scholarly journals A longitudinal study of suicide and suicide attempt in northwest of Iran: incidence, predictors, and socioeconomic status and the role of sociocultural status

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali Fakhari ◽  
Mostafa Farahbakhsh ◽  
Elham Davtalab Esmaeili ◽  
Hosein Azizi
Keyword(s):  
Socioeconomic Status ◽  
Longitudinal Study ◽  
Religious Commitment ◽  
Incidence Rates ◽  
Demographic Characteristics ◽  
Protective Effects ◽  
Wide Range ◽  
Multiple Variable ◽  
History Of

Abstract Background A detailed community-level understanding of socioeconomic status (SES) and sociocultural status (SCS) of suicides and suicide attempters (SAs) in a prospective design could have significant implications for policymakers at the local prevention and treatment levels. The effect of SCS and SES on SAs is poorly understood and investigated in Iran. The present study aimed to investigate the incidence, trend, and role of SES and SCS on suicide and SAs. Methods A longitudinal study was conducted based on the registry for SAs in Malekan County, Iran, from 2015 to 2018. Demographic characteristics, SES, SCS, incidence rates, and predictors of suicidal behaviors were measured via structured instruments. Simple and multiple logistic regressions were used to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results A total of 853 SAs (32 suicides and 821 attempts) were identified during the study. Trend analysis revealed that the suicide rate significantly decreased from 2014 (10.28) to 2018 (1.75) per 100,000. In the final multiple variable models, age (26–40), male sex, unemployment, antisocial activities, history of SA, hanging method, and season (spring) increased the suicide risk while religious commitment had protective effects on suicide. Conclusions Our findings indicated that demographic characteristics, low SES, and SCS are associated with suicide. In this county, trend of suicide and SA were decreased from 2014 to 2018. This study findings highlight the need to consider a wide range of contextual variables, socio-demographic, SES, and SCS in suicide prevention strategies. Improving inter-sectoral collaborations and policymakers’ attitudes are imperative for SA reduction.

Introduction: Emotion, History and the Arts

2018 ◽  
Vol 7 (2) ◽  
pp. 117-128 ◽  
Author(s):  
Erin Sullivan ◽  
Marie Louise Herzfeld-Schild
Keyword(s):  
Historical Change ◽  
Carson Mccullers ◽  
Emotional Life ◽  
Review Section ◽  
The Arts ◽  
Wide Range ◽  
War Correspondents ◽  
History Of ◽  
Johan Huizinga

This introduction surveys the rise of the history of emotions as a field and the role of the arts in such developments. Reflecting on the foundational role of the arts in the early emotion-oriented histories of Johan Huizinga and Jacob Burkhardt, as well as the concerns about methodological impressionism that have sometimes arisen in response to such studies, the introduction considers how intensive engagements with the arts can open up new insights into past emotions while still being historically and theoretically rigorous. Drawing on a wide range of emotionally charged art works from different times and places—including the novels of Carson McCullers and Harriet Beecher-Stowe, the private poetry of neo-Confucian Chinese civil servants, the photojournalism of twentieth-century war correspondents, and music from Igor Stravinsky to the Beatles—the introduction proposes five ways in which art in all its forms contributes to emotional life and consequently to emotional histories: first, by incubating deep emotional experiences that contribute to formations of identity; second, by acting as a place for the expression of private or deviant emotions; third, by functioning as a barometer of wider cultural and attitudinal change; fourth, by serving as an engine of momentous historical change; and fifth, by working as a tool for emotional connection across communities, both within specific time periods but also across them. The introduction finishes by outlining how the special issue's five articles and review section address each of these categories, while also illustrating new methodological possibilities for the field.

scholarly journals Role of Insulin in Health and Disease: An Update

2021 ◽  
Vol 22 (12) ◽  
pp. 6403
Author(s):  
Md Saidur Rahman ◽  
Khandkar Shaharina Hossain ◽  
Sharnali Das ◽  
Sushmita Kundu ◽  
Elikanah Olusayo Adegoke ◽  
...  
Keyword(s):  
Insulin Signaling ◽  
Basic Research ◽  
Future Research ◽  
Protective Effects ◽  
Glucose Levels ◽  
Physiological Processes ◽  
Blood Glucose Levels ◽  
Wide Range ◽  
Health And Disease

Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose levels in the bloodstream and induces glucose storage in the liver, muscles, and adipose tissue, resulting in overall weight gain. The modulation of a wide range of physiological processes by insulin makes its synthesis and levels critical in the onset and progression of several chronic diseases. Although clinical and basic research has made significant progress in understanding the role of insulin in several pathophysiological processes, many aspects of these functions have yet to be elucidated. This review provides an update on insulin secretion and regulation, and its physiological roles and functions in different organs and cells, and implications to overall health. We cast light on recent advances in insulin-signaling targeted therapies, the protective effects of insulin signaling activators against disease, and recommendations and directions for future research.

The role of exploratory mechanisms in evolution

1995 ◽  
Vol 349 (1329) ◽  
pp. 297-297
Keyword(s):  
Dynamic Instability ◽  
Specific Mechanism ◽  
Cellular Mechanisms ◽  
Selection Processes ◽  
Wide Range ◽  
Rapid Changes ◽  
Neuronal Processes ◽  
History Of ◽  
Variation And Selection

Many cellular mechanisms use a process of variation and selection to generate specific patterns. Among these, dynamic instability of microtubules has been shown to employ a specific mechanism to intentionally generate variation. In many systems the growth of neurons or neuronal processes is excessive, the final connections being established by stabilization of functional interactions. When changes in neuronal networks take place, such as in metamorphosis, use is made of the plasticity of neuronal connectivity. In the immune system, specific responses are generated by variation and selection. Processes that explore a wide range of conditions and a wide range of structures can be called exploratory processes. These are very robust and capable of responding to damage, variability in the environment and ontogenic changes in the organisms. Such robustness would be useful for adapting to changes that occur during phylogenetic changes as well. Given the extensive history of extinction and radiation in evolution, it may be supposed that these mechanisms have themselves been selected for their capacity to survive rapid changes in the organism and for their ability to generate cellular variation.

Etiology of Ventricular Septal Defects: An Epidemiologic Approach

PEDIATRICS ◽  
1985 ◽  
Vol 76 (5) ◽  
pp. 741-749
Author(s):  
Thomas B. Newman
Keyword(s):  
The United States ◽  
Incidence Rates ◽  
Identical Twins ◽  
Random Errors ◽  
Ventricular Septal Defects ◽  
Metabolic Disturbances ◽  
Cardiac Morphogenesis ◽  
Septal Defects ◽  
Wide Range ◽  
History Of

To investigate the recent 150% increase in the reported incidence of ventricular septal defects (VSDs) in the United States, the epidemiology of ventricular septal defects was examined. The apparent incidence of VSDs is highly dependent on case finding methods, and more complete diagnosis and reporting probably account for the increase in reported incidence. Variations in case ascertainment also account for the small differences in incidence in studies from different places. The several known risk factors for VSD, including a family history of congenital heart disease and exposure to certain drugs, infectious agents, and maternal metabolic disturbances, explain few cases. Incidence rates are similar in different races and seasons and are unrelated to maternal age, birth order, sex, and socioeconomic status. VSDs occur naturally in a wide range of mammals and in birds, which also have four-chambered hearts. Despite identical genes and similar prenatal environments, the concordance rate in identical twins is only about 10%. The consistency of incidence among individuals with widely differing genes and environments and the frequency of discordance in identical twins suggest that VSDs often occur as random errors in development, at a frequency largely determined by the complexity of normal cardiac morphogenesis. This hypothesis has two major implications: many VSDs are not preventable and parents need not feel responsible for VSDs in their children.

scholarly journals Cycling Pathways

2021 ◽  
Author(s):  
Henk-Jan Dekker
Keyword(s):  
Climate Change ◽  
The Netherlands ◽  
Political Struggle ◽  
The Road ◽  
Wide Range ◽  
The World ◽  
Road Space ◽  
History Of ◽  
On The Road

In an effort to fight climate change, many cities try to boost their cycling levels. They often look towards the Dutch for guidance. However, historians have only begun to uncover how and why the Netherlands became the premier cycling country of the world. Why were Dutch cyclists so successful in their fight for a place on the road? Cycling Pathways: The Politics and Governance of Dutch Cycling Infrastructure, 1920-2020 explores the long political struggle that culminated in today’s high cycling levels. Delving into the archives, it uncovers the important role of social movements and shows in detail how these interacted with national, provincial, and urban engineers and policymakers to govern the distribution of road space and construction of cycling infrastructure. It discusses a wide range of topics, ranging from activists to engineering committees, from urban commuters to recreational cyclists and from the early 1900s to today in order to uncover the long and all-but-forgotten history of Dutch cycling governance.

The role of molecular biology in the diff erential diagnosis of pancreatic cystic neoplasias

2021 ◽  
Vol 75 (5) ◽  
pp. 417-423
Author(s):  
Ivo Horný ◽  
Tomáš Hucl
Keyword(s):  
Precancerous Lesions ◽  
Clinical Status ◽  
Pancreatic Disease ◽  
Pancreatic Cysts ◽  
Cytological Examination ◽  
Asymptomatic Patients ◽  
Wide Range ◽  
Risk Of Malignancy ◽  
History Of

Summary: Pancreatic cysts have been detected ever more frequently in recent years due to the advanced and wider use of imaging methods. We find them on CT or MR also in asymptomatic patients who do not have a history of any pancreatic disease. Pancreatic cystic lesions represent a wide range of pathological changes from simple cysts through precancerous lesions to malignant cysts. Accurate dia­gnosis remains difficult despite the combination of clinical status evaluation, imaging findings, and bio­chemical and cytological examination. Molecular bio­logical examination of cyst aspirate obtained by endosonographic examination increases the detection rate of mucinous cysts (KRAS/GNAS/VHL) and cysts with a high risk of malignancy (KRAS/GNAS/p53/PIK3CA/PTEN/CDKN2A/SMAD4) and optimizes therapeutic approach. Larger prospective validation studies are necessary to make this costly and limited method a routine part of clinical practice. Key words: molecular bio­logy – neoplasia – pancreatic cysts

Before Kṛṣṇa

2021 ◽  
Author(s):  
Kanika Kishore Saxena
Keyword(s):  
Historical Data ◽  
Religious History ◽  
Religious Traditions ◽  
The Social ◽  
Wide Range ◽  
History Of ◽  
Coherent Picture

Mathura is famous for its association with Vāsudeva‒Kṛṣṇa, an important deity of the Hindu pantheon. However, apart from the sanctity attached to this place by Hindus, it has also provided conditions for the nurturing of Buddhist, Jaina, nāga and yakṣa traditions. This book engages in a wide range of epigraphic, archaeological and art historical data from the various sites in the Mathura area and weaves this to present a coherent picture of the variegated religious history of the area from c.600 CE to c.1000 CE, which witnessed various religions/cults/sects competing for attention and patronage. The chapters in this book have been divided according to religious traditions, namely, Jainism, Buddhism and Hinduism, along with the Kṛṣṇa, yakṣa, nāga, and mātṛkā cults. It raises many important issues related to Jainism, Hinduism, Buddhism and Jainism as well as older cults of the yakṣas and nāgas. The objects of donation ranged from images, stūpas, temples to tanks and gardens. Donations by monks and nuns; together with laity from different locations within and beyond Mathura, amply reflect on the social mosaic of the time. The role of monastics and laity, the nature of patronage, and the social and political underpinnings of the religious history are also examined, all within a long, diachronic frame. This book reveals the complexity of the religious history of Mathura to provide the reader a taste of its diversity and plurality.

Identity-Mapping in the Sardinian Bronze Age

1999 ◽  
Vol 2 (1) ◽  
pp. 35-55 ◽  
Author(s):  
Emma Blake
Keyword(s):  
Cultural Identity ◽  
Identity Formation ◽  
Bronze Age ◽  
Human Action ◽  
Demographic Characteristics ◽  
History Of ◽  
Distinct Boundary ◽  
Cultural Identity Formation ◽  
Material Record

The aim of this paper is to locate in the emergence and elaboration of Sardinia's Nuragic society, a narrative of cultural identity formation. The Nuragic period is typically defined in terms of economic, social, and demographic characteristics, and a Nuragic identity is implicitly taken to be a passive byproduct of these material circumstances. Such an account overlooks the role of identity in enabling and characterizing human action. The disjointed and contradictory Nuragic period transition preceded the formation of a coherent cultural identity. This identity, it will be argued, underwent a retrospective rearticulation to establish a distinct boundary between the Nuragic society and its antecedents. The material record illustrates clearly that the history of the Nuragic identity is implicated in social development on Sardinia in the second millennium BC.

Capital Yerevan during the years of the RA independence (1991-2018)

2020 ◽  
Author(s):  
Edik Minasyan
Keyword(s):  
Foreign Relations ◽  
Relevant Literature ◽  
Third Republic ◽  
National Archive ◽  
Cultural Life ◽  
Wide Range ◽  
History Of ◽  
The Republic ◽  
Sister Cities

The work presents a complete scientific research on the history of Yerevan in the period of the Third Republic of Armenia (1991-2018). The analysis of the materials of the RA National Archive, various press and other relevant literature shows the process of the establishment of the RA independent statehood, the socio-political, socio-economic-cultural life of Yerevan, the role of capital in the administrative-political system of the republic, its comprehensive assistance to Artsakh, foreign relations, including sister cities, international organizations and structures. The book is addressed to historians, political scientists, those interested in Yerevan’s history, and wide range of readers in general. (in Armenian).

The role of surface cohesion is wind-driven snow transport

2020 ◽  
Author(s):  
Francesco Comola ◽  
Johan Gaume ◽  
Jasper Kok ◽  
Michael Lehning
Keyword(s):  
Blowing Snow ◽  
Snow Surface ◽  
Wind Speeds ◽  
Wide Range ◽  
Bed Forms ◽  
Geophysical Processes ◽  
Order Of Magnitude ◽  
History Of ◽  
Snow Transport

<p>The wind-driven saltation of sediments, such as snow and sand, is responsible for a wide range of geophysical processes. Blowing-snow, in particular, affects snow surface properties and drives snow redistribution in alpine terrain. As such, it is of fundamental importance for avalanche mechanics. One of the most important controls on initiation and development of snow saltation is the surface cohesion induced by ice particle sintering. Although inter-particle cohesion is known to limit the number of grains lifted from the surface through aerodynamic entrainment and granular splash, the role of cohesion in the development of saltation from onset to steady state is still poorly understood. Using a numerical model based on the discrete element method, we show that saltation over cohesive beds sustains itself at wind speeds one order of magnitude smaller than those necessary to initiate it, giving rise to hysteresis in which the occurrence of transport depends on the history of the wind. Our results further suggest that saltation over cohesive beds requires much longer distances to saturate, thereby increasing the size of the smallest stable bed forms.</p>

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