scholarly journals Comparison of the Physical Characteristics and Behavior in ABC Transporter A1, A7 or Apolipoprotein E Knockout Mice with Lipid Transport Dysfunction

2021 ◽  
Vol 44 (12) ◽  
pp. 1851-1859
Author(s):  
Hiromi Tsushima ◽  
Kazuyo Yamada ◽  
Daisuke Miyazawa ◽  
Takeshi Ohkubo ◽  
Makoto Michikawa ◽  
...  
2006 ◽  
Vol 136 (2) ◽  
pp. 353-359 ◽  
Author(s):  
José M. Arbonés-Mainar ◽  
María A. Navarro ◽  
Sergio Acín ◽  
Mario A. Guzmán ◽  
Carmen Arnal ◽  
...  

2003 ◽  
Vol 90 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Maria C. G. Peluzio ◽  
Emir Miguel ◽  
Thaís C. Drumond ◽  
Giovana C. César ◽  
Helton C. Santiago ◽  
...  

We studied the effects of α-tocopheryl acetate supplementation on the development of fatty streaks and its ability to modulate the expression of monocyte chemoattractant protein (MCP)-1 in aortic lesions of apoliprotein E knockout mice. For this purpose, 16-week-old apolipoprotein E knockout mice received α-tocopherol supplemention ((800 mg)/kg diet) for 6 weeks. After this time, total and lipoprotein cholesterol in the serum, hepatic tocopherol, aortic lesion area and MCP-1 (protein and mRNA) expression were analysed. Our present results showed that the dietary supplementation with α-tocopherol did not reduce serum cholesterol nor change lipoprotein profile, but it reduced the area of the aortic lesion by 55%. The reduction in the lesion size was correlated with the reduced expression of MCP-1 mRNA and protein, as detected by real-time quantitative polymerase chain reaction and immunohistochemistry respectively. In conclusion, the results obtained here are relevant to the study of atherosclerosis, as they correlate the effectiveness of vitamin E supplementation in inhibiting the plaque formation with diminished expression of MCP-1 at the aortic lesion.


2012 ◽  
Vol 76 (8) ◽  
pp. 2031-2040 ◽  
Author(s):  
Kaori Higuchi ◽  
Yoshikazu Nakaoka ◽  
Wataru Shioyama ◽  
Yoh Arita ◽  
Takahiro Hashimoto ◽  
...  

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