scholarly journals HLA-SPREAD: a natural language processing based resource for curating HLA association from PubMed abstracts

BMC Genomics ◽  
2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Dhwani Dholakia ◽  
Ankit Kalra ◽  
Bishnu Raman Misir ◽  
Uma Kanga ◽  
Mitali Mukerji
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Semantic Analysis ◽  
Skin Diseases ◽  
Human Leukocyte ◽  
Relevant Information ◽  
Entity Recognition ◽  
Hla Association ◽  
Disease Associations

AbstractExtreme complexity in the Human Leukocyte Antigens (HLA) system and its nomenclature makes it difficult to interpret and integrate relevant information for HLA associations with diseases, Adverse Drug Reactions (ADR) and Transplantation. PubMed search displays ~ 146,000 studies on HLA reported from diverse locations. Currently, IPD-IMGT/HLA (Robinson et al., Nucleic Acids Research 48:D948–D955, 2019) database houses data on 28,320 HLA alleles. We developed an automated pipeline with a unified graphical user interface HLA-SPREAD that provides a structured information on SNPs, Populations, REsources, ADRs and Diseases information. Information on HLA was extracted from ~ 28 million PubMed abstracts extracted using Natural Language Processing (NLP). Python scripts were used to mine and curate information on diseases, filter false positives and categorize to 24 tree hierarchical groups and named Entity Recognition (NER) algorithms followed by semantic analysis to infer HLA association(s). This resource from 109 countries and 40 ethnic groups provides interesting insights on: markers associated with allelic/haplotypic association in autoimmune, cancer, viral and skin diseases, transplantation outcome and ADRs for hypersensitivity. Summary information on clinically relevant biomarkers related to HLA disease associations with mapped susceptible/risk alleles are readily retrievable from HLASPREAD. The resource is available at URL http://hla-spread.igib.res.in/. This resource is first of its kind that can help uncover novel patterns in HLA gene-disease associations.

scholarly journals HLA-SPREAD: A comprehensive resource for HLA associated diseases, drug reactions and SNPs across populations

2021 ◽  
Author(s):  
Dhwani Dholakia ◽  
Ankit Kalra ◽  
Uma Kanga ◽  
Mitali Mukerji
Keyword(s):  
Language Processing ◽  
Semantic Analysis ◽  
Skin Diseases ◽  
Named Entity Recognition ◽  
Human Leukocyte ◽  
Relevant Information ◽  
Entity Recognition ◽  
Drug Reactions ◽  
Hla Association ◽  
Disease Associations

ABSTRACTExtreme complexity in the HLA system and its nomenclature makes it difficult to interpret and integrate relevant information for HLA associations with diseases, Adverse Drug Reactions (ADR), Transplantation. PubMed search displays ~110,000 studies on Human Leukocyte Antigens (HLA) reported from, diverse locations and on multiple populations and IPD-IMGT/HLA database houses data on 28,320 HLA alleles till date. We developed an automated pipeline with a unified graphical user interface HLA-SPREAD that provides a structured information on SNPs, Populations, REsources, ADRs and Diseases information. Information on HLA was extracted from ~24 million PubMed abstracts extracted using Natural Language Processing (NLP). Python scripts were used to mine and curate information on diseases, filter false positives and categorize to 24 tree hierarchical groups and named Entity Recognition (NER) algorithms and semantic analysis to infer HLA association(s). This resource from 116 countries and 47 ethnic groups provides interesting insights on: markers associated with allelic/haplotypic association in autoimmune, cancer, viral and skin diseases, transplantation outcome and ADRs for hypersensitivity. Summary information on clinically relevant biomarkers related to HLA disease associations with mapped susceptible/risk alleles are readily retrievable from HLASPREAD. This resource is first of its kind that can help uncover novel patterns in HLA gene-disease associations.

scholarly journals Sentiment Analysis Techniques Applied to Raw-Text Data from a Csq-8 Questionnaire about Mindfulness in Times of COVID-19 to Improve Strategy Generation

2021 ◽  
Vol 18 (12) ◽  
pp. 6408
Author(s):  
Mario Jojoa Acosta ◽  
Gema Castillo-Sánchez ◽  
Begonya Garcia-Zapirain ◽  
Isabel de la Torre Díez ◽  
Manuel Franco-Martín
Keyword(s):  
Health Care ◽  
Natural Language Processing ◽  
Natural Language ◽  
Sentiment Analysis ◽  
Transfer Learning ◽  
Language Processing ◽  
Health Care Professionals ◽  
Ground Truth ◽  
Relevant Information ◽  
Free Text

The use of artificial intelligence in health care has grown quickly. In this sense, we present our work related to the application of Natural Language Processing techniques, as a tool to analyze the sentiment perception of users who answered two questions from the CSQ-8 questionnaires with raw Spanish free-text. Their responses are related to mindfulness, which is a novel technique used to control stress and anxiety caused by different factors in daily life. As such, we proposed an online course where this method was applied in order to improve the quality of life of health care professionals in COVID 19 pandemic times. We also carried out an evaluation of the satisfaction level of the participants involved, with a view to establishing strategies to improve future experiences. To automatically perform this task, we used Natural Language Processing (NLP) models such as swivel embedding, neural networks, and transfer learning, so as to classify the inputs into the following three categories: negative, neutral, and positive. Due to the limited amount of data available—86 registers for the first and 68 for the second—transfer learning techniques were required. The length of the text had no limit from the user’s standpoint, and our approach attained a maximum accuracy of 93.02% and 90.53%, respectively, based on ground truth labeled by three experts. Finally, we proposed a complementary analysis, using computer graphic text representation based on word frequency, to help researchers identify relevant information about the opinions with an objective approach to sentiment. The main conclusion drawn from this work is that the application of NLP techniques in small amounts of data using transfer learning is able to obtain enough accuracy in sentiment analysis and text classification stages.

scholarly journals Obtaining Knowledge in Pathology Reports Through a Natural Language Processing Approach With Classification, Named-Entity Recognition, and Relation-Extraction Heuristics

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Tomasz Oliwa ◽  
Steven B. Maron ◽  
Leah M. Chase ◽  
Samantha Lomnicki ◽  
Daniel V.T. Catenacci ◽  
...  
Keyword(s):  
Machine Learning ◽  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Named Entity Recognition ◽  
Entity Recognition ◽  
Classification Model ◽  
Supervised Machine Learning ◽  
Named Entity ◽  
Pathology Reports

PURPOSE Robust institutional tumor banks depend on continuous sample curation or else subsequent biopsy or resection specimens are overlooked after initial enrollment. Curation automation is hindered by semistructured free-text clinical pathology notes, which complicate data abstraction. Our motivation is to develop a natural language processing method that dynamically identifies existing pathology specimen elements necessary for locating specimens for future use in a manner that can be re-implemented by other institutions. PATIENTS AND METHODS Pathology reports from patients with gastroesophageal cancer enrolled in The University of Chicago GI oncology tumor bank were used to train and validate a novel composite natural language processing-based pipeline with a supervised machine learning classification step to separate notes into internal (primary review) and external (consultation) reports; a named-entity recognition step to obtain label (accession number), location, date, and sublabels (block identifiers); and a results proofreading step. RESULTS We analyzed 188 pathology reports, including 82 internal reports and 106 external consult reports, and successfully extracted named entities grouped as sample information (label, date, location). Our approach identified up to 24 additional unique samples in external consult notes that could have been overlooked. Our classification model obtained 100% accuracy on the basis of 10-fold cross-validation. Precision, recall, and F1 for class-specific named-entity recognition models show strong performance. CONCLUSION Through a combination of natural language processing and machine learning, we devised a re-implementable and automated approach that can accurately extract specimen attributes from semistructured pathology notes to dynamically populate a tumor registry.

Probing Patient Messages Enhanced by Natural Language Processing: A Top-Down Message Corpus Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
George Mastorakos ◽  
Aditya Khurana ◽  
Ming Huang ◽  
Sunyang Fu ◽  
Ahmad P. Tafti ◽  
...  
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Named Entity Recognition ◽  
Corpus Analysis ◽  
Entity Recognition ◽  
Message Content ◽  
Named Entity ◽  
Medical Concepts ◽  
Insight Into

Background. Patients increasingly use asynchronous communication platforms to converse with care teams. Natural language processing (NLP) to classify content and automate triage of these messages has great potential to enhance clinical efficiency. We characterize the contents of a corpus of portal messages generated by patients using NLP methods. We aim to demonstrate descriptive analyses of patient text that can contribute to the development of future sophisticated NLP applications. Methods. We collected approximately 3,000 portal messages from the cardiology, dermatology, and gastroenterology departments at Mayo Clinic. After labeling these messages as either Active Symptom, Logistical, Prescription, or Update, we used NER (named entity recognition) to identify medical concepts based on the UMLS library. We hierarchically analyzed the distribution of these messages in terms of departments, message types, medical concepts, and keywords therewithin. Results. Active Symptom and Logistical content types comprised approximately 67% of the message cohort. The “Findings” medical concept had the largest number of keywords across all groupings of content types and departments. “Anatomical Sites” and “Disorders” keywords were more prevalent in Active Symptom messages, while “Drugs” keywords were most prevalent in Prescription messages. Logistical messages tended to have the lower proportions of “Anatomical Sites,”, “Disorders,”, “Drugs,”, and “Findings” keywords when compared to other message content types. Conclusions. This descriptive corpus analysis sheds light on the content and foci of portal messages. The insight into the content and differences among message themes can inform the development of more robust NLP models.

scholarly journals EventEpi–A Natural Language Processing Framework for Event-Based Surveillance

2019 ◽  
Author(s):  
Auss Abbood ◽  
Alexander Ullrich ◽  
Rüdiger Busche ◽  
Stéphane Ghozzi
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Web Application ◽  
Fine Tuning ◽  
Entity Recognition ◽  
World Health ◽  
Support Vector ◽  
Event Based ◽  
Processing Framework

AbstractAccording to the World Health Organization (WHO), around 60% of all outbreaks are detected using informal sources. In many public health institutes, including the WHO and the Robert Koch Institute (RKI), dedicated groups of epidemiologists sift through numerous articles and newsletters to detect relevant events. This media screening is one important part of event-based surveillance (EBS). Reading the articles, discussing their relevance, and putting key information into a database is a time-consuming process. To support EBS, but also to gain insights into what makes an article and the event it describes relevant, we developed a natural-language-processing framework for automated information extraction and relevance scoring. First, we scraped relevant sources for EBS as done at RKI (WHO Disease Outbreak News and ProMED) and automatically extracted the articles’ key data: disease, country, date, and confirmed-case count. For this, we performed named entity recognition in two steps: EpiTator, an open-source epidemiological annotation tool, suggested many different possibilities for each. We trained a naive Bayes classifier to find the single most likely one using RKI’s EBS database as labels. Then, for relevance scoring, we defined two classes to which any article might belong: The article is relevant if it is in the EBS database and irrelevant otherwise. We compared the performance of different classifiers, using document and word embeddings. Two of the tested algorithms stood out: The multilayer perceptron performed best overall, with a precision of 0.19, recall of 0.50, specificity of 0.89, F1 of 0.28, and the highest tested index balanced accuracy of 0.46. The support-vector machine, on the other hand, had the highest recall (0.88) which can be of higher interest for epidemiologists. Finally, we integrated these functionalities into a web application called EventEpi where relevant sources are automatically analyzed and put into a database. The user can also provide any URL or text, that will be analyzed in the same way and added to the database. Each of these steps could be improved, in particular with larger labeled datasets and fine-tuning of the learning algorithms. The overall framework, however, works already well and can be used in production, promising improvements in EBS. The source code is publicly available at https://github.com/aauss/EventEpi.

scholarly journals Towards a scientific workflow featuring Natural Language Processing for the digitisation of natural history collections

2020 ◽  
Vol 6 ◽  
Author(s):  
David Owen ◽  
Laurence Livermore ◽  
Quentin Groom ◽  
Alex Hardisty ◽  
Thijs Leegwater ◽  
...  
Keyword(s):  
Deep Learning ◽  
Natural Language Processing ◽  
Natural History ◽  
Natural Language ◽  
Language Processing ◽  
Scientific Workflow ◽  
Entity Recognition ◽  
Research Activities ◽  
Handwritten Text ◽  
Segmented Images

We describe an effective approach to automated text digitisation with respect to natural history specimen labels. These labels contain much useful data about the specimen including its collector, country of origin, and collection date. Our approach to automatically extracting these data takes the form of a pipeline. Recommendations are made for the pipeline's component parts based on some of the state-of-the-art technologies. Optical Character Recognition (OCR) can be used to digitise text on images of specimens. However, recognising text quickly and accurately from these images can be a challenge for OCR. We show that OCR performance can be improved by prior segmentation of specimen images into their component parts. This ensures that only text-bearing labels are submitted for OCR processing as opposed to whole specimen images, which inevitably contain non-textual information that may lead to false positive readings. In our testing Tesseract OCR version 4.0.0 offers promising text recognition accuracy with segmented images. Not all the text on specimen labels is printed. Handwritten text varies much more and does not conform to standard shapes and sizes of individual characters, which poses an additional challenge for OCR. Recently, deep learning has allowed for significant advances in this area. Google's Cloud Vision, which is based on deep learning, is trained on large-scale datasets, and is shown to be quite adept at this task. This may take us some way towards negating the need for humans to routinely transcribe handwritten text. Determining the countries and collectors of specimens has been the goal of previous automated text digitisation research activities. Our approach also focuses on these two pieces of information. An area of Natural Language Processing (NLP) known as Named Entity Recognition (NER) has matured enough to semi-automate this task. Our experiments demonstrated that existing approaches can accurately recognise location and person names within the text extracted from segmented images via Tesseract version 4.0.0. Potentially, NER could be used in conjunction with other online services, such as those of the Biodiversity Heritage Library to map the named entities to entities in the biodiversity literature (https://www.biodiversitylibrary.org/docs/api3.html). We have highlighted the main recommendations for potential pipeline components. The document also provides guidance on selecting appropriate software solutions. These include automatic language identification, terminology extraction, and integrating all pipeline components into a scientific workflow to automate the overall digitisation process.

BUILD KNOWLEDGE GRAPH FROM HETEROGENEOUS DOCUMENTS

2021 ◽  
Vol 47 (05) ◽  
Author(s):  
NGUYỄN CHÍ HIẾU
Keyword(s):  
Information Retrieval ◽  
Deep Learning ◽  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Question Answering ◽  
Semantic Analysis ◽  
Knowledge Graph ◽  
Question Answering Systems ◽  
Knowledge Graphs

Knowledge Graphs are applied in many fields such as search engines, semantic analysis, and question answering in recent years. However, there are many obstacles for building knowledge graphs as methodologies, data and tools. This paper introduces a novel methodology to build knowledge graph from heterogeneous documents.  We use the methodologies of Natural Language Processing and deep learning to build this graph. The knowledge graph can use in Question answering systems and Information retrieval especially in Computing domain

Advances in Computational Linguistics and Text Processing Frameworks

2020 ◽  
pp. 217-244
Author(s):  
Ayush Srivastav ◽  
Hera Khan ◽  
Amit Kumar Mishra
Keyword(s):  
Neural Networks ◽  
Natural Language Processing ◽  
Natural Language ◽  
Computational Linguistics ◽  
Language Processing ◽  
Text Processing ◽  
Named Entity Recognition ◽  
Entity Recognition ◽  
Named Entity ◽  
Part Of Speech

The chapter provides an eloquent account of the major methodologies and advances in the field of Natural Language Processing. The most popular models that have been used over time for the task of Natural Language Processing have been discussed along with their applications in their specific tasks. The chapter begins with the fundamental concepts of regex and tokenization. It provides an insight to text preprocessing and its methodologies such as Stemming and Lemmatization, Stop Word Removal, followed by Part-of-Speech tagging and Named Entity Recognition. Further, this chapter elaborates the concept of Word Embedding, its various types, and some common frameworks such as word2vec, GloVe, and fastText. A brief description of classification algorithms used in Natural Language Processing is provided next, followed by Neural Networks and its advanced forms such as Recursive Neural Networks and Seq2seq models that are used in Computational Linguistics. A brief description of chatbots and Memory Networks concludes the chapter.

scholarly journals CLAMP – a toolkit for efficiently building customized clinical natural language processing pipelines

2017 ◽  
Vol 25 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Ergin Soysal ◽  
Jingqi Wang ◽  
Min Jiang ◽  
Yonghui Wu ◽  
Serguei Pakhomov ◽  
...  
Keyword(s):  
Natural Language Processing ◽  
User Interface ◽  
Natural Language ◽  
Language Processing ◽  
High Performance ◽  
Smoking Status ◽  
Entity Recognition ◽  
Graphic User Interface ◽  
Clinical Text ◽  
Clinical Natural Language Processing

Abstract Existing general clinical natural language processing (NLP) systems such as MetaMap and Clinical Text Analysis and Knowledge Extraction System have been successfully applied to information extraction from clinical text. However, end users often have to customize existing systems for their individual tasks, which can require substantial NLP skills. Here we present CLAMP (Clinical Language Annotation, Modeling, and Processing), a newly developed clinical NLP toolkit that provides not only state-of-the-art NLP components, but also a user-friendly graphic user interface that can help users quickly build customized NLP pipelines for their individual applications. Our evaluation shows that the CLAMP default pipeline achieved good performance on named entity recognition and concept encoding. We also demonstrate the efficiency of the CLAMP graphic user interface in building customized, high-performance NLP pipelines with 2 use cases, extracting smoking status and lab test values. CLAMP is publicly available for research use, and we believe it is a unique asset for the clinical NLP community.

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