scholarly journals Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Xavier Gallart-Palau ◽  
Benjamin S. T. Lee ◽  
Sunil S. Adav ◽  
Jingru Qian ◽  
Aida Serra ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Differences ◽  
White Matter ◽  
Cerebrovascular Disease ◽  
Mitochondrial Dysfunction ◽  
White Matter Pathology

Abstract 44: Associations of Atrial Fibrillation, Neuroimaging Measures of Cerebrovascular Disease and Alzheimer’S Disease-related Pathology, and Cognitive Impairment

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Jonathan Graff-Radford ◽  
Rosebud Roberts ◽  
Malini Madhavan ◽  
Alejandro Rabinstein ◽  
Ruth Cha ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
White Matter ◽  
Cerebrovascular Disease ◽  
Regression Models ◽  
Grey Matter ◽  
White Matter Hyperintensity ◽  
Carrier Status

The objective of this study was to investigate the cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer’s disease-related pathology, and their interaction with cognitive impairment. MRI scans of non-demented individuals (n=1044) from the population-based Mayo Clinic Study of Aging were analyzed for infarctions, total grey matter, hippocampal and white matter hyperintensity volumes. A subset of 496 individuals underwent FDG and C-11 Pittsburgh compound B (PiB) PET scans. We assessed the associations of atrial fibrillation with i) categorical MRI measures (cortical and subcortical infarctions) using multivariable logistic regression models, and with ii) continuous MRI measures ( hippocampal, total grey matter, and white matter hyperintensity volumes) and FDG-PET and PiB-PET measures using multivariable linear regression models, and adjusting for confounders. Among participants who underwent MRI (median age, 77.8, 51.6% male), 13.5% had atrial fibrillation. Presence of atrial fibrillation was associated with subcortical infarctions (odds ratio [OR], 1.83; p=0.002), cortical infarctions (OR, 1.91; p=0.03), total grey matter volume (Beta [β], -.025, p<.0001) after controlling for age, education, gender, APOE e4 carrier status, coronary artery disease, diabetes, history of clinical stroke, and hypertension. However, atrial fibrillation was not associated with white matter hyperintensity volume, hippocampal volume, Alzheimer’s pattern of FDG hypometabolism or PiB uptake. There was a significant interaction of cortical infarction (p for interaction=0.004) and subcortical infarction (p for interaction =0.015) with atrial fibrillation with regards to odds of mild cognitive impairment (MCI). Using subjects with no atrial fibrillation and no infarction as the reference, the OR (95% confidence intervals [CI]) for MCI was 2.98 (1.66, 5.35;p = 0.0002) among participants with atrial fibrillation and any infarction, 0.69 (0.36, 1.33;p= 0.27) for atrial fibrillation and no infarction, and 1.50 (0.96, 2.32;p = 0.07) for no atrial fibrillation and any infarction. These data highlight that atrial fibrillation is associated with MCI in the presence of infarctions.

Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease

2016 ◽  
Vol 146 ◽  
pp. 404-417 ◽  
Author(s):  
Lilian Calderón-Garcidueñas ◽  
Rafael Reynoso-Robles ◽  
Javier Vargas- Martínez ◽  
Aline Gómez-Maqueo-Chew ◽  
Beatriz Pérez-Guillé ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
White Matter ◽  
Mexico City ◽  
Neurovascular Unit ◽  
Potential Impact ◽  
White Matter Pathology

Dissociation between corpus callosum atrophy and white matter pathology in Alzheimer's disease

Neurology ◽  
1998 ◽  
Vol 51 (5) ◽  
pp. 1381-1385 ◽  
Author(s):  
S. J. Teipel ◽  
H. Hampel ◽  
G. E. Alexander ◽  
M. B. Schapiro ◽  
B. Horwitz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Corpus Callosum ◽  
White Matter Pathology

scholarly journals White matter pathology isolates the hippocampal formation in Alzheimer's disease

2010 ◽  
Vol 31 (2) ◽  
pp. 244-256 ◽  
Author(s):  
D.H. Salat ◽  
D.S. Tuch ◽  
A.J.W. van der Kouwe ◽  
D.N. Greve ◽  
V. Pappu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Hippocampal Formation ◽  
White Matter Pathology

In vivo parahippocampal white matter pathology as a biomarker of disease progression to Alzheimer's disease

2013 ◽  
Vol 521 (18) ◽  
pp. 4300-4317 ◽  
Author(s):  
Ana Solodkin ◽  
E. Elinor Chen ◽  
Gary W. Van Hoesen ◽  
Lennart Heimer ◽  
Ahmed Shereen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Disease Progression ◽  
White Matter Pathology

Corpus Callosum Measurement as an in Vivo Indicator for Neocortical Neuronal Integrity, but not White Matter Pathology, in Alzheimer's Disease

2000 ◽  
Vol 903 (1 VASCULAR FACT) ◽  
pp. 470-476 ◽  
Author(s):  
HARALD HAMPEL ◽  
STEFAN J. TEIPEL ◽  
GENE E. ALEXANDER ◽  
BARRY HORWITZ ◽  
PIETRO PIETRINI ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Corpus Callosum ◽  
White Matter Pathology

scholarly journals What do data‐driven Alzheimer’s disease subtypes tell us about white matter pathology and clinical progression?

2021 ◽  
Vol 17 (S1) ◽  
Author(s):  
Hanyi Chen ◽  
Eric de Silva ◽  
Carole H Sudre ◽  
Jo Barnes ◽  
Alexandra L. Young ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Data Driven ◽  
Clinical Progression ◽  
Disease Subtypes ◽  
White Matter Pathology
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