scholarly journals RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea

2022 ◽  
Author(s):  
Habib Zouali ◽  
Juliette Lemasson ◽  
Andreea Calugareanu ◽  
Christophe Battail ◽  
David Michonneau ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Chronic Gvhd ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
High Dose ◽  
Real Time Quantitative Pcr ◽  
Inflammatory Pathways ◽  
Adaptive Immune Cells ◽  
Wide Range ◽  
Transcriptomic Level

Cutaneous involvement of chronic graft-versus-host disease (cGVHD) has a wide range of manifestations including a lichenoid form with a currently assumed mixed Th1/Th17 signature and a sclerotic form with Th1 signature. Despite substantial heterogeneity of innate and adaptive immune cells recruited to the skin and of the different clinical manifestations, treatment depends mainly on the severity of the skin involvement, and relies on systemic, high-dose glucocorticoids alone or in combination with a calcineurin inhibitor. We performed the first study using RNAseq to profile and compare the transcriptome of lichen planus cGVHD (n=8), morphea cGVHD (n=5), and healthy controls (n=6). Our findings revealed shared and unique inflammatory pathways to each cGVHD subtype that are both pathogenic and targetable. In particular, the deregulation of IFN signaling pathway was strongly associated with cutaneous cGVHD, whereas the triggering receptor expressed on myeloid cells-1 (TREM-1) pathway was found to be specific of lichen planus and likely contributes to its pathogenesis. The results were confirmed at a protein level by performing immunohistochemistry staining and at a transcriptomic level using Real-Time quantitative PCR.

scholarly journals Lichen Planus in the Lines of Blaschko – A Case Report / Blaschko linearni lichen planus – prikaz slučaja

2011 ◽  
Vol 3 (4) ◽  
pp. 153-158
Author(s):  
Zorica Perić-Hajzler ◽  
Lidija Zolotarevski ◽  
Dušan Šofranac ◽  
Lidija Kandolf Sekulović
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Clinical Manifestations ◽  
Lichen Sclerosus ◽  
Skin Lesions ◽  
Linear Distribution ◽  
Blaschko Lines ◽  
Genetic Mosaicism ◽  
Mucous Membranes ◽  
Lines Of Blaschko

Abstract Lichen planus is an acquired inflammatory disease of the skin, mucous membranes and nails. It is characterized by pruritic polygonal livid papules. The disease was first described by Erasmus Wilson in 1869. It is primarily a disease of adults, and it usually occurs between the ages of 30 and 60, without gender predominance. The exact incidence and prevalence of this disease are unknown, but it is thought to affect less than 1% of the general population (0.14 to 0.80%) (1). A 63-year old male patient was admitted to our Department with itchy erythematous papules and plaques which appeared a month before admission. On admission, numerous erythematous and livid papules and plaques of polygonal shape up to 5 mm in diameter were present in the lines of Blaschko, along the left lower extremity, left side of the trunk and the left upper arm (Figures 1-3), while mucous membranes, nails and scalp were spared. Blaschko-linear distribution of skin lesions was first described by a German dermatologist Alfred Blaschko in 1901 in his work ”The distribution of nerves in the skin and their relationship to diseases of the skin”. In 1978, Happle first published that genetic mosaicism was the cause of these peculiar skin changes (1,4,6). Although knowledge of mosaicism in the skin was further elucidated in articles of several authors (Taieb in 1994, Bolognia in 1994, Heide 1996), the exact mechanism and molecular basis for the development of Blashcko linear distribution has not been fully clarified yet (5). Blaschko lines may be related to X-linked, congenital and inflammatory dermatoses, and they may be found in several skin conditions like segmental forms of atopic dermatitis, erythema multiforme, pemphigus vulgaris, vitiligo, and granuloma annulare. This is a case report of a patient with a rare form of lichen planus, with typical clinical manifestations and with Blaschko-linear distribution. Lichen planus in the lines of Blaschko was also described in several other dermatoses: lichen striatus, lichen sclerosus, morphea, porokeratosis of Mibelli, mucinosis follicularis and psoriasis vulgaris. The treatment included topical corticosteroids under occlusion, due to comorbidities, with satisfactory response. Other options include, topical calcineurin inhibitors, intralesional and systemic corticosteroids, retinoids, phototherapy and in resistant cases that severely affect the quality of life methotrexate, cyclosporine and thalidomide.

scholarly journals 023 RNA sequencing of chronic GVHD skin lesions identifies TREM1 as a possible therapeutic traget in lichen planus

2021 ◽  
Vol 141 (10) ◽  
pp. S152
Author(s):  
A. Calugareanu ◽  
J. Lemasson ◽  
H. Zouali ◽  
C. Battail ◽  
H. Le Buanec ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Lichen Planus ◽  
Chronic Gvhd ◽  
Skin Lesions

scholarly journals Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
Yi Liu ◽  
Xuelei Liang ◽  
Haixuan Wu ◽  
Fenglin Zhuo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lichen Planus ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Immunosuppressive Drugs ◽  
Overlap Syndrome ◽  
Systemic Lupus ◽  
Delayed Treatment ◽  
Multiple Biopsies

Introduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/systemic lupus erythematosus (SLE) overlap syndrome with hair loss as the first symptom.Case Presentation: A 48-year-old female presented with alopecia for half a year, and skin lesions accompanied by itching on her face, trunk, and limbs for 3 months. She had a history suggestive of photosensitivity. Laboratory tests and histopathology were performed for diagnosis. Histopathologic features of the upper arm and back of the hand were consistent with BLP, whereas the scalp lesion indicated LE. Laboratory examination indicated positive for antinuclear antibody (ANA) (1:160), leukopenia, increased urinary protein, decreased C3/C4, and normal BP180. The patient was given glucocorticoid combined with acitretin and immunosuppressive therapy after a definite diagnosis of BLP/SLE overlap syndrome. The lesions of the patient disappeared and some hair had regrown during the two years of follow-up.Conclusion: This is the first reported case of BLP/SLE overlap syndrome which responded well to glucocorticoids, retinoids, and immunosuppressive drugs. Multiple biopsies from characteristic lesions will guide doctors to avoid misdiagnoses and delayed treatment.

scholarly journals Systemic lupus erythematosus or lupus-like syndrome in patients with HIV infection: clinical case review

2021 ◽  
Vol 2 (1) ◽  
pp. 22-27
Author(s):  
Margarita A. Gromova ◽  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Hiv Infection ◽  
Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Clinical Manifestations ◽  
High Dose ◽  
Case Review ◽  
Systemic Lupus ◽  
Wide Range

Background. Due to multi-organ lesions and a wide range of clinical manifestations, human immunodeficiency virus (HIV infection) resembles systemic connective tissue diseases, particularly systemic lupus erythematosus (SLE). Similarity of immune disorders in patients with HIV infection and SLE may lead to misdiagnosis resulting in wrong tactics of treatment (prescribing immunosuppressive therapy instead of high-dose antiretroviral therapy). Aim. To report the HIV infection and SLE differential diagnosis challenges. Results. By January 2021, the analysis of national literature revealed two cases of HIV infection in young women, initially misdiagnosed with suspected SLE. In addition to two patients described in literature, one more female patient with SLE manifestations combined with advanced stage of HIV infection was examined. Conclusion. HIV and SLE differential diagnosis is the ultimate challenge for clinicians. Physicians should be especially apprehensive about HIV infection when making the diagnosis of SLE. SLE therapy in patients with HIV infection should be appointed according to strict indications.

Review of modern physiotherapeutic methods in treatment of acne

2019 ◽  
Vol 1 (7) ◽  
pp. 15-18 ◽  
Author(s):  
A. A. Kolodii ◽  
E. A. Shatokhina ◽  
R. I. Khalilullin
Keyword(s):  
Low Voltage ◽  
Cell Metabolism ◽  
Clinical Manifestations ◽  
Light Therapy ◽  
Skin Surface ◽  
Skin Lesions ◽  
Sebaceous Glands ◽  
Pathogenic Factors ◽  
Wide Range ◽  
The Impact

The article presents modern views on the pathogenesis of acne, as well as the analysis of the literature data on physiotherapy methods of treatment. Acne is the most common inflammatory chronic recurrent skin disease caused by changes in pilosebatsionnyh structures. Acne of varying severity affects 80-85 % of people in the age of 12-25 years and 11 % over the age of 25 years. This pathology has a wide range of clinical manifestations: patients have open and closed comedones, as well as inflammatory skin lesions, including papules, pustules and nodes. in modern literature, it is common to distinguish 4 main factors of acne development: pathological vulgar hyperkeratosis, increased secretion of the sebaceous glands, Propionibacterium acne activity, local inflammation. Correction of these four pathogenic factors is the aim of physiotherapeutic methods of acne treatment. Currently, the most popular are the following methods: Photodynamic therapy: this method is aimed to destruct P. Acne and sebaceous glands. The mechanism of action is based on the selective destruction of cells as a result of light - activated chemical reaction in the presence of a substance - photosensitizer. IPL (Intense Pulsed Light) therapy is a technique based on the use of a special intense pulsing light. The skin surface is exposed to incoherent pulses of visible light with a wavelength of 500-1 200 nm. it is believed that these impulses penetrate deeply into the follicle and photoactivating the porflrins of the microorganism and causing its death. Microcurrent therapy is a method of impact on the human body with the help of modulated pulse currents of low power (up to 1 mA) with minimum voltage and different frequency used for therapeutic or cosmetic effect. it is believed that the impact of low voltage currents has a positive effect on cell metabolism, increases the synthesis of adenosine triphosphate. The procedure, activates fibroblasts, improves microcirculation, normalizes the sebaceous glands and pore reduction. Also in the treatment of acne and post-acne are widely used two types of lasers: ablative type - provides a directed damage to the affected skin, including the epidermis, while laser radiation is approximately equally absorbed by all layers of the skin; non-ablative type - as a result of the radiation by this type of laser, there is a selective removal of pathological structures without damage of the epidermis. Radiation is selectively absorbed by these structures, but not by the epidermis. Reasonable combined administration of systemic and topical drugs in the combination with physiotherapeutic methods, allows to achieve a good clinical effect and improve the quality of life of patients with various forms of acne.

scholarly journals Tinea incognito: Clinical perspectives of a new imitator

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Samer Dhaher
Keyword(s):  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Systemic Steroid ◽  
Discoid Lupus Erythematosus ◽  
Wide Range ◽  
The Face ◽  
Tinea Incognito ◽  
A Prospective Study

Tinea incognito is a variant of dermatophyte infection of the skin modified by an erroneously applied topical or systemic steroid. Aim of the study: to describe the various clinic-epidemiological aspects of tinea incognito found among our patients. A prospective study was carried out in the Department of Dermatology, Basra Teaching Hospital, Basra, Iraq. The clinical diagnosis was confirmed by mycological tests. Clinical data were described in more detail and the lesions were classified according to the site, shape, and extent. Ninety cases of tinea incognito were seen, median age was 34years. The initial inaccurate diagnoses were eczema in 60 patients (67%), intertrigo in 16 (18 %) and psoriasis in 14 (15%) patients. The type of topical drugs applied was topical corticosteroid (potent and fluorinated) in most cases (54.4%), fixed drug combination creams in 36.6% and a topical calcineurin inhibitor in 5.5%. Commonly presented as acute eczema-like, on hands and trunk, discoid lupus erythematosus-like lesions on the face and psoriasiform lesions on the scalp. Due to the wide range of clinical manifestations, tinea incognito imitates many skin diseases and should, therefore, be considered in any chronic, erythematous, scaly skin lesions not responding to topical treatment.

scholarly journals Incidence and treatment outcome of oral lichen planus in Southeast Serbia in a 10-year period (1997-2007)

2009 ◽  
Vol 66 (6) ◽  
pp. 434-439 ◽  
Author(s):  
Ljiljana Kesic ◽  
Radmila Obradovic ◽  
Dragan Mihailovic ◽  
Goran Radicevic ◽  
Sasa Stankovic ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Manifestations ◽  
Systemic Corticosteroids ◽  
Short Course ◽  
Wide Range ◽  
Significant Difference ◽  
Oral Lichen

Background/Aim. Lichen planus is a chronic, immunologic, mucocutaneous disease with a wide range of clinical manifestations. The aim of this retrospective study was to evaluate the most common forms of oral lichen planus (OLP) and its symptoms and to describe treatment responses in patients during 10-year period. Methods. The study was conduced on 163 OLP patients who came in the Department of Oral medicine and Periodontology between 1997 and September 2007. Each case was classified into one of four clinical subtypes: reticular, atrophic, erosive-ulcerative, bullous. Results. There was no significant difference in patients age. Women were found to be significantly more likely to have OLP (p < 0.001). Corticosteroids were effective in reducing symptoms, erythema and healing ulcers. Improvement was shown over a long term in 61.35% patients. Over the long term 38.65% patients maintained the same type of OLP or it became a more severe type. Two patients (1.22%) developed oral carcinoma during the follow-up period. Conclusion. The response of patients with erosive OLP to a short course of systemic corticosteroids often was quite remarkable. However, symptoms and signs tended to recur after this treatment. Periodic examinations, patient education, medical treatment, monitoring of side-effects as well as follow-up biopsies are necessary for management of OLP patients.

scholarly journals A new index to assess the severity of Lichen planus in clinical practice

2020 ◽  
Vol 96 (3) ◽  
pp. 27-33
Author(s):  
Aleksandr V. Patrushev ◽  
Aleksei V. Samtsov ◽  
Aleksei V. Sukharev ◽  
Aleksandr A. Minchenko ◽  
Maxim V. Mamunov
Keyword(s):  
Lichen Planus ◽  
Pearson Correlation ◽  
Clinical Manifestations ◽  
Correlation Coefficients ◽  
Severity Index ◽  
Skin Lesions ◽  
Index Formula ◽  
Cronbach’S Alpha ◽  
Cronbach's Alpha ◽  
Severity Of The Disease

Purpose.Development and validation of the severity index of lichen planus (LP). Materials and methods.At the first stage, by means of theoretical substantiation, the main parameters and signs were identified that affect the severity of the disease and the quality of life of patients, which culminated in the derivation of the final index formula, which was called the lichen area and severity index (LPASI). At the second stage, LPASI was validated during the examination of 45 LP patients who were treated in the clinic of skin and venereal diseases of the Military Medical Academy in 20182019. Determination of LPASI was carried out by five dermatovenerologists independently of each other twice with an interval of one week. The analysis of the results was carried out using STATISTICA 10.0 programs and SPSS Statistics 17.0. The Spearman Brown and Pearson correlation coefficients were used to evaluate the intra-expert and inter-expert reliability of the index, and the Cronbach's alpha coefficient was calculated to assess the internal consistency of the scale. Results.The final formula for calculating LPASI is as follows: 0.2A+2B+5С+D, where A is the area of skin lesions in percentage, B is the severity of clinical manifestations on the skin, C is the severity of clinical manifestations on the oral mucosa and D is the severity of subjective sensations. The index can range from 0 to 82. The LPASI values for the whole group (n=45) were characterized by a normal distribution of the trait (p0.05), the minimum and maximum values varied from 7.2 to 42 points, the median was 22 points, the interquartile span from 14 to 27 points. The values of the Spearman Brown and Pearson coefficients were equal to 0.91 (95% CI 0.890.99) and 0,87 (95% CI 0.860.93), which indicates the reproducibility of the results and the reliability of the index. In this case, a high consistency between the selected features within the scale (Cronbach's alpha criterion 0.93) was established. Conclusion.Objectification of the severity of the disease using LPASI should become an integral part of the clinical examination of patients. The use of LPASI will allow to control the effectiveness of prescribed therapy, as well as to compare the results of scientific research.

scholarly journals Lichen planus ruber, current therapy: a systematic review

2021 ◽  
Vol 28 (2) ◽  
pp. 104-119
Author(s):  
M. M. Tlish ◽  
P. S. Osmolovskaya
Keyword(s):  
Lichen Planus ◽  
Clinical Manifestations ◽  
Small Sample ◽  
Current Therapy ◽  
Efficacy And Safety ◽  
Wide Range ◽  
Current Therapies ◽  
Randomised Controlled ◽  
Methods Of Treatment

Background. Lichen planus ruber is a common inflammatory disease of skin and mucous membranes with a chronic relapsing course, resistance to conventional therapy, diverse clinical manifestations and capacity of tumourisation. Dermatosis is often comorbid with various underlying gastrointestinal, cardiovascular illnesses and endocrinopathies. Women are more impacted than men (ratio 1.4:1), the disease lasts from 5 to 40 years.Objectives. Assessment of the efficacy and safety of current therapies for lichen planus ruber.Methods. The PubMed, Web of Science, Medline, eLibrary and Scopus databases were mined for randomised controlled studies on treatment of this dermatosis in the period of 2014–2020, and selected impactive publications within 1991–2012 were also included in the review. The following keywords were used: lichen planus [красный плоский лишай], systemic and local drugs [системные и местные препараты], phototherapy [фототерапия], physiotherapeutic methods of treatment [физиотерапевтические методы лечения]. Publications in peer-reviewed journals had priority. Content and descriptive analyses were used as research tools.Results. Therapy for lichen planus ruber is multicomponent including a wide range of techniques, mostly immune-stimulating but often unproved for efficacy and safety. Selected studies are small-sample. The review presents feasible drug-based and physiotherapeutic methods to tackle lichen planus ruber, their application by the disease clinical presentation and prevalence, patient’s personal discomfort, psycho-emotional status and comorbidity. We describe the mechanisms of action, clinical efficacy, application types and noxious side effects in practiced albeit sometimes contentious therapies.Conclusion. Further well-designed research is warranted to aim at enhanced efficacy, safety and long-term remission in therapy for lichen planus ruber.

Sign in / Sign up

Export Citation Format

Share Document