scholarly journals Androgenic Influences on Behavior, Body Weight, and Body Composition in a Model of Chronic Social Stress

Endocrinology ◽  
2007 ◽  
Vol 148 (12) ◽  
pp. 6145-6156 ◽  
Author(s):  
Mary M. N. Nguyen ◽  
Kellie L. K. Tamashiro ◽  
Susan J. Melhorn ◽  
Li Y. Ma ◽  
Stacy R. Gardner ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Adipose Tissue ◽  
Social Stress ◽  
Body Weight Loss ◽  
Oral Glucose ◽  
Lean Tissue ◽  
Chronic Social Stress ◽  
And Control

The visible burrow system (VBS) is a model used to study chronic social stress in colony-housed rats. A hierarchy develops among the males resulting in dominant (DOM) and subordinate (SUB) animals. Hierarchy-associated changes in body weight, body composition, behavior, and neuroendocrine measures have been observed. After 14 d of VBS housing, SUB animals have decreased body weight, elevated corticosterone, and decreased testosterone (T), compared with DOM animals and controls, placing SUB animals in an ideal endocrine state to regain lost body weight as adipose tissue. It is hypothesized that maintaining constant androgen concentrations in SUB males during stress will prevent body weight loss by maintaining more lean body mass. To test this, animals were gonadectomized and implanted with SILASTIC implants containing T, 5α-dihydrotestosterone (DHT), or cholesterol. Implants maintained constant physiological levels of T. Standard intact, T, and DHT implant colonies formed hierarchies, whereas cholesterol colonies did not. Androgen manipulations significantly altered offensive and defensive behaviors only on the first day of VBS housing. After VBS stress, intact, T, and DHT SUB animals weighed less and lost more adipose and lean tissue than DOM and control males, whereas DOM animals primarily lost adipose tissue. However, on recovery, DHT SUB animals maintained more lean tissue than intact SUB animals. Oral glucose tolerance tests revealed that glucose clears faster in stressed T-implanted males that have increased adipose tissue. Overall, these data suggest that constant androgen concentrations in SUB animals do not prevent weight loss and changes in body composition during stress but do so during recovery.

Social stress and recovery: implications for body weight and body composition

2007 ◽  
Vol 293 (5) ◽  
pp. R1864-R1874 ◽  
Author(s):  
Kellie L. K. Tamashiro ◽  
Mary M. N. Nguyen ◽  
Michelle M. Ostrander ◽  
Stacy R. Gardner ◽  
Li Yun Ma ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Adipose Tissue ◽  
Social Status ◽  
Social Stress ◽  
Energy Homeostasis ◽  
Body Weight Loss ◽  
Male Rats ◽  
Induced Changes

Social stress resulting from dominant-subordinate relationships is associated with body weight loss and altered body composition in subordinate (SUB) male rats. Here, we extend these findings to determine whether stress-induced changes in energy homeostasis persist when the social stress is removed, and the animal is allowed to recover. We examined body weight (BW), body composition, and relevant endocrine measures after one or two cycles of 14 days of social stress, each followed by 21 days of recovery in each rat's individual home cage. SUB lost significantly more BW during social housing in a visible burrow system (VBS) compared with dominant (DOM) animals. Weight loss during social stress was attributable to a decrease in adipose tissue in DOM and SUB, with an additional loss of lean tissue in SUB. During both 21-day recovery periods, DOM and SUB regained lost BW, but only SUB were hyperphagic. Following recovery, SUB had a relatively larger increase in adipose tissue and plasma leptin compared with DOM, indicating that body composition changes were dependent on social status. Control animals that were weight matched to SUB or male rats exposed to the VBS environment without females, and that did not form a social hierarchy, did not exhibit changes in body composition like SUB in the VBS. Therefore, chronic social stress causes social status-dependent changes in BW, composition and endocrine measures that persist after repeated stress and recovery cycles and that may ultimately lead to metabolic disorders and obesity.

Analysis of Adipose Tissue in Relation to Body Weight Loss in Man

1958 ◽  
Vol 13 (1) ◽  
pp. 129-134 ◽  
Author(s):  
Cecil Entenman ◽  
William H. Goldwater ◽  
Nell S. Ayres ◽  
Albert R. Behnke
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Adipose Tissue ◽  
Body Weight Loss

scholarly journals Adipose tissue inflammation contributes to body weight loss induced by experimental chronic food allergy in mice

2011 ◽  
Vol 1 (S1) ◽  
Author(s):  
Denise Carmona Cara ◽  
Luana PA Dourado ◽  
Mria LM Noviello ◽  
Debora M Alvarenga ◽  
Gustavo B Menezes ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Adipose Tissue ◽  
Food Allergy ◽  
Body Weight Loss ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

Hypocaloric diet with lower meal frequency did not affect weight loss, body composition and insulin responsiveness, but improved lipid profile: a randomized clinical trial

2021 ◽  
Author(s):  
Érika Duarte Grangeiro ◽  
Mariana Silva Trigueiro ◽  
Leysimar de Oliveira Siais ◽  
Hilana Moreira Paiva ◽  
Mauro Sola-Penna ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Lipid Profile ◽  
Randomized Clinical Trial ◽  
Body Weight Loss ◽  
Hypocaloric Diet ◽  
Meal Frequency ◽  
Insulin Responsiveness

Dietary approaches are essential to control obesity, but the effectiveness of changes in meal frequency (MF) as a strategy for body weight loss or maintenance remain unclear.

scholarly journals Carbohydrate-Responsive Gene Expression in the Adipose Tissue of Rats

Endocrinology ◽  
2010 ◽  
Vol 151 (1) ◽  
pp. 153-164 ◽  
Author(s):  
Kartik Shankar ◽  
Amanda Harrell ◽  
Ping Kang ◽  
Rohit Singhal ◽  
Martin J. J. Ronis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Composition ◽  
Body Weight ◽  
Adipose Tissue ◽  
Body Weight Gain ◽  
Caloric Intake ◽  
Oral Glucose ◽  
Sprague Dawley ◽  
Simple Carbohydrates ◽  
The Impact

Abstract Although obesity is often associated with high-fat diets, it can develop from a variety of meal patterns. Excessive intake of simple carbohydrates is one consistent eating behavior leading to obesity. However, the impact of overconsumption of diets with high carbohydrate to fat ratios (C/F) on body composition and global adipose tissue gene expression remains unclear. We used total enteral nutrition to evaluate the effects of caloric intake and C/F on body weight gain and development of obesity. Female Sprague Dawley rats were fed diets with either low C/F or high C/F (HC) (reflecting a 19.5-fold increase in C/F) at two levels of caloric intake: 187 or 220 kcal/kg3/4 · d (15% excess) for 4 wk. At the end of the study period, rats fed HC diets had about 20% higher body weight at either caloric intake compared with rats fed low C/F diets (P < 0.05). Body composition (assessed by nuclear magnetic resonance, computerized tomography, and adipose tissue weights) revealed higher percent fat mass (P < 0.05) in HC rats. Obesity was associated with increased serum resistin, leptin, fasting hyperinsulinemia, and insulin resistance after an oral glucose challenge (P < 0.05). Microarray analyses of adipose tissues revealed HC diets led to changes in 270 and 464 transcripts at 187 and 220 kcal/kg3/4 · d intakes. Genes regulating glucose transport, glycolysis, fatty acid and triglyceride biosynthesis, desaturation and elongation, adipogenesis, and adipokines were affected by HC diets. These results suggest that C/F and interactions with excessive caloric intake per se may regulate body composition and play important roles in the development of obesity and metabolic syndrome.

Reversing Type 2 Diabetes in a Primary Care-Anchored eHealth Web-based Lifestyle Coaching Program in Denmark: Randomized Controlled Trial (Preprint)

2021 ◽  
Author(s):  
Jeanette Reffstrup Christensen ◽  
Camilla Sortsø ◽  
Jørgen T Lauridsen ◽  
Pernille R Jakobsen ◽  
Ditte H Laursen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled ◽  
Number Of Patients ◽  
And Control

BACKGROUND Lifestyle interventions can delay and reverse the onset of type 2 diabetes (T2D) and decrease morbidity and mortality. Studies suggest that digital coaching based on real-time monitoring can lead to clinically relevant weight loss, as well as decreased or normalized hemoglobin A1c (HbA1c) for a significant number of patients. OBJECTIVE To assess whether an eHealth lifestyle coaching program (LIVA 2.0) for patients with T2D who are motivated for lifestyle changes leads to significant weight loss and decreased HbA1c, compared to usual care. METHODS In a randomized controlled single-blinded trial, 170 patients with T2D were enrolled from March 2018 to March 2019 and randomized to the intervention (100) and control (70) groups. Patients were recruited via their general practitioners, the Danish diabetes organization, and social media. The intervention comprised an initial face-to-face motivational interview followed by digital coaching. The same healthcare professional coach provided synchronous and asynchronous multimodal feedback and used digital behavioral change techniques enabled by an app providing live monitoring of lifestyle behaviors. Primary outcome was body weight. Secondary outcomes were changes in HbA1c, body composition, lipids, and quality of life at 6 months. RESULTS At 6 months, 75 patients (75%) in the intervention group and 53 patients (76%) in the control group remained in the study. Mean body weight loss was 4.2 kg (95% CI, 5.5- 3.0) in the intervention group vs 1.5 kg (95% CI, 2.57- 0.48) in the control group (P = .005). In the intervention group, 36 (52%) patients lost > 3% body weight, compared to 12 (32%) patients in the control group. Mean HbA1c was lower in both groups at 6 months, with reductions of 8.2% (95% CI, 11.01 to 5.29) and 5.5% (95% CI, 8.75 to 2.76) for the intervention and control groups, respectively (P = .203). In the intervention group, 24 (32%) had an HbA1c <6.5% at 6 months, compared to 8 (15%) in the control group (P = .03). CONCLUSIONS Reduction in body weight and remission rate for HbA1c, as well as improved body composition can be enhanced by using digital lifestyle coaching for patients with T2D. CLINICALTRIAL Trial Registration: Clinicaltrials.gov NCT03788915 https://clinicaltrials.gov/ct2/show/NCT03788915 International Registered Report Identifier (IRRID): DERR2-10.2196/19172 INTERNATIONAL REGISTERED REPORT RR2-10.2196/19172

scholarly journals The browning of white adipose tissue and body weight loss in primary hyperparathyroidism

EBioMedicine ◽  
2019 ◽  
Vol 40 ◽  
pp. 56-66 ◽  
Author(s):  
Yang He ◽  
Rui-xin Liu ◽  
Min-ting Zhu ◽  
Wen-bin Shen ◽  
Jing Xie ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Adipose Tissue ◽  
Primary Hyperparathyroidism ◽  
White Adipose Tissue ◽  
Body Weight Loss

scholarly journals Initial body composition and sex affects to the velocity of body weight loss: a PRONAF study

2015 ◽  
Vol 10 (4) ◽  
Author(s):  
Miguel Ángel Rojo-Tirado ◽  
Pedro José Benito Peinado ◽  
Ana Belén Peinado Lozano ◽  
Javier Butragueño Revenga ◽  
Francisco Javier Calderón Montero
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Body Weight Loss
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