Identification of germline mutations in men with early onset prostate cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 5045-5045
Author(s):  
Patrick Pilie ◽  
Anna M. Johnson ◽  
Kimberly A. Zuhlke ◽  
Linda A. Okoth ◽  
Scott Tomlins ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Onset ◽  
Germline Mutations

The role of germline mutations in the BRCA1/2 and mismatch repair genes in men ascertained for early-onset and/or familial prostate cancer

2015 ◽  
Vol 15 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Sofia Maia ◽  
Marta Cardoso ◽  
Paula Paulo ◽  
Manuela Pinheiro ◽  
Pedro Pinto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mismatch Repair ◽  
Early Onset ◽  
Germline Mutations ◽  
Mismatch Repair Genes ◽  
Repair Genes

scholarly journals Application Areas of Traditional Molecular Genetic Methods and NGS in relation to Hereditary Urological Cancer Diagnosis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Dmitry S. Mikhaylenko ◽  
Alexander S. Tanas ◽  
Dmitry V. Zaletaev ◽  
Marina V. Nemtsova
Keyword(s):  
Prostate Cancer ◽  
Bladder Cancer ◽  
Exome Sequencing ◽  
Hereditary Cancer ◽  
Early Onset ◽  
Molecular Genetic ◽  
Germline Mutations ◽  
Molecular Diagnostic ◽  
Hereditary Cancers ◽  
Cancer Prostate

Next generation sequencing (NGS) is widely used for diagnosing hereditary cancer syndromes. Often, exome sequencing and extended gene panel approaches are the only means that can be used to detect a pathogenic germline mutation in the case of multiple primary tumors, early onset, a family history of cancer, or a lack of specific signs associated with a particular syndrome. Certain germline mutations of oncogenes and tumor suppressor genes that determine specific clinical phenotypes may occur in mutation hot spots. Diagnosis of such cases, which involve hereditary cancer, does not require NGS, but may be made using PCR and Sanger sequencing. Diagnostic criteria and professional community guidelines developed for hereditary cancers of particular organs should be followed when ordering molecular diagnostic tests for a patient. This review focuses on urological oncology associated with germline mutations. Clinical signs and genetic diagnostic laboratory tests for hereditary forms of renal cell cancer, prostate cancer, and bladder cancer are summarized. While exome sequencing, or, conversely, traditional molecular genetic methods are the procedure of choice in some cases, in most situations, sequencing of multigene panels that are specifically aimed at detecting germline mutations in early onset renal cancer, prostate cancer, and bladder cancer seems to be the basic solution for molecular genetic diagnosis of hereditary cancers.

scholarly journals Rare germline mutations in African American men diagnosed with early‐onset prostate cancer

The Prostate ◽  
2018 ◽  
Vol 78 (5) ◽  
pp. 321-326 ◽  
Author(s):  
Jennifer L. Beebe‐Dimmer ◽  
Kimberly A. Zuhlke ◽  
Anna M. Johnson ◽  
Daniel Liesman ◽  
Kathleen A. Cooney
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Early Onset ◽  
African American Men ◽  
Germline Mutations

scholarly journals Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer

2007 ◽  
Vol 97 (6) ◽  
pp. 826-831 ◽  
Author(s):  
I Agalliu ◽  
E Karlins ◽  
E M Kwon ◽  
L M Iwasaki ◽  
A Diamond ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Onset ◽  
Brca2 Gene ◽  
Germline Mutations

scholarly journals Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene

2003 ◽  
Vol 72 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Stephen M. Edwards ◽  
Zsofia Kote-Jarai ◽  
Julia Meitz ◽  
Rifat Hamoudi ◽  
Questa Hope ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Onset ◽  
Brca2 Gene ◽  
Germline Mutations

scholarly journals BRCA Germline Mutations in Prostate Cancer: The Future Is Tailored

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 908
Author(s):  
Felice Crocetto ◽  
Biagio Barone ◽  
Vincenzo Francesco Caputo ◽  
Matteo Fontana ◽  
Ottavio de Cobelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cause Of Death ◽  
Germline Mutations ◽  
The Future

Prostate cancer (PCa) is the second most common neoplasm in men and the fifth leading cause of death worldwide [...]

scholarly journals Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer

The Prostate ◽  
2021 ◽  
Author(s):  
Elisa M. Ledet ◽  
Earle F. Burgess ◽  
Alexandra O. Sokolova ◽  
Ellen B. Jaeger ◽  
Whitley Hatton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Metastatic Prostate Cancer ◽  
Germline Mutations ◽  
Caucasian Men
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