thomas ◽  
Laxmi Radhakrishnan ◽  
Latha Abraham ◽  
Anna Matthai
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Case Reports ◽  
Muscle Cells ◽  
Ca 125 ◽  
Rare Entity ◽  
Cellular Atypia ◽  
Vascular Channels ◽  
Mesenchymal Tumours

Angioleiomyomas are benign mesenchymal tumours commonly occurring in the subcutis of extremities. They are typically composed of interlacing fascicles of smooth muscle cells with intersecting vascular channels. Angioleiomyomas of the uterus are rare with only very few case reports available in literature. Herein, we report a case of this rare entity in a 47-year-old woman owing to its highly unusual features of cellular atypia, raised CA-125 levels, and pseudo Meigs syndrome.

Immunogold localization of HMB-45 antigen in pulmonary lymphangiomyomatosis

1995 ◽  
Vol 53 ◽  
pp. 998-999
Author(s):  
J.M. Minda ◽  
E. Dessy ◽  
G. G. Pietra
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Room Temperature ◽  
Osmium Tetroxide ◽  
Muscle Cells ◽  
Ultrastructural Localization ◽  
Reproductive Age ◽  
Thin Sections ◽  
Smooth Muscle Proliferation ◽  
Hmb 45

Pulmonary lymphangiomyomatosis (PLAM) is a rare disease occurring exclusively in women of reproductive age. It involves the lungs, lymph nodes and lymphatic ducts. In the lungs, it is characterized by the proliferation of smooth muscle cells around lymphatics in the bronchovascular bundles, lobular septa and pleura The nature of smooth muscle proliferation in PLAM is still unclear. Recently, reactivity of the smooth muscle cells for HMB-45, a melanoma-related antigen has been reported by immunohistochemistry. The purpose of this study was the ultrastructural localization of HMB-45 immunoreactivity in these cells using gold-labeled antibodies.Lung tissue from three cases of PLAM, referred to our Institution for lung transplantation, was embedded in either Poly/Bed 812 post-fixed in 1% osmium tetroxide, or in LR White, without osmication. For the immunogold technique, thin sections were placed on Nickel grids and incubated with affinity purified, monoclonal anti-melanoma antibody HMB-45 (1:1) (Enzo Diag. Co) overnight at 4°C. After extensive washing with PBS, grids were treated with Goat-anti-mouse-IgG-Gold (5nm) (1:10) (Amersham Life Sci) for 1 hour, at room temperature.

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