scholarly journals Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Fan Luo ◽  
Kang-mei Zeng ◽  
Jia-xin Cao ◽  
Ting Zhou ◽  
Su-xia Lin ◽  
...  

Abstract Background Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown. Methods NSCLC patients undergoing radical resection and subsequent adjuvant chemotherapy from 2013 to 2017 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Fasted serum lipid levels were measured before and after chemotherapy. The optimal lipid cut-off values at baseline and fluctuation were determined using X-tile™. The fluctuations in serum lipid levels and disease-free survival (DFS) were assessed. Results Serum cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglyceride, apolipoprotein (Apo) A-I, and ApoB all significantly increased after adjuvant chemotherapy. X-tile determined 1.52 mmol/L of HDL-C and 0.74 g/L of ApoB as the optimal cut-off values before chemotherapy. Patients with HDL-C ≥ 1.52 mmol/L (median DFS: not reached vs. 26.30 months, P = 0.0005) and a decreased HDL-C level after adjuvant chemotherapy (median DFS: 80.43 vs. 26.12 months, P = 0.0204) had a longer DFS. An HDL-C level that increased by ≥ 0.32 mmol/L after chemotherapy indicated a worse DFS. A high baseline ApoB level were associated with a superior DFS. In the univariate analysis and the multivariate Cox analyses, a high baseline HDL-C level and a HDL-C reduction after adjuvant chemotherapy were independent indicators for superior DFS. High baseline HDL-C was related to N0-1 stage (χ2 = 6.413, P = 0.011), and HDL-C fluctuation was significantly correlated with specific chemotherapy regimens (χ2 = 5.002, P = 0.025). Conclusions Adjuvant chemotherapy increased various lipid levels in resected NSCLC patients. A higher HDL-C level before chemotherapy and a reduced HDL-C level after adjuvant chemotherapy were independent predictors of longer DFS in patients with curable NSCLC.

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4637 ◽  
Author(s):  
Xingchen Zhou ◽  
Wu Zhu ◽  
Minxue Shen ◽  
Yijing He ◽  
Cong Peng ◽  
...  

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.


2019 ◽  
Vol 31 (3) ◽  
pp. 193-197
Author(s):  
Olamoyegun A Michael

AimThis study aimed to determine the relationship between measures of obesity and serum lipid levels among hypertensive patients.MethodsThis was a cross-sectional study in which participants newly diagnosed with hypertension formed the study population. A range of demographic and anthropometric data was obtained, including weight, height, and waist and hip circumference. Fasting serum lipids were also measured, including total cholesterol, high density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Low density lipoprotein cholesterol (LDL-C) was calculated using Friedewald formula. Statistical analysis was then carried out to determine the relationship between anthropometric indices and lipid profile levels. ResultsThe study population consisted of 124 male and 290 female subjects with a mean age of 66±16.95 years (range, 30–100 years).The female subjects were older than the male subjects (p=0.020). Our analysis showed that 85%, 58.5% and 30.7% of the study population had abnormal waist circumference (WC), abnormal waist-hip ratio (WHR) and a body mass index (BMI) >25 kg/m2, respectively. Decreased HDL-C (70.1%) was the commonest lipid abnormality detected, followed by elevated LDL (6.0%). None of the anthropometric indices were independent predictors of abnormal lipid levels. However, advanced age and female sex were independent predictors for at least one serum lipid abnormality.ConclusionNone of the measures of obesity could independently predict abnormal lipid levels in individuals newly diagnosed with hypertension. However, female sex, advanced age and systolic blood pressure were independently associated with abnormal serum lipids. Encouraging regular exercise, and the possible addition of statins, may be beneficial in addressing both obesity and dyslipidaemia.


2021 ◽  
pp. 1-9
Author(s):  
Ryszard Tomasiuk ◽  
◽  
Igor Z Zubrzycki ◽  
Magdalena Wiacek ◽  
◽  
...  

The objective of this study was to analyze the dynamics and differences of changes in obesity-defining parameters such as body mass index (BMI), waist circumference (WC), total cholesterol (TC), tricarboxylic acid (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in representative samples from the US and South Korea in analogous sampling frames comprising the years 2007 - 2008 and 2009 - 2010. Differences in anthropometric parameters and serum lipid levels between specific sampling frames were evaluated using a t-test for unpaired data. Age-dependent changes were analyzed using the GLM technique and the Bonferroni-Dunn post-hock test. Among all subjects, the obesity defined by BMI is cross-correlated with an increase in WC. However, in extremely obese women in the United States, there is a lack of a direct relationship between BMI and WC. There was also a clear correlation between the relative change in WC and serum lipid levels in subjects of different ethnic groups. This study showed that BMI and WC could be interchangeably used to assess the health risks associated with increased serum lipid levels in US and South Korean populations


2019 ◽  
Vol 67 (3) ◽  
pp. 141-148
Author(s):  
Maryam Sameem ◽  
Muhammad Arshad

Coronary artery disease (CAD) is an inflammatory heart disease characterized by the narrowing of coronary arteries. Paraoxonase 3 (PON3) is a candidate gene for protection against CAD development as it reduces oxidative stress and lipid peroxidation. The present study aimed to explore the association of PON3 rs2375003 polymorphism with CAD development and serum lipid levels in the Pakistani population. Study subjects included 300 CAD patients and 300 age and sex matched healthy individuals. The genotyping of rs2375003 polymorphism was done using an allele specific polymerase chain reaction and serum lipid levels were determined. In this study, the genotype frequencies of rs2375003 polymorphismin in CAD patients were TT (2%), CT (8%), CC (90%) as compared to TT (3%), CT (6%), CC (91%) in the healthy subjects. No association was observed between rs2375003 polymorphism and CAD risk (p>0.05). The CT genotype of rs2375003 polymorphism marginally increased the risk for CAD development (OR: 1.36; 95% CI 0.72-2.56) by causing a marginal rise in total cholesterol, low density lipoprotein cholesterol and triglyceride levels, and a marginal drop in high density lipoprotein cholesterol levels. The CT genotype of rs2375003 polymorphism and altered lipid levels might act as potential risk factors in the etiology of CAD in the Pakistani population.


2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Peng-Fei Zheng ◽  
Rui-Xing Yin ◽  
Yao-Zong Guan ◽  
Bi-Liu Wei ◽  
Chun-Xiao Liu ◽  
...  

Abstract Background The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the Han and Maonan ethnic groups. Methods The genetic makeup of the SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs in 2467 unrelated subjects (Han, 1254; Maonan,1213) was obtained by using polymerase chain reaction and restriction fragment length polymorphism technique, combined with gel electrophoresis, and confirmed by direct sequencing. Results The genotype frequencies of SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs were different between Han and Maonan populations (P < 0.05); respectively. The SLC44A4 rs577272 SNP was associated with total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels in Maonan group. The NOTCH4 rs3134931 SNP was associated with triglyceride (TG) in Han; and TG and low-density lipoprotein cholesterol (LDL-C) levels in Maonan groups (P < 0.025–0.001). Stratified analysis according to gender showed that the SLC44A4 rs577272 SNP was associated with TC and HDL-C in Han and Maonan females; TC in Maonan males, meanwhile, the NOTCH4 rs3134931 SNP was associated with TG and HDL-C in Han males; TG in Han females; TG and LDL-C in Maonan males; and TG, HDL-C and LDL-C in Maonan females. Linkage disequilibrium analysis showed that the most common haplotype was rs577272G-rs3134931A (> 50%) in both Han and Maonan groups. The haplotype of rs577272G-rs3134931A was associated with TG and HDL-C in Han; and TC, TG and HDL-C in Maonan ethnic groups. Conclusions These results suggest that the relationship among SLC44A4 rs577272, NOTCH4 rs3134931 SNPs and serum lipid parameters may vary depending on the gender and/or ethnicity/race in some populations. Haplotypes could explain more changes in serum lipid parameters than any single SNP alone particularly for TC, TG and HDL-C.


2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Ping Huang ◽  
Rui-Xing Yin ◽  
Ke-Ke Huang ◽  
Xiao-Na Zeng ◽  
Tao Guo ◽  
...  

The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations. A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included. Serum low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels were higher in Mulao than in Han (P<0.05). The T allele carriers had higher serum LDL-C and ApoAI levels in Mulao, whereas they had lower high-density lipoprotein cholesterol (HDL-C) levels and ratio of ApoAI to ApoB in Han (P<0.05) than the T allele noncarriers. Subgroup analyses showed that the T allele carriers had higher HDL-C, LDL-C, and ApoAI levels in Mulao males and lower ApoAI levels and ratio of ApoAI to ApoB in Han males than the T allele noncarriers. The subjects with TT genotype in Han females also had higher total cholesterol, LDL-C, ApoAI, and ApoB levels than the subjects with CT or CC genotype. Serum lipid parameters were also correlated with several environmental factors in both ethnic groups. The differences in the association ofKLF14rs4731702 SNP and serum lipid levels between the two ethnic groups might partly result from different gene-environmental interactions.


2021 ◽  
Vol 12 ◽  
Author(s):  
Wang-Yu Cai ◽  
Xi Luo ◽  
Erxidi Chen ◽  
Houyi Lv ◽  
Kaiyou Fu ◽  
...  

ObjectiveTo evaluate associations between serum lipid levels and treatment outcomes in women undergoing assisted reproduction.Materials and MethodsThe study included 2011 women who underwent in vitro fertilization/intracytoplasmic sperm injection with fresh embryo transfer. Serum lipid evaluation included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Ovarian stimulation outcomes included endometrial thickness and the number of oocytes retrieved, and reproductive outcomes included live birth, clinical pregnancy, and miscarriage.ResultsHigher HDL-C quartiles were associated with more oocytes retrieved. Lower TC (quartile 1 odds ratio [OR] 1.59 [1.21–2.08], quartile 3 OR 1.36 [1.04–1.77]), LDL-C (quartile 1 OR 1.41 [1.07–1.86]), and TG (quartile 2 OR 1.39 [1.06–1.84]) were independently associated with clinical pregnancy after adjusting for potential confounders. Lower LDL-C (quartile 1 OR 2.22 [1.58–3.13], quartile 2 OR 1.78 [1.27–2.50], quartile 3 OR 1.51 [1.07–2.13]), TC (quartile 1 OR 1.39 [1.00–1.93]), TG (quartile 1 OR 1.44 [1.03–2.03], quartile 2 OR 1.46 [1.04–2.04], quartile 3 OR 1.44 [1.04–1.99]), and higher HDL-C (quartile 2 OR 0.71 [0.51–0.99]) were independently associated with live birth. Higher LDL-C (quartile 1 OR 0.44 [0.30–0.66], quartile 2 OR 0.49 [0.33–0.73], quartile 3 OR 0.63 [0.43–0.94]) and lower HDL-C (quartile 1 OR 1.60 [1.07–2.39]) were independently associated with miscarriage.ConclusionsSerum lipid levels were associated with treatment outcomes in women undergoing assisted reproduction.


2020 ◽  
Author(s):  
Fei Chen ◽  
Tongde Wu ◽  
Song Guo ◽  
Junwen Huang ◽  
Qiang Fu ◽  
...  

Abstract BackgroundIn recent decades, the serum lipid profile of apolipoprotein(a) (Lp(a)) level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/ApoA1) ratio were found more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the serum lipid levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were found associated with symptomatic IDH, no studies have been conducted to date for the evaluation of the association of Apo AI, Apo B, Lp(a) and Apo B/Apo AI levels with symptomatic IDH.MaterialsA total of 1,839 Chinese patients were recruited in the present study. 918 patients were diagnosed as IDH cases and were enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B and Apo B/Apo AI were examined and analyzed.ResultsThe patients in the control group were collected randomly from patients who were matched with the baseline levels of the aforementioned lipid molecular. The patients with IDH exhibited significantly higher TC, TG, LDL, Apo B and Lp(a) levels compared with the control subjects. The percentage of high-TC, high-TG, high-LDL, high-Apo B and high-Lp(a) were significantly higher in the IDH group. However, hyperlipidaemia was not associated with the degenerated segment of the IDH (P=0.201). The odds ratios (OR) for the incidence of IDH with an elevated LDL-C, TC, TG, Lp(a), Apo B and Apo B/Apo AI were 1.583, 1.74, 1.62, 1.58, 1.49 and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a) and incidence of IDH was significant (R2LDL=0.017; R2TC=0.004; R2TG=0.015; R2Apo B=0.004; R2LP(a)=0.021) (P<0.05). ConclusionsThe present study suggests that elevated levels of serum TC, TG, LDL, Apo B, Lp(a) and Apo B/Apo AI are associated with a higher risk for IDH.


2018 ◽  
Vol 38 (1) ◽  
Author(s):  
Qing-Hui Zhang ◽  
Rui-Xing Yin ◽  
Wu-Xian Chen ◽  
Xiao-Li Cao ◽  
Yu-Ming Chen

Little is known about the association of the TIMD4 (T-cell immunoglobulin and mucin domain 4 gene)-HAVCR1 (hepatitis A virus cellular receptor 1) variants and lipid metabolism, the risk of coronary heart disease (CHD) and ischemic stroke (IS). The present study aimed to determine the TIMD4-HAVCR1 variants, their haplotypes and gene–environment interactions on serum lipid levels, the risk of CHD and IS, and the lipid-lowering efficacy of atorvastatin in a southern Chinese Han population. Genotypes of three variants in 622 controls, 579 CHD, and 546 IS patients were determined by the Snapshot technology. Atorvastatin calcium tablet (20 mg/day) was given in 724 hyperlipidemic patients for 8 weeks after genotyping. The rs12522248 genotypic and allelic frequencies were different between controls and patients, and were associated with the risk of CHD and IS. The rs1501908G-rs12522248T-rs2036402T haplotype was associated with an increased risk of CHD; the G-C-T haplotype was associated with lower risk of CHD; and the C-C-C haplotype was associated with an increased risk of IS. Variants and their haplotypes in controls were associated with triglyceride (rs1501908), low-density lipoprotein cholesterol (LDL-C, rs1501908, G-T-T), high-density lipoprotein cholesterol (HDL-C, rs12522248, C-C-C) and the ratio of total cholesterol (TC) to HDL-C (C-C-C). Interactions of rs1501908- and rs2036402-alcohol (HDL-C); rs1501908- and rs12522248-high body mass index (hBMI, ≥24 kg/m2; TC); and TIMD4-HAVCR1 variants-atorvastatin on several lipid parameters were detected. Interactions of rs12522248TC/CC-hBMI, G-T-T-, and C-C-C-smoking on the risk of CHD; and C-C-C-smoking, C-C-C-, and G-C-T-hBMI on the risk of IS were also observed. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for CHD and IS.


2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093465
Author(s):  
Yunxue Bai ◽  
Ruicheng Huang ◽  
Lagen Wan ◽  
Rui Zhao

Objective The CYP2C19 genetic variation may be involved in the development of atherosclerotic cardiovascular disease (ASCVD). Serum lipid levels are important risk factors for ASCVD, but the effect of the CYP2C19 gene on serum lipid metabolism remains unclear. This retrospective cohort study investigated the relationship between the CYP2C19 gene polymorphism and serum lipid levels in patients with ischemic stroke (IS). Methods IS patients (n = 230) and control subjects (n = 100) were enrolled. All patients were diagnosed with IS via clinical manifestations and brain magnetic resonance imaging. All patients were genotyped. Results Triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and apolipoprotein B (ApoB) levels were significantly higher and high-density lipoprotein-cholesterol (HDL-c) and apolipoprotein A1 (ApoA1) levels were significantly lower in the IS group compared with the control group. Lower ApoA1 levels and higher ApoB levels were significant predictive factors for IS. Patients with higher ApoB levels had a higher risk of IS recurrence. Compared with extensive metabolizers, intermediate and poor CYP2C19 metabolizers had a higher risk of IS recurrence. Conclusions Our study indicates CYP2C19 gene polymorphisms are related to lipid metabolism in patients with IS. IS patients who are poor CYP2C19 metabolizers may have a higher risk of disease recurrence.


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