scholarly journals Characterization and performance of the Allegro™ STR 1000 single-use stirred tank bioreactor system

2015 ◽  
Vol 9 (S9) ◽  
Author(s):  
Kerem Irfan ◽  
Byron Rees ◽  
Tim Barrett ◽  
Bojan Markicevic ◽  
Camille Segarra
Keyword(s):  
Stirred Tank ◽  
Stirred Tank Bioreactor ◽  
Single Use ◽  
Bioreactor System ◽  
And Performance

scholarly journals Characterization and performance of the Allegro™ STR 200 single-use stirred tank bioreactor

2015 ◽  
Vol 9 (S9) ◽  
Author(s):  
Byron Rees ◽  
John Thompson ◽  
Bojan Isailovic ◽  
Kerem Irfan ◽  
Camille Segarra
Keyword(s):  
Stirred Tank ◽  
Stirred Tank Bioreactor ◽  
Single Use ◽  
And Performance

scholarly journals Performance of a continuously stirred tank bioreactor system connected in series for the biodegradation of thiocyanate and free cyanide

2017 ◽  
Vol 5 (2) ◽  
pp. 1936-1945 ◽  
Author(s):  
Lukhanyo Mekuto ◽  
Seteno K.O. Ntwampe ◽  
Clement E. Utomi ◽  
Mmabatho Mobo ◽  
John Baptist Mudumbi ◽  
...  
Keyword(s):  
Stirred Tank ◽  
Free Cyanide ◽  
Stirred Tank Bioreactor ◽  
In Series ◽  
Bioreactor System

Characterization of Hematopoietic Cell Expansion, Oxygen Uptake, and Glycolysis in a Controlled, Stirred-Tank Bioreactor System

1998 ◽  
Vol 14 (3) ◽  
pp. 466-472 ◽  
Author(s):  
P.C. Collins ◽  
L.K. Nielsen ◽  
S.D. Patel ◽  
E.T. Papoutsakis ◽  
W.M. Miller
Keyword(s):  
Oxygen Uptake ◽  
Cell Expansion ◽  
Hematopoietic Cell ◽  
Stirred Tank ◽  
Stirred Tank Bioreactor ◽  
Bioreactor System

scholarly journals Process development for expansion of human mesenchymal stromal cells in a 50L single-use stirred tank bioreactor

2017 ◽  
Vol 120 ◽  
pp. 49-62 ◽  
Author(s):  
Tristan Lawson ◽  
Daniel E. Kehoe ◽  
Aletta C. Schnitzler ◽  
Peter J. Rapiejko ◽  
Kara A. Der ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Process Development ◽  
Stirred Tank ◽  
Stirred Tank Bioreactor ◽  
Human Mesenchymal Stromal Cells ◽  
Single Use

scholarly journals An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes

2021 ◽  
Vol 105 (6) ◽  
pp. 2225-2242
Author(s):  
Cedric Schirmer ◽  
Rüdiger W. Maschke ◽  
Ralf Pörtner ◽  
Dieter Eibl
Keyword(s):  
Stirred Tank ◽  
Biotechnological Production ◽  
Comprehensive Overview ◽  
Stirred Tank Bioreactor ◽  
Stirred Bioreactor ◽  
Advantages And Disadvantages ◽  
Type Size ◽  
Single Use ◽  
Biotechnological Processes ◽  
Drive Systems

AbstractNo matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts.Key Points• Basic design of the most frequently used bioreactor type: the stirred tank bioreactor• Differences in most common seal types in stirred systems and fields of application• Comprehensive overview of commercially available bioreactor seal types• Increased use of magnetically driven agitation systems in single-use bioreactors

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