Bleomycin-associated lung toxicity in childhood cancer survivors.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9591-9591
Author(s):  
Alexandra Patricia Zorzi ◽  
Connie L Yang ◽  
Sharon Dell ◽  
Paul C. Nathan
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Lung Metastases ◽  
Univariate Analysis ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Current Recommendation ◽  
Cross Sectional

9591 Background: Bleomycin has been established as a pulmonary toxin, but the risk for toxicity in survivors of childhood cancer is poorly characterized. Methods: We conducted a cross-sectional study of lung function in survivors of childhood Hodgkin lymphoma and germ cell tumor treated with bleomycin at our institution between 1997 and 2010. We assessed their most recent post-therapy pulmonary function test (PFT). Spirometry and lung volumes were categorized as normal, restrictive, obstructive or mixed. Diffusing capacity of carbon monoxide (DLCO) was categorized as normal or abnormal. Results: 195 patients were treated with bleomycin. Ten died of non-pulmonary causes. Of 185 survivors, 143 (77%) had complete data available for analysis. Median cumulative bleomycin dose was 60U/m2 (IQR 30-60). Three patients (2%) had a history of acute bleomycin toxicity. PFTs were performed a median of 2.3 years (IQR 1.4-4.9) from completion of therapy. Spirometry was abnormal in 58 patients (41%); of whom 5 (9%) had respiratory symptoms. 42 (70%) had obstructive, 11 (18%) restrictive and 5 (9%) mixed ventilatory defects. Abnormalities were mild in 53 (91%), moderate in 3 (5%) and severe in 2 (4%). DLCO was abnormal in 27 patients, 26 (96%) of whom had mildly reduced DLCO and were asymptomatic. Univariate analysis did not demonstrate a significant association between gender, smoking, lung metastases, lung radiation, chemotherapy regimen, or autologous transplant and abnormal lung function. Disease relapse was associated with abnormal lung function (p=0.01). Smoking (p=0.04) and relapse (p=0.03) were associated with abnormal DLCO. The odds ratio of developing abnormal spirometry for each 1unit/m2 increase in bleomycin was 1.01 (95% CI 1.00-1.02, p=0.07). Conclusions: Childhood cancer survivors treated with bleomycin frequently have evidence of asymptomatic abnormalities on PFT. The current recommendation for pulmonary function testing in childhood cancer survivors appears justified.

Long-Term Effect of Anticancer Therapy on Dentition in Childhood Cancer Survivors: An Observational, Cross-Sectional Study

2021 ◽  
Author(s):  
Mohammad Atif ◽  
Vijay Prakash Mathur ◽  
Nitesh Tewari ◽  
Kalpana Bansal ◽  
Morankar Rahul ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Anticancer Therapy ◽  
Cross Sectional Study ◽  
Term Effect ◽  
Sectional Study ◽  
Cross Sectional ◽  
Long Term Effect

scholarly journals Predictors for participation in DNA self-sampling of childhood cancer survivors in Switzerland

2021 ◽  
Author(s):  
Nicolas Waespe ◽  
Sven Strebel ◽  
Denis Marino ◽  
Veneranda Mattiello ◽  
Fanny Muet ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Age Groups ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Cancer Predisposition ◽  
Second Primary ◽  
Cross Sectional ◽  
Cancer Predisposition Syndrome ◽  
Foreign Nationality

Research on germline genetic variants relies on a sufficient number of eligible participants which is difficult to achieve for rare diseases such as childhood cancer. With self-collection kits using saliva or buccal swabs, participants can contribute genetic samples conveniently from their home. We identified determinants of participation in DNA self-collection in this cross-sectional study. We invited 928 childhood cancer survivors in Switzerland with a median age of 26.5 years (interquartile range 18.8-36.5), of which 463 (50%) participated. Foreign nationality (odds ratio [OR] 0.5, 95%-confidence interval [CI] 0.4-0.7), survivors aged 30-39 years at study versus other age groups (OR 0.5, CI 0.4-0.8), and those with a known cancer predisposition syndrome (OR 0.5, CI 0.3-1.0) participated less. Survivors with a second primary neoplasm (OR 1.9, CI 1.0-3.8) or those living in a French or Italian speaking region (OR 1.3, 1.0-1.8) tended to participate more. We showed that half of survivors participate in germline DNA self-sampling relying completely on mailing of sample kits. Foreign nationality, age 30-39 years, and cancer predisposition syndromes were associated with less participation. More targeted recruitment strategies may be advocated for these subgroups. To increase participation in DNA self-sampling, understanding and perceptions of survivors need to be better understood.

Research Protocol: Cross-sectional Study (Survey)—The Fate of Moroccan Childhood Cancer Survivors

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Nadia Benaicha ◽  
Fouzia Msefer Alaoui ◽  
Adil. Najdi ◽  
Karima Elrhazi ◽  
O.D Diakité ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Research Protocol ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals High impact physical activity and bone health of lower extremities in childhood cancer survivors: A cross‐sectional study of SURfit

2020 ◽  
Vol 147 (7) ◽  
pp. 1845-1854
Author(s):  
Simeon J. Zürcher ◽  
Ruedi Jung ◽  
Sophie Monnerat ◽  
Christina Schindera ◽  
Prisca Eser ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Bone Health ◽  
Lower Extremities ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
High Impact ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Assessment of Late Effects in Childhood Cancer Survivors: A Cross Sectional Study

2020 ◽  
Author(s):  
Venkata Naga Malleswari Muddana ◽  
Biswajit Dubashi ◽  
S. Nirmala Devi ◽  
Smita Kayal ◽  
Prasanth Ganesan
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Factors affecting weight and body composition in childhood cancer survivors—cross-sectional study

2020 ◽  
Vol 14 ◽  
Author(s):  
Małgorzata Sawicka-Żukowska ◽  
Włodzimierz Łuczyński ◽  
Jakub Dobroch ◽  
Maryna Krawczuk-Rybak
Keyword(s):  
Body Composition ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Affecting

scholarly journals Factors affecting weight and body composition in childhood cancer survivors – cross sectional study

2019 ◽  
Author(s):  
Malgorzata Sawicka-Zukowska ◽  
Włodzimierz Łuczyński ◽  
Jakub Dobroch ◽  
Maryna Krawczuk-Rybak
Keyword(s):  
Cardiovascular Disease ◽  
Body Composition ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Paediatric Oncology ◽  
Solid Tumours ◽  
Control Group ◽  
Cross Sectional

Abstract Background Due to improved efficacy of antitumour treatment in the general population, there are increasingly more childhood cancer survivors. However, some of these survivors are at risk of distant complications including cardiovascular disease. We aimed to examine the risk of overweight/obesity and abnormal body composition in a large group of patients from our paediatric oncology centre. Method We used anthropometric methods and electrical bioimpedance to assess these features, and then determined their association with disease and treatment. Results We found patients treated for leukaemia/lymphoma (especially boys) had significantly higher rates of overweight/obesity compared to the other patient groups. In contrast, overweight/obesity was more common in girls among patients treated for solid tumours. Patients treated for leukaemia/lymphoma were characterized by a higher body fat content compared to those treated for solid tumours and controls. During treatment for cancer patients had a higher percentage of muscle mass deficiency compared to those in the control group. Our regression analysis showed time from completion of treatment, gender, and type of therapy (radiotherapy, megachemotherapy) were associated with body weight and body composition including fat and muscle content. Conclusions We recommend pediatricians and general practitioners should actively try to detect and prevent cardiovascular disease among childhood cancer survivors.

scholarly journals Health behaviors of caregivers of childhood cancer survivors: a cross-sectional study

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
In Young Cho ◽  
Nack-Gyun Chung ◽  
Hee Jo Baek ◽  
Ji Won Lee ◽  
Ki Woong Sung ◽  
...  
Keyword(s):  
Health Behaviors ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Socioeconomic status and pulmonary function, transition from childhood to adulthood: cross-sectional results from the polish part of the HAPIEE study

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e022638 ◽  
Author(s):  
Maciej Polak ◽  
Krystyna Szafraniec ◽  
Magdalena Kozela ◽  
Renata Wolfshaut-Wolak ◽  
Martin Bobak ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Lung Function ◽  
Pulmonary Function ◽  
Life Course ◽  
Social Mobility ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Low Ses ◽  
Cross Sectional ◽  
Downward Social Mobility

ObjectivePrevious studies have reported inverse associations between socioeconomic status (SES) and lung function, but less is known about whether pulmonary function is affected by SES changes. We aimed to describe the relationship of changes of SES between childhood and adulthood with pulmonary function.DesignCross-sectional study.ParticipantsThe study sample included 4104 men and women, aged 45–69 years, residents of Krakow, participating in the Polish part of the Health, Alcohol and Psychosocial Factors in Eastern Europe Project.Main outcomeForced expiratory volume (FEV1) and forced vital capacity (FVC) were assessed by the standardised spirometry procedure. Participants were classified into three categories of SES (low, moderate or high) based on information on parent’s education, housing standard during childhood, own education, employment status, household amenities and financial status.ResultsThe adjusted difference in mean FVC between persons with low and high adulthood SES was 100 mL (p=0.005) in men and 100 mL (p<0.001) in women; the differences in mean FEV1were 103 mL (p<0.001) and 80 mL (p<0.001), respectively. Upward social mobility and moderate or high SES at both childhood and adulthood were related to significantly higher FEV1and FVC compared with low SES at both childhood and adulthood or downward social mobility.ConclusionsLow SES over a life course was associated with the lowest lung function. Downward social mobility was associated with a poorer pulmonary function, while upward mobility or life course and moderate or high SES were associated with a better pulmonary function.

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