scholarly journals Sterilization and sanitizing of 3D-printed personal protective equipment using polypropylene and a Single Wall design

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Karstan Luchini ◽  
Shelly N. B. Sloan ◽  
Ryan Mauro ◽  
Aspram Sargsyan ◽  
Aundrea Newman ◽  
...  
Keyword(s):  
Bacterial Growth ◽  
Personal Protective Equipment ◽  
General Public ◽  
Healthcare Workers ◽  
Thermoplastic Polyurethane ◽  
Protective Equipment ◽  
E Coli ◽  
3D Printed ◽  
The Cost ◽  
N95 Respirators

Abstract Background The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic during the fall of 2019 and into the spring of 2020 has led to an increased demand of disposable N95 respirators and other types of personal protective equipment (PPE) as a way to prevent virus spread and help ensure the safety of healthcare workers. The sudden demand led to rapid modification, development, and dissemination of 3D printed PPE. The goal of this study was to determine the inherent sterility and re-sterilizing ability of 3D printed PPE in order to provide sterile equipment to the healthcare field and the general public. Methods Samples of polylactic acid (PLA), thermoplastic polyurethane (TPU) (infill-based designs) and polypropylene (single-wall hollow design) were 3D printed. Samples were inoculated with E. coli for 24 h and then sanitized using various chemical solutions or heat-based methods. The samples were then incubated for 24- or 72-h in sterile LB medium at 37°C, and bacterial growth was measured by optical density at 600nm. Statistical analysis was conducted using GraphPad Prism v8.2.1. Results Significant bacterial growth was observed in all PLA and TPU based samples following re-sterilization, regardless of the methods used when compared to controls (p < 0.05). The single-walled hollow polypropylene design was not only sterile following printing, but was also able to undergo re-sanitization following bacterial inoculation, with no significant bacterial growth (p > 0.05) observed regardless of sanitization method used. Conclusion The cost effectiveness, ease of sanitization, and reusability of 3D printed PPE, using our novel single-walled polypropylene design can help meet increased demands of PPE for healthcare workers and the general public that are needed to help decrease the viral transmission of the coronavirus disease of 2019 (COVID-19) pandemic. 3D printing also has the potential to lead to the creation and production of other sterile material items for the healthcare industry in the future. The ability to re-sterilize 3D printed PPE, as our design shows, would also contribute less to the increase in biomedical waste (BMW) being experienced by COVID-19.

scholarly journals Decontamination methods of personal protective equipment for repeated utilization in medical/surgical settings

2020 ◽  
Vol 8 (34) ◽  
pp. 27-39
Author(s):  
Abdurrahman Kharbat ◽  
Adin Mizer ◽  
Mimi Zumwalt
Keyword(s):  
Personal Protective Equipment ◽  
Healthcare Workers ◽  
Protective Equipment ◽  
Pilot Studies ◽  
Medical Supplies ◽  
Policy Statements ◽  
Repeated Use ◽  
Meta Analyses ◽  
N95 Respirators ◽  
Made In

The COVID-19 pandemic has affected citizens and healthcare workers worldwide due to a number of important factors. The transmission of the SARS CoV-2 microorganism, the pathogen that causes COVID-19 infection, occurs through droplet and aerosol spread due to coughs and sneezes from infected patients. A panicked public began hoarding medical supplies and personal protective equipment (PPE), leaving healthcare workers to care for patients without adequate protection. A literature review was conducted to better understand the options available to hospital and healthcare system administrators as they develop necessary protocols for the conservation and possible reuse of PPE. This review is based upon the peer-reviewed studies of various scientific investigators, biotechnology researchers, governmental agency health officials, including meta-analyses, preliminary/pilot studies, and policy statements. Current findings indicate that extended usage of N95 respirators is practical since there are methods available for the decontamination/repeated use of N95 respirators. In evaluating the efficacy of such methods, the safety of healthcare workers is important in deciding which method to recommend. Available evidence supports the use of the Bioquell Hydrogen Peroxide Vapor (HPV) system for decontaminating N95 respirators. Information on other PPE will also be discussed about more specific items. Informed decisions regarding the policies of hospitals and healthcare systems must be considered, and with the safety of healthcare workers in mind, both factors influenced the recommendations made in this comprehensive review.

scholarly journals Examining the Cost-effectiveness of Personal Protective Equipment for Formal Healthcare Workers in Kenya during the COVID-19 Pandemic

2021 ◽  
Author(s):  
Jacob Kazungu ◽  
Kenneth Munge ◽  
Kalin Werner ◽  
Nicholas Risko ◽  
Andres Vecino Ortiz ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Healthcare Worker ◽  
Personal Protective Equipment ◽  
Return On Investment ◽  
Healthcare Workers ◽  
Health Economic Evaluation ◽  
Response Strategy ◽  
Decision Analytic Model ◽  
Protective Equipment ◽  
The Cost

Abstract Background: Healthcare workers are at a higher risk of COVID-19 infection during care encounters compared to the general population. Personal Protective Equipment (PPE) have been shown to protect COVID-19 among healthcare workers, however, Kenya has faced PPE shortages that can adequately protect all healthcare workers. We, therefore, examined the health and economic consequences of investing in PPE for healthcare workers in Kenya. Methods: We conducted a cost-effectiveness and return on investment (ROI) analysis using a decision-analytic model following the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) guidelines. We examined two outcomes: 1) the cost per healthcare worker death averted, and 2) the cost per healthcare worker COVID-19 case averted. We performed a multivariate sensitivity analysis using 10,000 Monte Carlo simulations. Results: Kenya would need to invest $3.12 million to adequately protect healthcare workers against COVID-19. This investment would avert 416 and 30,041 healthcare worker deaths and COVID-19 cases respectively. Additionally, such an investment would result in a societal ROI of $170.64 million – equivalent to an 11.04 times return. Conclusion: Despite other nationwide COVID-19 prevention measures such as social distancing, over 70% of healthcare workers will still be infected if the availability of PPE remains scarce. As part of the COVID-19 response strategy, the government should consider adequate investment in PPE for all healthcare workers in the country as it provides a large return on investment and it is value for money.

scholarly journals Determining the source of transmission of SARS-CoV-2 infection in a healthcare worker

2020 ◽  
Author(s):  
Nasia Safdar ◽  
Gage K. Moreno ◽  
Katarina M. Braun ◽  
Thomas C. Friedrich ◽  
David H. O’Connor
Keyword(s):  
Infection Control ◽  
Healthcare Worker ◽  
Personal Protective Equipment ◽  
Healthcare Workers ◽  
Total Population ◽  
Protective Equipment ◽  
Hospital Infection Control ◽  
Risk Of Exposure ◽  
N95 Respirators ◽  
Cumulative Prevalence

BackgroundHealthcare workers (HCWs) are at the frontlines of the COVID-19 pandemic and are at risk of exposure to SARS-CoV-2 infection from their interactions with patients and in the community (1, 2). Limited availability of recommended personal protective equipment (PPE), in particular N95 respirators, has fueled concerns about whether HCWs are adequately protected from exposure while caring for patients. Understanding the source of SARS-CoV-2 infection in a HCW – the community or the healthcare system – is critical for understanding the effectiveness of hospital infection control and PPE practices. In Dane County, Wisconsin, community prevalence of SARS-CoV-2 is relatively low (cumulative prevalence of ~0.06% – positive cases / total population in Dane county as of April 17). Although SARS-CoV-2 infections in HCWs are often presumed to be acquired during the course of patient care, there are few reports unambiguously identifying the source of acquisition.ObjectiveTo determine the source of transmission of SARS-CoV-2 in a healthcare worker.

scholarly journals Assessment of N95 respirator decontamination and re-use for SARS-CoV-2

2020 ◽  
Author(s):  
Robert J. Fischer ◽  
Dylan H. Morris ◽  
Neeltje van Doremalen ◽  
Shanda Sarchette ◽  
M. Jeremiah Matson ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Personal Protective Equipment ◽  
Healthcare Workers ◽  
Nosocomial Transmission ◽  
Protective Equipment ◽  
Respiratory Protection ◽  
Single Use ◽  
N95 Respirators

The unprecedented pandemic of SARS-CoV-2 has created worldwide shortages of personal protective equipment, in particular respiratory protection such as N95 respirators. SARS-CoV-2 transmission is frequently occurring in hospital settings, with numerous reported cases of nosocomial transmission highlighting the vulnerability of healthcare workers. In general, N95 respirators are designed for single use prior to disposal. Here, we have analyzed four readily available and often used decontamination methods: UV, 70% ethanol, 70C heat and vaporized hydrogen peroxide for inactivation of SARS-CoV-2 on N95 respirators. Equally important we assessed the function of the N95 respirators after multiple wear and decontamination sessions.

scholarly journals Moldable Mask: A Reusable, Hot Water Moldable, Additively Manufactured Mask to Be Used as an N95 Alternative

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 7082
Author(s):  
Erica Martelly ◽  
Charles Li ◽  
Kenji Shimada
Keyword(s):  
Personal Protective Equipment ◽  
Early Stage ◽  
Hot Water ◽  
Protective Equipment ◽  
Viable Option ◽  
High Demand ◽  
Mask Design ◽  
3D Printed ◽  
N95 Respirators ◽  
At Home

There has been high demand for personal protective equipment (PPE) during the COVID-19 pandemic, especially N95 respirators. Unfortunately, at the early stage of the pandemic, the supply could not meet the demand for N95 respirators, leading to a shortage and unsafe reuse of this form of PPE. We developed the Moldable Mask to ease the demand for N95 respirators by creating a 3D-printed mask that uses a piece of N95 material as a filter. A sheet of N95 material could be used or one N95 respirator to be turned into two masks. The main feature of the mask is the ability to easily mold it in hot water to create a custom fit for each user. It can also be easily assembled at home with affordable materials. The final mask design was qualitatively fit tested on 13 subjects, with all subjects showing an improvement in fit with the hot water molding technique and 10 (77%) subjects passing the fit test. This shows that the Moldable Mask is a viable option for a safe, affordable N95 alternative when N95 mask supply is strained.

scholarly journals Medical Students Volunteering during COVID-19 Pandemic: Synopsis of Some Student-led Initiatives in Nepal

2021 ◽  
Vol 59 (240) ◽  
Author(s):  
Pragyan Basnet ◽  
Anjali Joshi
Keyword(s):  
Medical Students ◽  
Personal Protective Equipment ◽  
General Public ◽  
Healthcare Workers ◽  
Healthcare Professionals ◽  
Protective Equipment ◽  
Telemedicine Service ◽  
Raising Awareness ◽  
Security Personnel ◽  
Frontline Healthcare Workers

The efforts shown by healthcare professionals, security personnel and the general public in fighting Coronavirus Disease 2019 pandemic is highly appreciable. Medical students are future healthcare professionals and have the opportunity to volunteer and help their seniors fight Coronavirus Disease 2019 pandemic. In Nepal, we as medical students are contributing by raising awareness about Coronavirus Disease 2019 along with some innovative initiatives which are Project Personal Protective Equipment, Project Telemedicine and the ″Donate Plasma, Help Defeat COVID-19″ Campaign. Since we were able to support thousands of frontline healthcare workers with personal protective equipment and reduce burden in hospitals by providing telemedicine service, we believe such volunteering and initiations from medical students can be an inspiration for all students for future crises.

scholarly journals Effectiveness of an Ozone Disinfecting and Sanitizing Cabinet to Decontaminate a Surrogate Virus for SARS-CoV-2 on N-95 Masks

2020 ◽  
Author(s):  
Megan S. Beaudry ◽  
Julia C. Frederick ◽  
Megan E. J. Lott ◽  
William A. Norfolk ◽  
Travis C. Glenn ◽  
...  
Keyword(s):  
Personal Protective Equipment ◽  
Healthcare Workers ◽  
Ozone Treatment ◽  
Protective Equipment ◽  
Personal Protection ◽  
Medical Providers ◽  
Household Dust ◽  
Ms2 Bacteriophage ◽  
Innovative Methods ◽  
N95 Respirators

AbstractMedical demands during the COVID-19 pandemic have triggered a grave shortage of medical-grade personal protective equipment (PPE), especially, N95 respirators. N95 respirators are critical for the personal protection of medical providers and others when being exposed to individuals with infections caused by the SARS-CoV-2 coronavirus. To address the shortage of N95 respirators, innovative methods are needed to decontaminate coronaviruses from N95 respirators, allowing them to be safely reused by healthcare workers. For this research, we use a commercial ozone disinfecting cabinet to examine the efficacy of ozone-based disinfection of a conservative surrogate virus for SARS-CoV-2, the MS2 bacteriophage. Treatment of mask materials with enhanced ozone treatment resulted in 2.38-log 10 (>99%) reduction of phage from household dust masks and a range of 1.43-log 10 (96.2%) to 4-log 10 (99.99%) reductions of phage from common N95 mask materials.

scholarly journals Assessment of N95 respirator decontamination and re-use for SARS-CoV-2

2020 ◽  
Author(s):  
Robert J. Fischer ◽  
Dylan H. Morris ◽  
Neeltje van Doremalen ◽  
Shanda Sarchette ◽  
Jeremiah Matson ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Uv Radiation ◽  
Personal Protective Equipment ◽  
Healthcare Workers ◽  
Nosocomial Transmission ◽  
Protective Equipment ◽  
Respiratory Protection ◽  
Single Use ◽  
N95 Respirators

The unprecedented pandemic of SARS-CoV-2 has created worldwide shortages of personal protective equipment, in particular respiratory protection such as N95 respirators. SARS-CoV-2 transmission is frequently occurring in hospital settings, with numerous reported cases of nosocomial transmission highlighting the vulnerability of healthcare workers. In general, N95 respirators are designed for single use prior to disposal. Several groups have addressed the potential for re-use of N95 respirators from a mechanical or from a decontamination perspective. Here, we analyzed four different decontamination methods – UV radiation (260 – 285 nm), 70ºC heat, 70% ethanol and vaporized hydrogen peroxide (VHP) – for their ability to reduce contamination with infectious SARS-CoV-2 and their effect on N95 respirator function.

scholarly journals Protection Level and Reusability of a Modified Full-Face Snorkel Mask as Alternative Personal Protective Equipment for Healthcare Workers During the COVID-19 Pandemic

2020 ◽  
Author(s):  
Jean Schmitt ◽  
Lewis S. Jones ◽  
Elise A. Aeby ◽  
Christian Gloor ◽  
Berthold Moser ◽  
...  
Keyword(s):  
Personal Protective Equipment ◽  
Healthcare Workers ◽  
Large Scale ◽  
Low Cost ◽  
Face Mask ◽  
Protective Equipment ◽  
Additional Protection ◽  
Small Virus ◽  
3D Printed ◽  
Full Face

The worldwide outbreak of the COVID-19 drastically increased pressure on medical resources and highlighted the need for rapidly available, large-scale and low-cost personal protective equipment (PPE). In this work, an alternative full-face mask is adapted from a modified snorkel mask to be used as PPE with two medical grade filters and a 3D-printed adapter. As the mask covers the eyes, mouth and nose, it acts as a full-face shield, providing additional protection to healthcare workers. The filtration efficiency of different medical filters is measured for particles below 300 nm to cover the size of the SARS-CoV-2 and small virus-laden droplets. The filtration performance of the adapted full-face mask is characterized using NaCl particles below 500 nm and different fitting scenarios. The mask is compared to a commercial respirator and characterized according to the EN 149 standard, demonstrating that the protection fulfills the requirements for the FFP2 level (filtering face-piece 2, stopping at least 94% of airborne particles). The device shows a good resistance to several cycles of decontamination (autoclaving and ethanol immersion), is easy to be produced locally at low cost and helps addressing the shortage in FFP2 masks and face shields by providing adequate protection to healthcare workers against particles below 500 nm.

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