scholarly journals Quality of life after sialendoscopy: prospective non-randomized study

BMC Surgery ◽  
2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Giulianno Molina Melo ◽  
Murilo Catafesta Neves ◽  
Marcello Rosano ◽  
Christiana Maria Ribeiro Salles Vanni ◽  
Marcio Abrahao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Randomized Study ◽  
Health Impact ◽  
Young Female ◽  
Stone Disease ◽  
Symptom Duration ◽  
Level Of Evidence ◽  
The Impact

Abstract Background The symptomatic (swelling and pain) salivary gland obstructions are caused by sialolithiasis and salivary duct stenosis, negatively affecting quality of life (QOL), with almost all candidates for clinical measures and minimally invasive sialendoscopy. The impact of sialendoscopy treatment on the QOL has been little addressed nowadays. The objective is to prospectively evaluate the impact of sialendoscopy on the quality of life of patients undergoing sialendoscopy due to benign salivary obstructive diseases, measured through QOL questionnaires of xerostomia degree, the oral health impact profile and post sialendoscopy satisfaction questionnaires. Result 37 sialendoscopies were included, most young female; there were 64.5% sialolithiasis and 35.4% post-radioiodine; with 4.5 times/week painful swelling symptoms and 23.5 months symptom duration. The pre- and post-sialendoscopy VAS values were: 7.42 to 1.29 (p < 0.001); 86.5% and 89.2% were subjected to sialendoscopy alone and endoscopic dilatation respectively; 80.6% reported improved symptoms after sialendoscopy in the sialolithiasis clinic (p < 0.001). The physical pain and psychological discomfort domain scores were mostly impacted where sialendoscopy provided relief and improvement (p < 0.001). We found a positive correlation between sialendoscopy and obstructive stone disease (p < 0.001) and no correlation in sialendoscopy satisfaction in xerostomia patients (p = 0.009). Conclusions We found improved symptoms with overall good satisfaction after sialendoscopy correlated with stones; and a negative correlation between xerostomia. Our findings support the evident indication of sialendoscopy for obstructive sialolithiasis with a positive impact on QOL and probably a relative time-dependent indication for stenosis/other xerostomia causes that little improved QOL satisfaction. Level of evidence 2b—Prospective non-randomized study. Trial registration: WHO Universal Trial Number (UTN): U1111-1247-7028; Brazilian Clinical Trials Registry (ReBeC): RBR-6p8zfs.

scholarly journals Quality of Life After Sialendoscopy: Prospective Non-Randomized Study

2021 ◽  
Author(s):  
Giulianno Molina de Melo ◽  
Murilo Catafesta das Neves ◽  
Marcello Rosano ◽  
Christiana Maria Ribeiro Salles Vanni ◽  
Marcio Abrahao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Randomized Study ◽  
Health Impact ◽  
Young Female ◽  
Stone Disease ◽  
Symptom Duration ◽  
Almost All ◽  
The Impact

Abstract Background: The symptomatic (swelling and pain) salivary gland obstructions are caused by sialolithiasis and salivary duct stenosis, negatively affecting quality of life (QOL), with almost all candidates for clinical measures and minimally invasive sialendoscopy. The impact of sialendoscopy treatment on the QOL has been little addressed nowadays. The objective is to prospectively evaluate the impact of sialendoscopy on the quality of life of patients undergoing sialendoscopy due to benign salivary obstructive diseases, measured through QOL questionnaires of xerostomia degree, the oral health impact profile and post sialendoscopy satisfaction questionnaires. Result: 37 sialendoscopies were included, most young female: 64.5% sialolithiasis, 35.4% post-radioiodine; 4.5 times/week painful swelling; 23.5 months symptom duration; pre- and post-sialendoscopy VAS values: 7.42 to 1.29 (p<0.001); 86.5% and 89.2% were subjected to sialendoscopy alone and endoscopic dilatation respectively; 80.6% reported improved symptoms after sialendoscopy in the sialolithiasis clinic (p<0.001). The physical pain and psychological discomfort domain scores were mostly impacted where sialendoscopy provided relief and improvement (p<0.001). We found a positive correlation between sialendoscopy and obstructive stone disease (p<0.001) and no correlation in sialendoscopy satisfaction in xerostomia patients (p=0.009).Conclusions: We found improved symptoms with overall good satisfaction after sialendoscopy correlated with stones; and a negative correlation between xerostomia. Our findings support the evident indication of sialendoscopy for obstructive sialolithiasis with a positive impact on QOL and relative indication to xerostomia that barely improved QOL satisfaction.Trial Registration: WHO Universal Trial Number (UTN): U1111-1247-7028 Brazilian Clinical Trials Registry (ReBeC): RBR-6p8zfs

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

2018 ◽  
Vol 15 (1) ◽  
pp. 55-72
Author(s):  
Herlin Hamimi ◽  
Abdul Ghafar Ismail ◽  
Muhammad Hasbi Zaenal
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Wealth Distribution ◽  
Absolute Poverty ◽  
Before And After ◽  
The Status ◽  
Being There ◽  
The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

scholarly journals Positive impact of cladribine on quality of life in people with relapsing multiple sclerosis

2017 ◽  
Vol 24 (11) ◽  
pp. 1461-1468 ◽  
Author(s):  
Dayo Afolabi ◽  
Christo Albor ◽  
Lukasz Zalewski ◽  
Dan R Altmann ◽  
David Baker ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Positive Impact ◽  
Rank Correlation ◽  
Phase Iii ◽  
European Medicines Agency ◽  
Total N ◽  
The Impact ◽  
Relapsing Multiple Sclerosis

Background: A number of elements of the pivotal ‘cladribine tablets treating multiple sclerosis orally’ (CLARITY) trial have remained unpublished. Objective: To report the impact of cladribine on health-related quality of life (QoL) in people with relapsing multiple sclerosis (pwRMS). Methods: QoL data from the phase III trial of two different doses (3.5 and 5.25 mg/kg) of oral cladribine in pwRMS were acquired from the European Medicines Agency through Freedom of Information. Spearman’s rank correlation was used to analyse the relationship between baseline QoL scores and baseline Expanded Disability Status Scale (EDSS) scores. Responses of the Euro Quality of Life 5 Dimensions (EQ-5D) and Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaires were compared between treatment and control groups using univariate analyses of covariance. Results: In total, n = 5148 EQ-5D responses and n = 894 MSQOL-54 physical, mental health and dimension scores were extracted. Baseline EQ-5D indices correlated with EDSS scores. After 2 years, pwRMS taking 3.5 ( p = .001) and 5.25 mg/kg ( p = .022) reported significantly improved EQ-5D index scores compared with placebo. Positive, yet non-significant, differences were detected in MSQOL-54 scores between cladribine and placebo. Conclusion: Analysis of the CLARITY dataset suggests that, over and above its established clinical efficacy, cladribine leads to improved QoL over 96 weeks. ClinicalTrials.gov identifier: NCT00213135.

scholarly journals Impact of low vision services on the quality of life of low vision patients in Ghana

2016 ◽  
Vol 75 (1) ◽  
Author(s):  
Godwin O. Ovenseri-Ogbomo ◽  
Harriette Osafo-Agyei ◽  
Ralph E.U. Akpalaba ◽  
James Addy ◽  
Elizabeth O. Ovenseri
Keyword(s):  
Quality Of Life ◽  
Visual Acuity ◽  
Positive Impact ◽  
Low Vision ◽  
Care Quality ◽  
Eastern Region ◽  
Post Intervention ◽  
Low Vision Clinic ◽  
The Impact

Patients’ perspectives on the impact of clinical interventions have been recognised as critical elements in patient care. Quality-of-life instruments are designed to measure these perspectives. We used the National Eye Institute’s 25-item Visual Function Questionnaire (NEI VFQ) to measure the impact of optical low vision devices on the quality of life of 22 low vision patients who obtained and were using low vision devices from a secondary low vision clinic in the Eastern Region, Ghana. The study employed a pre- and post-intervention technique. We found statistically significant improvements in measured visual acuity and NEI VFQ scores in 8 of the 10 domains evaluated. We conclude that optical low vision devices have a positive impact on the quality of life of low vision patients in Ghana.Keywords: low vision; quality of life; visual acuity; visual impairment; Ghana

scholarly journals Perspectives of Entrepreneurial Orientation with the Quality of Life

2011 ◽  
Vol 3 (6) ◽  
pp. 388-394
Author(s):  
Salima Hafeez ◽  
Rashid Mehmood Chaudhry . ◽  
Muhammad Aslam Khan . ◽  
H.Mushtaq Ahmad . ◽  
Kashif Ur Rehman .
Keyword(s):  
Quality Of Life ◽  
Entrepreneurial Orientation ◽  
Third World ◽  
Dynamic Capabilities ◽  
Positive Impact ◽  
Well Being ◽  
Entrepreneurial Firms ◽  
The Third World ◽  
The Impact

The characteristics of entrepreneurial orientation is played important role in business. How do an entrepreneurial firms and individuals have taken the advantage in industry? This study explores the dynamic capabilities of the organization according to international performance. Our findings indicates the positive impact on dynamic capabilities of the business with perfectly use of this research framework. The main aspect of this paper is to analyse the impact of entrepreneurial orientation with the quality of life. Distinctive features of entrepreneurs and their contribution to the economy can make it possible for third world countries to grow their economies faster and provide financial means to enhance social, health, and environmental well-being (basic dimensions of quality of life), along with products and services that the poor need in these countries. Entrepreneurial orientation combined with organization learning and Quality of life (QOL) are enhanced the dynamic capability of the organization. Present conceptual research will provide the source of competitive advantage and mainstream line for further development of the business .We suggest that existing literature reconfiguring the different approaches for the entrepreneurial to capture the opportunities in world business. First, quality of life cannot possibly improve in inactive or weakening economic conditions; second, economic development in the third world countries cannot advance in a balanced and desirable manner without a major domestic entrepreneurship movement (Samli 2004, 2008a).

scholarly journals How University Acts in the Development of “Smart Cities”

2019 ◽  
Vol 71 ◽  
pp. 05011
Author(s):  
M. Afanasiev ◽  
M. Lysenkova
Keyword(s):  
Quality Of Life ◽  
Higher Education ◽  
Smart City ◽  
Positive Impact ◽  
Smart Cities ◽  
Territorial Development ◽  
Higher Education System ◽  
Impact Of Higher Education ◽  
The Impact

“Smart city” is a new model of territorial development, taking into account the growing importance of information, innovation and human capital. One of the main elements of the “smart city” is a developed system of higher education. The aim of this work was to study the impact of higher education on "smart" and innovative cities. The objectives of this work were to obtain quantitative characteristics of the impact of the University on the smart city. Approach to solving this problem was to build indicators based on indicators that characterize the quality of life, and ratings to compare cities on their basis. The hypothesis of the study is that the higher education system has a positive impact on the development of smart and innovative cities. A theoretically justified method of constructing an indicator of a certain direction of socio-economic development is a component analysis of indicators characterizing this direction. As a result, the rankings of Russian and foreign cities based on the characteristics of quality of life, which prove that education is a key indicator of the development of "smart" and innovative cities.

scholarly journals Impact of clinical pharmacist’s interventions on pharmacotherapy management in elderly patients on polypharmacy with mental health problems including quality of life: A prospective non-randomized study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Matej Stuhec ◽  
Nika Bratović ◽  
Aleš Mrhar
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Elderly Patients ◽  
Mental Health Problems ◽  
Randomized Study ◽  
The Elderly ◽  
Health Problems ◽  
Potentially Inappropriate Medications ◽  
The Impact

AbstractMental health problems (MHPs) are very common in the elderly and can have an important influence on their quality of life (QoL). There is almost no data on the impact of clinical pharmacists’ (CPs) interventions on the QoL including elderly patients and MHPs. The main aim of this study was to determinate the impact of (CP’s) interventions on the QoL and quality of pharmacotherapy. A prospective non-randomized pre-post study was designed which included residents of a nursing home aged 65 age or more with at least one MHP. Each patient also filled out the EQ-5D questionnaire. The medical review MR included drug-related problems (DRPs) and potentially drug-drug interactions (pDDIs), as well as potentially inappropriate medications (PIMs). After 2 months, the participants were interviewed again. The mean number of medications before the intervention was 12,2 ± 3,1 per patient and decreased to 10,3 ± 3,0 medications per patient (p < 0,05) (n = 24). The total number of PIMs and pDDIs was also reduced and QoL was also significantly higher (p < 0,05). A collaborative care approach with a CP led to a decrease of DRPs, pDDIs, PIMs, the total number of medications and to an improvement in the patients’ QoL.

scholarly journals The Impact of Routine Skin Care on the Quality of Life

Cosmetics ◽  
2020 ◽  
Vol 7 (3) ◽  
pp. 59 ◽  
Author(s):  
Lixia Zhang ◽  
Aldhel Adique ◽  
Pradipta Sarkar ◽  
Vinay Shenai ◽  
Murali Sampath ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Test Group ◽  
Well Being ◽  
Consumer Products ◽  
Skin Care ◽  
Main Study ◽  
New Mothers ◽  
The Impact

Importance: Consumers purchase a wide variety of consumer products and come into contact with these products on a daily basis. Manufacturers invest deeply in developing new products or improving existing products, in order to produce a positive impact on the lives of consumers. Objective: The goal of this study was to determine the impact of over-the-counter skin care products on the quality of life (QoL) of female consumers. Design and Measures: A QoL instrument developed for consumer products (the Farage QoL with an added Skin Care Module) was used to assess the impact of a 28-day facial skin care regimen using commercially available products formulated to improve elasticity, firmness and hydration, and to correct age- and sun-related skin color. Responses were collected prior to study commencement, at completion of the product usage stage, and after a period of withdrawal of the product with reversion to a basic skin care regimen. Participants: Two main study groups from Australia included 89 new mothers, i.e., women with children 2 years and under (mean age ± SD was 34 ± 4.8), and a national representative sample of 91 women (45 ± 12). An additional test group from China consisted of 40 younger cosmetic users (25 ± 4.3). The Skin Care Module was not included in the instrument for the third group. Results: After 28-days of usage, both test groups in the main study showed significant improvement in three of five items in the Skin Care Module (improved feelings of empowerment, happiness and self-esteem). Improvements persisted after 2 weeks of product withdrawal. In the main QoL instrument, the New Mothers group showed significant improvement in the Well-Being domain, driven by improvements in the Self-Image and Self Competence subdomains. The National Representative group showed improvements in the Energy and Vitality domain, driven by improvements in the Personal Pleasure, Physical State and Routine Activity subdomains. The additional group in the China study showed results similar to the New Mothers group. Conclusions and Relevance: A quality and efficacious skin care regimen can have a positive impact on the QoL of consumers. Differences in responses of the test groups were likely related to differences in the mean age and differences in time available to look after themselves.

PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) versus observation in patients with localized renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN 8143).

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. TPS684-TPS684 ◽  
Author(s):  
Lauren Christine Harshman ◽  
Maneka Puligandla ◽  
Naomi B. Haas ◽  
Mohamad Allaf ◽  
Charles G. Drake ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Overall Survival ◽  
Immune System ◽  
Clinical Outcomes ◽  
Clinical Stage ◽  
Randomized Study ◽  
Phase Iii ◽  
The Impact ◽  
Metastatic Rcc

TPS684 Background: The anti-PD-1 antibody nivo improves overall survival in metastatic RCC and is well tolerated. There is no standard adjuvant systemic therapy that increases overall survival (OS) over surgery alone for non-metastatic RCC. Priming the immune system prior to surgery with anti-PD-1 has shown an OS benefit compared to a pure adjuvant approach in mouse solid tumor models. The PROSPER RCC trial aims to improve clinical outcomes by priming the immune system prior to nephrectomy with neoadjuvant nivo and continued engagement with adjuvant blockade in patients with high risk M0 RCC compared to surgery alone. Methods: This global, unblinded, phase 3 National Clinical Trials Network study is currently accruing patients with clinical stage ≥T2 or node positive M0 RCC of any histology. Tumor biopsy prior to randomization is mandatory to ensure RCC and permits in depth correlative science. The investigational arm will receive two doses of nivo 240mg prior to surgery followed by adjuvant nivo for 9 months (q2 wks x 3 mo followed by 480mg q4 wks x 6 mo). The control arm will undergo standard nephrectomy followed by observation. Randomized patients are stratified by clinical T stage, node positivity, and histology. To enhance accrual and patient quality of life, key upcoming amendments are being instituted. These include biopsy only in the nivo arm, allowance of oligometastatic disease and bilateral renal masses that can be fully resected/ablated, and change of nivo dosing to q4 wks (1 neoadj; 9 adj). With accrual of 766 patients, there is 84.2% power to detect a 14.4% absolute benefit in recurrence-free survival (RFS) at 5 years assuming the ASSURE historical control of ~56% to 70% (HR = 0.70). The study is also powered to evaluate a significant increase in overall survival (HR 0.67). Safety, feasibility, and quality of life endpoints critical to adjuvant therapy considerations are incorporated. PROSPER RCC embeds a wealth of translational work aimed at investigating the impact of the baseline immune milieu, the changes induced by neoadjuvant anti-PD-1 priming, and how both correlate with clinical outcomes. Clinical trial information: NCT03055013.

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