scholarly journals Feasibility of adenosine stress cardiovascular magnetic resonance perfusion imaging in patients with MR-conditional transvenous permanent pacemakers and defibrillators

2022 ◽  
Vol 24 (1) ◽  
Author(s):  
Anna Giulia Pavon ◽  
Alessandra Pia Porretta ◽  
Dimitri Arangalage ◽  
Giulia Domenichini ◽  
Tobias Rutz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Magnetic Resonance ◽  
Image Quality ◽  
Diagnostic Value ◽  
Implantable Devices ◽  
Adenosine Stress ◽  
Stress Perfusion ◽  
Mr Conditional ◽  
Stress Cmr ◽  
Perfusion Cmr

Abstract Background The use of stress perfusion-cardiovascular magnetic resonance (CMR) imaging remains limited in patients with implantable devices. The primary goal of the study was to assess the safety, image quality, and the diagnostic value of stress perfusion-CMR in patients with MR-conditional transvenous permanent pacemakers (PPM) or implantable cardioverter-defibrillators (ICD). Methods Consecutive patients with a transvenous PPM or ICD referred for adenosine stress-CMR were enrolled in this single-center longitudinal study. The CMR protocol was performed using a 1.5 T system according to current guidelines while all devices were put in MR-mode. Quality of cine, late-gadolinium-enhancement (LGE), and stress perfusion sequences were assessed. An ischemia burden of ≥ 1.5 segments was considered significant. We assessed the safety, image quality and the occurrence of interference of the magnetic field with the implantable device. In case of ischemia, we also assessed the correlation with the presence of significant coronary lesions on coronary angiography. Results Among 3743 perfusion-CMR examinations, 66 patients had implantable devices (1.7%). Image quality proved diagnostic in 98% of cases. No device damage or malfunction was reported immediately and at 1 year. Fifty patients were continuously paced during CMR. Heart rate and systolic blood pressure remained unchanged during adenosine stress, while diastolic blood pressure decreased (p = 0.007). Six patients (9%) had an ischemia-positive stress CMR and significant coronary stenoses were confirmed by coronary angiography in all cases. Conclusion Stress perfusion-CMR is safe, allows reliable ischemia detection, and provides good diagnostic value.

Feasibility and prognostic value of adenosine stress perfusion cardiovascular magnetic resonance in patient with implantable device

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
A Pavon ◽  
AP Porretta ◽  
D Arangalage ◽  
T Rutz ◽  
S Hugelshofer ◽  
...  
Keyword(s):  
Image Quality ◽  
Prognostic Value ◽  
Stress Test ◽  
Implantable Device ◽  
Adenosine Stress ◽  
Stress Perfusion ◽  
Long Term Follow Up ◽  
Stress Cmr

Abstract Funding Acknowledgements Type of funding sources: None. Background stress CMR has a limited use in patients with implantable device, in order to the possible artefacts due to the metallic component and to the risk of adenosine interaction with cardiac pacing. The aim of the study was to assess the global feasibility and to assess the prognostic value of stress perfusion CMR in patients with implantable device. Materials and Methods we conducted a retrospective single-center longitudinal analysis of consecutive patients with an implantable device referred for stress CMR, performed using a 1.5 Tesla unit (Siemens Healthcare,MAGNETOM Aera, Erlangen-Germany). Protocol was adapted according to current guidelines. Cardiac follow-up [6 months to 7 years] was obtained by medical records of direct contact with patient’s cardiologist referral.  Results 44 patients were enrolled. 34 patients needed a continuous pacing during adenosine stress, that was settled in DOO in 14 (32%) and in VOO in 20 (45%). Device integrity was not compromised by CMR and not competitive atrial or ventricular stimulation was observed during examination. Image quality was good in 95% cases. 26% cases had a perfusion deficit corresponding to a previous scar, while 12% of patients had a positive stress test. All of them needed continuous pacing during stress test and underwent to a coronary angiography who confirmed the coronary stenosis.  In patients without inducible ischemia 2 patients experienced a Non-ST-elevation Myocardial Infarction after 6 and 2 years while no other cardiac symptoms or cardiac hospitalisation was remarkable during follow up. Conclusion adenosine stress CMR in patient who are pacemaker dependent during scanner is feasible, with an overall good image quality, proving an excellent diagnostic and prognostic value in a long term follow up even. Adenosine administration is safe and no the magnetic field interference with the correct functioning of the device have been shown in short or long term follow-up.

scholarly journals Safety, feasibility and prognostic value of stress perfusion CMR in patients with pacemaker

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
T Pezel ◽  
J Lacotte ◽  
S Toupin ◽  
P Garot ◽  
T Hovasse ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Cox Regression ◽  
Coronary Revascularization ◽  
Cardiovascular Death ◽  
Stress Perfusion ◽  
Major Adverse Cardiovascular Events ◽  
Inducible Ischemia ◽  
Mr Conditional ◽  
Stress Cmr ◽  
Perfusion Cmr

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Several studies have shown the excellent prognostic value of stress cardiovascular magnetic resonance (CMR). However, its prognostic value in patients with pacemaker (PM) remains unknown because most studies excluded PM patients. PURPOSE This study aimed to assess the prognostic value of vasodilator stress perfusion CMR in patients with PM. METHODS Consecutive patients with MR-conditional pacemakers referred for stress perfusion CMR at 1.5 T were followed for the occurrence of major adverse cardiovascular events (MACE), defined by cardiovascular death or nonfatal myocardial infarction. Cox regressions analyses were performed to determine the prognostic value of CMR-parameters. The quality of CMR was rated by two observers blinded to clinical details. Data on pacemaker and leads were collected pre- and post-CMR. RESULTS Of 224 patients who completed the stress CMR protocol, 2 patients had inconclusive stress CMR due to artefact and 203 patients (72.9% male, mean age 71.4 ± 8.7 years) completed the follow-up (median [interquartile range], 7.0 [5.2-7.3] years). Among those, 23 experienced a MACE (11.3%). Stress CMR was well tolerated with no major adverse events. All scans were completed successfully with no significant change in lead thresholds or pacing parameters. Overall, the image quality was rated good or excellent in 84.1% of segments. Using Kaplan-Meier analysis, inducible ischemia and late gadolinium enhancement (LGE) were significantly associated with the occurrence of MACE (hazard ratio, HR: 11.80 [95% CI, 4.63-30.30]; and HR: 6.74 [95% CI, 2.47-18.40], both p < 0.001; respectively). In multivariable Cox regression, inducible ischemia and LGE were independent predictors of a higher incidence of MACE (HR: 5.24 [95% CI, 2.61-14.40]; and HR: 2.98 [95% CI, 2.25-4.02]; both p < 0.001; respectively). In patients with ischemia, CMR-related coronary revascularization showed no benefit in reducing MACE (p = 0.25). CONCLUSION Stress CMR is safe, feasible and has a good discriminative prognostic value in consecutive patients with PM.

Adenosine Stress Perfusion CMR Accurately Identifies the Target Vessel for Revascularisation

2011 ◽  
Vol 20 ◽  
pp. S157
Author(s):  
J. Richardson ◽  
A. Bertaso ◽  
D. Wong ◽  
A. Nelson ◽  
H. Tayeb ◽  
...  
Keyword(s):  
Adenosine Stress ◽  
Stress Perfusion ◽  
Target Vessel ◽  
Adenosine Stress Perfusion ◽  
Perfusion Cmr

P3094Feasibility and prognostic value of vasodilator stress perfusion CMR in elderly patients > 75 years without known CAD

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Pezel ◽  
M Kinnel ◽  
T Hovasse ◽  
P Garot ◽  
T Unterseeh ◽  
...  
Keyword(s):  
High Risk ◽  
Myocardial Ischemia ◽  
Elderly Patients ◽  
Prognostic Value ◽  
Vasodilator Stress ◽  
Stress Perfusion ◽  
Inducible Ischemia ◽  
Stress Cmr ◽  
Perfusion Cmr

Abstract Background The World's ageing population with a life expectancy that is steadily increasing raises the question of the benefit of screening for coronary artery disease (CAD) in very old patients with high risk of CAD. Current guidelines discourage the performance of stress testing in asymptomatic elderly. Purpose To assess the prognostic value of vasodilator stress perfusion cardiac magnetic resonance (CMR) in elderly patients aged >75 years without previous known CAD. Material Consecutive elderly patients >75 years without known CAD referred for vasodilator stress perfusion CMR were followed for major adverse cardiovascular events (MACE) defined as cardiac death, non-fatal myocardial infarction or stroke. Univariable and multivariable Cox regressions for MACE were performed to determine the prognostic association of inducible ischemia or late gadolinium enhancement (LGE) by CMR beyond traditional clinical risk indexes. Results Of 754 elderly high risk patients (82.0±3.9 years, 48.4% men), 747 (99%) completed the CMR protocol, and among those 659 (88.2%) completed the follow-up (median follow-up 5.7±2.5 years). Reasons for failure to complete CMR included claustrophobia (n=3), declining participation (n=2) and intolerance to stress agent (n=2). Stress CMR was well tolerated without occurrence of death or severe disabling adverse event. Patients without inducible ischemia or LGE experienced a substantially lower annual rate of MACE (5.5% vs. 9.9% for those with ischemia and vs. 6.9% for those with ischemia and/or LGE). In a multivariable stepwise Cox regression including clinical characteristics and CMR indexes, the absence of inducible ischemia was an independent predictor of a lower incidence of MACE at follow-up (hazard ratio 0.46; 95% confidence interval: 0.34 to 0.62; p<0.001) (Figure 1A) and all-cause mortality (hazard ratio 0.67; 95% confidence interval: 0.45 to 0.97; p=0.037). When patients with early coronary revascularization (within 30 days of CMR) were censored on the day of revascularization, both presence of inducible ischemia and ischemia extent per segment maintained a strong association with MACE. Using Kaplan-Meier analyses, the presence of myocardial ischemia identified the occurrence of future CV events (p<0.001). Moreover, the absence of inducible ischemia was a predictor of a lower incidence of MACE less significant in men than in women (p<0.01) (Figure 1B). Conclusion Stress CMR is safe and has discriminative prognostic value in very elderly patients, with a very low negative event rate in patients without ischemia or infarction. Among elderly patients without known CAD, the presence of myocardial ischemia on vasodilator stress CMR was predictive of future CV event or death.

scholarly journals ACCURACY OF A POSITIVE ADENOSINE STRESS PERFUSION CMR TO IDENTIFY A SIGNIFICANT CULPRIT VESSEL STENOSIS

2011 ◽  
Vol 57 (14) ◽  
pp. E682
Author(s):  
Angela Bertaso ◽  
James D. Richardson ◽  
Adam J. Nelson ◽  
Dennis Wong ◽  
Hussam Tayeb ◽  
...  
Keyword(s):  
Adenosine Stress ◽  
Stress Perfusion ◽  
Vessel Stenosis ◽  
Adenosine Stress Perfusion ◽  
Perfusion Cmr

scholarly journals Impairment in Quantitative Microvascular Function in Non-Ischemic Cardiomyopathy as Demonstrated Using Cardiovascular Magnetic Resonance

2021 ◽  
Author(s):  
Jeremy A. Slivnick ◽  
Karolina M. Zareba ◽  
Vien T. Truong ◽  
Ellen Liu ◽  
Alexis Barnes ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Ischemic Cardiomyopathy ◽  
Systolic Function ◽  
Univariate Analysis ◽  
Myocardial Perfusion Reserve ◽  
Microvascular Function ◽  
Stress Perfusion ◽  
Visual Evaluation ◽  
Stress Cmr

Abstract Purpose Microvascular dysfunction (MVD)—defined as impaired augmentation of the microcirculation in response to stress—is present in various cardiovascular diseases and portends worse outcomes. We aimed to evaluate the relationship between MVD and non-ischemic cardiomyopathy (NICM) utilizing stress cardiovascular magnetic resonance (CMR) as compared to a cohort of control patients. Methods We retrospectively studied 41 consecutive patients with NICM (mean age 51 ± 14, 59% male) and 58 controls with preserved systolic function (mean age 51 ± 13, 31% male) who underwent adenosine stress CMR exams between 2011–2016. Microvascular function was assessed visually and with myocardial perfusion reserve index (MPRI), quantified using first pass perfusion imaging by comparing perfusion slopes of myocardium and blood pool at rest/stress. MVD was defined visually as presence of subendocardial stress perfusion defect and quantitatively by MPRI < 1.51. MPRI was compared between NICM and controls using univariate analysis and multivariable linear regression. Results Impaired MPRI was noted in 37 patients (23 in NICM and 14 in control cohorts). In patients with NICM, 23 (56%) had MVD by quantitative assessment, while 11 (27%) by visual evaluation. No differences in comorbidities were noted between cohorts. Compared with controls, NICM patients had lower rest perfusion slope (3.9 vs 4.9, p = 0.05), stress perfusion slope (8.8 vs 11.7, p < 0.001), and MPRI (1.41 vs 1.74, p = 0.02). MPRI remained associated with NICM after controlling for age, gender, hypertension, diabetes, and late gadolinium enhancement (log MPR, β coefficient = -0.17, p = 0.009). Conclusions MVD assessed with stress CMR is highly prevalent in NICM as compared to control patients with preserved systolic function. Quantitative MPRI assessment identities more NICM patients with MVD as compared to visual evaluation. NICM remains independently associated with an impaired MPRI after controlling for covariates. Further studies are needed to determine whether targeted therapies to treat MVD are beneficial in NICM.

Diagnostic Accuracy of Stress Perfusion CMR for Risk Stratification in Patients With MR-Conditional Pacemakers

2021 ◽  
Author(s):  
Théo Pezel ◽  
Jérôme Lacotte ◽  
Solenn Toupin ◽  
Fiorella Salerno ◽  
Mina Ait Said ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Diagnostic Accuracy ◽  
Stress Perfusion ◽  
Mr Conditional ◽  
Perfusion Cmr
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