scholarly journals 312 Low Dose Lipopolysaccharide (LPS) Exposure Potentiates High-Tidal Volume Ventilation (HTVV)-Induced Proinflammatory Cytokine Expression in Newborn Rat

2005 ◽  
Vol 58 (2) ◽  
pp. 408-408
Author(s):  
M Roth-Kleiner ◽  
R Ridsdale ◽  
L Cao ◽  
M Kuliszewski ◽  
I Tseu ◽  
...  
Keyword(s):  
Tidal Volume ◽  
Proinflammatory Cytokine ◽  
Low Dose ◽  
Cytokine Expression ◽  
High Tidal Volume ◽  
Newborn Rat ◽  
Proinflammatory Cytokine Expression ◽  
High Tidal Volume Ventilation ◽  
Volume Ventilation

scholarly journals Lipopolysaccharide Exposure Modifies High Tidal Volume Ventilation-Induced Proinflammatory Mediator Expression in Newborn Rat Lungs

2007 ◽  
Vol 61 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Matthias Roth-Kleiner ◽  
Ross Ridsdale ◽  
Lei Cao ◽  
Maciej Kuliszewski ◽  
Irene Tseu ◽  
...  
Keyword(s):  
Tidal Volume ◽  
High Tidal Volume ◽  
Newborn Rat ◽  
Proinflammatory Mediator ◽  
Rat Lungs ◽  
High Tidal Volume Ventilation ◽  
Volume Ventilation

Pentraxin 3 accelerates lung injury in high tidal volume ventilation in mice

2012 ◽  
Vol 51 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Juliana Monte Real ◽  
Graziela Machado Gruner Turco Spilborghs ◽  
Mariana Morato-Marques ◽  
Ricardo Pereira de Moura ◽  
Elnara Marcia Negri ◽  
...  
Keyword(s):  
Lung Injury ◽  
Tidal Volume ◽  
High Tidal Volume ◽  
Pentraxin 3 ◽  
High Tidal Volume Ventilation ◽  
Volume Ventilation

High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance

2003 ◽  
Vol 284 (5) ◽  
pp. L791-L798 ◽  
Author(s):  
James A. Frank ◽  
Jean-François Pittet ◽  
Hyon Lee ◽  
Micaela Godzich ◽  
Michael A. Matthay
Keyword(s):  
Lung Injury ◽  
Tidal Volume ◽  
Time Course ◽  
High Tidal Volume ◽  
Low Tidal Volume ◽  
Edema Fluid ◽  
High Tidal Volume Ventilation ◽  
Volume Ventilation ◽  
Air Space ◽  
Induced Changes

Tidal volume reduction during mechanical ventilation reduces mortality in patients with acute lung injury and the acute respiratory distress syndrome. To determine the mechanisms underlying the protective effect of low tidal volume ventilation, we studied the time course and reversibility of ventilator-induced changes in permeability and distal air space edema fluid clearance in a rat model of ventilator-induced lung injury. Anesthetized rats were ventilated with a high tidal volume (30 ml/kg) or with a high tidal volume followed by ventilation with a low tidal volume of 6 ml/kg. Endothelial and epithelial protein permeability were significantly increased after high tidal volume ventilation but returned to baseline levels when tidal volume was reduced. The basal distal air space fluid clearance (AFC) rate decreased by 43% ( P < 0.05) after 1 h of high tidal volume but returned to the preventilation rate 2 h after tidal volume was reduced. Not all of the effects of high tidal volume ventilation were reversible. The cAMP-dependent AFC rate after 1 h of 30 ml/kg ventilation was significantly reduced and was not restored when tidal volume was reduced. High tidal volume ventilation also increased lung inducible nitric oxide synthase (NOS2) expression and air space total nitrite at 3 h. Inhibition of NOS2 activity preserved cAMP-dependent AFC. Because air space edema fluid inactivates surfactant and reduces ventilated lung volume, the reduction of cAMP-dependent AFC by reactive nitrogen species may be an important mechanism of clinical ventilator-associated lung injury.

The effect of pentoxifylline on the pulmonary response to high tidal volume ventilation in rats

2008 ◽  
Vol 21 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Andrea Lessa ◽  
Cleide Suguihara ◽  
Shuming Xianyu ◽  
Dorothy Hehre ◽  
Carlos Devia ◽  
...  
Keyword(s):  
Tidal Volume ◽  
High Tidal Volume ◽  
Pulmonary Response ◽  
High Tidal Volume Ventilation ◽  
Volume Ventilation
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