Stability-indicating HPLC-DAD method for the determination of empagliflozin
Keyword(s):
Rp Hplc
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Abstract Background A stability-indicating RP-HPLC method was developed and validated for the estimation of empagliflozin drug and its tablet dosage form using a DAD detector. The mobile phase consisted of methanol/acetonitrile/0.1%OPA (75:20:5). The peak was observed at 2.54 min using 222.0 nm absorption maxima. Results Calibration curve plot was found within the range of 10–50 µg/mL. The coefficient of determination (R2) was found to be 0.9990. Forced degradation studies were performed for the empagliflozin in various conditions, and the results were calculated as %RSD values and were found to be within the limits. Conclusion The method was validated as per ICH guidelines with respect to all validation parameters.
2010 ◽
Vol 93
(2)
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pp. 523-530
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2014 ◽
Vol 2014
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pp. 1-7
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2020 ◽
Vol 10
(6)
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pp. 6610-6618
Stability indicating RP HPLC method for determination of levitiracetam in pharmaceutical formulation
2013 ◽
Vol 1
(04)
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pp. 45-54
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Keyword(s):
Rp Hplc
◽