scholarly journals Effect of caffeine on delayed-onset muscle soreness: a meta-analysis of RCT

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Janisa Andrea Maljadi ◽  
Patsorn Kaewphongsri ◽  
Kornkit Chaijenkij ◽  
Jatupon Kongtharvonskul

Abstract Background There are multiple strategies that have been suggested to attenuate delayed-onset muscle soreness (DOMS). Caffeine has been shown to assist with blocking pain associated with DOMS. However, currently there is still controversy over the effects of caffeine use. Main body We conducted a meta-analysis to compare pain associated with muscle soreness by both the VAS and indirect markers by CK of caffeine and placebo after exercise. The meta-analysis was carried out in accordance with the PRISMA guidelines. Relevant studies from Medline and Scopus published up to May 20, 2021, were included, which resulted in a total of 477 and 132 studies being retrieved from Scopus and Medline, respectively. Seven studies met the inclusion criteria, and in these, there were 68 persons in the caffeine group and 74 persons in the placebo group. A visual analog score of muscle soreness was recorded pre-exercise, immediately post-exercise, and at one to four days post-exercise; the scores at these time points in the caffeine group as compared to those in the placebo group progressed from 0.00 (95% CI − 0.51, 0.50) to − 0.20 (− 1.09, 0.69), − 0.92 (− 2.20, 0.36), − 1.02 (− 1.86, − 0.19), 0.00 (− 0.36, 0.36), and 0.18 (− 0.56, 0.92), respectively. No statistically significant differences were noted for CK between the two groups at 24 h post-exercise. Short conclusion Our meta-analysis results indicate that caffeine supplements reduce delayed-onset muscle soreness when compared to a placebo 48 h after exercise. However, at 24 h post-exercise, caffeine can reduce DOMS only in people who worked on resistant exercise. The CK used in this meta-analysis did not show any differences. Trial registration: PROSPERO CRD42021260248. Level of evidence I.

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Natthanichar Rattanaseth ◽  
Patteera Panyarapeepat ◽  
Janisa Andrea Muljadi ◽  
Kornkit Chaijenkij ◽  
Jatupon Kongtharvonskul

Abstract Background There are multiple strategies that have been suggested to attenuate delayed onset muscle soreness (DOMS). Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation. However, currently, there is still controversy. Main body of the abstract We conduct this meta-analysis according to the PRISMA guidelines. Relevant studies were included from Medline and Scopus from the date of inception to May 04th, 2021 that reported VAS score, blood markers (creatinine kinese (CK), tumor necrotic factor (TNF)-α and interleukin (IL)-6) and range of motion of either group. There were total of 13 studies including 202 and 176 persons in curcumin and placebo group. The unstandardized mean difference (UMD) of VAS muscle soreness in post-exercise, 1, 2, 3 and 4 days was − 0.12 (95% CI − 0.46, 0.22), − 0.38 (− 0.83, 0.08), − 0.67 (− 1.19, − 0.16), − 0.86 (− 1.38, − 0.34), − 0.81 (− 1.27, − 036) and − 1.24 (− 1.50, − 0.99) scores lower in curcumin when compared to placebo. The UMD of CK was − 11.07 (95% CI − 24, 1.86), − 37.51 (− 68.04, − 6.97), − 45.40 (− 95.67, 4.86), − 53.33 (− 128.11, 21.45), − 90.98 (− 173.45, − 8.51) and 117.84 (− 338.69, 574.37) lower in curcumin when compared to placebo. No statistically significantly differences were noted for IL-6, TNF-α and ROM between two groups. Short conclusion This meta-analysis suggested that curcumin supplement reduced delayed onset muscle soreness and CK after exercise in 1, 2, 3, and 4 days when compared to placebo. However, TNF and IL were not affected by curcumin ingestion. Level of evidence I.


Author(s):  
Yutan Wang ◽  
Hongmei Lu ◽  
Sijun Li ◽  
Yuanyuan Zhang ◽  
Fanghong Yan ◽  
...  

Objective: To comprehensively compare the effectiveness of cold and heat therapies for delayed onset muscle soreness using network meta-analysis. Methods: Eight Chinese and English databases were searched from date of establishment of the database to 31 May 2021. Cochrane risk-of-bias tool was used to analyse the included randomized controlled trials. Potential papers were screened for eligibility, and data were extracted by 2 independent researchers. Results: A total of 59 studies involving 1,367 patients were eligible for this study. Ten interventions were examined: contrast water therapy, phase change material, the novel modality of cryotherapy, cold-water immersion, hot/warm-water immersion, cold pack, hot pack, ice massage, ultrasound, and passive recovery. Network meta-analysis results showed that: (i) within 24 h after exercise, hot pack was the most effective for pain relief, followed by contrast water therapy; (ii) within 48 h, the ranking was hot pack, followed by the novel modality of cryotherapy; and (iii) over 48 h post-exercise, the effect of the novel modality of cryotherapy ranked first. Conclusion: Due to the limited quality of the included studies, further well-designed research is needed to draw firm conclusions about the effectiveness of cold and heat therapies for delayed onset muscle soreness. Lay Abstract The effects of different methods of cold and heat therapy on pain in patients with delayed onset muscle soreness are debated, and there is uncertainty regarding the most effective of these therapies. The aim of this study was to evaluate the effects of different cold and heat treatments on pain in patients with delayed onset muscle soreness. Using network meta-analysis and ranking, it was found that, within 48 h post-exercise, use of hot-pack was superior to other interventions, whereas, over 48 h post-exercise, cryotherapy was the optimal intervention for pain relief in patients with delayed onset muscle soreness.


2016 ◽  
Vol 32 (1) ◽  
pp. 249-250
Author(s):  
Fernando Kenji Nampo ◽  
Vinícius Cavalheri ◽  
Solange de Paula Ramos ◽  
Enilton Aparecido Camargo

2020 ◽  
Author(s):  
Thilo Hotfiel ◽  
Svenja Höger ◽  
Armin M. Nagel ◽  
Michael Uder ◽  
Wolfgang Kemmler ◽  
...  

Abstract Background: The impact of compression on overexertion-related muscle injuries such as delayed-onset muscle soreness (DOMS) is a subject of controversy. Identifying the mechanisms, optimal conditions, and application settings under which compression therapy may alter muscle metabolism and improve recovery is crucial. The purpose of this study was to investigate the effects of wearing below-knee compression garments during exercise and a post-exercise period of 6 hours on clinical, functional, and morphological outcomes in DOMS in the lower limb.Methods: Eighteen healthy volunteers (age: 24.1 ±3.6 years, BMI 22.7 ± 2.7 kg/m2) were enrolled in this controlled laboratory study. Repeated measures were aquired at baseline (T0), 6 h (T1), and 48 h (T2) after a standardized eccentric and plyometric exercise protocol, with the participants wearing a compression garment (21-22 mmHg) on a randomly selected calf during and for the first 6 h after exercise. Magnet resonance imaging (MRI) was performed using a 3T scanner for quantification of intramuscular edema (T2 signal intensity (SI), T2 time, and manual volume segmentation); jump height, calf circumference, ankle dorsiflexion (DF), creatine kinase (CK) levels, and muscle soreness were assessed for clinical and functional evaluation. Results: DOMS was confirmed in all participants after 48 h, with a significant increase in muscle soreness (p < 0.001) and CK levels (p = 0.001), decrease in jump height (p < 0.01), and the presence of intramuscular edema (p < 0.01) in both the compressed and non-compressed limbs. No differences between the compressed and non-compressed limbs were observed for muscle soreness and jump height at any point in time. Similarly, MRI T2 SI, T2 time, soreness, and manual segmentation revealed no significant effect of the compression treatment. The assessment of calf circumference and DF showed no statistically significant changes at any point of time in either the compression or non-compression limb (p = 1.0). Conclusions: The continuous application of below-knee compression garments during combined eccentric and plyometric exercise and until 6 h post-exercise has no significant effect on clinical signs of DOMS, jump performance, or the development of intramuscular edema observed in MRI.


Motricidade ◽  
2018 ◽  
Vol 14 (2-3) ◽  
pp. 129-137 ◽  
Author(s):  
Aline Machado Araujo ◽  
Rodrigo Kohn Cardoso ◽  
Airton José Rombaldi

The study aimed to review the literature on the effects related to post-exercise of graduated compression garments (GCGs) use on muscle recovery and delayed onset muscle soreness. The search was performed in Pubmed/Medline, Bireme, Scielo, and Lilacs electronic databases using the following descriptors in English: "compression clothing", "physical exercise", "recovery", "physical activity", "compression stockings" and "delayed onset muscle soreness". The search resulted in 102 articles and after removing duplicates, applying exclusion criteria and checking the reference lists, nine studies fulfilled the criteria and were included in the review. Seven studies associated the use of GCGs with reduction of delayed muscle soreness and improvement in performance after the use of compression clothes. However, the methodological quality of the studies, using PEDro scale, presented an average of 5.1±0.9 points (out of a total of 11 points), classified as intermediate. In conclusion, although the positive effects of using CGCs on improving recovery and reduction of delayed muscle soreness after physical exercises are almost consensual, the insufficient methodological quality of the included studies requires careful consideration of the results.


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