scholarly journals Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis

2020 ◽  
Vol 49 (1) ◽  
Author(s):  
Arikin Abdeyrim ◽  
Shizhi He ◽  
Yang Zhang ◽  
Gulbostan Mamtali ◽  
Aibadla Asla ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Meta Analysis ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Node Ratio

Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Head & Neck ◽  
2018 ◽  
Vol 40 (5) ◽  
pp. 1082-1090 ◽  
Author(s):  
Yoav P. Talmi ◽  
Robert P. Takes ◽  
Eran E. Alon ◽  
Iain J. Nixon ◽  
Fernando López ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Neck Squamous Cell Carcinoma ◽  
Node Ratio

scholarly journals The prognostic value of lymph node ratio in survival of head-and-neck squamous cell carcinoma

2018 ◽  
Vol 23 (1) ◽  
pp. 35 ◽  
Author(s):  
Mohammad Shirkhoda ◽  
RezaEshraghi Samani ◽  
Maryam Hadji ◽  
Faramarz Beheshtifard ◽  
SeyedMohammad Mehdi Ghaffari Hamedani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Neck Squamous Cell Carcinoma ◽  
Node Ratio

scholarly journals Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 486
Author(s):  
Juan P. Rodrigo ◽  
Mario Sánchez-Canteli ◽  
Fernando López ◽  
Gregory T. Wolf ◽  
Juan C. Hernández-Prera ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been demonstrated to be of prognostic value in various cancers. In this systematic review and meta-analysis, we investigated the prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed a systematic search in PubMed for publications that investigated the prognostic value of TIL in LSCC. A meta-analysis was performed including all studies assessing the association between TIL counts in hematoxylin-eosin (HE)-stained sections, for CD8+ and/or CD3+/CD4+ TIL and overall survival (OS) or disease-free survival (DFS). The pooled meta-analysis showed a favorable prognostic role for stromal TIL in HE sections for OS (HR 0.57, 95% CI 0.36–0.91, p = 0.02), and for DFS (HR 0.56, 95% CI 0.34–0.94, p = 0.03). High CD8+ TIL were associated with a prolonged OS (HR 0.62, 95% CI 0.4–0.97, p = 0.04) and DFS (HR 0.73, 95% CI 0.34–0.94, p = 0.002). High CD3+/CD4+ TIL demonstrated improved OS (HR 0.32, 95% CI 0.16–0.9, p = 0.03) and DFS (HR 0.23, 95% CI 0.10–0.53, p = 0.0005). This meta-analysis confirmed the favorable prognostic significance of TIL in LSCC. High stromal TIL evaluated in HE sections and intra-tumoral and stromal CD3+, CD4+ and/or CD8+ TIL might predict a better clinical outcome.

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