Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis

Abstract Background The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aimed to examine associations of seropositivity to these agents with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods A total of 12,471 HCHS/SOL participants with baseline data on self-reported physician-diagnosed asthma, and antibodies anti-H. pylori and anti-HAV were included in this cross-sectional analysis. Multivariable logistic regression models were used to estimate the odds ratios and 95% confidence intervals for the overall associations of seropositivity to each agent with asthma. Analyses were also stratified by Hispanic/Latino background. Effect modification by smoking status and nativity were tested. An analysis restricted to individuals with spirometry-defined chronic obstructive pulmonary disease (COPD) was also considered. Results The weighted overall prevalence of asthma was 16.6%. The weighted seroprevalence of H. pylori was 56.6% and of HAV was 76.6%, and they significantly differed by Hispanic/Latino background. After accounting for age, sex, education and other key confounders, we found no associations between H. pylori or HAV seropositivity with asthma (with and without COPD), either for all individuals combined or for any of the six specific backgrounds. There were no significant interactions by smoking and nativity. Conclusion Our findings did not provide support for the role of H. pylori or HAV, as evidence of the hygiene hypothesis in asthma among the large and diverse Hispanic/Latino populations of the HCHS/SOL. Trial registration NCT02060344

Download Full-text

Seroprevalence and determinants of Helicobacter pylori infection in the Hispanic Community Health Study/Study of Latinos

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2021.02.042 ◽

2021 ◽

Author(s):

Sabrina H. Tsang ◽

M. Larissa Avilés-Santa ◽

Christian C. Abnet ◽

Maximo O. Brito ◽

Martha L. Daviglus ◽

...

Keyword(s):

Helicobacter Pylori ◽

Community Health ◽

Helicobacter Pylori Infection ◽

Health Study ◽

Hispanic Community

Download Full-text

Exploring the Association of Self-Reported Physical Activity with Peripheral Arterial Disease Severity: A Cross-Sectional Study from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Database

10.21203/rs.3.rs-520665/v1 ◽

2021 ◽

Author(s):

Monira Ibrahim Aldhahi ◽

Mohammed M. Alshehri ◽

Abdulfattah Saeed Alqahtani

Keyword(s):

Physical Activity ◽

Community Health ◽

Sex Education ◽

Ankle Brachial Index ◽

Health Study ◽

Cross Sectional ◽

Physically Active ◽

Metabolic Equivalents ◽

Hispanic Community ◽

Physically Inactive

Abstract Background Engaging in physical activity (PA) has been proved to reduce the risk of developing cardiovascular diseases. In patients with peripheral artery disease (PAD), diminished PA predicts high overall mortality. However, it is unknown to what extent participation in PA is associated with PAD severity. Therefore, the overarching aim of this study was to investigate the association between PAD severity and PA levels using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) database. Methods This was a cross-sectional cohort study that included 495 participants with PAD and a total of 14,536 participants without PAD from the HCHS/SOL database. The Global Physical Activity Questionnaire was administered to assess the time spent weekly in performing moderate to vigorous PA (MVPA) during work, leisure time, and transportation. The Ankle–Brachial Index (ABI) was used to measure PAD. PA status was categorized on the basis of MVPA as follows: physically active (MVPA ≥ 150 min) and physically inactive (combined MVPA < 150 min). Eventually, the total sample was then classified as follows: normal ABI and physically active, normal ABI but physically inactive, PAD and physically active, and PAD but physically inactive. Regression models were used to investigate the association between different types of PA and the severity of PAD. Results Of the participants, 235 (47%) were involved in no to insufficient PA, and 260 (53%) engaged in at least 150 min/week of MVPA. The majority of participants (54%) with mild PAD were physically active, and 58% of those with severe PAD were physically inactive. After adjustment for covariates (age, sex, education, smoking status, body mass index, and statins), inactive people with a diagnosis of PAD were more likely to have severe PAD (β = .79, p = .02). In addition, decreases in work-related PA, total metabolic equivalents, and total PA were associated with increased PAD severity. Conclusions It was found that MVPA patterns were associated with PAD severity, and they explained high severity among patients with PAD who were physically inactive. These findings highlight the necessity of interventions in increasing PA in these participants. Future studies are required to identify appropriate exercise regimens or home-based programs to help patients with severe PAD meet the current PA recommendations.

Download Full-text

Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Genome Biology ◽

10.1186/s13059-019-1831-z ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 14

Author(s):

Robert C. Kaplan ◽

Zheng Wang ◽

Mykhaylo Usyk ◽

Daniela Sotres-Alvarez ◽

Martha L. Daviglus ◽

...

Keyword(s):

Community Health ◽

Gut Microbiome ◽

Alpha Diversity ◽

Amplicon Sequencing ◽

Shannon Index ◽

Health Study ◽

Rrna Gene ◽

Cross Sectional ◽

Hispanic Community ◽

The Usa

Abstract Background Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

Download Full-text

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos

Alzheimer s & Dementia ◽

10.1002/alz.12250 ◽

2020 ◽

Author(s):

Christian Agudelo ◽

Wassim Tarraf ◽

Benson Wu ◽

Douglas M. Wallace ◽

Sanjay R. Patel ◽

...

Keyword(s):

Cognitive Decline ◽

Community Health ◽

Health Study ◽

Sleep Patterns ◽

Hispanic Community

Download Full-text

Perceived dental care need and actual oral health status in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Journal of Public Health Dentistry ◽

10.1111/jphd.12453 ◽

2021 ◽

Vol 81 (1) ◽

pp. 84-84

Keyword(s):

Health Status ◽

Oral Health ◽

Community Health ◽

Dental Care ◽

Oral Health Status ◽

Health Study ◽

Hispanic Community

Download Full-text

Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

Kidney Medicine ◽

10.1016/j.xkme.2021.02.015 ◽

2021 ◽

Author(s):

Stephanie M. Toth-Manikowski ◽

Ana C. Ricardo ◽

Christian R. Salazar ◽

Jinsong Chen ◽

Tasneem Khambaty ◽

...

Keyword(s):

Periodontal Disease ◽

Community Health ◽

Health Study ◽

Hispanic Community

Download Full-text

Cardiovascular Disease Risk Factors in the Hispanic/Latino Population: Lessons From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Progress in Cardiovascular Diseases ◽

10.1016/j.pcad.2014.07.006 ◽

2014 ◽

Vol 57 (3) ◽

pp. 230-236 ◽

Cited By ~ 67

Author(s):

Martha L. Daviglus ◽

Amber Pirzada ◽

Gregory A. Talavera

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Community Health ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cardiovascular Disease Risk Factors ◽

Health Study ◽

Latino Population ◽

Hispanic Community

Download Full-text

The Role of Stress in Understanding Differences in Sedentary Behavior in Hispanic/Latino Adults: Results From the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0608 ◽

2016 ◽

Vol 13 (3) ◽

pp. 310-317 ◽

Cited By ~ 9

Author(s):

Elizabeth Vásquez ◽

Garrett Strizich ◽

Linda Gallo ◽

Simon J. Marshall ◽

Gina C. Merchant ◽

...

Keyword(s):

Community Health ◽

Sedentary Behavior ◽

Stress Reduction ◽

Self Report ◽

Health Study ◽

Sedentary Behaviors ◽

Ancillary Study ◽

Hispanic Community ◽

Latino Adults ◽

Sedentary Activities

Background:Chronic stress and/or lifetime traumatic stress can create a self-reinforcing cycle of unhealthy behaviors, such as overeating and sedentary behavior, that can lead to further increases in stress. This study examined the relationship between stress and sedentary behavior in a sample of Hispanic/Latino adults (N = 4244) from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.Methods:Stress was measured as the number of ongoing difficulties lasting 6 months or more and as lifetime exposure to traumatic events. Sedentary behavior was measured by self-report and with accelerometer. Multivariable regression models examined associations of stress measures with time spent in sedentary behaviors adjusting by potential confounders.Results:Those who reported more than one chronic stressor spent, on average, 8 to 10 additional minutes per day in objectively measured sedentary activities (P < .05), whereas those with more than one lifetime traumatic stressor spent (after we adjusted for confounders) 10 to 14 additional minutes in sedentary activities (P < .01) compared with those who did not report any stressors. Statistical interactions between the 2 stress measures and age or sex were not significant.Conclusion:Interventions aimed at reducing sedentary behaviors might consider incorporating stress reduction into their approaches.

Download Full-text