scholarly journals Three years of growth hormone treatment in young adults with Prader-Willi syndrome: sustained positive effects on body composition

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Layla Damen ◽  
Stephany H. Donze ◽  
Renske J. Kuppens ◽  
Nienke E. Bakker ◽  
Laura C. G. de Graaff ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Young Adults ◽  
Body Composition ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Positive Effects

scholarly journals Growth hormone treatment for adults with Prader-Willi syndrome: another point of view

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Harry J. Hirsch ◽  
Varda Gross-Tsur
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Motor Development ◽  
Growth Hormone Treatment ◽  
Genetic Diagnosis ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Positive Effects ◽  
Long Term Treatment ◽  
Risk Of Cancer

AbstractGrowth hormone treatment for children with Prader Willi syndrome (PWS) has shown proven benefits not only in increasing final height but also with positive effects on body composition and motor development. In a recent letter to the editor, Hoybye and colleagues recommend growth hormone treatment for adults with PWS based exclusively on the genetic diagnosis and without regard for growth hormone secretory status. We question whether the benefits of growth hormone treatment in PWS adults, mainly improvement in body composition, are significant enough to justify the as yet unkown consequences of long-term treatment in an adult population. Morbidity and mortality in PWS are mainly due to complications of obesity, and growth hormone treatment does not result in a decrease in BMI or waist circumference. Increases in insulin-like factor-1 as a result of growth hormone treatment over the course of several decades in PWS adults raises concern over possible increase risk of cancer. Compliance with daily injections is likely to be poor. We suggest that efforts to provide appropriate dietary and exercise regimens may be more beneficial and cost-effective than advocating for growth hormone treatment for adults with PWS.

scholarly journals Time for a general approval of growth hormone treatment in adults with Prader–Willi syndrome

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Charlotte Höybye ◽  
◽  
Anthony J. Holland ◽  
Daniel J. Driscoll
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Transition Period ◽  
Neurodevelopmental Disorder ◽  
Hormone Treatment ◽  
Psychomotor Development ◽  
Prader Willi Syndrome ◽  
Gh Treatment ◽  
Beneficial Effects ◽  
Positive Effects

AbstractPrader-Willi syndrome (PWS) is a complex, multi-system, neurodevelopmental disorder characterised by neonatal muscular hypotonia, short stature, high risk of obesity, hypogonadism, intellectual disabilities, distinct behavioural/psychiatric problems and abnormal body composition with increased body fat and a deficit of lean body mass. Growth hormone (GH) deficiency and other hormone deficiencies are common due to hypothalamic dysfunction. In children with PWS GH treatment has been widely demonstrated to improve body composition, normalise height and improve psychomotor development. In adults with PWS, GH’s main effects are to maintain normal body structure and metabolism. The positive effects of GH treatment on body composition, physical fitness and beneficial effects on cardiovascular risk markers, behaviour and quality of life in adults with PWS are also well established from several studies. GH treatment is approved for treatment of children with PWS in many countries, but until recently not as a treatment in young adults in the transition period or for adults in general. In this commentary we want to draw attention to the uneven global use of GH treatment, specifically in adults with PWS, and advocate for GH treatment to be approved internationally, not just for children, but also for adults with PWS and based only on the diagnosis of genetically confirmed PWS.

Effects of growth hormone treatment on growth and body composition in Prader-Willi syndrome: a preliminary report

1997 ◽  
Vol 86 (S423) ◽  
pp. 60-62 ◽  
Author(s):  
AC Lindgren ◽  
L. Hagenäs ◽  
J. Müller ◽  
S. Blichfeldt ◽  
M. Rosenborg ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Preliminary Report ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome

O0055 IMPACT OF LONG TERM GROWTH HORMONE TREATMENT ON BODY COMPOSITION IN PRADER-WILLI SYNDROME (PWS)

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S28-S29
Author(s):  
A. O. Scheimann ◽  
W. J. Klish ◽  
B. Hayslett ◽  
N. Lafuente ◽  
D. Orellana ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome

scholarly journals Eight Years of Growth Hormone Treatment in Children With Prader-Willi Syndrome: Maintaining the Positive Effects

2013 ◽  
Vol 98 (10) ◽  
pp. 4013-4022 ◽  
Author(s):  
N. E. Bakker ◽  
R. J. Kuppens ◽  
E. P. C. Siemensma ◽  
R. F. A. Tummers-de Lind van Wijngaarden ◽  
D. A. M. Festen ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Positive Effects

Growth hormone treatment of children with Prader-Willi syndrome affects linear growth and body composition favourably

2007 ◽  
Vol 87 (1) ◽  
pp. 28-31 ◽  
Author(s):  
AC Lindgren ◽  
L Hagenäs ◽  
J Müller ◽  
S Blichfeldt ◽  
M Rosenborg ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Linear Growth ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome

Growth hormone treatment improves body composition in adults with Prader-Willi syndrome

2003 ◽  
Vol 58 (5) ◽  
pp. 653-661 ◽  
Author(s):  
Charlotte Höybye ◽  
Agneta Hilding ◽  
Hans Jacobsson ◽  
Marja Thorén
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome
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