Clustering of subpatent infections in households with asymptomatic rapid diagnostic test-positive cases in Bioko Island, Equatorial Guinea independent of travel to regions of higher malaria endemicity: a cross-sectional study

Abstract Background Prevalence of falciparum malaria on Bioko Island remains high despite sustained, intensive control. Progress may be hindered by high proportions of subpatent infections that are not detected by rapid diagnostic tests (RDT) but contribute to onward transmission, and by imported infections. Better understanding of the relationship between subpatent infections and RDT-detected infections, and whether this relationship is different from imported versus locally acquired infections, is imperative to better understand the sources of infection and mechanisms of transmission to tailor more effective interventions. Methods Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed on a sub-set of samples from the 2015 Malaria Indicator Survey to identify subpatent infections. Households with RDT(+) individuals were matched 1:4 with households with no RDT(+) individuals. The association between living in a household with an RDT(+) individual and having a subpatent infection was evaluated using multivariate hierarchical logistic regression models with inverse probability weights for selection. To evaluate possible modification of the association by potential importation of the RDT(+) case, the analysis was repeated among strata of matched sets based on the reported eight-week travel history of the RDT(+) individual(s). Results There were 142 subpatent infections detected in 1,400 individuals (10.0%). The prevalence of subpatent infections was higher in households with versus without an RDT(+) individual (15.0 vs 9.1%). The adjusted prevalence odds of subpatent infection were 2.59-fold greater (95% CI: 1.31, 5.09) for those in a household with an RDT(+) individual compared to individuals in a household without RDT(+) individuals. When stratifying by travel history of the RDT(+) individual, the association between subpatent infections and RDT(+) infections was stronger in the strata in which the RDT(+) individual(s) had not recently travelled (adjusted prevalence odds ratio (aPOR) 2.95; 95% CI:1.17, 7.41), and attenuated in the strata in which recent travel was reported (aPOR 1.76; 95% CI: 0.54, 5.67). Conclusions There is clustering of subpatent infections around RDT(+) individual(s) when both imported and local infection are suspected. Future control strategies that aim to treat whole households in which an RDT(+) individual is found may target a substantial portion of infections that would otherwise not be detected.

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Prevalence of Systemic Hypertension Among HIV-Infected and HIV-Uninfected Young Adults

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx162.138 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S59-S59 ◽

Cited By ~ 2

Author(s):

Patrick Ryscavage ◽

William Still ◽

Vimbai Nyemba ◽

Kristen Stafford

Keyword(s):

Young Adults ◽

Hiv Infection ◽

Cross Sectional Study ◽

Hiv Care ◽

Systemic Hypertension ◽

Prevalence Odds Ratio ◽

Cross Sectional ◽

University Of Maryland ◽

History Of ◽

Perinatally Acquired

Abstract Background Advances in HIV care and treatment have resulted in perinatally infected children aging into adulthood. These patients may be at higher risk of HIV-associated non-AIDS conditions, including systemic hypertension (HTN). This study examined the association between HIV infection and the prevalence of HTN among young adults receiving care in West Baltimore. Methods We conducted a cross-sectional study of young adults with perinatally-acquired (PA) HIV frequency matched on race and sex to a stratified random sample of young adults with non perinatally-acquired (NPA) HIV and HIV-uninfected young adults (UI). All subjects were aged 18–29 years of age as of September 1, 2014. The outcome of HTN was ascertained through chart review (two systolic blood pressure measurements > = 140 mmHg or diastolic > = 90 mmHg at least three months apart; and/or physician prescription for an antihypertensive mediation). Logistic regression was used to estimate adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (CI) for the association between HIV infection and HTN. All data were collected from clinics within the University of Maryland Medical System. Results Three hundred and twenty-four patients were included in the study, 108 per exposure group. The prevalence of HTN was 23% among PA patients, 10% among NPA patients, and 9% among UI patients. The median age was 24 (IQR 22 - 26), 95% were African American, and 42% were male. PA patients had the highest prevalence of chronic kidney disease (CKD) and dyslipidemia (19% and 13% respectively) compared with NPA (1% and 3%) and UI (0% and 5%). PA patients had 3 (95% CI 1.4 - 6.6) times the base odds (controlling for matching variables) of prevalent HTN compared with UI patients and NPA had 1.1 times the base odds (95% CI 0.5 - 2.7) compared with UI patients. After controlling for race, gender, family history of HTN, and CKD, the prevalence odds ratio for HTN was 2.7 (95% CI 1.06 - 7.0) times higher for PA compared with UI, and 1.3 (95% CI 0.5 - 3.4) times higher for NPA compared with UI. Conclusion Our findings suggest that the prevalence of HTN among young adults with PA HIV is significantly higher than sex and race matched UI patients of similar age. HIV providers should carefully monitor these patients for the development of HTN, particularly as they enter adulthood. Disclosures All authors: No reported disclosures.

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Associations of intake of antioxidant vitamins and fatty acids with asthma in pre-school children

Public Health Nutrition ◽

10.1017/s1368980012004363 ◽

2012 ◽

Vol 16 (11) ◽

pp. 2040-2045 ◽

Cited By ~ 15

Author(s):

Kozue Nakamura ◽

Keiko Wada ◽

Yukari Sahashi ◽

Yuya Tamai ◽

Michiko Tsuji ◽

...

Keyword(s):

Fatty Acids ◽

School Children ◽

Maternal Education ◽

Cross Sectional Study ◽

Antioxidant Vitamins ◽

Cross Sectional ◽

Parental History ◽

Logistic Regression Models ◽

Dietary Record ◽

History Of

AbstractObjectiveIncreasing childhood asthma rates may be due to changing dietary lifestyle. We investigated the association of dietary intake of antioxidant vitamins and fatty acids with asthma in Japanese pre-school children.DesignCross-sectional study.SettingSchool-based survey on lifestyle/diet and health status in children in Japan.SubjectsParents of 452 children aged 3–6 years completed a questionnaire on the children's and parents’ lifestyle and demographics. Children were classified into asthma cases and non-asthma cases in accordance with the ATS-DLD (American Thoracic Society and Division of Lung Diseases of the National Heart, Lung, and Blood Institute) questionnaire. Children's diet was assessed using a 3 d dietary record completed by parents. Children's age, sex, BMI, history of food allergy, maternal age, parental history of allergy, maternal education, family size and second-hand smoking were included as covariates. Logistic regression models were used to examine the association between children's diet and asthma.ResultsCompared with children with the lowest intake tertile for vitamin C and vitamin E, those in the highest were significantly inversely associated with asthma; adjusted OR (95 % CI) were 0·35 (0·14, 0·88) and 0·32 (0·12, 0·85), respectively. A statistically significant trend was also observed. Fruit intake showed an inverse but insignificant association with asthma. There were no associations of any type of fatty acids with asthma.ConclusionsThese data suggest that children with high intakes of vitamins C and E may be associated with a reduced prevalence of asthma.

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The Transmission Potential of Sars-Cov-2 during the Early Outbreak

Journal of Saidu Medical College, Swat ◽

10.52206/jsmc.2021.11.4.681 ◽

1969 ◽

Vol 11 (4) ◽

pp. 211-216

Author(s):

Hamzullah Khan

Keyword(s):

Tertiary Care ◽

Cross Sectional Study ◽

Care Hospital ◽

District Health ◽

Cross Sectional ◽

Travel History ◽

Social Distancing ◽

Transmission Potential ◽

Epidemic Area ◽

History Of

Background: The newly emerging respiratory disease called COVID-19 , originated from a metropolitan city of the HubeiProvince of China, called Wuhan, in Dec 2019, demonstrated its epidemic potential with a rapid spread of this virus across the globein just 2 months period. This highlights the higher rate of transmissibility of this virus and further its higher morbidity and mortalityspecially in aged population or people with co-morbidities and immune gap.Objectives: To determine the clinical significance of travel history to an epidemic area and social distancing with COIVD -19infections.Material and methods: This cross sectional study was conducted in major/only tertiary care hospital of Nowshera in collaborationwith District Health Office, Nowshera from 15th Feb to 24th April 2020. Relevant information's were recorded in a predesignedproforma prepared in SPSS version 25th for descriptive and inferential analysis.Results: Out of total 378 suspects/patients, 272(72%) were males and 106(28%) females. The Mean with Standard deviation ofage of the suspects was 35+16.1 years. A significant relationship of an increase in age with positive cases (Chi-squarevalue=10.73, p=0.013) was observed. 13/41(31.70%) of the positive cases had a history of travel to an epidemic area. A statisticallysignificant relationship between COVID-19 infection and travel history (Chi-Square=5.86, p=0.015) was noted. The probability ofthe infection in patients/suspects with history of travel to an epidemic area was 2.38 times(OR=2.38, 95%CI, 2.5-14.9). The relativerisk of infection was (rr=1.75, 95%CI, 1.16-4.88) as compared to suspects with no contact(rr=0.81, 95%CI, 0.6-1.0) respectively.Conclusion: There is a significant impact of travel history to an area with COVID19 epidemics. This data also speaks itself on theimportance of social distancing in terms of history of travel to combat COVID-19.Key words: COVID-19, Travel history, Social distancing, risk assessment, probability of disease, correlation of disease.

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The Association between Peanut and Peanut Butter Consumption and Cognitive Function among Community-Dwelling Older Adults

Journal of Prevention of Alzheimer's Disease ◽

10.14283/jpad.2021.32 ◽

2021 ◽

pp. 1-6

Author(s):

E.W. Katzman ◽

S.J. Nielsen

Keyword(s):

Cognitive Function ◽

Peanut Butter ◽

Cross Sectional Study ◽

Community Dwelling ◽

Digit Symbol Substitution Test ◽

Sectional Study ◽

Cross Sectional ◽

Logistic Regression Models ◽

Symbol Substitution ◽

History Of

Background: Many studies have focused on the association between diet and cognitive function. While a subset of these studies focused on a diet that includes tree nuts (TN), there is limited data on the association between peanut and peanut butter consumption (P/PB) and cognitive health. Objective: This study investigated the association of P/PB consumption and cognitive function. Design: This was a cross-sectional study using 2011-2014 NHANES data. Participants/setting: Individuals 60-80 years old in 2011-2014 NHANES who had two 24-hour dietary recalls, cognitive function tests, and education level and with no history of stroke. Measurements: P/PB and TN consumption was measured as well as participant performance on the CERAD Word Learning subtest (CERAD W-L), Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). Scores from the three cognitive tests were dichotomized. Individuals were classified as either P/PB consumers or non-consumers and TN consumers or non-consumers. Logistic regression models examined associations between P/PB consumption, tree nut consumption, and cognitive function with adjusted models including age, sex, and education as covariates. Results: A total of 2,454 adults, aged 60-80 years old (mean age=69.4) participated. Approximately half were male (48%), 18% were P/PB consumers, and 14% consumed TN. Participants who did not consume P/PB were more likely to do poorly on the CERAD W-L (adjusted OR=1.56, 95% CI 1.24-1.97; p<0.05), AFT (adjusted OR=1.29, 95% CI 1.03-1.61; p<0.05), and DSST (adjusted OR=1.43, 95% CI 1.12-1.82; p<0.05) when compared to those who did consume P/PB. Conclusions: These findings suggest an association between P/PB consumption and cognitive function; however, this is a cross sectional study and a causal relationship cannot be established. More studies are needed to determine causality.

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Individual and school environment factors associated with overweight in adolescents of the municipality of Rio de Janeiro, Brazil

Public Health Nutrition ◽

10.1017/s1368980010003162 ◽

2011 ◽

Vol 14 (5) ◽

pp. 914-922 ◽

Cited By ~ 4

Author(s):

Letícia de Oliveira Cardoso ◽

Inês Rugani Ribeiro de Castro ◽

Fabio da Silva Gomes ◽

Iuri da Costa Leite

Keyword(s):

School Environment ◽

Rio De Janeiro ◽

Context Effects ◽

Cross Sectional Study ◽

City Region ◽

Prevalence Odds Ratio ◽

Cross Sectional ◽

Environment Factors ◽

Logistic Regression Models ◽

Probabilistic Sampling

AbstractObjectiveTo identify the association of individual and school environment factors with overweight among adolescents.DesignCross-sectional study. Sociodemographic and behavioural information was collected using an anonymous self-administered questionnaire. Indicators on human and physical resources of the schools were based on information collected in interviews with school principals. Overweight was defined based on the BMI Z-score for age and sex recommended by WHO. Logistic regression models were used for statistical analysis.SettingRio de Janeiro, Brazil.SubjectsBy means of a two-stage (classrooms and students) probabilistic sampling, subjects comprised 1632 students enrolled in the last year of primary education of the municipal public school network, stratified by city region.ResultsThe mean prevalence of overweight at schools was 17·2 %, ranging from 0 % to 50 %. Adolescents more likely to be overweight were those who attended schools without knives and forks or ceramic/glass plates for students in the school refectory (prevalence odds ratio (POR) = 1·40; P = 0·04), those whose head of household had completed between 8 and 10 years of schooling (POR = 1·46; P = 0·03), those who did not live with both parents (POR = 1·24; P = 0·06) and those who had not practised physical activity outside school on at least 1 d in the 7 d before the study (POR = 1·56; P = 0·04).ConclusionsSociodemographic and behavioural variables of adolescents and school characteristics were associated with overweight, confirming individual and context effects on this health disorder. Studies such as the present one, identifying variables in context, may support actions to prevent overweight among adolescents.

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Understanding the Importance of Fatherhood among Men Living with HIV in Ontario

Journal of the International Association of Providers of AIDS Care (JIAPAC) ◽

10.1177/23259582211016133 ◽

2021 ◽

Vol 20 ◽

pp. 232595822110161

Author(s):

Luke Thomas Kyne ◽

Mark H. Yudin ◽

Tsegaye Bekele ◽

Mona Loutfy ◽

Sean B. Rourke ◽

...

Keyword(s):

Regression Models ◽

Secondary Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Logistic Regression Models ◽

Fertility Desires ◽

Women Living With Hiv ◽

African Caribbean ◽

History Of ◽

Living With Hiv

While pregnancy and motherhood have become paramount clinical issues for women living with HIV, parenting has received less attention among men living with HIV (MLWH). We conducted a secondary analysis of a cross-sectional study assessing fertility desires and intentions of MLWH using a 5-point Likert scale based on the question: “Being a father is important to me”. Logistic regression models were fit to calculate unadjusted and adjusted odds ratios (ORs) and confidence intervals (CIs) for significant correlates. Of the 276 respondents, 118 were heterosexual, 158 were gay, bisexual, 2-spirit, or queer (GBTQ), 55% had never parented before, and 65% wanted to parent. 191 (69%) respondents agreed that fatherhood was important to them. In unadjusted analyses, heterosexuality (OR 1.52; 95% CI 1.15 to 2.03), African/Caribbean/Black ethnicity (OR 1.57; 95% CI 1.12 to 2.19), African/Caribbean birthplace (OR 1.48; 95% CI 1.06 to 2.05), and history of parenting (OR 1.60; 95% CI 1.10 to 2.39) were significantly (p < 0.05) associated with importance of fatherhood. However, none of these variables were significant in adjusted analyses. From the unadjusted model, factors such as sexual orientation, ethnicity, and current parenthood may influence how MLWH value fatherhood, suggesting HIV and fatherhood is complex and must be explored further.

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Suicidal Ideation Among Medical Students in Dammam, Saudi Arabia

Crisis ◽

10.1027/0227-5910/a000720 ◽

2020 ◽

pp. 1-6

Author(s):

Mohammed Madadin ◽

Ritesh G. Menezes ◽

Maha A. Alassaf ◽

Abdulaziz M. Almulhim ◽

Mahdi S. Abumadini ◽

...

Keyword(s):

Saudi Arabia ◽

Medical Students ◽

Suicidal Ideation ◽

General Health Questionnaire ◽

Cross Sectional Study ◽

Eastern Province ◽

Cross Sectional ◽

The Past ◽

Depression Subscale ◽

History Of

Abstract. Background: Medical students are at high risk of suicidal ideation. Aim: We aimed to obtain information on suicidal ideation among medical students in Dammam located in the Eastern Province of Saudi Arabia. Method: This cross-sectional study was conducted at the College of Medicine affiliated with Imam Abdulrahman Bin Faisal University in the Eastern Province of Saudi Arabia. Suicidal ideation in the past 12 months was assessed based on responses to four questions in the depression subscale of the General Health Questionnaire 28 (GHQ-28). In addition, data were collected to examine the association of suicidal ideation with various factors. Results: We found that 1 in 3 medical students in the study had suicidal ideation in the past 12 months, while around 40% had lifetime suicidal ideation. Suicidal ideation was associated with feelings of parental neglect, history of physical abuse, and dissatisfaction with academic performance. Limitations: The cross-sectional nature of this study limits its ability to determine causality regarding suicidal ideation. Conclusion: These rates are considerably high when compared with rates from studies in other countries around the world. This study provides a reference in the field of suicidology for this region of Saudi Arabia.

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DYSLIPIDEMIA IN THYROID DISORDERS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i7.1308 ◽

2020 ◽

Vol 4 (7) ◽

Author(s):

Kashish Narula ◽

Narendra Kumar Dara ◽

Shyam Lal Meena

Keyword(s):

Lipid Metabolism ◽

Thyroid Dysfunction ◽

Cross Sectional Study ◽

Control Group ◽

Thyroid Disorders ◽

Cross Sectional ◽

Carbohydrate And Lipid Metabolism ◽

History Of ◽

Thyroid Profile ◽

Basal Energy Expenditure

Background: Thyroid hormones influence nearly all major metabolic pathways. Their most obvious and well-known action is the increase in basal energy expenditure obtained by acting on protein, carbohydrate and lipid metabolism. The lipid metabolism is more influenced by the thyroid hormone. Methods: A cross-sectional study was conducted on 100 patients with suspicion of thyroid disorders were taken as cases. One hundred patients with normal thyroid profile and no history of other chronic diseases were taken as control group. Results: The serum TC, TG and LDL levels in hypothyroid individuals (both overt and subclinical) were significantly higher than euthyroid subjects but the levels were comparable between hyperthyroid and euthyroid group. Conclusion: Dyslipidemias are associated with thyroid disorders, so biochemical screening for thyroid dysfunction in all dyslipidemic patients. Therefore, patients presenting with dyslipidemia are recommended for investigation to explore thyroid dysfunction. Keywords: Thyroid profile, Total cholesterol, Triglycerides and LDL

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Metabolic Syndrome in HIV-patients in Antiretroviral Therapy

Current HIV Research ◽

10.2174/1570162x18666200609115615 ◽

2020 ◽

Vol 18 (6) ◽

pp. 388-395

Author(s):

Daniel Vargas-Pacherrez ◽

Helma P. Cotrim ◽

Leonardo Pires ◽

Vitor Cunha ◽

Vitor Coelho ◽

...

Keyword(s):

Metabolic Syndrome ◽

Antiretroviral Therapy ◽

International Diabetes Federation ◽

Cross Sectional Study ◽

People Living With Hiv ◽

Anthropometric Data ◽

Cross Sectional ◽

History Of ◽

Family History Of Hypertension ◽

Living With Hiv

Introduction: The global prevalence of metabolic syndrome (MS) among people living with HIV/AIDS varies from 20% to 33%. Objective: to estimate the prevalence of metabolic syndrome and associated factors in a group of HIV-infected patients on antiretroviral therapy. Methods: This is a cross-sectional study with HIV-infected patients from a reference center in Bahia, Brazil. We evaluated clinical, socio-demographic and anthropometric data. MS was defined according to the guidelines of International Diabetes Federation. Results: We evaluated 152 patients with mean age of 47.3±11.6 years, 59.2% male. The main comorbidities detected were diabetes (3.3%) hypertriglyceridemia (9.3%) and metabolic syndrome (MS,38.2%). Patients with MS were predominantly women (55.2% vs 31.9%; p=0.005), older [52.1 (10.4) vs 44.3 (11.3); p<0.001], and had overweight (74.1% vs 23.4%; p<0.001). After multivariate analysis MS remained associated with age (OR = 1.076; 95% CI: 1.030 – 1.125), female sex (OR = 2.452; 95% CI: 1.114 – 5.374) and family history of hypertension (OR = 3.678; 95% CI: 1.431 – 9.395). Conclusion: Almost half of the HIV-infected patients in Bahia presents with MS which seems to be driven by classical risk factors.

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Comparison of Non-radiographic Axial Spondyloarthritis and Ankylosing Spondyltis from a Single Rheumatology Hospital in Morocco

Current Rheumatology Reviews ◽

10.2174/1573397115666190222195923 ◽

2020 ◽

Vol 16 (3) ◽

pp. 240-244 ◽

Cited By ~ 2

Author(s):

Nessrine Akasbi ◽

Siar Nihad ◽

Zoukal Sofia ◽

El Kohen Khadija ◽

Harzy Taoufik

Keyword(s):

Disease Burden ◽

Axial Spondyloarthritis ◽

Univariate Analysis ◽

Cross Sectional Study ◽

Low Back ◽

New Classification ◽

Cross Sectional ◽

Asas Criteria ◽

History Of ◽

High Level

Background: According to the new classification criteria developed by The Assessment of SpondyloArthritis International Society, patients with axial spondyloarthritis (axSpA) can be classified in 2 subgroups: Patients with radiographic axial spondyloarthritis: ankylosing spondylitis patients (AS) and those with non-radiographic axial spondyloarthritis (nr-axSpA). Objective: The aim of the present study is to describe and discuss the differences and similarities between the two subgroups. Patients and Methods: A cross-sectional study was conducted in a single rheumatology hospital in Morocco. These included patients diagnosed as having axial spondyloarthritis according to ASAS criteria 2010, during a period of 6 years. The AS and the nr-axSpA subgroups were compared for the various axSpA-related variables. Results: Of the 277 patients with a diagnosis of axial SpA who were included in this study, 160 had AS and 117 had nr-axSpA. AS and nr-ax-SpA shared a similar age at diagnosis, similar prevalence of low back pain, lumbar stiffness, extra-articular manifestations, BASDAI and BASFI. In the multivariate analysis, AS patients were mainly male with cervical stiffness, enthesitis, coxitis and high level of ESR (erythrocyte sedimentation rate). The females generally had a family history of SpA and arthritis and were associated to the nr-axSpA form in the univariate analysis. Conclusion: This was the first study to characterise patients with AS and nr-axSpA in Morocco. Consistent with other studies published, this study showed that patients with nr-axSpA and patients with AS shared a comparable degree of disease burden.

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