scholarly journals Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma

BMC Genomics ◽  
2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Ping Liu ◽  
Ruoxu Chen ◽  
Xudong Zhang ◽  
Ruiting Fu ◽  
Lin Tao ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Immune Cell ◽  
Molecular Subtype ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
High Grade ◽  
Serous Ovarian Carcinoma ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Antigen Presenting

Abstract Background High-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous ovarian carcinoma molecular subtypes that are sensitive to immunotherapy, no precise molecular subtype has been proposed to date. Immune cell infiltration and immune checkpoints are highly correlated with immunotherapy. Here, we investigated immune cell infiltration and immune checkpoint values for prognosis and precise immunotherapy for high-grade serous ovarian carcinoma based on molecular subtype classification. Results “High antigen-presenting cells infiltration molecular subtype of high-grade serous ovarian carcinoma” was identified in immune cell infiltration profiles. Each of the three immune cell infiltration clusters (A, B, and C) demonstrated distinct immune cell characterization, with immune cell infiltration cluster C exhibiting high antigen-presenting cell infiltration, improved prognosis, and higher sensitivity to immunotherapy. Programmed death-1/programmed death ligand 1 has a prognostic and predictive role that can help classify molecular subtypes. Conclusions Our findings redefined a unique molecular subtype of high-grade serous ovarian carcinoma, suggesting that high-grade serous ovarian carcinoma patients with higher antigen-presenting cell infiltration and programmed death-1/programmed death ligand 1 expression can benefit from precise immunotherapy.

scholarly journals Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC

2019 ◽  
Vol 14 (4) ◽  
pp. 628-640 ◽  
Author(s):  
Karolina Edlund ◽  
Katrin Madjar ◽  
Johanna S.M. Mattsson ◽  
Dijana Djureinovic ◽  
Cecilia Lindskog ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Prognostic Impact ◽  
Immune Cell Infiltration ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

2016 ◽  
Vol 22 (18) ◽  
pp. 4746-4755 ◽  
Author(s):  
Brandon Leonard ◽  
Gabriel J. Starrett ◽  
Matthew J. Maurer ◽  
Ann L. Oberg ◽  
Mieke Van Bockstal ◽  
...  
Keyword(s):  
T Cell ◽  
Ovarian Carcinoma ◽  
Clinical Outcomes ◽  
Cell Infiltration ◽  
High Grade ◽  
T Cell Infiltration ◽  
Serous Ovarian Carcinoma ◽  
Apobec3g Expression

scholarly journals Increased Immune Gene Expression and Immune Cell Infiltration in High-Grade Astrocytoma Distinguish Long-Term from Short-Term Survivors

2012 ◽  
Vol 189 (4) ◽  
pp. 1920-1927 ◽  
Author(s):  
Andrew M. Donson ◽  
Diane K. Birks ◽  
Stephanie A. Schittone ◽  
Bette K. Kleinschmidt-DeMasters ◽  
Derrick Y. Sun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Immune Gene ◽  
Immune Cell Infiltration ◽  
High Grade ◽  
Short Term ◽  
Immune Gene Expression ◽  
High Grade Astrocytoma

scholarly journals BRAFV600E in Papillary Thyroid Carcinoma Is Associated with Increased Programmed Death Ligand 1 Expression and Suppressive Immune Cell Infiltration

Thyroid ◽  
2014 ◽  
Vol 24 (9) ◽  
pp. 1385-1393 ◽  
Author(s):  
Trevor E. Angell ◽  
Melissa G. Lechner ◽  
Julie K. Jang ◽  
Adrian J. Correa ◽  
Jonathan S. LoPresti ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Papillary Thyroid ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0204513 ◽  
Author(s):  
Kenichi Harano ◽  
Ying Wang ◽  
Bora Lim ◽  
Robert S. Seitz ◽  
Stephan W. Morris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Immune Cell ◽  
Molecular Subtype ◽  
Cell Infiltration ◽  
Immune Cell Infiltration

scholarly journals Markers of T Cell Infiltration and Function Associate with Favorable Outcome in Vascularized High-Grade Serous Ovarian Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82406 ◽  
Author(s):  
Katelin N. Townsend ◽  
Jaeline E. Spowart ◽  
Hassan Huwait ◽  
Sima Eshragh ◽  
Nathan R. West ◽  
...  
Keyword(s):  
T Cell ◽  
Ovarian Carcinoma ◽  
Favorable Outcome ◽  
Cell Infiltration ◽  
High Grade ◽  
T Cell Infiltration ◽  
Serous Ovarian Carcinoma ◽  
Function Associate ◽  
And Function

scholarly journals Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

2020 ◽  
Vol 26 (20) ◽  
pp. 5411-5423 ◽  
Author(s):  
Aline Talhouk ◽  
Joshy George ◽  
Chen Wang ◽  
Timothy Budden ◽  
Tuan Zea Tan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Carcinoma ◽  
Molecular Subtype ◽  
High Grade ◽  
Serous Ovarian Carcinoma ◽  
Development And Validation

scholarly journals PATH-53. IMMUNOLOGICAL PROFILING OF MUTATIONAL AND TRANSCRIPTIONAL SUBGROUPS IN PEDIATRIC AND ADULT HIGH-GRADE GLIOMAS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi155-vi155
Author(s):  
Michael Bockmary ◽  
Frederick Klauschen ◽  
Cecile Maire ◽  
Stefan Rutkowski ◽  
Manfred Westphal ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Cell ◽  
High Grade Glioma ◽  
Small Sample ◽  
Histological Diagnosis ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
High Grade ◽  
Checkpoint Inhibition ◽  
High Grade Gliomas

Abstract Immunological treatment strategies, including checkpoint inhibition, are currently under investigation for high-grade gliomas, but their success is limited. Hence, it is crucial to determine immunological pathways that can be targeted and to identify subgroups of patients likely to benefit from immunotherapies. Previous studies are still limited by comparably small sample sizes and there is only few data about specific immunological mechanisms in pediatric high-grade glioma. We gathered published gene expression data from 1135 adult and pediatric high-grade gliomas and applied a machine learning technique to determine their mutational (K27, G34, IDHmut, IDHwt) and transcriptional subtype. Subsequently, immune cell infiltration and functional immune pathway signatures were evaluated in correlation to histological diagnosis, age, transcriptional and mutational subtype. T-SNE analysis and unsupervised hierarchical clustering was applied to detect subgroup-specific immune microenvironments across all high-grade glioma subtypes. Four distinct microenvironmental phenotypes of immune cell infiltration were identified, which can be stratified into vascular, monocytic/stromal, monocytic/T-cell and APC/NK/T-cell dominant immune clusters. Immune cell infiltration correlated strongly with transcriptional and mutational subtypes but was independent of age and histological diagnosis (p< 0.01). H3F3A mutated tumors had significantly fewer tumor infiltrating lymphocytes and macrophages. By including functional pathways and correlating the expression of immunostimulatory and inhibitory receptor/ligand interactions, we were able to define the immunological microenvironment and to identify possible immunological subtypes associated with poor prognosis as well as subtypes that might be especially amenable to checkpoint inhibition. In addition, comparisons of overall survival with the immunological microenvironment and specifically with immune checkpoint molecules revealed diverse correlations within the transcriptional and mutational subgroups. In conclusion, we shat that mutational and transcriptional subgroups of pediatric and adult high-grade gliomas are characterized by distinct immunological tumor microenvironments. Our analysis demonstrates the immunological heterogeneity within this entity and emphasizes an immune specific stratification of subgroups for upcoming immunotherapy trials.

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