scholarly journals Progress on the roles of MEF2C in neuropsychiatric diseases

2022 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhikun Zhang ◽  
Yongxiang Zhao
Keyword(s):  
Neuropsychiatric Disorders ◽  
Autism Spectrum ◽  
Embryonic Brain ◽  
Mads Box ◽  
Myocyte Enhancer Factor 2 ◽  
Neuropsychiatric Diseases ◽  
Spectrum Disorders ◽  
The Relationship ◽  
Embryonic Brain Development ◽  
Enhancer Factor

AbstractMyocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer’s disease (AD). Here, we review the relationship between MEF2C and neuropsychiatric disorders, and provide further insights into the mechanism of these diseases.

Comparing psychopathology rates across autism spectrum disorders and intellectual disabilities

2018 ◽  
Vol 12 (5/6) ◽  
pp. 163-172 ◽  
Author(s):  
Martyn Matthews ◽  
Elliot Bell ◽  
Brigit Mirfin-Veitch
Keyword(s):  
Autism Spectrum ◽  
Case Review ◽  
Community Based ◽  
Content Type ◽  
Adults With Learning Disabilities ◽  
Review Protocol ◽  
Spectrum Disorders ◽  
Adults With Asd ◽  
Anxiety Depression ◽  
The Relationship

Purpose The purpose of this paper is to compare the rates and patterns of comorbid anxiety, depression and ADHD across people with: autism spectrum disorder (ASD) plus intellectual disability (ID), ASD/no ID (AS/HFA) and ID only. Design/methodology/approach Data were obtained using structured file review and two psychometric screening instruments. File reviews used a modified version of the Case Review Protocol from the Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities. Screening employed the Reiss Screen for Maladaptive Behaviour and the ASD-Comorbidity-Adults scale. Findings Levels of anxiety, depression and ADHD were high for all three groups, and greater than in general population studies. Between groups, the AS/HFA sample had significantly higher anxiety, while the ASD/ID group had significantly greater ADHD. Groups did not differ on measures of depression or total psychopathology. Levels of ADHD, but not anxiety or depression, increased with severity of ID and ASD symptoms. Research limitations/implications More research is needed on the relationship between ASD and both anxiety and ADHD, particularly the identification of these comorbid conditions and their treatment. Practical implications Rigorous screening for comorbid mental health conditions is required to achieve the best outcomes for adults with ASD. Originality/value The study used a broader community-based sample than previous comorbidity research. Including adults with ID but without ASD enabled a comparison of types and rates of disorder across three distinct but related groups with neurodevelopmental disorders.

scholarly journals Hyperacusis in Autism Spectrum Disorders

2021 ◽  
Vol 11 (4) ◽  
pp. 547-556
Author(s):  
Ali A. Danesh ◽  
Stephanie Howery ◽  
Hashir Aazh ◽  
Wafaa Kaf ◽  
Adrien A. Eshraghi
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Assessment And Treatment ◽  
Spectrum Disorders ◽  
The Relationship

Hyperacusis is highly prevalent in the autism spectrum disorder (ASD) population. This auditory hypersensitivity can trigger pragmatically atypical reactions that may impact social and academic domains. Objective: The aim of this report is to describe the relationship between decreased sound tolerance disorders and the ASD population. Topics covered: The main topics discussed include (1) assessment and prevalence of hyperacusis in ASD; (2) etiology of hyperacusis in ASD; (3) treatment of hyperacusis in ASD. Conclusions: Knowledge of the assessment and treatment of decreased sound tolerance disorders within the ASD population is growing and changing.

scholarly journals The Role of Iron in the Pathogenesis of Autism Spectrum Disorders in Children

2018 ◽  
Vol 17 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Olga V. Kostina
Keyword(s):  
Autism Spectrum Disorders ◽  
Iron Metabolism ◽  
Biochemical Parameters ◽  
Children With Autism ◽  
Neuropsychiatric Disorders ◽  
Perinatal Period ◽  
Autism Spectrum ◽  
Spectrum Disorders ◽  
The Brain

The review presents an analysis of the mechanisms of iron effect on the brain development. The importance of iron deficiency in the perinatal period is considered as a risk factor for the development of neuropsychiatric disorders in children with autism spectrum disorders (ASDs). Possible causes of sideropenia are discussed; data on haematological and biochemical parameters characterizing iron metabolism in children with ASDs are presented. The demand for studying the role of iron metabolism imbalance in the development of neuropsychiatric disorders in order to clarify pathogenetic mechanisms of ASDs and to determine methods for their correction is emphasized.

scholarly journals Society and people diagnosed with autism spectrum disorder: an analysis of message descriptors of social media

2019 ◽  
Vol 24 (4) ◽  
pp. 744-755
Author(s):  
Olga A. Vazhenina ◽  
Lidiya K. Lobodenko
Keyword(s):  
Social Media ◽  
Autism Spectrum Disorders ◽  
Digital Media ◽  
Autism Spectrum ◽  
Media Space ◽  
English Speaking ◽  
Spectrum Disorders ◽  
The Impact ◽  
The Relationship ◽  
Social Media Tool

The authors investigate the process of humanization of society in relation to people with autism spectrum disorders and its relationship with the reception of problems of this category of population by society. The authors based on the descriptors of messages in social media published in the digital media space. The article reveals the relationship between the content of messages in social media, as well as the tools of this type of media and the overall degree of humanization of society at both social and political levels. The typological features of such a social media tool as a hashtag, when covering the problems of people with autism spectrum disorders, as well as the impact of these features on the reception of messages on this topic by both domestic and English-speaking users are noted.

Gluten Intolerance and Neurodevelopmental Disorders: Is Nitric Oxide the Common Biomarker Linking These Conditions?

2016 ◽  
Vol 69 (1) ◽  
pp. 54-55 ◽  
Author(s):  
Keith Fluegge
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
Air Pollutant ◽  
Clinical Feature ◽  
Nutrient Deficiencies ◽  
Hyperactivity Disorder ◽  
Spectrum Disorders ◽  
The Relationship

Cruchet et al. attempt to tease out the myths and facts surrounding the growing popularity of certain dietary approaches in the management of neurodevelopmental disorders, like attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs). The authors identify a particular exclusionary-type approach that seeks to eliminate dietary gluten. Although the relationship between celiac disease (CD) and ADHD/ASD is not well established, a repeated clinical feature noted in CD is the elevated levels of nitric oxide in serum and urine. Elevated oxidative stress has also been observed in neurodevelopmental conditions, and the author of this correspondence has been the first to propose that chronic, environmental exposure to the air pollutant, nitrous oxide may contribute to these oxidative stress profiles through neural cholinergic perturbation. Therefore, the purpose of this correspondence is to highlight this biochemical connection between these conditions so as to identify the clinical populations who may realize the greatest benefit of these dietary approaches, while minimizing any potential risk of nutrient deficiencies.

The Relationship Between Sleep Problems and Daytime Behavior in Children of Different Ages With Autism Spectrum Disorders

PEDIATRICS ◽  
2012 ◽  
Vol 130 (Supplement 2) ◽  
pp. S83-S90 ◽  
Author(s):  
Darryn M. Sikora ◽  
Kyle Johnson ◽  
Traci Clemons ◽  
Terry Katz
Keyword(s):  
Autism Spectrum Disorders ◽  
Sleep Problems ◽  
Autism Spectrum ◽  
Different Ages ◽  
Spectrum Disorders ◽  
The Relationship

scholarly journals Restricted and repetitive behaviors in autism spectrum disorders: The relationship of attention and motor deficits

2013 ◽  
Vol 25 (3) ◽  
pp. 773-784 ◽  
Author(s):  
Susan M. Ravizza ◽  
Marjorie Solomon ◽  
Richard B. Ivry ◽  
Cameron S. Carter
Keyword(s):  
Autism Spectrum Disorders ◽  
Motor Control ◽  
Motor System ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Motor Deficits ◽  
Attentional Orienting ◽  
Restricted And Repetitive Behaviors ◽  
Spectrum Disorders ◽  
The Relationship

AbstractRestricted and repetitive behaviors (RRBs) are hallmark symptoms of autism spectrum disorders (ASDs); however, it has proven difficult to understand the mechanisms underlying these behaviors. One hypothesis suggests that RRBs are the result of a core deficit in attention. Alternatively, abnormalities of the motor system may constitute the central mechanism underlying RRBs, given motor deficits observed in ASDs. In this experiment, we investigated the etiology of RRBs and the relationship between attention and motor deficits. Movement impairments (a) may be indirectly related to attention deficits, (b) may result from a shared compromised process, or (c) may be independent. Twenty-two adolescents with ASD and 20 typically developing participants performed a spatial attention task. Movement impairments were assessed with a rhythmic tapping task. Attentional orienting and motor control were found to be related and supported the hypothesis that these impairments in ASD arise from a shared process. In contrast, measures of attention switching and motor control were found to be independent. Stereotyped behaviors, as assessed by parental ratings, were related more to the degree of motor impairment than to deficits of attention. These results suggest that both attentional orienting deficits and stereotyped RRBs are related to a compromised motor system.

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