scholarly journals Pharmaceutical nanotechnology: from the bench to the market

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Zaed M. Mazayen ◽  
Amira M. Ghoneim ◽  
Rasha S. Elbatanony ◽  
Emad B. Basalious ◽  
Ehab R. Bendas
Keyword(s):  
Kidney Diseases ◽  
Physical Stability ◽  
Surface Hydrophobicity ◽  
Main Body ◽  
Characterization Methods ◽  
Factors Affecting ◽  
Supercritical Fluid Technology ◽  
Different Types ◽  
Skin Conditions ◽  
Biological Performance

Abstract Background Nanotechnology is considered a new and rapidly emerging area in the pharmaceutical and medicinal field. Nanoparticles, as drug delivery systems, impart several advantages concerning improved efficacy as well as reduced adverse drug reactions. Main body Different types of nanosystems have been fabricated including carbon nanotubes, paramagnetic nanoparticles, dendrimers, nanoemulsions, etc. Physicochemical properties of the starting materials and the selected method of preparation play a significant aspect in determining the shape and characteristics of the developed nanoparticles. Dispersion of preformed polymers, coacervation, polymerization, nano-spray drying and supercritical fluid technology are among the most extensively used techniques for the preparation of nanocarriers. Particle size, surface charge, surface hydrophobicity and drug release are the main factors affecting nanoparticles physical stability and biological performance of the incorporated drug. In clinical practice, many nanodrugs have been used for both diagnostic and therapeutic applications and are being investigated for various indications in clinical trials. Nanoparticles are used for the cure of kidney diseases, tuberculosis, skin conditions, Alzheimer’s disease, different types of cancer as well as preparation of COVID-19 vaccines. Conclusion In this review, we will confer the advantages, types, methods of preparation, characterization methods and some of the applications of nano-systems.

scholarly journals Whole-Body Regeneration in Sponges: Diversity, Fine Mechanisms, and Future Prospects

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 506
Author(s):  
Alexander Ereskovsky ◽  
Ilya E. Borisenko ◽  
Fyodor V. Bolshakov ◽  
Andrey I. Lavrov
Keyword(s):  
Single Species ◽  
Whole Body ◽  
Phylogenetic Position ◽  
Main Body ◽  
Regenerative Processes ◽  
Cellular Mechanisms ◽  
Different Types ◽  
Dissociated Cells ◽  
Shed Light ◽  
Regeneration Processes

While virtually all animals show certain abilities for regeneration after an injury, these abilities vary greatly among metazoans. Porifera (Sponges) is basal metazoans characterized by a wide variety of different regenerative processes, including whole-body regeneration (WBR). Considering phylogenetic position and unique body organization, sponges are highly promising models, as they can shed light on the origin and early evolution of regeneration in general and WBR in particular. The present review summarizes available data on the morphogenetic and cellular mechanisms accompanying different types of WBR in sponges. Sponges show a high diversity of WBR, which principally could be divided into (1) WBR from a body fragment and (2) WBR by aggregation of dissociated cells. Sponges belonging to different phylogenetic clades and even to different species and/or differing in the anatomical structure undergo different morphogeneses after similar operations. A common characteristic feature of WBR in sponges is the instability of the main body axis: a change of the organism polarity is described during all types of WBR. The cellular mechanisms of WBR are different across sponge classes, while cell dedifferentiations and transdifferentiations are involved in regeneration processes in all sponges. Data considering molecular regulation of WBR in sponges are extremely scarce. However, the possibility to achieve various types of WBR ensured by common morphogenetic and cellular basis in a single species makes sponges highly accessible for future comprehensive physiological, biochemical, and molecular studies of regeneration processes.

scholarly journals Traditional uses, phytochemistry, pharmacology and toxicity of Arisaema (Areaceae): a review

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Heena Ali ◽  
Ubaid Yaqoob
Keyword(s):  
Skin Irritation ◽  
Clinical Applications ◽  
Human Populations ◽  
Main Body ◽  
Anticancer Activities ◽  
Medicinal Uses ◽  
The World ◽  
Different Types ◽  
Tropical Areas ◽  
Medicinal Properties

Abstract Background The genus Arisaema (Areaceae), popularly known as cobra lilies and jack in pulpit is mainly found in temperate to tropical areas of all continents except South America, Europe and Australia and contain about more than 250 species. Arisaema genus is being used by the different folks of human populations for medicinal as well as food purposes. Arisaema plants are used for the treatment of different types of diseases. There have been several attempts to highlight different aspects of genus Arisaema by describing it in terms of phytochemistry and medicinal uses. The present study is, however, an attempt to put together all the former data available related to the phytochemistry and medicinal uses of genus Arisaema. Main body The phytochemicals of the plant include alkaloids, phenols, terpenes, flavonoids, lectins, saponins, glycosides, triterpenoids, stigmasterols, n-alkanes, n-alkanols sitosterols, campesterol, oxalates, coumarins, tannins etc. Moreover, the properties such as antioxidant, antifungal, antibacterial, insecticidal, antimicrobial, cytotoxic, nematocidal, antiallergic antitumour and anticancer activities are also shown by the plants belonging to genus Arisaema. Arisaema plants have been traditionally used to treat various ailments such as resolving phlegm, dampness, and to treat asthma, bronchitis, cold, cough, and laryngitis etc. It has been found that there are several species which are toxic by nature. The development of clinical applications of arisaematis rhizomes had been seriously constrained due to its toxic properties like, mouth and lingua pain, even respiration slowing and suffocation, mucous membrane and skin irritation etc. and this toxicity of arisaematis rhizomes is due to raphide components. Conclusions The collection of data available on the phytochemistry of genus Arisaema is not sufficient as further work is required to do on phytochemical and medicinal basis. The data available on phytochemistry and medicinal properties of the plants belonging to genus Arisaema throws light on various species of Arisaema which are medicinally important and have been exploited to treat different types of diseases in the world.

Deceleration of sliding motorcycles (mainly scooters) in accident reconstructions

2017 ◽  
Vol 232 (7) ◽  
pp. 866-876 ◽  
Author(s):  
Carlo Cialdai ◽  
Dario Vangi ◽  
Antonio Virga
Keyword(s):  
Urban Areas ◽  
Test Session ◽  
Road Accidents ◽  
Factors Affecting ◽  
Different Types ◽  
Energy Dissipated ◽  
Comparison Of The Results ◽  
Two Wheeler ◽  
The Impact ◽  
Good Agreement

This paper presents an analysis of the situation in which a two-wheeler (i.e. a motorcycle, where the term motorcycles includes scooters) falls over to the side and then successively slides; this typically occurs in road accidents involving this type of vehicle. Knowing the deceleration rate of the sliding phase allows the kinetic energy dissipated and the speed of the motorcycle just before the fall to the ground to be calculated. These parameters are very important in the analysis and reconstruction of accidents. The work presented in this paper was developed in two experimental test sessions on fully faired motorcycles which are mainly of the scooter type and widely used in urban areas. In the first session, sliding tests were carried out, with the speed in the range 10–50 km/h, on three different types of road surface. Analysis of the evidence allowed the dissipative main phases of motion of the motorcycle (the impact with the ground, the rebounds and the stabilized swiping) to be identified and some factors affecting the phenomenon to be studied. The coefficient of average deceleration was calculated using two typical equations. The second test session consisted of drag tests. In these tests, the motorcycle, which had previously laid on its side, was dragged for a few metres at a constant speed of about 20 km/h, while the drag force was measured. A comparison of the results obtained in these tests with those obtained in the sliding tests yielded very good agreement in the coefficients of deceleration.

Treating Afro hair loss: signs, symptoms and specialist interest

2021 ◽  
Vol 10 (5) ◽  
pp. 190-197
Author(s):  
Ingrid Wilson
Keyword(s):  
Black Women ◽  
Hair Loss ◽  
Factors Affecting ◽  
Different Types ◽  
Recent Developments ◽  
Hair Care ◽  
Care Practices ◽  
The Aesthetic ◽  
The Impact ◽  
Symptoms And Signs

This article explores the different types of hair loss that black women may experience more than other groups of patients. Properties of African hair and the impact of hair care practices are discussed, as well as factors affecting the presentation of other hair loss conditions. It is important for the aesthetic practitioner to be able to distinguish between the temporary forms of hair loss that they can help to treat and the permanent or scarring forms of hair loss, which need a prompt referral to a dermatologist with a specialist interest in hair. Prompt recognition and referral can help to delay the progression of hair loss. The symptoms and signs that patients and practitioners should be alerted to are explored, as well as the treatments that can help and where referrals may be necessary. Recent developments and gaps in knowledge are summarised.

scholarly journals Mutual fund investors perception in India-a study

2017 ◽  
Vol 7 (1.1) ◽  
pp. 60
Author(s):  
R. Udhayasankar ◽  
K. Maran
Keyword(s):  
Mutual Funds ◽  
Mutual Fund ◽  
Financial Risk ◽  
Fund Raising ◽  
Factors Affecting ◽  
Derivative Instruments ◽  
Different Types ◽  
Small Investors ◽  
Investment Option ◽  
Short Span

Mutual fund is four decades old in India.  It was started by UTI during the year 1964 with few schemes for small investors. During this short span of time it has made tremendous growth in Indian small investors. But now a day’s its volume of investors and sources of investment also growing tremendous level. Moreover mutual fund scheme have added new dimension to overcome financial risk of small investors and also in fund raising capacity of corporate sectors. Mutual fund investors can diversify even more by purchasing different kind of stocks which will helps to spreading out investors’ money across different types of derivative instruments and hence it reduces the risk tremendously up to certain extent and it is automatically diversify in a predetermined category of investments. This serves bridge work between small investors and corporate sectors likewise considering those points in this paper is an attempt to know the investors’ perceptions towards selected mutual funds. This paper makes an attempt to identify various factors affecting perception of investors regarding investment in mutual funds. The findings will helpful to identify the investors’ interest base and factors clearly and it reveals that the investors consider mutual funds as flexible investment option and it creates interest of investment among small investors.

scholarly journals Early-Age Cracking in Concrete: Causes, Consequences, Remedial Measures, and Recommendations

2018 ◽  
Vol 8 (10) ◽  
pp. 1730 ◽  
Author(s):  
Md. Safiuddin ◽  
A. Kaish ◽  
Chin-Ong Woon ◽  
Sudharshan Raman
Keyword(s):  
Service Life ◽  
Concrete Structures ◽  
Real Life ◽  
Early Age ◽  
Structural Elements ◽  
Remedial Measures ◽  
Curing Conditions ◽  
Factors Affecting ◽  
Different Types ◽  
Service Conditions

Cracking is a common problem in concrete structures in real-life service conditions. In fact, crack-free concrete structures are very rare to find in real world. Concrete can undergo early-age cracking depending on the mix composition, exposure environment, hydration rate, and curing conditions. Understanding the causes and consequences of cracking thoroughly is essential for selecting proper measures to resolve the early-age cracking problem in concrete. This paper will help to identify the major causes and consequences of the early-age cracking in concrete. Also, this paper will be useful to adopt effective remedial measures for reducing or eliminating the early-age cracking problem in concrete. Different types of early-age crack, the factors affecting the initiation and growth of early-age cracks, the causes of early-age cracking, and the modeling of early-age cracking are discussed in this paper. A number of examples for various early-age cracking problems of concrete found in different structural elements are also shown. Above all, some recommendations are given for minimizing the early-age cracking in concrete. It is hoped that the information conveyed in this paper will be beneficial to improve the service life of concrete structures. Concrete researchers and practitioners may benefit from the contents of this paper.

scholarly journals Extraction and Nano-Sized Delivery Systems for Phlorotannins to Improve Its Bioavailability and Bioactivity

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 625
Author(s):  
Tianjian Tong ◽  
Xiaoyang Liu ◽  
Chenxu Yu
Keyword(s):  
Functional Food ◽  
Delivery Systems ◽  
Food Supplements ◽  
Polyphenol Compounds ◽  
Characterization Methods ◽  
Natural Polyphenol ◽  
Different Types ◽  
Anti Hiv ◽  
Anti Inflammation

This review aims to provide an informative summary of studies on extraction and nanoencapsulation of phlorotannins to improve their bioavailability and bioactivity. The origin, structure, and different types of phlorotannins were briefly discussed, and the extraction/purification/characterization methods for phlorotannins were reviewed, with a focus on techniques to improve the bioactivities and bioavailability of phlorotannins via nano-sized delivery systems. Phlorotannins are promising natural polyphenol compounds that have displayed high bioactivities in several areas: anticancer, anti-inflammation, anti-HIV, antidiabetic, and antioxidant. This review aims to provide a useful reference for researchers working on developing better utilization strategies for phlorotannins as pharmaceuticals, therapeuticals, and functional food supplements.

scholarly journals Community-based interventions for preventing COVID-19 transmission in low- and middle-income countries:  A systematic review

2020 ◽  
Author(s):  
Master R.O. Chisale ◽  
Sheena Ramazanu ◽  
Joseph Tsung-Shu Wu ◽  
Frank W. Sinyiza ◽  
Thokozani Bvumbwe ◽  
...  
Keyword(s):  
Systematic Review ◽  
World Health ◽  
Flow Diagram ◽  
Main Body ◽  
Community Based Interventions ◽  
Community Based ◽  
Middle Income ◽  
Factors Affecting ◽  
Middle Income Countries ◽  
Low And Middle Income

Abstract Background World Health Organisation (WHO) has approved and recommended several public health measures to halt the Coronavirus Disease 2019 (COVID-19) pandemic. The implementation of recommended interventions vary between higher income and Low and Middle-Income Countries (LMICs). The economical constraints within LMICs posed challenges in accessing resources for COVID-19 prevention. The study aimed to identify the workable community-based interventions being utilised in LMICs.Main body We applied systematic review approach for this study. Included articles were searched in eight online databases. The analysis was guided by the acceptable of best practice developed by the PROSPERO and COCHRANE for systematic search and selection of articles using pre-defined search terms. Furthermore, a PRISMA flow diagram was used to show the number of articles retrieved, retained, excluded with rationales given for every action. Studies conducted on community-based intervention for preventing COVID-19 and levels of knowledge, attitudes and practice (KAP) on community-based intervention for preventing COVID-19 regardless of the design were included. A mixed method appraisal tool (MMAT) was used to appraise studies.Six studies from LMICs were included for detail analysis after the systematic review screening process from 10,100 articles. The quality assessment using MMAT tool appraised these articles were all in highest quality. Among the six articles, 10 community-based interventions were implemented in LMICs. The three key workable and implemented interventions are: use of masks, social distance and hand wash. The review identified varying levels of KAP between LMICs and social-demographical factors affecting KAP in these settings.Conclusion This systematic review has identified the community-based interventions implemented in LMICs to prevent COVID-19 during the pandemic and key factors affecting the level of KAP among the population. This study re-affirms the importance of effective and suitable implementation of the identified interventions. More studies need to be conducted in LMICs to establish the effectiveness and adoption of the implemented and recommended interventions.

scholarly journals A Contribution to the Study of Factors affecting the Quality and Composition of Potatoes

1905 ◽  
Vol 1 (3) ◽  
pp. 347-357 ◽  
Author(s):  
S. F. Ashby
Keyword(s):  
Sandy Soils ◽  
Factors Affecting ◽  
Different Types

The work was undertaken with the hope of establishing some connexion between the characters of soils as shown by chemical and mechanical analyses, and the quality and composition of the potatoes grown on them. As regards quality, most attention has been given to the occurrence of ‘blackening’ after cooking, especially after a second warming up, and an attempt has been made to get at the cause of this phenomenon. This defect has been often complained of by potato growers and dealers, and seriously affects the price of samples marketed for consumption in towns where the largest buyers are hotels and restaurants which demand a potato capable of keeping its colour after a second steaming. ‘Blackening’ is often associated with sandy soils heavily manured with farmyard dung or town manure, and it has been observed in tubers grown with spring dressings of kainite; concordant opinions, however, are not to be had from practical men, and in fact the defect may arise on the most widely different types of soil. In order to exclude disturbances due to variety, ‘Up to Date,’ as one of the most widely grown sorts, has alone been investigated.

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