scholarly journals Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
David B. Seifer ◽  
Geralyn Lambert-Messerlian ◽  
Glenn E. Palomaki ◽  
Robert M. Silver ◽  
Corette Parker ◽  
...  

Abstract Background Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental perfusion. Vitamin D plays an important role in pregnancy influencing implantation, angiogenesis and placental development. The objective of this study was to determine whether there is an association between serum vitamin D levels, and anti-angiogenic factors at the time of delivery and the occurrence of preeclampsia. Methods This nested case control study analyzed frozen serum samples at the time of delivery and related clinical data from women with singleton liveborn pregnancies who had participated in studies of the NICHD Stillbirth Collaborative Research Network. Women with a recorded finding of preeclampsia and who had received magnesium sulfate treatment prior to delivery were considered index cases (N = 56). Women without a finding of preeclampsia were controls (N = 341). Results Women with preeclampsia had 14.5% lower serum vitamin D levels than women in the control group (16.5 ng/ml vs. 19 ng/ml, p = 0.014) with 64.5% higher sFlt-1 levels (11,600 pg/ml vs. 7050 pg/ml, p < 0.001) and greater than 2 times higher endoglin levels (18.6 ng/ml vs. 8.7 ng/ml, < 0.001). After controlling for gestational age at delivery and maternal BMI, vitamin D levels were 0.88 times lower (P = 0.051), while endoglin levels were 2.5 times higher and sFlt-1 levels were 2.1 times higher than in control pregnancies (P < 0.001). Conclusions Women with preeclampsia at time of delivery have higher maternal antiangiogenetic factors and may have lower maternal serum vitamin D levels. These findings may lead to a better understanding of the underlying etiology of preeclampsia as well as possible modifiable treatment options which could include assuring adequate levels of maternal serum vitamin D prior to pregnancy.

Author(s):  
Bobbili Tarun Kesava Naidu ◽  
Kavya Baddireddy

Background: Alopecia areata is an autoimmune disorder of anagen hair follicle leading to distressing and relapsing non-scarring hair loss. Vitamin D is an immunomodulator and plays a role in regulating normal hair cycle. Recent evidence suggests inconsistent association between vitamin D deficiency and alopecia areata.Methods: This case control study included 70 newly diagnosed cases of alopecia areata and 70 healthy controls. Competitive chemiluminescence immunoassay was used to determine and compare the serum vitamin D (25‑hydroxyvitamin D) levels between these groups. Also, the serum vitamin D levels correlation with severity of the disease was studied. ANOVA test and student t test were used for the statistical analysis.Results: Serum Vitamin D levels were significantly decreased in alopecia areata patients than in controls (p<0.05). There was no stastically significant relationship between serum 25-OH Vitamin D levels and severity of the disease (p=0.06).Conclusions: Prevalence of serum 25 (OH) deficiency was significantly higher in alopecia areata group. However no significant relation was found with disease severity.


2011 ◽  
Vol 22 (10) ◽  
pp. 1471-1482 ◽  
Author(s):  
John R. Davies ◽  
Yu-Mei Chang ◽  
Helen Snowden ◽  
May Chan ◽  
Susan Leake ◽  
...  

2018 ◽  
Vol 24 (3) ◽  
pp. 633-640 ◽  
Author(s):  
Jorrit L Opstelten ◽  
Simon S M Chan ◽  
Andrew R Hart ◽  
Fiona D M van Schaik ◽  
Peter D Siersema ◽  
...  

2017 ◽  
Vol 152 (5) ◽  
pp. S59 ◽  
Author(s):  
Jorrit Opstelten ◽  
Simon Chan ◽  
Andrew Hart ◽  
Fiona van Schaik ◽  
Peter D. Siersema ◽  
...  

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