scholarly journals Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiangling Li ◽  
Yanjun Guan ◽  
Chaochao Li ◽  
Tieyuan Zhang ◽  
Fanqi Meng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Immune Cells ◽  
Peripheral Nerve Injuries ◽  
Local Inflammatory Response ◽  
Inflammatory Microenvironment ◽  
Free Treatment ◽  
Immunomodulatory Potential

AbstractVarious immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI.

Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population

Blood ◽  
2009 ◽  
Vol 113 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Bin Zhang ◽  
Rui Liu ◽  
Dan Shi ◽  
Xingxia Liu ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
Immune Cells ◽  
Cell Contact ◽  
Multilineage Differentiation ◽  
Immunomodulatory Effects ◽  
Cd11b Expression ◽  
Dendritic Cell Population

Abstract Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, exert immunomodulatory effects on immune cells, even dendritic cells (DCs). However, whether they influence the destiny of full mature DCs (maDCs) remains controversial. Here we report that MSCs vigorously promote proliferation of maDCs, significantly reduce their expression of Ia, CD11c, CD80, CD86, and CD40 while increasing CD11b expression. Interestingly, though these phenotypes clearly suggest their skew to immature status, bacterial lipopolysaccharide (LPS) stimulation could not reverse this trend. Moreover, high endocytosic capacity, low immunogenicity, and strong immunoregulatory function of MSC-treated maDCs (MSC-DCs) were also observed. Furthermore we found that MSCs, partly via cell-cell contact, drive maDCs to differentiate into a novel Jagged-2–dependent regulatory DC population and escape their apoptotic fate. These results further support the role of MSCs in preventing rejection in organ transplantation and treatment of autoimmune disease.

scholarly journals Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration

2021 ◽  
pp. 102482
Author(s):  
Tito Sumarwoto ◽  
Heri Suroto ◽  
Ferdiansyah Mahyudin ◽  
Dwikora Novembri Utomo ◽  
Romaniyanto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Adipose Mesenchymal Stem Cells

scholarly journals The Role of Tumor-Associated Macrophages in Leukemia

2019 ◽  
Vol 143 (2) ◽  
pp. 112-117 ◽  
Author(s):  
Yueyang Li ◽  
M. James You ◽  
Yaling Yang ◽  
Dongzhi Hu ◽  
Chen Tian
Keyword(s):  
Stem Cells ◽  
Innate Immunity ◽  
Mesenchymal Stem Cells ◽  
Immune Cells ◽  
Leukemia Cell ◽  
Tumor Associated Macrophages ◽  
Intrinsic Factors ◽  
Different Types ◽  
Tumor Growth And Metastasis

In addition to intrinsic factors, leukemia cell growth is influenced by the surrounding nonhematopoietic cells in the leukemic microenvironment, including fibroblasts, mesenchymal stem cells, vascular cells, and various immune cells. Despite the fact that macrophages are an important component of human innate immunity, tumor-associated macrophages (TAMs) have long been considered as an accomplice promoting tumor growth and metastasis. TAMs are activated by an abnormal malignant microenvironment, polarizing into a specific phenotype and participating in tumor progression. TAMs that exist in the microenvironment of different types of leukemia are called leukemia-associated macrophages (LAMs), which are reported to be associated with the progression of leukemia. This review describes the role of LAMs in different leukemia subtypes.

Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries

Life Sciences ◽  
2019 ◽  
Vol 221 ◽  
pp. 99-108 ◽  
Author(s):  
Forouzan Yousefi ◽  
Fahimeh Lavi Arab ◽  
Karim Nikkhah ◽  
Houshang Amiri ◽  
Mahmoud Mahmoudi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Novel Approaches

The role of mesenchymal stem cells in the reconstruction of nerve injuries in the hand

2013 ◽  
Vol 154 (15) ◽  
pp. 574-580
Author(s):  
Vilmos Bíró
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Recent Literature ◽  
Experimental Studies ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Ongoing Research ◽  
Basic Characteristics ◽  
Future Direction

At present the end results of reconstruction of peripheral nerve injuries cannot be considered unequivocally advantageous. It seems that the level of reconstructive possibilities of these injuries has already peaked. Hence, ongoing research focuses on experimental studies to further improve results. One of the methods is the joint usage of pluripotent mesenchymal stem cells with tissue inductive polypeptides (growth factors) and frame structures to enhance the attachment of these cells with the aim creating new neural tissue (tissue engineering). The conditions to create new tissue can be further improved by gene technology. Based on recent literature data, the author summarizes the basic characteristics of the method related to nerve injuries, and the possibilities and modalities of clinical applications. In conclusion, future direction is a the wider use of stem cells, however, the currently established surgical and rehabilitation methods have to be performed at high levels since stem cell research data are not established in the clinical setting yet. Orv. Hetil., 2013, 154, 574–580.

scholarly journals Biological relevance of cell-in-cell in cancers

2019 ◽  
Vol 47 (2) ◽  
pp. 725-732 ◽  
Author(s):  
Hannah L. Mackay ◽  
Patricia A.J. Muller
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Genomic Instability ◽  
Immune Cells ◽  
Living Cell ◽  
Cancer Biology ◽  
Tumour Cells ◽  
Mutant P53 ◽  
The Past

Abstract Cell-in-cell (CIC) is a term used to describe the presence of one, usually living, cell inside another cell that is typically considered non-phagocytic. Examples of this include tumour cells inside tumour cells (homotypic), mesenchymal stem cells inside tumour cells (heterotypic) or immune cells inside tumour cells (heterotypic). CIC formation can occur in cell lines and in tissues and it has been most frequently observed during inflammation and in cancers. Over the past 10 years, many researchers have studied CIC structures and a few different models have been proposed through which they can be formed, including entosis, cannibalism and emperipolesis among others. Recently, our laboratory discovered a role for mutant p53 in facilitating the formation of CIC and promoting genomic instability. These data and research by many others have uncovered a variety of molecules involved in CIC formation and have started to give us an idea of why they are formed and how they could contribute to oncogenic processes. In this perspective, we summarise current literature and speculate on the role of CIC in cancer biology.

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