scholarly journals Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alaa Abdelqader Altaweel ◽  
Abdel Aziz Baiomy Abdullah Baiomy ◽  
Hazem Shawky Shoshan ◽  
Hisham Abbas ◽  
Ahmed Abdel-Shakour Abdel-Hafiz ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Loss ◽  
Bone Formation ◽  
Histological Evaluation ◽  
Osteogenic Potential ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Study Group ◽  
Radiographic Findings ◽  
Cissus Quadrangularis

Abstract Background This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. Material and methods Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distractor activation, patients were randomly divided into two equal groups according to administered drug (placebo and Cissus quadrangularis group). After a consolidation period, distractors were removed and implants were inserted. Clinical evaluation was done to assess wound healing, and distractor and implant stability. Histological evaluation was performed at time of implant insertion. Radiographic evaluation was performed to assess bone volume and density after distraction, as well as, density and bone loss around implant. Results Radiographic and histological results showed that bone formation and maturation of study group were faster than that of control group. There was a significant increased bone density in distracted area and around implant in study group than control group. A significant bone loss at end of consolidation period, and around implant at end of the study was reported in control group than study group. Conclusion Cissus quadrangularis administration during the consolidation period is associated with increased osteogenic potential of distracted bone. The histological and radiographic findings of current study proved that Cissus quadrangularis not only enhances rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time. Trial registration This study was retrospectively registered on www.ClinicalTrial.gov: NCT04669795-17\12\2020.

scholarly journals Clinical and Radiological Evaluation of Marginal Bone Loss around Dental Implants Restored with Zirconium vis-à-vis Porcelain Fused to Metal: An In Vivo Study

2020 ◽  
Vol 08 (01) ◽  
pp. 17-21
Author(s):  
Udey Singh Wirring ◽  
Tarun Kalra ◽  
Manjit Kumar ◽  
Ajay Bansal ◽  
Aquib Javaid
Keyword(s):  
Bone Loss ◽  
Dental Implants ◽  
Test Group ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Marginal Bone Loss ◽  
Zirconia Crowns ◽  
Bone Level ◽  
The Difference

Abstract Introduction Marginal bone level is the criterion for implant success. Patient expectations for more natural looking implant restorations created the need to restore implants with more esthetically pleasing materials like Zirconia rather than conventional porcelain-fused to-metal (PFM) crowns. The aim of this study was to evaluate marginal bone loss around dental implants clinically and radiographically when restored with Zirconia and PFM prosthesis. Materials and Methods Two groups (control and test) were formed with 14 patients each. In the control group, the subjects were rehabilitated with PFM crowns and in the test group, the subjects were rehabilitated with Zirconia crowns. Rehabilitation was done after the healing period of 3 months. Radiographic evaluation was done at regular (baseline, 3rd, 6th, and 12th month) intervals. Results The results were statistically analyzed. Keeping in mind the limitations of the study, it was revealed that the difference in the crestal bone resorption in both the groups was not significant.

scholarly journals Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats

2017 ◽  
Vol 25 (3) ◽  
pp. 95-98 ◽  
Author(s):  
Nizamettin Guzel ◽  
Emrah Sayit ◽  
Osman Aynaci ◽  
Servet Kerimoglu ◽  
Esin Yulug ◽  
...  
Keyword(s):  
Bone Formation ◽  
Fracture Healing ◽  
Ginkgo Biloba ◽  
Kirschner Wire ◽  
Ginkgo Biloba Extract ◽  
Histological Evaluation ◽  
Control Group ◽  
Sprague Dawley ◽  
Level Of Evidence ◽  
Significant Difference

ABSTRACT OBJECTIVES: Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS: Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire. The G. biloba groups received 60 mg/kg oral G. biloba extract once daily. No medication was given to the control groups. On days 7, 21 and 35, both sets of femurs were evaluated radiologically and histopathologically. RESULTS: Histological evaluation revealed that the G. biloba groups had significant differences at 21 and 35 days (p<0.05). The G. biloba group showed a significant difference in terms of bone formation on day 21 when compared to the control group (p<0.05). CONCLUSIONS: This study indicated that the use of G. biloba extract accelerated fracture healing. Both radiological and histological differences were detected, but the histological differences were more remarkable. Level of Evidence I, High Quality Randomized Trial.

Use of Alendronate in Postoperative Period for Prevention of Hip Implant Aseptic Instability

2009 ◽  
Vol 16 (3) ◽  
pp. 36-44
Author(s):  
Svetlana Semenovna Rodionova ◽  
T N Turgumbaev ◽  
S S Rodionova ◽  
T N Turgumbaev
Keyword(s):  
Calcium Carbonate ◽  
Bone Density ◽  
Bone Tissue ◽  
Postoperative Period ◽  
Main Group ◽  
Control Group ◽  
Study Group ◽  
Surgical Team ◽  
Tissue Mass ◽  
Mineral Bone Density

Assessment of the alendronate influence upon the course of adaptive remodeling of bone tissue adjacent to the implant was performed. Dynamics of mineral bone density (BMD) changes in Gruen zones was compared for 2 groups of female patients. The groups were similar by age, nosology. All operations were performed by the same surgical team with application of one type of implant (Zweymuller). During the first post-operative year patients from the study group (n=38) were taken alendronate (Fosamax-70) once a week and at least 1200 mg of calcium carbonate daily (either as calcium containing food products or calcium carbonate preparations). Patients from control group (n=94) were taken only calcium carbonate by the same scheme within the first postoperative year. It was detected that although by 6th postoperative month alendronate did not decraese BMD loss as compared to controls, within the interval of 6-15 months it significantly increased bone tissue mass accretion. In group of alendronate patients monthly accretion of bone tissue in some Gruen zones (except for R4) was twice and more higher than in control group. Fifteen months later patients from the main group showed BMD deficit only in R4 zone. In the rest of zones bone tissue mass exceeded the basic values and in the majority of zones that increase was trustworthy. In control group BMD deficit was preserved in two proximal zones (R6 and R7) and in zone R6 it even increased as compared to the results of the previous study (12 months after operation).

scholarly journals Clinical and radiographic evaluation of the effectiveness of treatment of apical periodontitis with the use of the author`s technique of vacuum-bolus irrigation of root canals

2016 ◽  
Vol 12 (1) ◽  
pp. 31-37 ◽  
Author(s):  
И. Куратов ◽  
I. Kuratov ◽  
М. Нагаева ◽  
M. Nagaeva
Keyword(s):  
Apical Periodontitis ◽  
Endodontic Treatment ◽  
Cortical Plate ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Study Group ◽  
Main Study ◽  
Root Canals ◽  
Bone Trabeculae ◽  
The Impact

A device and techniques for vacuum-bolus irrigation of root canals are developed on the basis of the analysis of existing methods of medical treatment of root canals in endodontic treatment. A comparative assessment of the impact of different variables of vacuum on the degree of cleaning of the root canal model was carried out in an invitro experiment and the optimal values of vacuum and exposure time were pointed out. In the clinical part of the study 52 patients aged from 25 to 44 years with a diagnosis of apical periodontitis were treated and dynamically monitored during one year (the author`s vacuum-bolus technique was applied to 32 patients of the main study group in the course of endodontic irrigation of root canals; while 20 patients of the control group experienced a standard irrigation method with the use of endodontic syringe in the course of endodontic treatment). Criteria of the modified periapical index (PAI) were used to assess the efficacy of treatment. It was found that after 12 months, 90,5 % of patients of the main study group had no signs of demineralization of bone tissue, the orientation of bone trabeculae of cancellous bone and cortical plate were recovering. Thus, the vacuum-boluc irrigation of root canals can help us improve the efficiency of treatment of destructive forms of apical periodontitis.

scholarly journals Autogenous Bone and Bioactive Glass around Implants Placed Simultaneously with Ridge Splitting for the Treatment of Horizontal Bony Defects: A Randomised Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Walid Elamrousy ◽  
Mohamed Osama ◽  
Dalia Rasheed Issa
Keyword(s):  
Clinical Trial ◽  
Bone Loss ◽  
Bioactive Glass ◽  
T Test ◽  
Autogenous Bone ◽  
Control Group ◽  
Study Group ◽  
Bone Width ◽  
Comparison Results ◽  
Significant Difference

Objective. To compare using autogenous bone with or without bioactive glass in ridge splitting of horizontal bone defects combined with simultaneous implant placement. Materials and Methods. In control group, bone expansion was performed and autogenous bone was used to augment the intercortical bone defect. In study group, autogenous bone was mixed with bioactive glass (1 : 1 in volume). In both groups, the implants were inserted simultaneously with ridge splitting. Six months following implant insertion, bone width and height were evaluated. Statistical analysis utilizing paired Student’s t-test was used for comparing results within the same group, whereas independent samples t-test was used for intergroup variables comparison. Results. The mean bone width and labial and mesiodistal crestal bone height values were increased significantly in both groups from baseline to 6 months postoperatively. Comparing the two groups showed nonstatistical significant difference regarding the labial crestal bone loss, while the ridge width gain values were significantly higher in the study group than in the control group. The mesiodistal bone loss was significantly higher in control group than in study group. Conclusion. Autogenous bone was mixed with bioactive glass (1 : 1 in volume) to fill intercortical defect created after ridge splitting to decrease peri-implant bone resorption associated with autogenous bone alone. This trial is registered with clinical trial registration: NCT04814160.

scholarly journals Assessment of Levels of Glycosylated Hemoglobin in Patients with Periodontal Pathologies: A Comparative Study

2017 ◽  
Vol 18 (6) ◽  
pp. 506-509 ◽  
Author(s):  
Saurabh Wahi ◽  
Alok Tripathi ◽  
Shradha Wahi ◽  
Vikas D Mishra ◽  
Abhishek P Singh ◽  
...  
Keyword(s):  
Comparative Study ◽  
Clinical Examination ◽  
Periodontal Diseases ◽  
Glycosylated Hemoglobin ◽  
Ease Of Use ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Study Group ◽  
The Mean ◽  
Hba1c Levels

ABSTRACT Introduction One of the potential sources for the occurrence of various systemic pathologies, such as cardiovascular diseases, cerebrovascular diseases, and respiratory diseases is periodontitis. Testing of glycosylated hemoglobin (HbA) is a highly standardized procedure and is becoming increasingly popular these days due to its cost-effectiveness and ease of use. Literature quotes numerous studies associating the periodontal diseases with various hemoglobin markers in diabetic and nondiabetic patients. Hence, we planned the present study to assess the levels of HbA in patients with periodontitis among nondiabetic patients. Materials and methods For the present study, a total of 50 nondiabetic subjects who reported to the department with the chief complaint of periodontitis were included. Another set of 50 nondiabetic individuals were included in the present study of comparable age in whom no periodontitis was detected clinically. Clinical examination and radiographic evaluation was performed for the selection of the cases for the study group. The patients were sent to the laboratory after the clinical examination, for the testing of HbA. Testing of the hemoglobin A1c (HbA1c) levels of all the subjects and controls was performed and values were noted and evaluated. Results Nonsignificant results were obtained while comparing the mean HbA1c concentrations among the study group and the control group. Nonsignificant results were obtained while comparing the mean HbA1c levels among males and females. While comparing the mean HbA1c levels between the study group and the control group divided on the basis of body mass index, nonsignificant results were obtained. Conclusion In nondiabetic subjects, no significant correlation could be observed between periodontitis and HbA1c levels. Clinical significance The HbA1c cannot be used as a reliable maker for differentiation of patients with periodontal pathologies from patients free of periodontal pathologies. How to cite this article Wahi S, Tripathi A, Wahi S, Mishra VD, Singh AP, Sinha N. Assessment of Levels of Glycosylated Hemoglobin in Patients with Periodontal Pathologies: A Comparative Study. J Contemp Dent Pract 2017;18(6):506-509.

scholarly journals Histological Assessment of Bone Regeneration by Octacalcium Phosphate and Bone Matrix Gelatin Composites in a Rat Mandibular Defect Model

2018 ◽  
Author(s):  
Fereydoon Sargolzaei Aval ◽  
Eshaghali Saberi ◽  
Mohammad Reza Arab ◽  
Narjes Sargolzaei ◽  
Esmaeel Zare ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Matrix ◽  
Octacalcium Phosphate ◽  
Bone Defects ◽  
Osteogenic Potential ◽  
Control Group ◽  
New Bone Formation ◽  
Mandibular Bone

Objective: Regeneration of bone defects remains a challenge for maxillofacial and reparative surgeons. The purpose of this histological study was to assess the osteogenic potential of octacalcium phosphate (OCP) and bone matrix gelatin (BMG) alone and in combination in artificially created mandibular bone defects in rats. The quality of the newly formed bone was also evaluated. Methods: Thirty-six male Sprague Dawley rats (6-8 weeks old with 120-150 g weight) were randomly divided into four groups. Defects (3 mm in diameter and 2 mm in depth) were created in the mandible of rats and filled with 6 mg of OCP, BMG or a combination of both (1/4 ratio), respectively. Defects were left unfilled in the control group. To assess osteoinduction and bone regeneration and determine the quality of the newly formed bone, tissue specimens were harvested at seven, 14, and 21 days post-implantation. The specimens were processed, stained with hematoxylin and eosin (H&amp;E) and histologically analyzed under light microscopy. Results: In the experimental groups, new bone formation was initiated at the margins of defects from seventh day after implantation. At the end of the study period, the amount of the newly formed bone increased and the bone was relatively mature. Osteoinduction and new bone formation were greater in OCP/BMG group. In the control group, slight amount of new bone had been formed at the defect margins (next to host bone) on day 21. Conclusion: Combination of OCP/BMG may serve as an optimal biomaterial for treatment of mandibular bone defects.

Osteoporosis and fragility fracture

2018 ◽  
Author(s):  
Kassim Javaid
Keyword(s):  
Bone Density ◽  
Bone Loss ◽  
Bone Formation ◽  
Bone Mass ◽  
Fragility Fracture ◽  
Peak Bone Mass ◽  
Early Adulthood ◽  
Multifactorial Disease ◽  
The Uk ◽  
Rate Of Bone Loss

Osteoporosis is defined as a systemic bone disease with reduction in both bone density and microarchitectural integrity, resulting in an increase in fragility fracture risk. It is a multifactorial disease which, through effects on bone formation and resorption, reduces the peak bone mass achieved during early adulthood and increases the rate of bone loss in later adulthood. Osteoporosis is clinically silent until a fragility fracture occurs. There are 3 million patients with osteoporosis in the UK, with over 200 000 fractures per year and 80 000 hip fractures. This chapter addresses the causes, clinical features, diagnosis, and management of osteoporosis.

Effects of autologous platelet rich plasma gel and calcium phosphate biomaterials on bone healing in an ulnar ostectomy model in dogs

2009 ◽  
Vol 22 (06) ◽  
pp. 460-466 ◽  
Author(s):  
J.-G. Grand ◽  
E. Dalibert ◽  
B. Fellah ◽  
O. Gauthier ◽  
G.W. Niebauer ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Healing ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Long Bone ◽  
Histological Evaluation ◽  
Radiographic Evaluation ◽  
New Bone Formation ◽  
Prp Gel

SummaryThe aim of the study was to evaluate the bone healing properties of an osteopromotive platelet rich plasma (PRP) gel in combination with osteoconductive calcium phosphate (CaP) ceramic granules in a long-bone critical size defect in dogs. A standardised 2 cm long ulnar ostectomy was performed bilaterally in four dogs to compare new-bone formation by CaP matrix with and without association with PRP. Radiographic and histological evaluations were performed blindly. Radiographic evaluation was performed at three, six, nine, 12 and 16 weeks postoperatively. Quantitative measurements of new-bone formation were compared using statistical analysis. At explantation 16 weeks after surgery, no significant ossification was present, neither with CaP granules alone nor in association with PRP gel, and there was no difference of radiodensity between the groups. Qualitative histological evaluation demonstrated for both types of implants the presence of non-mineralised fibrous connective tissue around the CaP granules. New-bone formation was only present to a very small extent within the macropores of the CaP granules at the distal boneimplant interface. In our model which exhibited very limited osteoconduction, neither the CaP granules alone nor in association with PRP were sufficient to stimulate bone healing. In this canine model employing a critical size ulnar gap, the combination of CaP granules and PRP did not effectively promote bone regeneration.

scholarly journals Potential Bone Regenerative Effects of DFDBA, Simvastatin and Platelet Rich Fibrin, Radiographically and Histologically of Intra-Bony Periodontal Defects in White New Zealand Rabbits

2021 ◽  
Vol 9 (D) ◽  
pp. 72-80
Author(s):  
Asma M. Sarag El-dien ◽  
Shereen Fathy ◽  
Yasmine Alaa El-din
Keyword(s):  
New Zealand ◽  
Bone Density ◽  
Periodontal Regeneration ◽  
Bone Allograft ◽  
Negative Control Group ◽  
Negative Control ◽  
Histological Evaluation ◽  
Control Group ◽  
Freeze Dried ◽  
New Zealand Rabbits

AIM: This study aimed to evaluate and to compare the regenerative power of simvastatin, Demineralized Freeze-Dried Bone Allograft (DFDBA) allograft, platelets rich Fibrin (PRF), and a combination of these materials radiographically and histologically in the intra-bony periodontal defects in white New Zealand rabbits. MATERIALS AND METHODS: This study was conducted on 54 defects in 27 adult male rabbits (n = 27) which were divided into three groups according to the follow-up preplanned scheduled for 1, 2, and 3 weeks. The selected materials were induced as following: A=DFDBA, B=Simvastatin, C= PRF, D=A+C, E=B+C, and F=negative (control group). The intra-bony periodontal defects were induced as the form of one osseous wall defect of 10 mm height, 4 mm depth between the first and the second molars. Then, samples were prepared for histological evaluation. Radiographic assessment was done using computed tomography radiography which was carried at different time intervals as the following baseline, 1, 2, and 3 weeks later. Statistical analysis was performed using ANOVA. RESULTS: After evaluating the results, macroanatomy, radiographically, and histologically, it is thus confirmed that DFDBA allograft combined with PRF create the best bone regenerative results, followed by DFDBA, Simvastatin, simvastatin+ PRF, control group, and finally PRF. CONCLUSION: All of the materials examined in this study showed different percentage in terms of bone density and bone regenerative effects. However, the best results for bone density of the DFDBA + PRF group were recorded after 3 weeks. Thus, the study concludes that a combination of DFDBA + PRF reflects the best properties of both materials in terms of bone density results of the defect. Such results are particularly significant for the selection of bone regeneration materials, and generally, for periodontal regeneration.

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