scholarly journals Melatonin Patterns and Levels During the Human Menstrual Cycle and After Menopause

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Gail A Greendale ◽  
Paula Witt-Enderby ◽  
Arun S Karlamangla ◽  
Fahima Munmun ◽  
Sybil Crawford ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Longitudinal Analysis ◽  
Outcome Measure ◽  
Cross Sectional ◽  
Chronological Aging ◽  
Menstrual Cycles ◽  
Menopause Transition ◽  
The Mean ◽  
Urine Assay ◽  
Human Menstrual Cycle

Abstract Context Melatonin may play a role in the regulation of the human menstrual cycle and may decline with menopause and/or aging. Objective The objective of this work is to investigate the relations between melatonin and the menstrual cycle, menopause, and aging. Methods This was a cross-sectional and longitudinal analysis of 20 participants from the Study of Women’s Health Across the Nation (SWAN) Daily Hormone Study (DHS). The outcome measure was first-morning urine assay of 6-sulfatoxymelatonin (aMT6s), a gauge of melatonin. For each participant, aMT6s was measured daily during one premenopausal cycle with evidence of luteal activity (ELA) and one postmenopausal collection with no evidence of luteal activity (NELA). Results In addition to the organized patterns of hormone metabolites (estrone conjugates [E1c], and pregnanediol glucuronide [PdG]) and gonadotropins that characterized ovulatory menstrual cycles, there was a late luteal rise in aMT6s. In NELA collections, there was no periodicity of E1c, PdG, gonadotropins, or aMT6s. The strongest predictors of aMT6s levels were PdG values 11 to 12 days prior to aMT6s (β = 1.46, P = .001 and β = 1.44, P = .001, respectively). E1c and gonadotropins were not statistically significantly associated with aMT6s. Mean aMT6s in premenopause was 53.5 ng/mL, greater than the mean of 37.4 ng/mL in postmenopausal samples from the same women (P = .0002). Conclusions This study confirms a late luteal melatonin rise, likely signaled by progesterone, which may influence menstrual cycle pacemaker control. Melatonin declined from premenopause to postmenopause. A high correlation between menopause transition stage and age precludes distinction between the influences of ovarian and chronological aging.

scholarly journals Urinary 8-Hydroxy-2′-deoxyguanosine (8-OHdG) Concentrations and Menstrual Cycle Characteristics in Female University Students

2018 ◽  
Vol 15 (12) ◽  
pp. 2616
Author(s):  
Shoko Konishi ◽  
Jun Yoshinaga ◽  
Yukiko Nishihama ◽  
Yu Onoda ◽  
Youichi Chisaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Menstrual Cycle ◽  
University Students ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Menstrual Pain ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Menstrual Cycles ◽  
The Mean

Higher concentrations of oxidative stress biomarkers are found in women with polycystic ovary syndrome (PCOS) and endometriosis, conditions linked to irregular menstrual cycles and menstrual pain. The aim of the present study was to test whether women with higher oxidative stress are more likely to show irregular menstrual cycles and severe menstrual pain compared with women with lower oxidative stress. A cross-sectional study was conducted targeting female university students with a mean (SD) age of 20.5 (1.8) years (n = 188). Participants completed a questionnaire on reproductive characteristics and anthropometry and kept a menstrual cycle diary for 5 consecutive months. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), cotinine, and creatinine concentrations were measured once during the study period. The mean (SD) value of the urinary 8-OHdG concentration was 4.7 (2.0) μg/g of creatinine. A total of 1021 menstrual cycles were recorded. The participants were categorized as either having regular (68%) or irregular (18%) cycles or oligomenorrhea (13%) or polymenorrhea (1%). The urinary 8-OHdG concentration did not significantly differ across menstrual cycle regularity or pain categories. Even after adjusting for age, body mass index (BMI), and urinary cotinine concentrations, having irregular cycles or more severe menstrual pain was not associated with urinary 8-OHdG concentration.

Plasma bradykininogen and reproductive cycles: studies during the oestrous cycle and pregnancy in the rat, and in the human menstrual cycle

1976 ◽  
Vol 54 (6) ◽  
pp. 941-947 ◽  
Author(s):  
M. McDonald ◽  
A. M. Perks
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Oestrous Cycle ◽  
Menstrual Cycles ◽  
Late Luteal Phase ◽  
Human Menstrual Cycle ◽  
Reproductive Cycles ◽  
In Pregnancy

Plasma bradykininogen levels have been shown to rise about threefold late in pregnancy in the rat. However, they declined sharply 1–2 days before delivery.Plasma bradykininogen levels remained relatively unchanged through most the oestrous and menstrual cycles (rat, man). However, they showed a fall at two similar periods, in both cycles. A smaller decline occurred in metoestrus in the rat, and (probably) in the late luteal phase in the human. The largest fall took place around the time of ovulation in both the oestrous and the menstrual cycles. The decline was about 59% in the rat and 42% in the human. Bradykininogen showed no similar changes in the blood of male human controls. The suggestion that bradykinin could be involved in ovulation is discussed.

FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE IN SERUM DURING THE MENSTRUAL CYCLE DETERMINED BY RADIOIMMUNOASSAY

1968 ◽  
Vol 59 (2) ◽  
pp. 298-306 ◽  
Author(s):  
Melvin L. Taymor ◽  
Toshihiro Aono ◽  
Carolyn Pheteplace
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Fold Increase ◽  
Serum Levels ◽  
Consistent Pattern ◽  
Menstrual Cycles ◽  
The Mean ◽  
Level 1 ◽  
High Level

ABSTRACT The serum levels of FSH and LH were determined in 11 normal menstrual cycles by radioimmunoassay. The results of LH assay demonstrated a consistent pattern with a sharp 3 to 4 fold increase occurring on the average 13.9 days before the next menses. The changes in FSH levels during the cycle were neither as marked nor as consistent. Three distinct patterns seemed to emerge. However, the mean levels of FSH from the 11 cycles demonstrated a significant high level 12 days before, a low level 1 day before and another rise 1 day after the midcycle peak of LH.

scholarly journals Normative data for the 6-min walk test in 11–14 year-olds: a population-based study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mario Kasović ◽  
Lovro Štefan ◽  
Vilko Petrić
Keyword(s):  
Normative Data ◽  
Outcome Measure ◽  
Population Based ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Walk Test ◽  
Target Groups ◽  
Cross Sectional ◽  
Population Based Study ◽  
The Mean

Abstract Background The 6-min walk test (6MWT) has become an established measure for assessing exercise capacity in children with chronic diseases. However, little evidence has been provided regarding population-based normal data in healthy children. The main purpose of the study was to provide normative data in a large sample of children. Methods In this cross-sectional study, 4352 children between 11 and 14 years were recruited (66% girls). The main outcome measure was the distance walked for six minutes. Sex- and age-specific percentile values (5th, 15th, 25th, 50th, 75th, 85th and 95th) for the 6MWT were created and the differences and correlations were examined by the analysis of variance and Pearson’s coefficient of correlation. Results The mean distance walked in 6 min was 576 ± 93 m in boys and 545 ± 92 m in girls, respectively. The mean walking speed for boys and girls was 98 ± 5 m/min and 91 ± 6 m/min. Older boys and girls performed better, compared to their younger counterparts (p for age < 0.001). The 6MWT was significantly correlated with age (r = 0.24, p < 0.001), height (r = 0.09, p < 0.001), weight (r =  − 0.13, p < 0.001) and body-mass index (r =  − 0.26, p < 0.001). Conclusions This is the first population-based study aiming to provide normative data for the 6MWT in healthy children between 11 to 14 years. Children in lower percentiles are ‘target groups’ for special intervention aiming to enhance the performance.

scholarly journals PERBEDAAN PENGARUH PENGGUNAAN ALAT KONTRASEPSI IUD DAN SUNTIK TERHADAP SIKLUS HAID PEREMPUAN DI KECAMATAN MARPOYAN DAMAI PEKANBARU

2012 ◽  
Vol 11 (2) ◽  
pp. 1
Author(s):  
Ikhwani Ratna ◽  
Irdayanti Irdayanti
Keyword(s):  
Side Effects ◽  
Menstrual Cycle ◽  
T Test ◽  
Statistical Techniques ◽  
Cross Sectional ◽  
Menstrual Cycles ◽  
Sample Data ◽  
The Difference

This study aims to determine the difference of the menstrual cycle between the user of IUD contraception and the inject contraception and to know the side effects of these two devices towards the women in Marpoyan Damai the District, Pekanbaru. The population of this study is all the new users of IUD and inject contraception in Merpoyan Damai disctrikck, Pekanbaru, from January to March 2012, 69 women are using IUD and 564 women using injection. This study is non-experimental descriptive analytic cross sectional approach and Slovin technique is used for taking the sample. Data is analyzed using by statistical techniques to an independent t-test. The results suggest P is 0.006 with significantly less than 0.05, it means that there is a significant differences between menstrual cycles of women who used the IUD contraception and who usess injection contraception.

scholarly journals HUBUNGAN STRES DENGAN SIKLUS MENSTRUASI PADA MAHASISWA PRODI DIII KEBIDANAN STIKES KARYA HUSADA SEMARANG

2017 ◽  
Vol 3 (1) ◽  
pp. 23
Author(s):  
Maftuchah Maftuchah
Keyword(s):  
Menstrual Cycle ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Health Science ◽  
Cross Sectional ◽  
Menstrual Cycles ◽  
Central Java ◽  
Science College ◽  
Keywords Stress ◽  
Correlation Design

Latar Belakang: Sebagian besar perempuan di Indonesia pada tahun 2010 yang berusia 10-59 tahun melaporkan 68% mengalami haid teratur dan 13,7% mengalami masalah siklus haid yang tidak teratur dalam 1 tahun terakhir. Sedangkan di Jawa Tengah tahun 2010 diketahui perempuan yang berumur 10-59 tahun dengan siklus haid teratur sebanyak 70,4%, tidak teratur 13,1%, belum haid  6,8% dan tidak menjawab 9,7%. Tujuan Penelitian: Mengetahui hubungan stress dengan siklus menstruasi pada mahasiswa prodi DIII Kebidanan STIKES Karya Husada Semarang. Metode Penelitian: Jenis penelitian correlation dengan desain cross sectional. Populasi yaitu mahasiswa DIII kebidanan STIKES Karya Husada Semarang semester V tahun 2015 sejumlah 69 mahasiswa dengan sampel 59 mahasiswa dengan teknik simple random sampling. Analisis data menggunakan analisis univariat dan analisis bivariat. Hasil Penelitian: Stres yang dialami oleh mahasiswa prodi DIII Kebidanan sebagian besar adalah stess ringan sebanyak 40 responden (67,8%). Siklus menstruasi mahasiswa prodi DIII Kebidanan sebagian besar adalah normal sebanyak 46 responden (78,0%). Kesimpulan : Ada hubungan antara stres dengan siklus menstruasi pada mahasiswa prodi DIII Kebidanan (Pvalue = 0,000). Kata kunci: Stress; siklus menstruasi THE CORRELATION BETWEEN STRESS AND MENSTRUAL CYCLE TO THE DIPLOMA III OF MIDWIFERY STUDENTS’ KARYA HUSADA HEALTH SCIENCE COLLEGE SEMARANG Abstrack Background: Most women in Indonesia in 2010 were aged 10-59 years reported a 68% had regular menstruation and 13.7% experienced problems irregular menstrual cycles in the past 1 year. Whereas in Central Java in 2010 known women aged 10-59 years with regular menstrual cycles as much as 70.4%, 13.1% irregular, yet menstruation 6.8% and 9.7% did not answer. Objective: To determine the correlations between stress and menstrual cycle to the diploma iii of midwifery students’ Karya Husada Health Science College Semarang. Method: This research was a correlation design with cross-sectional. The population was all students of DIII midwifery STIKES Karya Husada Semarang fifth semester of 2015,  they were 69 students. The sample was 59 female students with sampling techniques using simple random sampling. The Date were analyzed using univariate and bivariate analyzes. Results: The stress experienced by the students of DIII of midwifery mostly mild stres they were 40 respondents (67.8%). The menstrual cycle of students DIII of Midwifery are mostly normal they were 46 respondents (78.0%). There was an association between stress and the menstrual cycle to the students of DIII the Midwifery (Pvalue = 0.000). Keywords: Stress;  menstrual cycle 

A Comparison between the Effectiveness of Norethisterone and Dydrogesterone for treatment of Irregular Menstrual Cycle

2021 ◽  
Vol 15 (11) ◽  
pp. 2876-2878
Author(s):  
Asma Yasin ◽  
Madiha Afzal ◽  
Uzma Aziz
Keyword(s):  
Patient Satisfaction ◽  
Menstrual Cycle ◽  
Prospective Study ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Coagulation Disorder ◽  
Menstrual Cycles ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Abnormal uterine bleeding is defined as irregularities in the menstrual cycle involving frequency, regularity, duration, and volume of flow outside of pregnancy. Up to 1/3rd of women experience abnormal uterine bleeding in their life, with irregularities most commonly occurs at menarche and perimenopause due to disruption of the hypothalamic-pituitary-ovarian axis. Aim: To compare the effectiveness of Norethisterone and Dydrogesterone for the treatment of irregular menstrual cycles due to abnormal uterine bleeding of ovulatory or endometrial dysfunction and to check for patient satisfaction after the use of prescribed hormones by taking their feedback. Methods: This observational, comparative, cohort-prospective study was conducted on 100 nonpregnant women between the ages of 15-45 years who presented with complaints of irregular menstruation in gynae outdoor of AMTH for 6 months from April 2021 to September 2021. After excluding pelvic pathology, known thyroid disease, coagulation disorder, or use of the contraceptive method, the participants were divided into Group A and Group B, each having 50 participants. Results: The mean age±SD of the participants in Group A was 29±3.4 while Group B had mean age±SD was 29.5±3.6. In Group A, 38(76%) patients reported a regular menstrual cycle after 3 months of use while 12(24%) patients complained of persistent irregular menstrual cycle despite 3 months use of Norethisterone with compliance in Group B using Dydrogesterone, 22(44%) patients had regular menstrual cycles while 28(56%) patients had persistent irregular menstrual cycles after three months of use. Conclusion: So we concluded from our study that Norethisterone had a better cycle control than Dydrogesterone. Keywords: Abnormal uterine bleeding of ovulatory and/or endometrial dysfunction, Norethisterone, Dydrogesterone,

scholarly journals Premature childbirth: pregnant women's characteristics of a population in the South area of São Paulo

2016 ◽  
Vol 16 (4) ◽  
pp. 427-435 ◽  
Author(s):  
Aline Zorzim Berger ◽  
◽  
Vivian Inácio Zorzim ◽  
Elias Ferreira Pôrto ◽  
Fábio Marcon Alfieri
Keyword(s):  
Pregnant Women ◽  
High School Graduates ◽  
Sao Paulo ◽  
São Paulo ◽  
The South ◽  
Cross Sectional ◽  
Menstrual Cycles ◽  
The Mean ◽  
Clinical Conditions ◽  
Determining Factor

Abstract Objectives: to identify the characteristics of pregnant women who had premature child-birth (PPT) in the South region of São Paulo city. Methods: a cross-sectional observational study with a data collection of 122 medical files on pregnant women who had PPT in 2013. The collected data were analyzed by a statistical package, Graphpad Prism 6. As for the variables that were shown to be significant in the multivariate regression, an analysis was performed in a dichotomous form by odds ratio. Results: the mean age of the pregnant women was 24.9 years old. Of the 122 pregnant women, 34.4% were included in the age group considered to be at risk by the Ministry of Health. The predominant race was mixed (46.2%). 41.8% were high school graduates. Regarding to personal background, the history on urinary infection was mostly mentioned (37.5%). In relation to family history regarding clinical conditions, 43% had diabetes history and 61% had hypertension. As for gynecological history, 37.5% reported having dysmenorrhea during menstrual cycles. Multivariate analysis was performed and found that particularly hypertension and dysmenorrhea were the most significant. Conclusions: Regarding to women´s risk factors for premature childbirth, the most determining factor was dysmenorrhea, followed by hypertension.

scholarly journals Hubungan kontrasepsi hormonal dengan siklus menstruasi

2020 ◽  
Vol 4 (1) ◽  
pp. 6-12
Author(s):  
Ferilia Adiesti ◽  
Fitria Edni Wari
Keyword(s):  
Menstrual Cycle ◽  
Hormonal Contraception ◽  
Prevalence Ratio ◽  
Hormonal Contraceptive ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Menstrual Cycles ◽  
Cycle Disorders ◽  
Quantitative Descriptive

Latar belakang: Kontrasepsi hormonal merupakan kontrasepsi yang mengandung hormon progestin saja maupun kombinasi dengan kandungan estrogen dan progestin. Metode kontrasepsi hormonal memiliki banyak efek samping, salah satunya gangguan siklus menstruasi, metrorhagia, menorhagia. Akseptor sering menghentikan kontrasepsi hormonal karena gangguan siklus menstruasi. Tujuan penelitian: Diketahuinya hubungan kontrasepsi hormonal dengan siklus menstruasi. Metode : Penelitian ini merupakan penelitian deskriptif kuantitatif dengan pendekatan cross sectional. Populasi yang digunakan adalah 80 ibu akseptor kontrasepsi hormonal, dimana pengambilan sampel secara total sampling. Analisa bivariat  dengan uji chi-square (α) ≤ 0,05 dan Prevalence Ratio (PR). Hasil: Sebagian besar responden kontrasepsi hormonal progestin 36 (85,7 %) dan lebih dari setengah responden kontrasepsi hormonal kombinasi 20 (52,6 %) mengalami ketidaknormalan siklus menstruasi. Hasil uji statistik chi square menunjukkan bahwa ada hubungan antara kontrasepsi hormonal dengan siklus menstruasi (p=0,0030,05) dan PR 1,629 (CI=1,176-2,256) Simpulan: Terdapat hubungan antara penggunaan alat kontrasepsi hormonal dengan siklus menstruasi, akseptor kontrasepsi hormonal progestin beresiko 1,6 kali lebih besar mengalami ketidaknormalan siklus menstruasi dibanding akseptor kontrasepsi hormonal kombinasi.Background: Hormonal contraception is a contraceptive containing progestin-only hormones or a combination of estrogen and progestin content. Hormonal contraceptive methods have many side effects, one of which is menstrual cycle disorders, metrorhagia, menorhagia. Acceptors often stop hormonal contraception because of menstrual cycle disorders. Objectives: Knowed the relationship of hormonal contraception with the menstrual cycle. Method: This study is a quantitative descriptive study with cross sectional approach. The population used was 80 mothers of hormonal contraceptive acceptors, where total sampling was taken. Bivariate analysis with chi-square test (α) ≤ 0.05 and Prevalence Ratio (PR). Results: Most respondents of progestin hormonal contraception 36 (85.7%) and more than half of the respondents in combination hormonal contraception 20 (52.6%) experienced abnormal menstrual cycles. Chi square statistical test results show that there is a relationship between hormonal contraception with the menstrual cycle (p = 0.003 0.05) and PR 1.629 (CI = 1,176-2,256) Conclusion: There is a relationship between the use of hormonal contraception with the menstrual cycle, Progestin hormonal contraceptive acceptors are 1.6 times more likely to experience abnormal menstrual cycles than combined hormonal contraceptive acceptors.

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