scholarly journals Forest malaria and prospects for anti-malarial chemoprophylaxis among forest goers: findings from a qualitative study in Lao PDR

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Monnaphat Jongdeepaisal ◽  
Soulixay Inthasone ◽  
Panarasri Khonputsa ◽  
Vilayvone Malaphone ◽  
Kulchada Pongsoipetch ◽  
...  

Abstract Background Despite significant decline in malarial incidence and mortality in countries across the Greater Mekong Subregion, the disease remains a public health challenge in the region; transmission continues mainly among people who visit forests in remote areas, often along international borders, where access to primary healthcare is limited. In the absence of effective vector-control measures and limited exposure periods, malaria chemoprophylaxis has been proposed as a strategy to protect forest goers. As a rarely used approach for indigenous populations, questions remain about its feasibility and acceptability. Drawing on in-depth interviews with forest goers and stakeholders, this article examines opportunities and challenges for implementation of anti-malarial chemoprophylaxis for forest goers in Lao PDR. Methods In-depth interviews were conducted with 16 forest goers and 15 stakeholders in Savannakhet province, Lao PDR. Interview topics included experience of malaria prevention and health services, and perceptions of prophylaxis as a potential component of malaria elimination strategy. The interviews were transcribed and coded using inductive and deductive approaches for qualitative thematic analysis. Results In ethnically and geographically diverse villages, awareness of malaria risk prompts forest goers to protect themselves, albeit sub-optimally using available preventive measures. Stakeholders highlighted challenges for targeting at-risk populations and approaches to address forest malaria in southern Lao PDR. Among policymakers, choice and cost of anti-malarials, particularly their efficacy and source of funding, were key considerations for the feasibility of malaria prophylaxis. Acceptability of prophylaxis among forest goers was also influenced by the complexity of the regimen, including the number of tablets and timing of doses. Implementation of prophylaxis may be affected by a lack of transportation and communication barriers in remote communities. Conclusion Adding prophylaxis to existing malaria control activities requires strengthening the capacity of local health workers in Lao PDR. Ideally, this would be part of an integrated approach that includes strategies to address the other febrile illnesses that forest goers describe as priority health concerns. The prophylactic regimen also requires careful consideration in terms of effectiveness and simplicity of dosing.

2021 ◽  
Author(s):  
Monnaphat Jongdeepaisal ◽  
Soulixay Inthasone ◽  
Panarasri Khonputsa ◽  
Vilayvone Malaphone ◽  
Kulchada Pongsoipetch ◽  
...  

Abstract Background Despite significant decline in malarial incidence and mortality in countries across the Greater Mekong Subregion, the disease remains a public health challenge. Transmission continues mainly among people who visit forests in remote areas, often along international borders, where access to primary healthcare is limited. In the absence of effective vector-control measures and limited periods of exposure, malaria chemoprophylaxis has been proposed as a strategy to protect forest goers. As a rarely used approach for indigenous populations, questions remain about its feasibility and acceptability. Drawing on in-depth interviews with forest goers and stakeholders, this article examines opportunities and challenges for implementation of antimalarial chemoprophylaxis for forest goers in Lao PDR.Methods In-depth interviews were conducted with 16 forest goers and 15 stakeholders in Savannakhet province, Lao PDR. Interview topics included experience of malaria prevention and health services, and perceptions of prophylaxis as a potential component of malaria elimination strategy. The interviews were transcribed and coded using inductive and deductive approaches for qualitative thematic analysis.Results In ethnically and geographically diverse villages, awareness of malaria risk prompts forest goers to protect themselves, albeit suboptimality using available preventive measures. Stakeholders highlighted challenges for targeting at-risk populations and approaches to address forest malaria in southern Laos. Among policymakers, choice and cost of antimalarials, particularly their efficacy and source of funding, were key considerations for the feasibility of malaria prophylaxis. Acceptability of prophylaxis among forest goers was also influenced by the complexity of the regimen, including the number of tablets and timing of doses. Implementation of prophylaxis may be affected by a lack of transportation and communication barriers in remote communities. Conclusion Adding prophylaxis to existing malaria control activities requires strengthening the capacity of local health workers in Lao PDR. Ideally, this would be part of an integrated approach that includes strategies to address the other febrile illnesses that forest goers describe as priority health concerns. The prophylactic regimen also requires careful consideration in terms of effectiveness and simplicity of dosing.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Monnaphat Jongdeepaisal ◽  
Mom Ean ◽  
Chhoeun Heng ◽  
Thoek Buntau ◽  
Rupam Tripura ◽  
...  

Abstract Background In the Greater Mekong Subregion, adults are at highest risk for malaria, particularly those who visit forests. The absence of effective vector control strategies and limited periods of exposure during forest visits suggest that chemoprophylaxis could be an appropriate strategy to protect forest goers against malaria. Methods Alongside a clinical trial of anti-malarial chemoprophylaxis in northern Cambodia, qualitative research was conducted, including in-depth interviews and observation, to explore the acceptability of malaria prophylaxis for forest goers, the implementation opportunities, and challenges of this strategy. Results Prophylaxis with artemether–lumefantrine for forest goers was found to be acceptable under trial conditions. Three factors played a major role: the community’s awareness and perception of the effectiveness of prophylaxis, their trust in the provider, and malaria as a local health concern. The findings highlight how uptake and adherence to prophylaxis are influenced by the perceived balance between benefits and burden of anti-malarials which are modulated by the seasonality of forest visits and its influence on malaria risk. Conclusions The implementation of anti-malarial prophylaxis needs to consider how the preventive medication can be incorporated into existing vector-control measures, malaria testing and treatment services. The next step in the roll out of anti-malarial prophylaxis for forest visitors will require support from local health workers.


2021 ◽  
Vol 53 (03) ◽  
pp. 127-134
Author(s):  
Rajendran R ◽  

Alappuzha district was severely affected by floods due to the intense rainfall in August 2018. A three member team with the assistance of local health workers was entrusted to assess the post flood situation and to assist the local health department to extend expertise mainly to control infectious diseases and propose suggestions regarding hygiene and sanitary measures to be taken for health and wellbeing of the community. Among the infectious diseases, Leptospirosis poses a significant public health issue in the flood affected areas of Alappuzha district. Majority of households had taken chemoprophylaxis for Leptospirosis as per standard protocol as also temporary rehabilitation camps in the flood affected areas. There was no episode of Acute Diarrheal Diseases (ADD), found in clusters in any of the areas. The number of dengue fever cases reported in post flood period was less when compared to previous year. Risk assessment is essential in post-disaster situations mainly concerned with the rapid implementation of control measures through refurbishment and improvement of health care delivery. The findings presented relate to an assessment carried out in Alappuzha district in September 2018 that included epidemiological situation analysis, appraisal of laboratory facilities for microbiology investigations, evaluation of health facilities and infrastructure available at Local Self Governments (LSGs).


2021 ◽  
Author(s):  
Monnaphat Jongdeepaisal ◽  
Panarasri Khonputsa ◽  
Orathai Prasert ◽  
Suphitsara Maneenet ◽  
Kulchada Pongsoipetch ◽  
...  

Abstract Background Across the Greater Mekong Sub-region, malaria remains a dangerous infectious disease, particularly for people who visit forested areas where residual transmission continues. Because vector control measures offer incomplete protection to forest goers, chemoprophylaxis has been suggested as a potential supplementary measure for malaria prevention and control. To implement prophylaxis effectively, additional information is needed to understand forest goers’ activities and their willingness to use malaria prevention measures, including prophylaxis, and how it could be delivered in communities. Drawing on in-depth interviews with forest goers and stakeholders, this article examines the potential acceptability and implementation challenges of malaria prophylaxis for forest goers in northeast Thailand. Methods In-depth interviews were conducted with forest goers (n = 11) and stakeholders (n = 16) including healthcare workers, community leaders, and policymakers. Interviews were audio-recorded, transcribed and coded using NVivo, employing inductive and deductive approaches, for thematic analysis.Results Forest goers were well aware of their (elevated) malaria risk and reported seeking care for malaria from local health care providers. Forest goers and community members have a close relationship with the forest but are not a homogenous group: their place and time-at-risk varied according to their activities and length of stay in the forest. Among stakeholders, the choice and cost of antimalarial prophylactic regimen - its efficacy, length and complexity, number of tablets, potential side effects, and long-term impact on users - were key considerations for its feasibility. They also expressed concern about adherence to the preventive therapy and potential difficulty treating malaria patients with the same regimen. Prophylaxis was considered a low priority in areas with perceived accessible health system and approaching malaria elimination.Conclusions In the context of multi-drug resistance, there are several considerations for implementing malaria prophylaxis: the need to target forest goers who are at-risk with a clear period of exposure, to ensure continued use of vector control measures and adherence to prophylactic antimalarials, and to adopt an evidence-based approach to determine an appropriate regimen. Beyond addressing current intervention challenges and managing malaria incidence in low-transmission setting, it is crucial to keep malaria services available and accessible at the village level and provide support, especially in areas home to highly mobile populations.


PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260936
Author(s):  
Stevens Bechange ◽  
Anne Roca ◽  
Elena Schmidt ◽  
Munazza Gillani ◽  
Leena Ahmed ◽  
...  

This paper is based on qualitative research carried out in a diabetic retinopathy (DR) programme in three districts of Pakistan. It analyses the organisation and delivery of DR services and the extent to which the interventions resulted in a fully functioning integrated approach to DR care and treatment. Between January and April 2019, we conducted 14 focus group discussions and 37 in-depth interviews with 144 purposively selected participants: patients, lady health workers (LHWs) and health professionals. Findings suggest that integration of services was helpful in the prevention and management of DR. Through the efforts of LHWs and general practitioners, diabetic patients in the community became aware of the eye health issues related to uncontrolled diabetes. However, a number of systemic pressure points in the continuum of care seem to have limited the impact of the integration. Some components of the intervention, such as a patient tracking system and reinforced interdepartmental links, show great promise and need to be sustained. The results of this study point to the need for action to ensure inclusion of DR on the list of local health departments’ priority conditions, greater provision of closer-to-community services, such as mobile clinics. Future interventions will need to consider the complexity of adding diabetic retinopathy to an already heavy workload for the LHWs.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
V Canal ◽  
A Ubiali ◽  
D Resi ◽  
P Pandolfi ◽  
M P Fantini

Abstract Background Notification of confirmed or suspected cases of Malaria is compulsory in Italy. It is essential to optimize control measures in case of imported and indigenous events, considering that the main local vector, Anopheles labranchiae, is still present in Italy. Methods Descriptive analysis of malaria cases notified from Bologna local health authority (AUSL) from January 2000 to December 2019. Results In the period 2000-2019, out of the 248 Malaria cases notified to the AUSL, 161 were males, and 87 were females, with median age of 33 (IQR: 42-25). All the cases were sporadic and travel-related. The main reasons for travelling were: return to the country of origin (n = 139, 56,0%), tourism (n = 39, 15,7%), work (n = 30, 12,1%), and immigration (n = 13, 5,2%). 86 (34,7%) cases were born in Italy, 43 (17,3%) in Nigeria, 27 (10,9%) in Cameroon, and 17 (6,9%) in Ghana. The cases were imported from Nigeria (n = 56, 22,9%), Cameroon (n = 30, 12,2%), Ghana (n = 26, 10,6%), Ivory Coast (n = 24, 9,8%). Most of the cases were not taking any drug for Malaria chemoprophylaxis (n = 214, 86,6%), 20 cases (8,1%) properly completed the prophylaxis, while 13 cases (5,3%) started chemoprophylaxis but they didn't complete it. The etiological agent identified was Plasmodium falciparum in 176 cases (71,0%), P. vivax in 26 cases (10,5%). Among the former cases 49 (32,2%) were contracted in Nigeria, 29 (19,1%) in Cameroon, 23 (15,1%) in Ghana, 20 (13,2%) in Ivory Coast, 10 (6,6%) in Senegal. 11 (68,8%) cases of P. vivax were contracted in Pakistan. Conclusions Epidemiological data collected from Bologna AUSL are consistent with those described from Istituto Superiore di Sanità: the majority of cases was comprised of foreigners, the great majority of cases was imported from Africa. P. Falciparum was prevalent in Africa while P. vivax was prevalent in Asia. Key messages The knowledge of the epidemiological situation allows public health workers to advise international travelers focusing on those most at risk of contracting Malaria. Periodic assessment of local epidemiology is necessary to evaluate if data are consistent with those described from international literature.


1997 ◽  
Vol 36 (8-9) ◽  
pp. 223-228
Author(s):  
A. Petruck ◽  
F. Sperling

The control strategy of a combined sewer system incorporating three stormwater storage tanks with overflows presented here attempts to consider all aspects of acute CSO effects. These are the hydraulic and the composition components as well as the time factor. The result is an integrated approach, which is not based on the classic emission view (i.e. reduction of volume), but on pollution criteria (i.e. possible harm to the biotic community). The aim is to reduce the exceeding of critical peak values of the CSO components at critical time intervals. Control decisions will be based on continuous measurements in the sewer system and in the receiving stream. Furthermore the measurements are carried out to determine the effects (both hydraulic and chemical) of particular CSO discharges in order to evolve the critical values for the project area. The chemical and physical measurements are accompanied by a biological monitoring programme. Macroinvertebrates are sampled upstream and downstream of outfalls and at a reference site. This allows the evaluation of the control measures on an ecological basis, and thus an assessment of the ecological potential of radar-aided real-time control of the combined sewer systems.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Samuel Lumborg ◽  
Samuel Tefera ◽  
Barry Munslow ◽  
Siobhan M. Mor

AbstractThis study explores the perceived influence of climate change on the health of Hamer pastoralists and their livestock in south-western Ethiopia. A combination of focus group discussions and key informant interviews were conducted with Hamer communities as well as local health workers, animal health workers and non-governmental organisation (NGO) staff. Thematic framework analysis was used to analyse the data. Reductions in rangeland, erratic rainfall, recurrent droughts and loss of seasonality were perceived to be the biggest climate challenges influencing the health and livelihoods of the Hamer. Communities were travelling greater distances to access sufficient grazing lands, and this was leading to livestock deaths and increases in ethnic violence. Reductions in suitable rangeland were also precipitating disease outbreaks in animals due to increased mixing of different herds. Negative health impacts in the community stemmed indirectly from decreases in livestock production, uncertain crop harvests and increased water scarcity. The remoteness of grazing lands has resulted in decreased availability of animal milk, contributing to malnutrition in vulnerable groups, including children. Water scarcity in the region has led to utilisation of unsafe water sources resulting in diarrhoeal illnesses. Further, seasonal shifts in climate-sensitive diseases such as malaria were also acknowledged. Poorly resourced healthcare facilities with limited accessibility combined with an absence of health education has amplified the community’s vulnerability to health challenges. The resilience and ambition for livelihood diversification amongst the Hamer was evident. The introduction of camels, increase in permanent settlements and new commercial ideas were transforming their livelihood strategies. However, the Hamer lack a voice to express their perspectives, challenges and ambitions. There needs to be collaborative dynamic dialogue between pastoral communities and the policy-makers to drive sustainable development in the area without compromising the values, traditions and knowledge of the pastoralists.


2021 ◽  
pp. 104973232110035
Author(s):  
Felicia Casanova ◽  
Felicia M. Knaul ◽  
Natalia M. Rodriguez

South Florida agricultural regions, home to Latinx immigrant farmworkers, report higher rates of late-stage breast cancer diagnosis than national, state, and county-level averages. We conducted a community-based qualitative study on the needs, health knowledge gaps, barriers to breast cancer screening, and the role of community health workers (CHWs) in supporting the community’s access to early detection services. We conducted three CHW focus groups (FGs) ( n = 25) and in-depth interviews ( n = 15), two FGs ( n = 18) and in-depth interviews ( n = 3) with farmworker community members, and informal interviews with cancer clinicians ( n = 7). Using a grounded theory approach, five core themes regarding the community’s barriers to accessing health care services emerged: (a) lack of information; (b) social and economic barriers; (c) cultural factors; (d) fears and mistrust; and (e) psychosocial concerns. Findings yield implications for community health practice, the potential impact of CHWs, and the production of breast cancer education to improve health equity along with the care continuum.


2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S317-S317
Author(s):  
Kartavya J Vyas

Abstract Background With nearly three-fourths of the U.S. population isolated in their homes between early March and the end of May, almost all of whom regularly watch television (TV), it was no surprise that companies began to purchase airtime on major television networks to advertise (ad) their brands and showcase their empathy with the populace. But how would the coronavirus disease 2019 (COVID-19) epidemic curve have changed had these same dollars been allocated to proven preventive interventions? Methods Performance and activity metrics on all COVID-19 related TV ads that have aired in the U.S. between February 26th and June 7th, 2020, were provided by iSpot.tv, Inc., including expenditures. COVID-19 incidence and mortality data were collected from the Centers for Disease Control and Prevention (CDC). Descriptive statistics were performed to calculate total TV ad expenditures and other performance metrics across industry categories. Leveraging a previously published stochastic agent-based model that was used to assess the cost-effectiveness of non-pharmaceutical interventions to control COVID-19, the number of cases that would have been prevented had these same dollars been used for preventive interventions was calculated using cost-effectiveness ratios (CERs), the cost divided by cases prevented. Results A total of 1,513 companies purchased TV airtime during the study period, totaling approximately 1.1 million airings, 215.5 billion impressions, and $2.7 billion in expenditures; most of the expenditures were spent by the restaurant (15.9%), electronics and communications (15.4%), and vehicle (13.7%) industries. The CERs for PPE and social distancing measures were $13,856 and $29,552, respectively; therefore, had all of these TV ad dollars instead been allocated to PPE or social distancing measures, approximately 194,908 and 91,386 cases of COVID-19 may have been prevented by the end of the study period, respectively. Figure 2. COVID-19 cases prevented had TV ad expenditures been reallocated for interventions. Conclusion Americans were inundated with COVID-19 related TV ads during the early months of the pandemic and companies are now showing some signs to relent. In times of disaster, however, it is paramount that the private sector go beyond showcasing their empathy and truly become socially responsible by allocating their funds to proven prevention and control measures. Disclosures All Authors: No reported disclosures


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