Ecological risk factors of soil-transmitted helminths infections in Ifedore district, Southwest Nigeria

Abstract Background Soil-Transmitted Helminths are a group of parasites that cause gastrointestinal infections in humans and require the soil to develop into their infective forms. Ecological factors such as soil temperature, soil pH and rainfall patterns are, however, important determinants for the successful transmission of soil helminths as they play a major role in their abundance and survival in the soil. The study investigated the ecological factors influencing the transmission of soil-transmitted helminths in Ifedore district, Southwest Nigeria. Results Out of the one hundred and ninety-two (192) soil samples from the study area, one hundred and fifty-two 152 (79.2%) were positive for the presence of soil helminths’ larvae and ova. Higher occurrence of soil helminths was recorded during the rainy months (n = 416) than during the months with no records of rainfall (n = 290). Sandy soil had the highest number of soil helminths 285 (40.4%), while clay soil recorded the least 88 (12.5%). Soil temperature showed negative correlations with the occurrence of Ancylostoma duodenale (r = − 0.53) and Strongyloides stercoralis larvae (r = − 0.36), while soil conductivity showed positive correlations with the occurrence of Ascaris lumbricoides (r = 0.28) and A. duodenale (r = 0.34). Conclusion It is evident from the study that ecological factors played a significant role in the occurrence and abundance of soil-transmitted helminths. This research is important for predicting and monitoring soil-transmitted helminthiasis in endemic countries, and to devise effective control measures.

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Occurrence of Soil-transmitted Helminths from Selected Dumpsites and Farmlands in Calabar, Nigeria

Annual Research & Review in Biology ◽

10.9734/arrb/2021/v36i530371 ◽

2021 ◽

pp. 14-22

Author(s):

Edema Enogiomwan Imalele ◽

Effanga Emmanuel Offiong ◽

Usang Anok Ukam ◽

Aramushu Willington Urimaneh ◽

Henshaw Victoria Utibe

Keyword(s):

Strongyloides Stercoralis ◽

Dry Season ◽

Soil Samples ◽

Effective Control ◽

Soil Nematode ◽

Helminth Parasites ◽

Wet Season ◽

Potential Health ◽

Soil Transmitted Helminths ◽

Farmland Soils

Aims: The present study investigated the prevalence and intensity of soil-transmitted helminth contamination in dumpsite and farmland soils in Calabar, Cross River State, Nigeria. Methodology: Soil samples were randomly collected from selected dumpsites and farmlands from July to December 2019. 200 soil samples (100 samples each from dumpsites and farmland) were collected. Soil samples were analysed using Zinc sulphate flotation technique whereas soil nematode extraction for hookworm and Strongyloides larvae was carried out using the modified Baermann technique. Results: Of the 200 soil samples examined, 131 (65.5%) were positive for ova/larvae of one or more parasites. Dumpsite soils were highly contaminated with ova/larvae of soil-transmitted helminths than farmland soils with a prevalence of 79% (n=79) and 52% (n=52) respectively (P=.02). Farmlands had the highest mean intensity (6.75±1.88) of contamination with ova/larvae of soil-transmitted helminths compared to dumpsite soils (1.68±0.14). Ascaris lumbricoides recorded the highest occurrence (35.5%) (P=.003) in soil samples examined. A. lumbricoides (40%) and Trichuris trichiura (6%) contamination was higher in dumpsite soils, while Strongyloides stercoralis larvae (34%) and hookworm (10%) contamination was higher in farmland soils. Dumpsite soils recorded the highest number of parasites (84%) in the wet season, while farmland soils recorded the highest number of parasites (92%) in the dry season (P=.11). Generally, parasitic ova/larvae were more prevalent in the dry season (91%) than in the wet season (73%) (P=.33). S. stercoralis (33%) was more prevalent in the wet season followed while A. lumbricoides (43%) recorded highest occurrence in the dry season. Conclusion: This study revealed the potential health risk of contracting soil-transmitted helminth parasites in soils around farmlands and dumpsites in Calabar, Nigeria. It is therefore important that a combination of sanitation and health education be put in place for effective control of soil-transmitted helminths.

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A Nursery Outbreak of Multiple-Aminoglycoside-Resistant Escherichia coli

Infection Control ◽

10.1017/s0195941700061038 ◽

1984 ◽

Vol 5 (11) ◽

pp. 519-524 ◽

Cited By ~ 7

Author(s):

Robert R Gaynes ◽

Diane Simpson ◽

Sally A. Reeves ◽

Robert C. Noble ◽

Clyde Thornsberry ◽

...

Keyword(s):

Escherichia Coli ◽

Neonatal Intensive Care ◽

Control Measures ◽

Effective Control ◽

Blood Isolate ◽

E Coli ◽

Feeding Duration ◽

Matched Case ◽

Continuous Feeding ◽

The One

AbstractIn the neonatal intensive care unit (NICU) of one hospital, 16 infants became colonized or infected with multiply-resistant Escherichia coli (MR-E.coli) over an 8-month period. Isolates were obtained from blood, urine, and sputum of three patients and from rectal surveillance cultures of 13 patients. The one patient with the blood isolate died. A matched case-control study identified continuous feeding (nine of 16 cases vs. one of 16 controls, p ≤ 0.001) and receipt of aminoglycosides (p ≤ 0.03) as risk factors. For case-babies not exposed to continuous feeding, duration of bolus feeding was significantly greater than for their controls (cases, 22 days; controls, 7 days; p ≤ 0.02). All 16 isolates were the same serotype and were resistant to amikacin, tobramycin, kanamycin, and gentamicin. The epidemiologic investigation suggested that MR-E. coli may have spread from person-to-person on the hands of personnel and that MR-E. coli persisted in the NICU for 8 months until effective control measures were instituted.

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Characterizing the effectiveness of COVID-19 mitigation measures: A data-centric approach (Preprint)

10.2196/preprints.21321 ◽

2020 ◽

Author(s):

Lukman Olagoke ◽

Ahmet E. Topcu

Keyword(s):

Control Measure ◽

Control Measures ◽

World Health ◽

Mitigation Measures ◽

Effective Control ◽

The World ◽

Decision Making Processes ◽

And Performance ◽

Health Organization ◽

The Impact

BACKGROUND COVID-19 represents a serious threat to both national health and economic systems. To curb this pandemic, the World Health Organization (WHO) issued a series of COVID-19 public safety guidelines. Different countries around the world initiated different measures in line with the WHO guidelines to mitigate and investigate the spread of COVID-19 in their territories. OBJECTIVE The aim of this paper is to quantitatively evaluate the effectiveness of these control measures using a data-centric approach. METHODS We begin with a simple text analysis of coronavirus-related articles and show that reports on similar outbreaks in the past strongly proposed similar control measures. This reaffirms the fact that these control measures are in order. Subsequently, we propose a simple performance statistic that quantifies general performance and performance under the different measures that were initiated. A density based clustering of based on performance statistic was carried out to group countries based on performance. RESULTS The performance statistic helps evaluate quantitatively the impact of COVID-19 control measures. Countries tend show variability in performance under different control measures. The performance statistic has negative correlation with cases of death which is a useful characteristics for COVID-19 control measure performance analysis. A web-based time-line visualization that enables comparison of performances and cases across continents and subregions is presented. CONCLUSIONS The performance metric is relevant for the analysis of the impact of COVID-19 control measures. This can help caregivers and policymakers identify effective control measures and reduce cases of death due to COVID-19. The interactive web visualizer provides easily digested and quick feedback to augment decision-making processes in the COVID-19 response measures evaluation. CLINICALTRIAL Not Applicable

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African Sustainability Advocacy Against Extractivism

INTERdisciplina ◽

10.22201/ceiich.24485705e.2015.7.52408 ◽

2015 ◽

Vol 3 (7) ◽

Author(s):

Patrick Bond

Keyword(s):

Social Reproduction ◽

Fossil Fuels ◽

Social Economic ◽

Social Activism ◽

Ecological Factors ◽

Energy Economics ◽

Extractive Industries ◽

The One ◽

Political Economic ◽

Critical Challenge

Abstract | The challenge of interdisciplinary intellectual and strategic work in the extractive industries is particularly acute at the interface of research and social activism. Numerous social movements which are dedicated to sustainability fail to ‘connect the dots’ between their campaigns and broader political-economic and political-ecological visions. This is becoming a critical challenge in Africa, where the extreme damage done by mining and fossil fuels has generated impressive resistance.However, the one obvious place to link these critiques from African activists was the Alternative Mining Indaba in Cape Town in February 2015, and a survey of narratives at that event leads to pessimism about interdisciplinary politics. The potential for much greater impact and deeper critiques of unsustainable extractivism lies in greater attention to combining social reproduction and production (as do eco-feminists), and to tackling social, economic, political and ecological factors with a more explicit structuralist critique and practical toolkit. Areas such as energy, economics and climate are ripe for linkages. One reason for optimism is a climate justice declaration made by leading civil society activists in Maputo in April 2015.

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Infection control measures in times of antimicrobial resistance: a matter of solidarity

Bioethics News ◽

10.1007/s40592-020-00119-9 ◽

2020 ◽

Vol 38 (S1) ◽

pp. 47-55 ◽

Cited By ~ 1

Author(s):

Babette Rump ◽

Aura Timen ◽

Marlies Hulscher ◽

Marcel Verweij

Keyword(s):

Well Being ◽

Multidrug Resistant ◽

Additional Benefit ◽

Control Measures ◽

Individual Autonomy ◽

Compensation Policy ◽

Public Interests ◽

Infection Control Measures ◽

Baseline Levels ◽

The One

AbstractControl measures directed at carriers of multidrug-resistant organisms are traditionally approached as a trade-off between public interests on the one hand and individual autonomy on the other. We propose to reframe the ethical issue and consider control measures directed at carriers an issue of solidarity. Rather than asking “whether it is justified to impose strict measures”, we propose asking “how to best care for a person’s carriership and well-being in ways that do not imply an unacceptable risk for others?”. A solidarity approach could include elevating baseline levels of precaution measures and accepting certain risks in cases where there is exceptionally much at stake. A generous national compensation policy that also covers for costs related to dedicated care is essential in a solidarity approach. An additional benefit of reframing the questions is that it helps to better acknowledge that being subjected to control measures is a highly personal matter.

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Tolerance and Control. Developing a language policy for an EMI university in Uzbekistan

Sociolinguistica - International Yearbook of European Sociolinguistics / Internationales Jahrbuch für europäische Soziolinguistik ◽

10.1515/soci-2020-0013 ◽

2020 ◽

Vol 34 (1) ◽

pp. 217-237

Author(s):

Andrew Linn ◽

Anastasiya Bezborodova ◽

Saida Radjabzade

Keyword(s):

Higher Education ◽

Language Policy ◽

Control Measures ◽

The Other ◽

Language Policies ◽

Language Ecology ◽

English Only ◽

English Medium Instruction ◽

The One ◽

And Control

AbstractThis article presents a practical project to develop a language policy for an English-Medium-Instruction university in Uzbekistan. Although the university is de facto English-only, it presents a complex language ecology, which in turn has led to confusion and disagreement about language use on campus. The project team investigated the experience, views and attitudes of over a thousand people, including faculty, students, administrative and maintenance staff, in order to arrive at a proposed policy which would serve the whole community, based on the principle of tolerance and pragmatism. After outlining the relevant language and educational context and setting out the methods and approach of the underpinning research project, the article goes on to present the key findings. One of the striking findings was an appetite for control and regulation of language behaviours. Language policies in Higher Education invariably fall down at the implementation stage because of a lack of will to follow through on their principles and their specific guidelines. Language policy in international business on the other hand is characterised by a control stage invariably lacking in language planning in education. Uzbekistan is a polity used to control measures following from policy implementation. The article concludes by suggesting that Higher Education in Central Asia may stand a better chance of seeing through language policies around English-Medium Instruction than, for example, in northern Europe, based on the tension between tolerance on the one hand and control on the other.

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Effectiveness of Epidemic Preventive Policies and Hospital Strategies in Combating COVID-19 Outbreak in Taiwan

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18073456 ◽

2021 ◽

Vol 18 (7) ◽

pp. 3456

Author(s):

Ting Wan Tan ◽

Han Ling Tan ◽

Man Na Chang ◽

Wen Shu Lin ◽

Chih Ming Chang

Keyword(s):

Mortality Rate ◽

Incidence Rate ◽

Risk Ratio ◽

Early Stage ◽

Control Measures ◽

Polymerase Chain Reaction Test ◽

Effective Control ◽

Nasopharyngeal Swab ◽

Preventive Strategies ◽

Epidemic Control

(1) Background: The implementation of effective control measures in a timely fashion is crucial to control the epidemic outbreak of COVID-19. In this study, we aimed to analyze the control measures implemented during the COVID-19 outbreak, as well as evaluating the responses and outcomes at different phases for epidemic control in Taiwan. (2) Methods: This case study reviewed responses to COVID-19 and the effectiveness of a range of control measures implemented for epidemic control in Taiwan and assessed all laboratory-confirmed cases between 11 January until 20 December 2020, inclusive of these dates. The confirmation of COVID-19 infection was defined as the positive result of a reverse-transcriptase–polymerase-chain-reaction test taken from a nasopharyngeal swab. Test results were reported by the Taiwan Centers for Disease Control. The incidence rate, mortality rate, and testing rate were compiled, and the risk ratio was provided to gain insights into the effectiveness of prevention measures. (3) Results and Discussion: This study presents retrospective data on the COVID-19 incidence rate in Taiwan, combined with the vital preventive control measures, in a timeline of the early stage of the epidemic that occurred in Taiwan. The implementation of multiple strategy control measures and the assistance of technologies to control the COVID-19 epidemic in Taiwan led to a relatively slower trend in the outbreak compared to the neighboring countries. In Taiwan, 766 confirmed patients were included, comprised of 88.1% imported cases and 7.2% local transmission cases, within the studied period. The incidence rate of COVID-19 in Taiwan during the studied period was 32 per million people, with a mortality rate of 0.3 per million people. Our analysis showed a significantly raised incidence risk ratio in the countries of interest in comparison to Taiwan during the study period; in the range of 1.9 to 947.5. The outbreak was brought under control through epidemic policies and hospital strategies implemented by the Taiwan Government. (4) Conclusion: Taiwan’s preventive strategies resulted in a drastically lower risk for Taiwan nationals of contracting COVID-19 when new pharmaceutical drug or vaccines were not yet available. The preventive strategies employed by Taiwan could serve as a guide and reference for future epidemic control strategies.

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Molecular Identification of Mushroom Species in Italy: An Ongoing Project Aimed at Reinforcing the Control Measures of an Increasingly Appreciated Sustainable Food

Sustainability ◽

10.3390/su13010238 ◽

2020 ◽

Vol 13 (1) ◽

pp. 238

Author(s):

Alice Giusti ◽

Enrica Ricci ◽

Laura Gasperetti ◽

Marta Galgani ◽

Luca Polidori ◽

...

Keyword(s):

Selection Process ◽

Winning Strategy ◽

Control Measures ◽

Effective Control ◽

Mushroom Poisoning ◽

Clinical Samples ◽

Similar Species ◽

Mushroom Species ◽

Ongoing Research ◽

Genotypic Analysis

Proper investment in mushroom production (farming and wild mushroom picking activities) may represent a winning strategy for many countries, including Italy, to better face the problems of food security and environmental impact, and to break away from imports, enhancing the local products. However, the risk related to the consumption of poisoning species requires governments to implement or reinforce effective control measures to protect consumers. Mushroom identification by phenotype observation is hardly applicable if morphologically-similar species, non-whole specimens, or clinical samples are involved. Genotypic analysis is a valid alternative. An ongoing research project involving the Experimental Zooprophylactic Institute of Lazio and Tuscany, the regional Mycological Inspectorate, the Tuscany Mycological Groups Association, and the Department of Veterinary Sciences of the University of Pisa aims to reinforce the collaboration among institutions for the management of mushroom poisoning. The core’s project aims to develop an internal genetic database to support the identification of wild and cultivated mushroom species in the Italian territory. The database will include Internal Transcribed Spacer (ITS) sequences retrieved from official databases (the NCBI GenBank and the BOLD system) which are considered to be reliable, after a proper selection process, and sequences from specimens collected directly and identified by expert mycologists. Once it is validated, the database will be available and further implementable by the official network of national laboratories.

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Timing and Route of Contamination of Patient Rooms With Healthcare-Associated Pathogens

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.1066 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s412-s412

Author(s):

Sarah Redmond ◽

Jennifer Cadnum ◽

Basya Pearlmutter ◽

Natalia Pinto Herrera ◽

Curtis Donskey

Keyword(s):

Acute Care Hospital ◽

Current Control ◽

Pathogen Transmission ◽

Control Measures ◽

Effective Control ◽

Portable Devices ◽

Care Hospital ◽

Spa Typing ◽

Persistent Problem ◽

Healthcare Associated

Background: Transmission of healthcare-associated pathogens such as Clostridioides difficile and methicillin-resistant Staphylococcus aureus (MRSA) is a persistent problem in healthcare facilities despite current control measures. A better understanding of the routes of pathogen transmission is needed to develop effective control measures. Methods: We conducted an observational cohort study in an acute-care hospital to identify the timing and route of transfer of pathogens to rooms of newly admitted patients with negative MRSA nares results and no known carriage of other healthcare-associated pathogens. Rooms were thoroughly cleaned and disinfected prior to patient admission. Interactions of patients with personnel and portable equipment were observed, and serial cultures for pathogens were collected from the skin of patients and from surfaces, including those observed to come in contact with personnel and equipment. For MRSA, spa typing was used to determine relatedness of patient and environmental isolates. Results: For the 17 patients enrolled, 1 or more environmental cultures became positive for MRSA in rooms of 10 patients (59%), for C. difficile in rooms of 2 patients (12%) and for vancomycin-resistant enterococci (VRE) in rooms of 2 patients (12%). The patients interacted with an average of 2.4 personnel and 0.6 portable devices per hour of observation. As shown in Figure 1, MRSA contamination of the floor occurred rapidly as personnel entered the room. In a subset of patients, MRSA was subsequently recovered from patients’ socks and bedding and ultimately from the high-touch surfaces in the room (tray table, call button, bedrail). For several patients, MRSA isolates recovered from the floor had the same spa type as isolates subsequently recovered from other sites (eg, socks, bedding, and/or high touch surfaces). The direct transfer of healthcare-associated pathogens from personnel or equipment to high-touch surfaces was not detected. Conclusions: Healthcare-associated pathogens rapidly accumulate on the floor of patient rooms and can be transferred to the socks and bedding of patients and to high-touch surfaces. Healthcare facility floors may be an underappreciated source of pathogen dissemination not addressed by current infection control measures.Funding: NoneDisclosures: None

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Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67

BMC Genomics ◽

10.1186/s12864-021-07555-9 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Cui Zhang ◽

Cihan Oguz ◽

Sue Huse ◽

Lu Xia ◽

Jian Wu ◽

...

Keyword(s):

Dna Sequences ◽

Malaria Parasite ◽

Vaccine Development ◽

De Novo ◽

Gene Families ◽

Plasmodium Yoelii ◽

Control Measures ◽

Effective Control ◽

Malaria Parasites ◽

Rodent Malaria

Abstract Background Rodent malaria parasites are important models for studying host-malaria parasite interactions such as host immune response, mechanisms of parasite evasion of host killing, and vaccine development. One of the rodent malaria parasites is Plasmodium yoelii, and multiple P. yoelii strains or subspecies that cause different disease phenotypes have been widely employed in various studies. The genomes and transcriptomes of several P. yoelii strains have been analyzed and annotated, including the lethal strains of P. y. yoelii YM (or 17XL) and non-lethal strains of P. y. yoelii 17XNL/17X. Genomic DNA sequences and cDNA reads from another subspecies P. y. nigeriensis N67 have been reported for studies of genetic polymorphisms and parasite response to drugs, but its genome has not been assembled and annotated. Results We performed genome sequencing of the N67 parasite using the PacBio long-read sequencing technology, de novo assembled its genome and transcriptome, and predicted 5383 genes with high overall annotation quality. Comparison of the annotated genome of the N67 parasite with those of YM and 17X parasites revealed a set of genes with N67-specific orthology, expansion of gene families, particularly the homologs of the Plasmodium chabaudi erythrocyte membrane antigen, large numbers of SNPs and indels, and proteins predicted to interact with host immune responses based on their functional domains. Conclusions The genomes of N67 and 17X parasites are highly diverse, having approximately one polymorphic site per 50 base pairs of DNA. The annotated N67 genome and transcriptome provide searchable databases for fast retrieval of genes and proteins, which will greatly facilitate our efforts in studying the parasite biology and gene function and in developing effective control measures against malaria.

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