Therapeutic Potential Role of miRNAs in Pancreatic and Prostate Cancer Cells

2022 ◽  
pp. 239-274
Author(s):  
Loutfy H. Madkour
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Potential Role ◽  
Therapeutic Potential ◽  
Prostate Cancer Cells

scholarly journals Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells

2021 ◽  
Vol 16 (1) ◽  
pp. 19-26
Author(s):  
Hongmei Song ◽  
Xuxiao Ye ◽  
Tao Liang ◽  
Dongliang Yan ◽  
Zuowei Li
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cell ◽  
Therapeutic Potential ◽  
Transcript Level ◽  
Prostate Cancer Cells ◽  
Transwell Assay ◽  
Dapi Staining ◽  
Cancer Tissues

The present study was undertaken to decipher the role of HOXC10 gene in regulating the growth and metastasis of prostate cancer. The results revealed significant (p<0.05) up-regulation of HOXC10 gene in human prostate cancer tissues and cell lines. The silencing of HOXC10 transcript level significantly (p<0.05) inhibited the growth and colony formation of DU145 and 22Rv1 prostate cancer cells. The DAPI staining revealed that inhibition of DU145 and 22Rv1 prostate cancer cell viability was due to the induction of apoptosis. The transwell assay showed that HOXC10 significantly (p<0.05) inhibits the invasion of prostate cancer cells. The Western blotting revealed that HOXC10 gene exerts its effects via modulation of Ras/Raf/MEK/ERK signaling cascade. Collectively, the results point towards the therapeutic potential of HOXC10 in the treatment of prostate cancer.

scholarly journals Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G1 to S Phase

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56692 ◽  
Author(s):  
Shalini Murthy ◽  
Min Wu ◽  
V. Uma Bai ◽  
Zizheng Hou ◽  
Mani Menon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells

scholarly journals Role of WNT5A receptors FZD5 and RYK in prostate cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (43) ◽  
pp. 27293-27304 ◽  
Author(s):  
Stefanie Thiele ◽  
Ariane Zimmer ◽  
Andy Göbel ◽  
Tilman D. Rachner ◽  
Sandra Rother ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells
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