scholarly journals Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Wiryawan Permadi ◽  
Hartanto Bayuaji ◽  
Kevin Dominique Tjandraprawira ◽  
Dian Tjahyadi ◽  
Harris Harlianto ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Secondary Data ◽  
Oocyte Retrieval ◽  
Indonesian Population ◽  
Study Recruitment ◽  
Biochemical Pregnancy ◽  
Significant Difference ◽  
Cycle Group ◽  
Recruitment Period

Abstract Objective To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (112/351) frozen cycles. AMH was significantly higher in frozen cycle group (p = 0.04). Ovulatory disorder was significantly higher in frozen cycle group (p = 0.001). Among patients aged ≤ 30, fresh cycle group had significantly higher LBR (p = 0.02). Among those with ovulatory disorder, LBR was significantly higher with frozen cycle. No significant LBR difference was noted with other infertility causes. When stratified according to pregnancy order, frozen cycle patients had significantly higher birth lengths (p = 0.03) but not length of gestation nor neonatal birthweights. There was no significant difference in the proportion of biochemical pregnancy resulting in LBR (p = 0.08). To conclude, frozen cycle provided higher LBR among patients with ovulatory disorder but fresh cycle was beneficial among patients aged ≤ 30.

scholarly journals Frozen vs. Fresh Cycles IVF Outcomes: Retrospective study from an Indonesian IVF centre

2021 ◽  
Author(s):  
Wiryawan Permadi ◽  
Hartanto Bayuaji ◽  
Kevin Tjandraprawira ◽  
Dian Tjahyadi ◽  
Harris Harlianto ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Secondary Data ◽  
Oocyte Retrieval ◽  
Vitro Fertilization ◽  
Indonesian Population ◽  
Biochemical Pregnancy ◽  
Significant Difference ◽  
Cycle Group ◽  
Recruitment Period

Abstract Objective to compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018−31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (112/351) frozen cycles. AMH was significantly higher in frozen cycle group (p = 0.04). Ovulatory disorder was significantly higher in frozen cycle group (p = 0.001). Among patients aged ≤ 30, fresh cycle group had significantly higher LBR (p = 0.02). Among those with ovulatory disorder, LBR was significantly higher with frozen cycle. No significant LBR difference was noted with other infertility causes. When stratified according to pregnancy order, frozen cycle patients had significantly higher birth lengths (p = 0.03) but not length of gestation nor neonatal birthweights. There was no significant difference in the proportion of biochemical pregnancy resulting in LBR (p = 0.08).

Predictive Model for Live Birth at 12 Months After Starting In-Vitro Fertilization Treatment

MedPharmRes ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 5-20
Author(s):  
Vu Ho ◽  
Toan Pham ◽  
Tuong Ho ◽  
Lan Vuong
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cox Regression ◽  
Financial Burden ◽  
Oocyte Retrieval ◽  
Operating Characteristics ◽  
Vitro Fertilization ◽  
Cox Regression Analysis ◽  
Significant Difference

IVF carries a considerable physical, emotional and financial burden. Therefore, it would be useful to be able to predict the likelihood of success for each couple. The aim of this retrospective cohort study was to develop a prediction model to estimate the probability of a live birth at 12 months after one completed IVF cycle (all fresh and frozen embryo transfers from the same oocyte retrieval). We analyzed data collected from 2600 women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) at a single center in Vietnam between April 2014 and December 2015. All patients received gonadotropin-releasing hormone (GnRH) antagonist stimulation, followed by fresh and/or frozen embryo transfer (FET) on Day 3. Using Cox regression analysis, five predictive factors were identified: female age, total dose of recombinant follicle stimulating hormone used, type of trigger, fresh or FET during the first transfer, and number of subsequent FET after the first transfer. The area under the receiver operating characteristics curve for the final model was 0.63 (95% confidence interval [CI] 0.60‒0.65) and 0.60 (95% CI 0.57‒0.63) for the validation cohort. There was no significant difference between the predicted and observed probabilities of live birth (Hosmer-Lemeshow test, p > 0.05). The model developed had similar discrimination to existing models and could be implemented in clinical practice.

scholarly journals In Vitro Fertilization Outcome After Intracytoplasmic Sperm Injection with Fresh and with Frozen-Thawed Epididymal Spermatozoa

KnE Medicine ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Hilma Putri Lubis
Keyword(s):  
In Vitro Fertilization ◽  
Intracytoplasmic Sperm Injection ◽  
Oocyte Retrieval ◽  
Epididymal Sperm ◽  
Vitro Fertilization ◽  
Fertilization Rates ◽  
Sperm Aspiration ◽  
Significant Difference ◽  
Epididymal Spermatozoa

<p><strong>Introduction</strong></p><p>Testicular epididymal sperm aspiration (TESA) is one of the method  to retrieve sperm from the testes in men with azoospermia. The aim of the study is to compare the In vitro fertilization (IVF) outcome of intracytoplasmic sperm injection (ICSI)-ET cycles with fresh testicular epididymal spermatozoa obtained on the same day with  oocyte retrieval and with frozen-thawed testicular epididymal spermatozoa.</p><p><strong>Material &amp; Methods</strong></p><p>A retrospective comparative analysis of  patients who underwent fresh TESA and frozen-thawed TESA in ICSI-ET cycles from January 2012 to December 2014 in Halim Fertility Center was done. Fresh testicular epididymal sperm aspiration (fresh TESA) was performed on the same day with oocyte retrieval in 28 cycles and the frozen-thawed testicular epididymal sperm aspiration (frozen-thawed TESA) was used in 30 cycles.  </p><p><strong>Results</strong></p><p>The two groups were comparable in terms of the ages of male and female patients, etiology of infertility and duration of infertility. Fertilization rates in fresh TESA group were 53,5% and in frozen-thawed TESA group, fertilization rates were 50%. There was no statistically significant difference between the groups. Clinical pregnancy rates in fresh TESA group were 35,7%  and in frozen-thawed TESA group, clinical pregnancy rates were 26,7% and statistically there was no significant difference between the groups.</p><p><strong>Conclusion</strong></p>There is no significant difference in the in vitro fertilization outcome of intracytoplasmic sperm injection (ICSI)-ET cycles between fresh TESA and frozen-thawed TESA .

scholarly journals Correlation Between Vascular Endothelial Growth Factor (VEGF) and Ovarian Hyperstimulation Syndrome (OHSS); A Retrospective Study.

2020 ◽  
pp. 1-13
Keyword(s):  
Retrospective Study ◽  
In Vitro Fertilization ◽  
Ovarian Hyperstimulation Syndrome ◽  
Clinical Parameter ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Duration Of Hospitalization ◽  
Endothelial Growth Factor

Abstract Purpose: In the context of in vitro fertilization treatment ovarian hyperstimulation syndrome can lead to a serious illness. Its pathogenesis is not fully understood, but is associated with several cytokines, enzymes and growth factors. VEGF is considered among others to be a significant factor. The aim of the present study was to investigate whether there are correlations between VEGF serum concentrations and clinical and biochemical parameters of ovarian hyperstimulation syndrome. Thus, VEGF could be used as a clinical parameter of ovarian hyperstimulation syndrome. Methods: Three patient groups were formed in which VEGF measurements were performed. In the first group, patients with ovarian hyperstimulation syndrome after stimulation treatment and hospitalization were examined. In the second group, patients with stimulation for in vitro fertilization but without OHSS were considered and in the third group, patients without stimulation treatment were recorded. The groups were comparatively statistically evaluated. Results: There was a clear association between the VEGF scores and duration of hospitalization in the diseased patients. The VEGF determinations did not differentiate between stimulated patients with and without ovarian hyperstimulation syndrome. However, there was a significant difference between stimulated and unstimulated patients. Conclusion: The determination of VEGF seems to be of limited use as a clinically useful parameter for the assessment and prognosis of ovarian hyperstimulation syndrome. Methodological weakness of the retrospective study design should be a reason for caution in interpreting the results.

scholarly journals Determination of oxidative stress balance in follicular fluid

2018 ◽  
Vol 42 (1-2) ◽  
pp. 51-58
Author(s):  
Teja Fabjan ◽  
Eda Vrtačnik-Bokal ◽  
Kristina Kumer ◽  
Joško Osredkar
Keyword(s):  
Oxidative Stress ◽  
Follicular Fluid ◽  
Polycystic Ovary ◽  
Oocyte Retrieval ◽  
Control Group ◽  
Reactive Oxygen Metabolites ◽  
Female Reproduction ◽  
Vitro Fertilization ◽  
Significant Difference

AbstractBackground:The role of oxidative stress in female reproduction is an area that needs more investigation. This study aims to assess the oxidative stress levels in follicular fluid (FF) samples of women undergoing in vitro fertilization (IVF) and to relate them to different diagnoses.Methods:A total of 199 woman were enrolled; 37 of them were diagnosed with polycystic ovary syndrome (PCOS), 71 with endometriosis and 41 with tubal factor infertility (TFI) and 50 of the patients were used as a control group. A sample of FF was collected from each patient at an oocyte retrieval day and analyzed for oxidative stress by measuring a class of reactive oxygen metabolites (ROMs) (dROMs test) and also analyzed for the plasma antioxidant test (PAT).Results:The data analyzed in FF were related to different diagnoses. Groups were not significantly different in age and body mass index (BMI), except for the PCOS group. There was a significant difference between dROMs and PAT levels in FF of patients vs. control group. The same finding was seen when the dROM/PAT ratio was used.Conclusions:We conclude that the evaluation of oxidative stress in FF needs more investigation with regard to markers in the follicular microenvironment.

scholarly journals Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?

2019 ◽  
pp. 1
Author(s):  
Ayse Zehra Ozdemir ◽  
Pervin Karli
Keyword(s):  
Birth Weight ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Ongoing Pregnancy ◽  
Vitro Fertilization ◽  
Biochemical Pregnancy ◽  
Significant Difference ◽  
Frozen Embryo Transfers

<p><strong>OBJECTIVE:</strong> Nowadays, fresh embryo transfers and frozen embryo transfers are frequently employed in the treatment of in vitro fertilization. This study aims to compare the pregnancy outcomes in patients who underwent fresh embryo transfers and frozen embryo transfers.<br /><strong></strong></p><p><strong>STUDY DESIGN:</strong> All patients who underwent fresh embryo transfers and frozen embryo transfers at the in vitro fertilization center, Ondokuz Mayis University between 2010 and 2017 were screened retrospectively and the pregnancy results were evaluated at one-year follow-up. The study included a total of 912 transfers, 679 of which were fresh embryo transfers and 233 were fresh embryo transfers, in 756 patients. Comparisons were made in terms of biochemical pregnancy, clinical pregnancy rate, ongoing pregnancy, and live birth rate.</p><p><strong>RESULTS:</strong> Ectopic pregnancy, biochemical pregnancy, and abortus in fresh embryo transfers were found to be significantly more than that in frozen embryo transfers (p=0.001). However, no statistically significant difference in terms of clinical or ongoing pregnancy rate or live birth rate was observed. Birth weight was significantly lower in fresh embryo transfers than in frozen embryo transfers (p=0.001, p= 0.031). Multiple pregnancies preeclampsia, preterm labor, and placental abruption did not show a statistically significant difference in fresh embryo transfers and frozen embryo transfers. Yet, gestational diabetes was significantly more in frozen embryo transfers (p=0.011).</p><p><strong>CONCLUSIONS:</strong> Early pregnancy complications in fresh embryo transfers are higher than that in frozen embryo transfers. In terms of neonatal results, higher birth weight and gestational diabetes are more prevalent in frozen embryo transfers. In this study, it has been shown that fresh embryo transfers are more often associated with negative pregnancy outcomes. frozen embryo transfers can be better for pregnancy results</p>

scholarly journals Cumulative Live Birth Rates of Women ≥ 38 Years With Poor, Normal and High Ovarian Response

2021 ◽  
Author(s):  
Conghui Liu ◽  
Yu Li ◽  
Hong Jiang ◽  
Xuemei Wang ◽  
Feng Ni ◽  
...  
Keyword(s):  
Live Birth ◽  
Live Birth Rate ◽  
Oocyte Retrieval ◽  
Ovarian Response ◽  
Fresh Embryo Transfer ◽  
Vitro Fertilization ◽  
Logistic Regression Models ◽  
Significant Difference ◽  
The Relationship

Abstract Background Previous studies have reported that live birth rate (LBR) decreased with aging, however, no study has evaluated the cumulative LBR (CLBR) in accordance with the ovarian response in advanced maternal age (AMA) patients. This study aims to investigate the relationship between the ovarian response and the CLBR in AMA patients. Methods 913 women ≥ 38 years underwent in vitro fertilization (IVF) and fresh embryo transfer (ET) between January 2014 and June 2019 were enrolled in this retrospective study. All subjects were categorized into three groups, poor ovarian response (POR) group: 1–3 oocytes retrieved (n = 127), normal ovarian response (NOR) group: 4–15 oocytes retrieved, and high ovarian response (HOR) group: more than 15 oocytes retrieved. The primary outcome was the CLBR in one oocyte retrieval cycle after transfer of all fresh and frozen embryos. Logistic regression models were used to derive the odds ratio (OR) to identify the relationship of CLBR with different ovarian response, adjusting for age and body mass index. Results Compared with women in POR group, the women in other groups (NOR and HOR groups) achieved higher CLBR [adjusted OR (aOR) = 2.12, 95% confidence interval (CI), 1.16–4.38 for NOR group; aOR = 2.93, 95% CI, 1.44–5.97 for HOR]. The LBR of the fresh ET and the neonate characteristics showed no significant difference among the three groups. Conclusion Ovarian response is significantly associated with CLBR in women with advanced age.

scholarly journals Comparison of Bromocriptine and Hydroxyethyl Starch for Reducing Ohss in in Vitro Fertilization Patients: A Retrospective Study

2021 ◽  
Author(s):  
Qiaoli Zhang ◽  
Yanmin Ma ◽  
Xiaomeng Bu ◽  
Chanwei Jia ◽  
Yanjun Liu ◽  
...  
Keyword(s):  
Renal Function ◽  
Retrospective Study ◽  
Hydroxyethyl Starch ◽  
Clinical Effectiveness ◽  
Oocyte Retrieval ◽  
Rectal Administration ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization

Abstract Background: The ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication associated with controlled ovarian hyperstimulation (COS) during assisted reproductive technology (ART) treatment, and effective preventive measures are urgently needed. The dopamine agonist can mitigate OHSS incidence through a decreased vascular permeability via reduced vascular endothelial growth factor (VEGF) production. This study evaluated the clinical effectiveness of bromocriptine, an alternative DA, for prevention of OHSS in high risk women.Methods: The retrospective study population consisted of women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles with GnRH antagonist protocols, at risk of OHSS. The study group included 52 women given 2.5 mg bromocriptine daily by rectal insertion for 5 days beginning on the day of oocyte retrieval; the control group included 52 women given 500 ml intravenous (I.V.) hydroxyethyl starch (HES) daily for 5 days also beginning on the day of oocyte retrieval. The outcomes of ovarian stimulation, incidence and severity of OHSS, blood-related indicators, biochemical indicators (liver and renal function), and coagulation and fibrinolytic activities were compared.Results: The groups were not significantly different in age, estradiol concentration on the day of human chorionic gonadotropin injection, or number of retrieved oocytes. The occurrence of mild (13.46% vs 15.48%) and moderate (7.69% vs 5.77%) OHSS were not significantly different between bromocriptine and HES groups (P>0.05). No cases of severe or late OHSS were recorded in either group. Only hemocratin levels were significantly higher and activated partial thromboplastin time was significantly lower in the bromocriptine group (P<0.05) compared to the HES group on Day 5 after oocyte retrieval. No difference in liver or renal function was found between groups.Conclusions: Prophylactic rectal administration of bromocriptine was as effective as I.V. HES for prevention of OHSS.

scholarly journals The effect of Propofol versus Dexmedetomidine as anesthetic agents for oocyte pick-up on in vitro fertilization (IVF) outcomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Özcan Budak ◽  
Mehmet Sühha Bostancı ◽  
AyçaTaş Tuna ◽  
Veysel Toprak ◽  
Hüseyin Çakiroğlu ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Oocyte Retrieval ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Anesthetic Agents ◽  
Significant Difference ◽  
Embryo Number ◽  
Group 2

AbstractThis study aimed to evaluate the effects of propofol and dexmedetomidine over different timescales on the IVF outcomes for transvaginal oocyte retrieval (TVOR). Twenty-four rats included in the study were divided into two main groups and three subgroups were subjected to the ovulation induction process. Group 1 was administered propofol (100 mg/kg i.v.) and group 2 were administered dexmedetomidine (25 µg/kg i.p.) The oviduct collection procedure was completed within 15 min for subgroup Pro15min, Dex15min (n = 4), within 16 to 30 min for subgroup Pro30min, Dex30min (n = 4) and within 31 to 60 min for subgroup Pro60min, Dex60min (n = 4) after euthanasia. The total number of oocytes was counted. After in vitro fertilization, the number and quality of embryos were evaluated. The number of pups born were evaluated after embryo transfer. The embryo number, quality and pup count decreased as the administration time for propofol increased (p < 0.05). No statistically significant difference was found between the dexmedetomidine subgroups for embryo number, quality and pup count(p > 0.05). As the exposure time to propofol increased, the number and quality of embryos obtained, and the pup count, decreased. The use of dexmedetomidine had no negative impacts on the number of embryos, their quality or the number of pups.

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