scholarly journals Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Siwei Bi ◽  
Jun Gu ◽  
Chenggong Hu
Keyword(s):  
Thoracic Spine ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Neurogenic Tumor ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Neurogenic Tumors ◽  
Laboratory Examinations ◽  
First Time

Abstract Background Kimura’s disease is a rare, benign chronic inflammatory disease of unknown etiology that mostly affects Asians. The disease typically presents as subcutaneous masses in the head or neck region that are predominantly found in the preauricular and submandibular areas. Case presentation A 7-year-old boy presenting with paralysis of both lower extremities and a thoracic spine dumbbell mass was initially diagnosed with a neurogenic tumor, but the pathological and laboratory examinations confirmed the diagnosis of Kimura’s disease. The paralysis symptom disappeared rapidly, but the patient had developed a recurrent mass in the cervical vertebral canal at the 9-month follow-up. Conclusion To our knowledge, no prior published literature has revealed Kimura’s disease cases that mimic dumbbell neurogenic tumors. Here, we report such a case of Kimura’s disease for the first time and provide a brief review of the literature.

scholarly journals Unusual presentation of Kimura’s disease: a case series

2017 ◽  
Vol 3 (4) ◽  
pp. 535
Author(s):  
Aarti S. Salunke ◽  
Ravindranath B. Chavan ◽  
Vasudha A. Belgaumkar ◽  
Neelam Bhatt
Keyword(s):  
Case Series ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Good Prognosis ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Peripheral Eosinophilia ◽  
Unusual Site ◽  
Head And Neck Region ◽  
Subcutaneous Nodules

<p style="margin-bottom: 0in; line-height: 100%;" align="JUSTIFY">Kimura’s disease is a rare chronic inflammatory disease of unknown etiology, presenting as painless subcutaneous nodules with lymphadenopathy and peripheral eosinophilia, mainly disturbing the head and neck region. It mainly affects Asian males in their 2nd to 4th decade of life. Kimura’s disease, although difficult to diagnose clinically, should be considered in the differential diagnosis of patients who have a primary lymphadenopathy with eosinophilia with or without subcutaneous nodules. It should be investigated accordingly as the disease has an indolent course and good prognosis. Herein we report two cases of Kimura’s disease, of which one had unusual site of involvement. </p>

scholarly journals Kimura’s disease with recurrent bilateral lacrimal gland involvement in a male Japanese child successfully treated with cyclosporine A

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Keisuke Sugimoto ◽  
Takuji Enya ◽  
Yuichi Morimoto ◽  
Rina Oshima ◽  
Kohei Miyazaki ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Upper Eyelid ◽  
Laboratory Findings ◽  
Eyelid Swelling ◽  
Old Japanese ◽  
Subcutaneous Mass ◽  
The Masses

Abstract Background Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, that are typically localized to the neck and head. Involvement of the lacrimal glands and limbs is uncommon and seldom reported. Case presentation We report a case of a 4-year-old Japanese boy presenting with bilateral upper eyelid swelling with nodular subcutaneous lesions and peripheral eosinophilia. Based on clinical, histopathological, and laboratory findings, the patient was diagnosed with KD. An itchy subcutaneous mass on the left arm developed at the age of 14 years. Treatment with steroids was effective. However, as the steroids were tapered after the patient developed side effects, the masses relapsed within a few months. Treatment with cyclosporine A was then initiated, which led to an improvement of clinical features and serial levels of cytokines. Conclusions We report a rare case of KD with a peculiar clinical presentation. The patient responded well to treatment with cyclosporine A.

Kimura's disease: case report and brief review of the literature

1994 ◽  
Vol 108 (11) ◽  
pp. 1005-1007 ◽  
Author(s):  
Mette Nyrop
Keyword(s):  
Neck Region ◽  
Malignant Tumour ◽  
Chronic Inflammatory Disease ◽  
Surgical Removal ◽  
Kimura’S Disease ◽  
Review Of The Literature ◽  
Fine Needle Aspirate ◽  
Japanese People ◽  
Head And Neck Region ◽  
Disease Case

AbstractKimura's disease is a chronic inflammatory disease which often presents as a tumour-like swelling in the head and neck region with or without lymphadenopathy. Most cases have been described predominantly in Chinese and Japanese people. The lesion is benign, but it may easily be mistaken for a malignant tumour. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia (ALHE), from which it probably should be distinguished as a separate entity. The diagnosis may be suggested by a fine needle aspirate, but is established by a biopsy. The treatment of choice is surgical removal.A case of Kimura's disease in a Caucasian male of 12 years' duration is presented together with a brief review of the literature.

scholarly journals Kimura Disease of the Parotid Gland: Management Approach

2022 ◽  
Vol 4 (1) ◽  
pp. 01-03
Author(s):  
Hafeza MS ◽  
Vanitha Palanisamy
Keyword(s):  
Parotid Gland ◽  
Frozen Section ◽  
Neck Region ◽  
Unknown Etiology ◽  
Management Approach ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Parotid Neoplasm ◽  
The Right

Here we present a 43-years old Malay man with Kimura’s disease of the right parotid gland. Asian men have a predisposition for this chronic inflammatory disorder of unknown etiology mostly presenting at the head and neck region. The management in dealing with this patient is not straight forward as the presentation mimics a subcutaneous tumor-like mass in which main differential diagnosis includes lymphoproliferative disorders and parotid neoplasm. Moreover, cytological investigation is inadequate, and this necessitates the use intra-operative frozen section prior to tumor debulking. Without proper investigation, misdiagnosis can occur and potentially expose the patient to unnecessary extensive surgical procedures. Here we discuss step by step approach in managing this patient.

scholarly journals The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

2021 ◽  
Vol 18 (12) ◽  
pp. 6525
Author(s):  
Vladimíra Radochová ◽  
Romana Koberová Ivančaková ◽  
Ondřej Heneberk ◽  
Radovan Slezák
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
University Hospital ◽  
Unknown Etiology ◽  
Transformation Rate ◽  
Oral Lichen

Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

scholarly journals Schwannoma Located in Nasopharyngeal Region

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Fadlullah Aksoy ◽  
Alper Yenigun ◽  
Erol Senturk ◽  
Orhan Ozturan
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Neck Region ◽  
Case Presentation ◽  
Head And Neck Region ◽  
Nerve Sheath ◽  
Swallowing Difficulties ◽  
First Time ◽  
Slow Growing

Schwannoma is a tumor which has neuroectoderm origins, is hard, well-circumscribed, encapsulated, and slow growing benign cranial tumor, and may autonomously grow out of the nerve sheath of peripheral nerves. It is mostly seen in the head and neck region. In the paranasal sinus and nose areas, it is seen at a rate of 4%. The diagnosis is mostly made after histopathological examination. In this paper, a Schwannoma case observed in the nasopharyngeal region was presented in a 20-year-old female who had complaints of sleeping with open mouth, snoring, foreign body feeling in throat, and swallowing difficulties. The tumor was extracted via transoral approach. No recurrence was observed during follow-up over the next year. This case presentation is presented for the first time in the literature in English.

scholarly journals Kimura Disease: A case report and review of literature

2018 ◽  
Vol 17 (1) ◽  
pp. 152-154
Author(s):  
Partha Pratim Sinha Roy ◽  
Parthasarathi Ghosh ◽  
Dwaipayan Samaddar ◽  
Gautam Das
Keyword(s):  
Case Report ◽  
Inflammatory Disease ◽  
Medical Science ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Review Of Literature ◽  
Kimura Disease ◽  
Head And Neck Region ◽  
Blood Eosinophilia

Kimura disease is a rare chronic inflammatory disease with angiolymphatic proliferation of unknown etiology predominantly seen among young Asian males. It classically shows a triad of non-tender subcutaneous masses predominantly in head and neck region with tissue and blood eosinophilia and raised serum IgE level. Here we present a case report of a 24 years male with bilateral pre-auricular and post-auricular swelling for 6 years. The diagnosis of Kimura disease was made on the basis of clinical and histopathological examination.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.152-154

scholarly journals Kimura’s Disease With Recurrent Bilateral Lacrimal Gland Involvement in a Male Japanese Child Successfully Treated With Cyclosporine A

2021 ◽  
Author(s):  
Keisuke Sugimoto ◽  
Takuji Enya ◽  
Yuichi Morimoto ◽  
Rina Oshima ◽  
Kohei Miyazaki ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Upper Eyelid ◽  
Laboratory Findings ◽  
Eyelid Swelling ◽  
Old Japanese ◽  
Subcutaneous Mass ◽  
The Masses

Abstract BackgroundKimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, typically localized to the neck and head. Involvement of the lacrimal glands and limbs is uncommon and seldom reported. Case presentationWe report a case of a 4-year-old Japanese boy presenting with bilateral upper eyelid swelling with nodular subcutaneous lesions and peripheral eosinophilia. Based on clinical, histopathological, and laboratory findings, the patient was diagnosed with KD. An itchy subcutaneous mass on the left arm developed at the age of 14 years. Treatment with steroids was effective, but the masses relapsed within a few months as the steroids were tapered after the patient developed side effects. Treatment with cyclosporine A was initiated, which led to the improvement of clinical features and serial levels of cytokines. ConclusionsWe report a rare case of KD with a peculiar clinical presentation. The patient responded well to treatment with CsA.

scholarly journals Bilateral Posterior Auricular Masses: A Case of Kimura’s Disease

2021 ◽  
pp. 014556132110455
Author(s):  
Fengyang Xie ◽  
Yan Kou ◽  
ShuaiJun Zhang ◽  
Li Shi ◽  
Jie Han ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Asian Population ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Subcutaneous Tissues ◽  
Adults And Children ◽  
Blood Eosinophils

Kimura’s disease (KD) is currently considered a rare chronic inflammatory disease of unknown etiology. It is more common in the Asian population, especially in young and middle-aged men, and can involve the lymph nodes, salivary glands, and subcutaneous tissues. It has been reported in adults and children, and is often accompanied by elevated peripheral blood eosinophils and elevated serum immunoglobulin E (IgE). Herein, we report a case of KD in a 46-year-old man with bilateral masses behind the ears since childhood that had gradually enlarged over 40 years. The patient’s peripheral blood eosinophils were elevated, and interestingly, homocysteine levels were also elevated. After surgical resection of the bilateral posterior auricular masses, follow-up over 5 years indicated good recovery and no signs of recurrence.

scholarly journals Kimura’s Disease in a Female Patient: Case Report and Review of the Literature

2018 ◽  
Vol 3 (8) ◽  
Keyword(s):  
Female Patient ◽  
Immunoglobulin E ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Excisional Biopsy ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
Kimura’S Disease ◽  
Patient Case ◽  
Head And Neck Region

Kimura’s disease is a rare chronic inflammatory disease of uncertain cause, manifesting commonly as a painless swelling of the subcutaneous tissue in the head and neck region with predilection for peri auricular areas. A significant increase in serum levels of immunoglobulin E and eosinophilia in the peripheral blood and in tissues has been associated with this disorder. Many cases of nephropathy in patients with Kimura’s Disease had been reported in the literature. Excisional biopsy for histopathological evaluation is the only way to confirm the diagnosis of Kimura’s Disease. We report a case of Kimura’s disease in a 26-year- old female patient who presented to our clinic with painless right retro-auricular swellings.

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