scholarly journals Investigating dizziness symptom in adult cases with Crimean-Congo hemorrhagic fever using various scales

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Adem Bora ◽  
Seyit Ali Büyüktuna ◽  
Kasım Durmuş ◽  
Berat Baturay Demirkıran ◽  
Yasin Aslan ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Disease Severity ◽  
Daily Living ◽  
Clinical Symptoms ◽  
Hemorrhagic Fever ◽  
The Self ◽  
Multicenter Studies ◽  
Pathophysiological Mechanisms ◽  
Crimean Congo Hemorrhagic Fever ◽  
Vestibular Symptoms

Abstract Background This study was to investigate the frequency of self-reported dizziness symptom in cases with Crimean-Congo hemorrhagic fever (CCHF) and the severity of dizziness, if any, by using various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. Results The frequency of dizziness in CCHF cases included in the study was 11.11% and all the cases were involved in the mild category in terms of disease severity. When the results of the scales applied to all of the cases were evaluated in general, it was seen that there was no vertigo or dizziness. Conclusion According to the results of the present study, we consider that multicenter studies with large series investigating pathophysiological mechanisms underlying these clinical symptoms are needed in order to evaluate dizziness symptom and to make definitive interpretations in CCHF disease.

scholarly journals Mice Orally Immunized with a Transgenic Plant Expressing the Glycoprotein of Crimean-Congo Hemorrhagic Fever Virus

2011 ◽  
Vol 18 (12) ◽  
pp. 2031-2037 ◽  
Author(s):  
S. M. Ghiasi ◽  
A. H. Salmanian ◽  
S. Chinikar ◽  
S. Zakeri
Keyword(s):  
Transgenic Plants ◽  
Transgenic Plant ◽  
Disease Transmission ◽  
Clinical Symptoms ◽  
Hemorrhagic Fever ◽  
Oral Immunization ◽  
Negative Control ◽  
Significant Rise ◽  
Knockout Mouse Model ◽  
Crimean Congo Hemorrhagic Fever

ABSTRACTWhile Crimean-Congo hemorrhagic fever (CCHF) has a high mortality rate in humans, the associated virus (CCHFV) does not induce clinical symptoms in animals, but animals play an important role in disease transmission to humans. Our aim in this study was to examine the immunogenicity of the CCHFV glycoprotein when expressed in the root and leaf of transgenic plants via hairy roots and stable transformation of tobacco plants, respectively. After confirmatory analyses of transgenic plant lines and quantification of the expressed glycoprotein, mice were either fed with the transgenic leaves or roots, fed the transgenic plant material and injected subcutaneously with the plant-made CCHFV glycoprotein (fed/boosted), vaccinated with an attenuated CCHF vaccine (positive control), or received no treatment (negative control). All immunized groups had a consistent rise in anti-glycoprotein IgG and IgA antibodies in their serum and feces, respectively. The mice in the fed/boosted group showed a significant rise in specific IgG antibodies after a single boost. Our results imply that oral immunization of animals with edible materials from transgenic plants is feasible, and further assessments are under way. In addition, while the study of CCHF is challenging, our protocol should be further used to study CCHFV infection in the knockout mouse model and virus neutralization assays in biosafety level 4 laboratories.

The effect of activities of daily living on the self-care agency of patients in a cardiovascular surgery clinic

2017 ◽  
Vol 35 (2) ◽  
pp. 78-85 ◽  
Author(s):  
Papatya Karakurt ◽  
Necla Kasimoğlu ◽  
Aybike Bahçeli ◽  
Sebahat Atalikoğlu Başkan ◽  
Burcu Ağdemir
Keyword(s):  
Activities Of Daily Living ◽  
Daily Living ◽  
Cardiovascular Surgery ◽  
Self Care ◽  
The Self ◽  
Care Agency

scholarly journals Comparison of the Serum Levels of Interferon-α in the Patients With Crimean-Congo Hemorrhagic Fever Based on Disease Severity

2016 ◽  
Vol 1 (2) ◽  
pp. 58-62
Author(s):  
Maliheh Metanat ◽  
Masoud Salehi ◽  
Anita Ale Nabi ◽  
Masoume Noori Jangi ◽  
Alireza Noori Jangi ◽  
...  
Keyword(s):  
Disease Severity ◽  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Interferon Α ◽  
Crimean Congo Hemorrhagic Fever

scholarly journals Diagnosis of internal carotid artery stenosis in a patient referred to a physiotherapist for dizziness

2019 ◽  
Vol 11 (4) ◽  
pp. 373
Author(s):  
Ryan Boggs ◽  
Michael Ross ◽  
Michael Tall
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Clinical Decision Making ◽  
Internal Carotid ◽  
Clinical Symptoms ◽  
Artery Stenosis ◽  
Left Internal Carotid Artery ◽  
Vascular Compromise

ABSTRACT PURPOSEThe purpose of this report is to describe the diagnostic focus of the clinical decision-making process for a patient referred to a physiotherapist for treatment of persistent dizziness, who was subsequently diagnosed with severe stenosis of the internal carotid arteries. CASE DESCRIPTIONThe patient was a 79-year-old man who was referred to a physiotherapist by his primary care physician for the treatment of persistent intermittent dizziness. The patient’s dizziness began 6 months prior insidiously; it was worsening over time and now interfered with activities of daily living. The patient denied cervical pain or headaches, numbness or tingling in his extremities, difficulty maintaining balance with walking, unsteadiness, muscle weakness, dysphagia, drop attacks, diplopia or dysarthria. At the physiotherapist’s initial evaluation, cervical range of motion was moderately restricted in all motions and his dizziness was elicited with changes in head position. The patient’s neurological examination was unremarkable. Due to positional complaints of dizziness, a Dix–Hallpike test was used to screen for benign paroxysmal positional vertigo, which was positive for symptoms reproduction; however, no nystagmus was noted. The patient also became diaphoretic and exhibited significant discoloration of his face during the test. OUTCOMESDue to concern over vascular compromise, carotid duplex ultrasonography and magnetic resonance angiography were completed and revealed near complete occlusion of the left internal carotid artery at its origin. The patient subsequently underwent a left internal carotid endarterectomy with resolution of symptoms and a return to all activities of daily living. DISCUSSIONCarotid artery stenosis, although frequently asymptomatic until severe, may manifest as complaints of dizziness that mimic peripheral vestibular dysfunction. Appropriate and prudent screening and referral is necessary if clinical symptoms suggestive of vascular compromise are present.

Evaluation of Platelet Activity Markers in Prognostic Value of Children with Crimean-Congo Hemorrhagic Fever

2020 ◽  
Vol 15 (03) ◽  
pp. 123-128
Author(s):  
Ahmet Sami Güven ◽  
Fatma Duksal ◽  
Özge Metin Akcan ◽  
Utku Aygüneş ◽  
Mehmet Burhan Oflaz
Keyword(s):  
Disease Severity ◽  
Prognostic Value ◽  
Severe Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Prognostic Index ◽  
Hemorrhagic Fever ◽  
Healthy Children ◽  
Distribution Width ◽  
Crimean Congo Hemorrhagic Fever ◽  
Significant Difference

Abstract Objective The aim of this study is to investigate the prognostic value of platelet (PLT) activity markers in children with Crimean-Congo hemorrhagic fever (CCHF) and compare results with healthy controls. Materials and Methods A total of 135 patients with CCHF and 100 healthy children were included in this retrospective study. Mean age was 12.4 ± 3.3 years in CCHF group, and 92 patients were male. We measured PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and mean platelet mass (MPM) as PLT activity markers. Results A statistically significant decrease in MPM and PLT, and significantly higher levels of PDW and activated partial thromboplastin time (aPTT) and no significant difference in MPV were observed in patients with CCHF compared with controls. Although there were no significant differences between the severe and nonsevere CCHF groups in term of MPV and PDW, the MPM value was significantly decreased in severe patients (p < 0.001). Furthermore, MPM values were inversely correlated with aPTT (r = −0.617, p = 0.015), and positively correlated with PLT (r = 0.703, p < 0.001) which are considered likely to be indicators of disease severity. Multivariate logistic regression analysis revealed MPM as an independent risk factor for severe disease. Conclusion Our study demonstrated that MPM values were decreased in severe cases compared with nonsevere in children with CCHF. The MPM as an indicator of PLT activation at the time of diagnosis in children with CCHF can be used as a prognostic index for disease severity.

scholarly journals Crimean-Congo hemorrhagic fever virus antibody prevalence in Mauritanian livestock (cattle, goats, sheep and camels) is stratified by the animal’s age

2021 ◽  
Vol 15 (4) ◽  
pp. e0009228
Author(s):  
Ansgar Schulz ◽  
Yahya Barry ◽  
Franziska Stoek ◽  
Aliou Ba ◽  
Jana Schulz ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Small Ruminants ◽  
Hemorrhagic Fever ◽  
Immunofluorescence Assay ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Prevalence Studies ◽  
Hemorrhagic Fever Virus ◽  
Generalized Linear Mixed Effects ◽  
The Impact

Crimean-Congo hemorrhagic fever virus (CCHFV) is one of the most widespread zoonotic arthropod-borne viruses in many parts of Africa, Europe and Asia. It belongs to the family of Nairoviridae in the genus of Orthonairovirus. The main reservoir and vector are ticks of the genus Hyalomma. Livestock animals (such as cattle, small ruminants and camels) develop a viremias lasting up to two weeks with absence of clinical symptoms, followed by seroconversion. This study was carried out to assess risk factors that affect seroprevalence rates in different species. In total, 928 livestock animal samples (cattle = 201; sheep = 247; goats = 233; camels = 247) from 11 out of 13 regions in Mauritania were assayed for CCHFV-specific immunoglobulin G (IgG) antibodies using enzyme-linked immunosorbent assays (ELISA) (including a novel indirect camel-IgG-specific CCHFV ELISA). Inconclusive results were resolved by an immunofluorescence assay (IFA). A generalized linear mixed-effects model (GLMM) was used to draw conclusions about the impact of certain factors (age, species, sex and region) which might have influenced the CCHFV antibody status of surveyed animals. In goats and sheep, about 15% of the animals were seropositive, whereas in cattle (69%) and camels (81%), the prevalence rate was significantly higher. On average, cattle and camels were up to twice to four times older than small ruminants. Interestingly, the seroprevalence in all species was directly linked to the age of the animals, i.e. older animals had significantly higher seroprevalence rates than younger animals. The highest CCHFV seroprevalence in Mauritania was found in camels and cattle, followed by small ruminants. The large proportion of positive animals in cattle and camels might be explained by the high ages of the animals. Future CCHFV prevalence studies should at least consider the age of surveyed animals in order to avoid misinterpretations.

scholarly journals Reliability and validity of the self-reported Activities of Daily Living Scale for people with mental illness

2018 ◽  
Vol 31 (2) ◽  
pp. 115-124 ◽  
Author(s):  
Ay-Woan Pan ◽  
Chao-Yi Wu ◽  
LyInn Chung ◽  
Tsyr-Jang Chen
Keyword(s):  
Mental Illness ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Rasch Analysis ◽  
Reliability And Validity ◽  
Measurement Model ◽  
Patient Reported Outcome Measures ◽  
The Self ◽  
Patient Reported ◽  
Four Levels

Background/objectives Patient-reported outcome measures have been found to be an effective method of reflecting client perspectives on their personal health condition. The primary aim of this study was to determine the reliability and validity of the self-reported Activities of Daily Living Scale (sf-ADLS) using Rasch analysis in Taiwan. Methods A total of 455 people were included in this study; 224 were persons with mental illness and 231 were healthy adults. We applied Rasch analysis as the means of testing the psychometrics of the scale. Results The final version of the sf-ADLS used in this study included 14 items, with no differential item functioning being discernible on the gender variable. The scale was found to be of use in classifying the subjects into four levels of independence. Conclusions The revised sf-ADLS conforms to the Rasch measurement model in the formulation of a unidimensional scale. The scale can be used to measure the level of independence with acceptable reliability (internal consistency as 0.9) and validity.

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