scholarly journals Development and application of a chemical profiling method for the assessment of the quality and consistency of the Pelargonium sidoides extract

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Se Mi Yu ◽  
Sung Jun Kim ◽  
Yeong Cheol Yoon ◽  
Jong Hoon Kim
Keyword(s):  
Profile Analysis ◽  
Pearson Correlation ◽  
Herbal Medicines ◽  
Correlation Coefficients ◽  
Chemical Profile ◽  
Chemical Profiling ◽  
Pelargonium Sidoides ◽  
Accuracy And Precision ◽  
Consistency Evaluation

AbstractThe evaluation of chemical similarity is very significant for the evaluation and standardization of the quality of herbal medicines as the biological activity of herbal medicines depends on the composition and proportion of many individual components. Many health organizations have recommended chemical profiling for the quality and consistency evaluation of herbal medicines. In this study, chemical profiling was performed to evaluate the similarity between batches of Pelargonium sidoides maltodextrin mixture (PMM) from EPs® 7630, a Pelargonium sidoides extract preparation. For chemical profile analysis, 7 common peaks were selected from 27 different PMM batches and specificity, linearity, accuracy, and precision tests were performed to develop the analytical method. The Pearson correlation coefficients of the similarity for all 27 batches manufactured over the years were higher than 0.90, indicating that quality consistency is well ensured over the years. This profiling method confirms the chemical profile of various commercial products using not only PMM but also Pelargonium sidoides extract and shows that it can be applied to standardization of quality.

Depression and Inflammatory Markers in Veterans With Multiple Sclerosis

2021 ◽  
pp. 109980042110500
Author(s):  
Pamela Newland ◽  
Yelyzaveta Basan ◽  
Ling Chen ◽  
Gregory Wu
Keyword(s):  
Multiple Sclerosis ◽  
Inflammatory Markers ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
The United States ◽  
Biological Mechanisms ◽  
The Central Nervous System ◽  
Brain And Spinal Cord ◽  
The Brain

Multiple sclerosis (MS), an inflammatory neurodegenerative disease of the central nervous system (CNS), afflicts over one per thousand people in the United States. The pathology of MS typically involves lesions in several regions, including the brain and spinal cord. The manifestation of MS is variable and carries great potential to negatively impact quality of life (QOL). Evidence that inflammatory markers are related to depression in MS is accumulating. However, there are barriers in precisely identifying the biological mechanisms underlying depression and inflammation. Analysis of cytokines provides one promising approach for understanding the mechanisms that may contribute to MS symptoms. Methods: In this pilot study, we measured salivary levels of interleukin (IL)-6, IL-1beta (β), and IL-10 in 24 veterans with MS. Descriptive statistics were reported and Pearson correlation coefficients were obtained between cytokines and depression. Results: The anti-inflammatory cytokine IL-10 was significantly negatively associated with depression in veterans with MS (r = −0.47, p = .024). Conclusion: Cytokines may be useful for elucidating biological mechanisms associated with the depression and a measure for nurses caring for veterans with MS.

scholarly journals Correlations Between Clinical Trial Outcomes Based on Symptoms, Functional Impairments, and Quality of Life in Children and Adolescents With ADHD

2017 ◽  
Vol 23 (13) ◽  
pp. 1578-1591 ◽  
Author(s):  
David R. Coghill ◽  
Alain Joseph ◽  
Vanja Sikirica ◽  
Mark Kosinski ◽  
Caleb Bliss ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Rating Scale ◽  
Controlled Trial ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Parent Report ◽  
Functional Impairments ◽  
Risk Avoidance

Objective: To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. Method: Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference). Results: Changes in ADHD Rating Scale IV (ADHD-RS-IV) total score generally correlated moderately with changes in Child Health and Illness Profile−Child Edition: Parent Report Form (CHIP-CE:PRF) Achievement and Risk Avoidance ( r ≈ .4), but weakly with Resilience, Satisfaction, and Comfort ( r ≈ .2); and moderately with Weiss Functional Impairment Rating Scale–Parent (WFIRS-P) total score ( r ≈ .5). CHIP-CE:PRF Achievement and Risk Avoidance correlated moderately to strongly with WFIRS-P total score ( r ≈ .6). Conclusion: The ADHD-RS-IV, CHIP-CE:PRF, and WFIRS-P capture distinct but interconnected aspects of treatment response in individuals with ADHD.

scholarly journals Orthodontic Treatment Characteristics and Outcomes in an Educational Setting

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
T. Al-Jewair ◽  
V. Ryan ◽  
S. Warunek
Keyword(s):  
Treatment Duration ◽  
Orthodontic Treatment ◽  
Treatment Time ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Educational Setting ◽  
Dental Esthetics ◽  
Treatment Characteristics ◽  
The Mean

Background. To assess and correlate orthodontic treatment characteristics and outcomes in an educational setting. Methods. A total of 287 patients were included. Independent chart reviews were conducted to gather demographic and pretreatment diagnostic information. Posttreatment digital records were graded with the ABO C-R Eval and the CCA methods. Pearson correlation coefficients were calculated to determine associations between variables. Results. Of the 287 patients, 122 (42.5%) were male and 165 (57.5%) were female. The total average treatment time was 33.87 ± 10.28 months, with a range from 11 to 75 months. The mean ABO C-R Eval score was 29.10 ± 8.59 points. The parameters with the highest scores were buccolingual inclination and occlusal contacts. The mean CCA score was 3.36 ± 2.05 points. The highest scores were recorded for dental esthetics and management of the periodontium. Higher ABO DI scores were weakly correlated with longer treatment times (r = 0.258; p<0.001). ABO C-R Eval scores showed a weakly significant association with treatment duration (r = 0.162; p=0.006), while CCA scores were moderately associated with treatment duration (r = 0.451; p<0.001). Conclusions. As treatment duration increased, the total ABO C-R Eval and CCA scores tended to increase; thus, quality of treatment outcomes decreased. A significant positive correlation was also found with the ABO DI score and treatment duration.

scholarly journals Corruption of the Pearson correlation coefficient by measurement error: estimation, bias, and correction under different error models

2019 ◽  
Author(s):  
Edoardo Saccenti ◽  
Margriet H. W. B. Hendriks ◽  
Age K. Smilde
Keyword(s):  
Pearson Correlation ◽  
Measurement Techniques ◽  
Life Sciences ◽  
Real Life ◽  
Correlation Coefficients ◽  
Gene Expressions ◽  
Science Data ◽  
Real Life Data ◽  
Comprehensive Measurement

ABSTRACTCorrelation coefficients are abundantly used in the life sciences. Their use can be limited to simple exploratory analysis or to construct association networks for visualization but they are also basic ingredients for sophisticated multivariate data analysis methods. It is therefore important to have reliable estimates for correlation coefficients. In modern life sciences, comprehensive measurement techniques are used to measure metabolites, proteins, gene-expressions and other types of data. All these measurement techniques have errors. Whereas in the old days, with simple measurements, the errors were also simple, that is not the case anymore. Errors are heterogeneous, non-constant and not independent. This hampers the quality of the estimated correlation coefficients seriously. We will discuss the different types of errors as present in modern comprehensive life science data and show with theory, simulations and real-life data how these affect the correlation coefficients. We will briefly discuss ways to improve the estimation of such coefficients.

scholarly journals YouTube as a source of information about orthodontic clear aligners

2020 ◽  
Vol 90 (3) ◽  
pp. 419-424 ◽  
Author(s):  
Gokay Ustdal ◽  
Ayca Ustdal Guney
Keyword(s):  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Search Term ◽  
Sources Of Information ◽  
The Poor ◽  
Significant Difference ◽  
The Rich ◽  
Video Group ◽  
Rich Content

ABSTRACT Objectives To evaluate the content, reliability, and quality of videos about orthodontic clear aligners on YouTube. Materials and Methods Researchers used the Google Trends website to determine that the most frequently used search term for orthodontic clear aligners on the Internet was: “Invisalign.” A search was then conducted on YouTube using the key word “Invisalign.” From the first 140 results, 100 videos were selected for analysis. A 13-point content score was used to classify poor-content and rich-content videos, and the global quality scale (GQS) was used to examine quality of the videos. To evaluate reliability of the information, a five-question scale was used. The Mann-Whitney U-test, χ2 test, and Pearson correlation coefficients were used for statistical evaluations. Results Of the YouTube videos, 33 were classified as rich content and 67 as poor content. Most videos (73%) were uploaded by laypeople, and most uploaders (71%) were women. The most commonly discussed content was instructions (65%), followed by procedure (57%) and pain (52%). Regarding the GQS, most of the videos were evaluated as moderate quality (51%). Compared with the poor-content video group, the rich-content video group had a significantly higher GQS score (P = .004). There was no significant difference between the poor-content and rich-content groups regarding information reliability (P &gt; .05). Conclusions Video content on YouTube relating to aligner orthodontics was generally insufficient. The quality of videos was moderate, but the reliability of information was generally poor. Specialists should refer patients to reliable sources of information.

scholarly journals Accounting Education and Labor Market Needs

2019 ◽  
Vol 11 (2) ◽  
pp. 209
Author(s):  
MESHARI ALHUSSAIN
Keyword(s):  
Labor Market ◽  
Field Study ◽  
Public Universities ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Inductive Method ◽  
Teaching Staff ◽  
Arithmetic Means ◽  
Study Plan

The study aimed at identifying the appropriateness of educational outputs in the Saudi public universities for the labor market from the point of view of graduates from the specialization of accounting and finance by investigating the following axes (Motivation in specialization identification, teaching staff in universities, the appropriateness of the study plan for the labor market, and the extent of knowledge of professional tests) and its impact on the quality of educational outputs. The study adopted the inductive method trough reviewing the previous studies regarding the research subject. On the field study, the study used the questionnaire as the study tool. On the statistical side, the following statistical analyzes were conducted (frequencies, percentages, arithmetic means and standard deviations), as well as Pearson correlation coefficients to determine the relationships between the variables of the study. The study population consisted of all graduates from the accounting and finance departments of the Saudi public universities working in the public sector or the private sector or self-employed " entrepreneurial". The field study was carried out in 2018 and the number of participants was (125) graduates from Saudi public universities and (80%) of the participants were under the age of (30) years. This is an excellent percentage as the study focused more on graduates. The study concluded the approval of the sample on each of the following: (the specialization identification was their personal desire, the teaching staff at the university is characterized by knowledge and eruditeness, the quality of study plans in universities and their knowledge of the study plan and its requirements, quality of educational outputs). It also concluded that the most prominent obstacles for graduates in the professional tests was the high financial fees of professional tests. In addition to there was no relationship between the specialization identification and the quality of educational outputs, while there was a relationship between (the efficiency of the teaching staff, the study plan, and the professional tests) and the quality of the educational outputs.

Patient-reported outcomes (PROs) with ibrutinib-rituximab in Waldenström macroglobulinemia (WM): Results from iNNOVATE.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 8018-8018
Author(s):  
Alessandra Tedeschi ◽  
Meletios A. Dimopoulos ◽  
Judith Trotman ◽  
Ramón Garcia-Sanz ◽  
David MacDonald ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Single Agent ◽  
Correlation Coefficients ◽  
Subscale Score ◽  
Trade Mark ◽  
Meaningful Improvement ◽  
Patient Reported ◽  
Clinical Trial Information

8018 Background: Anemia and fatigue can impair quality of life in patients (pts) with WM. Ibrutinib (ibr) as single agent or in combination with RTX is FDA-approved for WM. In pts with RTX-refractory WM, single-agent ibr induced meaningful improvements in PROs (Trotman, EHA 2017). In iNNOVATE, ibr-RTX (IR) produced higher rates of sustained hemoglobin improvement and meaningful improvements in PROs versus placebo-RTX (R; Dimopoulos NEJM 2018). Here, we report detailed PRO analyses from iNNOVATE. Methods: Pts with symptomatic WM requiring therapy were randomized to daily 420 mg oral ibr or placebo, both with RTX (375 mg/m2/week IV at weeks 1–4 and 17–20). PRO measures included FACIT-Fatigue (FACIT-F), FACT-An total score (TS) and anemia subscale score (AS), and EQ-5D-5L (EuroQol Research Foundation. EQ-5D is a trade mark of the EuroQol Research Foundation) visual analog scale (VAS), and utility score (US). Results: For 150 randomized pts (n=75/arm), most common reasons for initiating therapy were fatigue (61%), constitutional symptoms (32%), and anemia (32%). Baseline PRO scores were comparable in both arms. At a median follow-up of 26.5 mo, numerically more pts showed clinically meaningful improvement in FACIT-F, TS, and AS with IR than R (Table). Median time to PRO improvement was short (1-2 mo) in both arms. At week 25, the Pearson correlation coefficients were 0.28, 0.29, and 0.26 for changes in hemoglobin levels vs changes in FACIT-F, TS and AS, respectively, in the IR arm; no meaningful correlations were observed on R. The correlation coefficients were -0.32, -0.33, -0.35 and -0.26 for changes in IgM levels vs changes in FACIT-F, TS, AS, and EQ-VAS, respectively, for IR and 0.29 and 0.35 vs FACIT-F and TS for R. Conclusions: Clinical response and improvements in anemia with IR are consistent with more pts showing clinically meaningful improvement in PROs versus R. Changes in IgM correlate with improvements in PROs. Clinical trial information: NCT02165397. [Table: see text]

Adaptation of the Quality of Life in Autism Scale for use in Bangladesh

2021 ◽  
Vol 7 (1) ◽  
pp. 960-966
Author(s):  
SM Abul Kalam Azad ◽  
Nur E Nahid Shilvy ◽  
Ata A Rabby
Keyword(s):  
Quality Of Life ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Parent Report ◽  
Autism Spectrum ◽  
World Health ◽  
Special Schools ◽  
Test Retest Reliability ◽  
Parent Version

Parents of children with developmental disabilities, particularly Autism Spectrum disorder, are known to be at risk for high levels of psychological distress. The present study aimed to adapt the Quality of Life in Autism Questionnaire (QoLA, parent-version) in the context of Bangladeshi culture. The sample included 50 participants. Participants were selected from the Institute of Paediatric Neurology and Autism (IPNA, BSMMU) and some special schools of Dhaka city. World Health Organization’s (WHO, 2009) guidelines were followed in translating the QoLA and adaptation for use in Bangladesh. For the parent-report version of the QoLA, Cronbach’s coefficients were 0.880 and 0.725 for part A and part B subscale items, respectively. The Pearson correlation coefficients for the test-retest reliability were r =0.964 for part A of the scale and r = 0.954 for part B. These psychometric properties are comparable to those obtained in the initial QoLA validation study (Eapen et al. 2014). Results of this study demonstrate that the Bangla version of the QoLA (Parent version) provides a valid measure of quality of life and is suitable for use in Bangladesh. Bioresearch Commu. 7(1): 960-966, 2021 (January

scholarly journals The correlation between health status and quality of life in southern Brazil

2008 ◽  
Vol 126 (5) ◽  
pp. 257-261 ◽  
Author(s):  
Carlos Zubaran ◽  
Karina Persch ◽  
Desire Tarso ◽  
Ana Ioppi ◽  
Juan Mezzich
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Correlation Coefficients ◽  
Healthcare Services ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Health Related

CONTEXT AND OBJECTIVE: The interconnections between quality of life and health status as assessed via questionnaires have not been thoroughly investigated. The objective of this study was to investigate a possible correlation between the constructs of general health status and quality of life as assessed by the Portuguese versions of two questionnaires recently adapted and tested in Brazil. DESIGN AND SETTING: This was a cross-sectional study in which two self-administered questionnaires were used. This investigation was conducted at healthcare services associated with the Universidade de Caxias do Sul, Brazil. METHODS: This study presents data from a sample of 120 volunteers who completed the Portuguese versions of the Personal Health Scale and the Multicultural Quality of Life Index questionnaires. Bivariate linear regression analysis and Pearson correlation coefficients were generated from the scores of the two questionnaires. RESULTS: A significant correlation between the concepts of quality of life and health status as evaluated by the Portuguese versions of both questionnaires was observed. Almost all of the health-related questions displayed strong correlations with the overall concept of quality of life. The magnitude of this correlation accounted for almost half of the observed variance. CONCLUSIONS: These findings indicate that, within this sample, health-related issues were key factors for the overall experience of wellbeing and quality of life. The similarities observed across the different groups indicate that the interrelation between health status and quality of life was homogenous, regardless of presence and/or type of ailments.

scholarly journals The use of the computerized version of quality of life and health status questionnaires in a community sample in southern Brazil

2011 ◽  
Vol 129 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Carlos Zubaran ◽  
Ivanor Tres
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Data Collection ◽  
Pearson Correlation ◽  
Community Sample ◽  
Correlation Coefficients ◽  
Southern Brazil ◽  
Cross Sectional ◽  
Study Results

CONTEXT AND OBJECTIVE: Computerized data collection is an efficient process and well accepted by patients with different disorders. Although computer-based systems have been used to assess health status and quality of life in various areas of healthcare, there is a lack of studies to investigate the effectiveness of these instruments in Brazil. The aims here were to assess the usability of the Portuguese-language versions of the Personal Health Scale (PHS) and the Multicultural Quality of Life Index (MQLI) in southern Brazil and to determine the correlation between these two questionnaires. DESIGN AND SETTING: This was a cross-sectional community-based survey in which participants completed computerized versions of these two questionnaires. METHODS: In a survey conducted in 16 different locations, 458 volunteers completed both questionnaires. Pearson correlation coefficients were generated between the scores of the two questionnaires. The inclusion criteria allowed all volunteers who were able to understand the questions in both questionnaires to participate in the study. RESULTS: The percentage of proper data collection via the computerized versions of the two questionnaires combined was 97.45%. A significant correlation (P < 0.01) between the PHS and the MQLI was observed. CONCLUSION: The computerized versions of the PHS and MQLI demonstrated efficient data collection patterns during the field survey trials. Health-related issues were significantly correlated with the overall experience of wellbeing and quality of life. The computerized versions of the PHS and MQLI are valid tools for research and clinical use in Brazil

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